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Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer’s disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： Wei-wei Jia Hua-wei Lin Min-guang yang ya-ling Dai yan-yi Ding Wen-shan Xu Si-nuo Wang ya-jun Cao Sheng-xiang liang Zhi-fu Wang Cong Chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina The Institute of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

Objective Studies have shown that electroacupuncture(EA)can alleviate cognitive impairments from Alzheimer’s disease(AD)by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK),but the specific mechanism involved remains to be ***,this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial *** The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKα1-subunit conditional knockout(AMPKα1-cKO)were used for *** evaluate the effects of EA treatment on cognitive function,the T-maze and Morris water maze were *** addition,chemical exchange saturation transfer,thioflavin staining,transmission electron microscopy,mitochondrial membrane potential,and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 *** Both APP/PS1 mice and AMPKα1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory *** of the AMPK/peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)pathway increased pathological amyloid-β(Aβ)deposition and aggravