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Journal of Analysis and Testing 2020年第1期4卷 1-12页

作者： ya-li bai Zhi-Dan Hong Tian-Yi Zhang Bao-Dong Cai Yuan-Zhen Zhang Yu-Qi Feng Department of Chemistry Wuhan UniversityWuhan 430072People’s Republic of China Frontier Science Center for Immunology and Metabolism Wuhan UniversityWuhanPeople’s Republic of China Zhongnan Hospital Wuhan UniversityWuhan 430072HubeiPeople’s Republic of China

An improved method is described for the fast and sensitive determination of multiple endogenous steroid hormones in steroidogenic pathway by liquid chromatography-tandem mass spectrometry(LC-MS/MS),in which serum samples,after a simple protein precipitation and a derivatization by 2-hydrazinopyridine(HP),were subjected to LC-MS *** protein precipitation of serum samples is achieved via adding acetonitrile,while the derivatization of endogenous steroid hormones in serum samples after protein precipitation is performed using 2-hydrazinopyridine as a derivatization *** derivatives of the steroid hormones exhibit good detection sensitivity in LC-MS *** range of the improved method for the target steroid hormones is in two orders of magnitude and the correlation coefficients(r)are in the range from 0.9885 to *** limits of detection(signal/noise=3)range from 0.07 to 65.26 ng/*** recoveries are between 80.2 and 116.4%with acceptable intra-and inter-day relative standard deviations(RSDs)ranging from 0.3 to 18.9%.The improved method can be applied to explore the differences of steroid hormones between healthy controls and polycystic ovary syndrome patients.

关键词： Steroid profiling Polycystic ovary syndrome 2-Hydrazinopyridine LC-MS/MS

AI enhances drug discovery and development

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National Science Review 2024年第3期11卷 52-54页

作者： Fang bai Shiliang li Honglin li Shanghai Institute for Advanced Immunochemical Studies and School of life Science and Technology ShanghaiTech University lingang Laboratory Innovation Center for AI and Drug Discovery East China Normal University

The advent of the third wave of artificial intelligence(AI) heralds a new era in drug discovery. AI-powered techniques can be characteristic of identifying features that are difficult for humans to interpret from big ...

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Shexiang Tongxin Dropping Pill Promotes Angiogenesis through VEGF/eNOS Signaling Pathway on Diabetic Coronary Microcirculation Dysfunction

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Chinese Journal of Integrative Medicine 2024年第10期30卷 886-895页

作者： CUI Xin-yu liU Tian-hua bai ya-li ZHANG Meng-di li Guo-dong ZHANG Yu-ting YUAN Yue-ying ZHANG ya-wen YU li-shuang HAN li-na WU yan School of Traditional Chinese Medicine Beijing University of Chinese Medicine Key Laboratory of Traditional Chinese Medicine Syndrome and Formula Ministry of Education Beijing University of Chinese Medicine Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine

Objective: To study the effect of Shexiang Tongxin Dropping Pill(STDP) on angiogenesis in diabetic cardiomyopathy mice with coronary microcirculation dysfunction(CMD). Methods: According to a random number table, 6 of 36 SPF male C57BL/6 mice were randomly selected as the control group, and the remaining 30 mice were injected with streptozotocin intraperitoneally to replicate the type 1 diabetes model. Mice successfully copied the diabetes model were randomly divided into the model group, STDP low-dose group [15 mg/(kg·d)], medium-dose group [30 mg/(kg·d)], high-dose group [60 mg/(kg·d)], and nicorandil group [15 mg/(kg·d)], 6 in each group. The drug was given by continuous gavage for 12 weeks. The cardiac function of mice in each group was detected at the end of the experiment, and coronary flow reserve(CFR) was detected by chest Doppler technique. Pathological changes of myocardium were observed by hematoxylin-eosin staining, collagen fiber deposition was detected by masson staining, the number of myocardial capillaries was detected by platelet endothelial cell adhesion molecule-1 staining, and the degree of myocardial hypertrophy was detected by wheat germ agglutinin staining. The expression of the vascular endothlial growth factor(VEGF)/endothelial nitric oxide synthase(eNOS) signaling pathway-related proteins in myocardial tissue was detected by Western blot. Results: Compared with the model group, medium-and high-dose STDP significantly increased the left ventricular ejection fraction and left ventricular fraction shortening(Plial growth factor receptor 2, phosphoinositide 3-kinase, protein kinase B, and eNOS(P<0.05 or P<0.01). Co

关键词： Shexiang Tongxin Dropping Pill angiogenesis coronary microcirculation dysfunction diabetic cardiomyopathy type 1 diabetes

High-lattice-adapted surface modifying Na_(4)MnV(PO_(4))_(3) for better sodium storage

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Nano Research 2024年第4期17卷 2728-2735页

作者： Chongran Song Shiyu li Ying bai International Joint Research Laboratory of New Energy Materials and Devices of Henan Province School of Physics and ElectronicsAcademy for Advanced Interdisciplinary StudiesHenan UniversityKaifeng 475004China

Sodium-ion batteries(SIBs)are required to possess long cycle life when used for large-scale energy *** polyanionic Na_(4)MnV(PO_(4))_(3)(NMVP)reveals good cyclic stability due to its unique three-dimensional(3D)frame structure,but it still faces the challenge of interfacial degradation in practical *** this work,NASICON-type Na_(1.3)Al_(0.7)Ti_(1.3)(PO_(4))_(3)(NATP)was deposited on the surface of NMVP to promote interface stability by surface modification and gradient *** a result,the optimized NMVP@2%NATP released a capacity retention of 44.8%after 1000 cycles at 5 C,much higher than that of the initial NMVP(28.9%).The enhanced electrochemical performance was mainly attributed to NATP coating acting as a fast ion transport carrier and physical barrier,significantly facilitating the Na^(+)diffusion and isolating side reaction at the electrode/electrolyte *** the other hand,Ti_(4)^(+)and Al^(3+)cations from the NATP were partially doped inside the NMVP surface to boost the transport of Na^(+),and the perfect lattice matching of NVMP and NATP improved the interface and structural stability accompanying long *** work demonstrated the effectiveness of surface modification with high lattice match material and provided new perspectives for high energy density solid-state SIBs.

关键词： high-lattice-adapted cathode surface modification sodium-ion batteries

Continuous-flow synthesis of polysubstituted γ-butyrolactones via enzymatic cascade catalysis

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Chinese Chemical Letters 2024年第4期35卷 404-408页

作者： liliang Chu Xiaoyan Zhang Jianing li Xuelei Deng Miao Wu ya Cheng Weiping Zhu Xuhong Qian Yunpeng bai State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China The Extreme Optoelectromechanics Laboratory School of Physics and Materials ScienceEast China Normal UniversityShanghai 200241China

Polysubstituted chiral γ-butyrolactones are the core structural units of many natural products and high value-added flavors and fragrances used in the food and cosmetic industry. Current enzymatic cascade synthesis of these molecules faces the problems of low enzyme activity and phase separation in batch reaction, resulting in low productivity. Herein, we report a new continuous-flow process to synthesize the optically pure Nicotiana tabacum lactone(3S,4S)-4a and whisky lactone(3R,4S)-4b from α,β-unsaturatedγ-ketoesters. A new ene reductase(ER) from Swingsia samuiensi(Ss ER) and a carbonyl reductase(Ss CR)were engineered by directed evolution to improve their activity and thermostability. The continuous-flow preparative reactions were performed in two 3D microfluidic reactors, generating(3S,4S)-4a(99% ee and87% de) and(3R,4S)-4b(99% ee and 98% de) with space-time yields 3 and 7.4 times higher than those of the batch reactions. The significant enhancement in the productivity of enzyme cascade catalysis brought by cutting-edge continuous microfluidic technology will benefit the general multi-enzyme catalytic systems in the future.

关键词： Enzyme catalysis Cascade catalysis Directed evolution Continuous-flow γ-Butyrolactones

Stellar Populations of AGN-host Dwarf Galaxies Selected with Different Methods

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Research in Astronomy and Astrophysics 2024年第6期24卷 52-67页

作者： Xiejin li 赵应和 Jinming bai Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650011China

In this paper we investigate the stellar populations and star formation histories of 235 active galactic nucleus(AGN)-host dwarf galaxies,consisting of four samples identified separately with different methods(i.e.,radio,X-ray,mid-IR and variability),utilizing the synthesis code STARliGHT and spectra from the Sloan Digital Sky Survey Data Release *** results show that the variability sample is the oldest,while the mid-IR sample is the youngest,for which the luminosity at 4020?is dominated(>50%)by the young population(tlight-weighted mean stellar age of the whole sample is in general about 0.7 dex younger than the optical sample studied in Cai et *** compare the population results between fitting models with and without a power-law(PL)component and find that the neglect of a PL component would lead to an under-and over-estimation by 0.2 and0.1 dex for the light-and mass-weighted mean stellar age,respectively,for our sample of dwarf galaxies,which has a mean fractional contribution of~16%from the *** addition,we obtain further evidence for a possible suppression of star formation in the host galaxy by the central *** also find that there exists an anticorrelation between the extinction-corrected[O III]luminosity and light-weighted mean stellar age,confirming our previous finding that there is a physical connection between AGN and star-forming activities in AGN-host dwarfs.

关键词： galaxies:dwarf galaxies:active galaxies:stellar content

Effects of Number of Bleed Holes on Shock-Wave/Boundary-Layer Interactions in a Transonic Compressor Stator

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Journal of Thermal Science 2024年第2期33卷 611-624页

作者： li bai ZHOU Xun LUO Lei DU Wei School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China

An extensive numerical investigation is conducted to characterize the flow separation control in a transonic compressor cascade with a porous *** bleed holes are arranged on the suction surface in a single row,two staggered rows and three staggered *** each bleed scheme,five bleed pressure ratios are examined at an inlet Mach number of *** results indicate that the aerodynamic performance of the cascade is significantly improved by the porous *** the single-row scheme,the maximum reduction in total pressure losses is 57%.For the two-staggered-row and three-staggered-row schemes,there is an optimal bleed pressure ratio of 1.0,and the maximum reductions in total pressure loss are 68% and 75%,*** low loss in the cascade is due to the well-controlled boundary *** new local supersonic region created by the bleed hole is the key reason for the improved boundary *** vortex induced by side bleeding provides another mechanism for delaying flow *** the bleed holes could create multiple local supersonic regions,which reduce the range of the adverse pressure gradient that the boundary layer needs to *** is the reason why cascades with more bleed holes perform better.

关键词： transonic compressor stator shock wave/boundary layer interaction porous bleed number of bleed holes

GCAGA: A Gini Coefficient-Based Optimization Strategy for Computation Offloading in Multi-User-Multi-Edge MEC System

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Computers, Materials & Continua 2024年第6期79卷 5083-5103页

作者： Junqing bai Qiuchao Dai Yingying li School of Computing Xi’an Shiyou UniversityXi’an710065China Product Center Wingtech Technology(Wuxi)Co.Wuxi214028China

To support the explosive growth of Information and Communications Technology(ICT),Mobile Edge Comput-ing(MEC)provides users with low latency and high bandwidth service by offloading computational tasks to the network’s ***,resource-constrained mobile devices still suffer from a capacity mismatch when faced with latency-sensitive and compute-intensive emerging *** address the difficulty of running computationally intensive applications on resource-constrained clients,a model of the computation offloading problem in a network consisting of multiple mobile users and edge cloud servers is studied in this *** a user benefit function EoU(Experience of Users)is proposed jointly considering energy consumption and time *** EoU maximization problem is decomposed into two steps,i.e.,resource allocation and offloading *** offloading decision is usually given by heuristic algorithms which are often faced with the challenge of slow convergence and poor ***,a combined offloading algorithm,i.e.,a Gini coefficient-based adaptive genetic algorithm(GCAGA),is proposed to alleviate the *** proposed algorithm optimizes the offloading decision by maximizing EoU and accelerates the convergence with the Gini *** simulation compares the proposed algorithm with the genetic algorithm(GA)and adaptive genetic algorithm(AGA).Experiment results show that the Gini coefficient and the adaptive heuristic operators can accelerate the convergence speed,and the proposed algorithm performs better in terms of convergence while obtaining higher *** simulation code of the proposed algorithm is available:https://***/Grox888/Mobile_Edge_Computing/tree/GCAGA.

关键词： Mobile edge computing multi-user-multi-edge joint optimization Gini coefficient adaptive genetic algorithm

Variations of sediment organic phosphorus and organic carbon during the outbreak and decline of algal blooms in Lake Taihu,China

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Journal of Environmental Sciences 2024年第5期139卷 34-45页

作者： Jiehua Wang Xiuling bai Wenchao li Pingping Zhang Mengdi Zhang Haoran Wang Yingge bai College of Geography and Environmental Science Henan UniversityKaifeng 475004China Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of EducationKaifeng 475004China National Demonstration Center for Environment and Planning Henan UniversityKaifeng 475004China Surrey International Institute Dongbei University of Finance and EconomicsDalian 116000China

In this study,sediment organic phosphorus(OP)and organic carbon(OC)in Lake Taihu,China,as well as their relationships,were analyzed during the outbreak and decline of algal blooms(ABs)over a five-month field *** results showed synchronous temporal changes in the sediment OP and OC contents with the development of *** addition,there was a significant positive correlation between the sediment OP and OC(plipids and DNA-P)and orthophosphate monoester during the ABs outbreak and decline,*** active OC contents and proportions in the sediments in the ABs outbreak were significantly lower than those observed in the ABs decline period,demonstrating the significant impacts of the ABs outbreak and decline on the sediment OC and OP in Lake Taihu.

关键词： Algal blooms Organic phosphorus Organic carbon Sediment ^(31)P NMR Lake Taihu

SCAB1 coordinates sequential Ca^(2+) and ABA signals during osmotic stress induced stomatal closure in Arabidopsis

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Science China(life Sciences) 2024年第1期67卷 1-18页

作者： Tianren Zhang li bai yan Guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China

Hyperosmotic stress caused by drought is a detrimental threat to plant growth and agricultural productivity due to limited water *** are gateways of transpiration and gas exchange,the swift adjustment of stomatal aperture has a strong influence on plant drought *** intensive investigations of stomatal closure during drought stress in past decades,little is known about how sequential signals are integrated during complete ***,we discovered that the rapid Ca^(2+) signaling and subsequent abscisic acid(ABA)signaling contribute to the kinetics of both F-actin reorganizations and stomatal closure in Arabidopsis thaliana,while STOMATAL CLOSURE-RELATED ACTIN BINDING PROTEIN1(SCAB1)is the molecular switch for this entire *** the early stage of osmotic shock responses,swift elevated calcium signaling promotes SCAB1 phosphorylation through calcium sensors CALCIUM DEPENDENT PROTEIN KINASE3(CPK3)and *** phosphorylation restrained the microfilament binding affinity of SCAB1,which bring about the Factin disassembly and stomatal closure *** the osmotic stress signal continued,both the kinase activity of CPK3 and the phosphorylation level of SCAB1 attenuated *** further found that ABA signaling is indispensable for these attenuations,which presumably contributed to the actin filament reassembly process as well as completion of stomatal ***,the dynamic changes of SCAB1 phosphorylation status are crucial for the kinetics of stomatal *** together,our results support a model in which SCAB1 works as a molecular switch,and directs the microfilament rearrangement through integrating the sequentially generated Ca^(2+) and ABA signals during osmotic stress induced stomatal closure.

关键词： calcium signal ABA stomatal movement microfilaments kinase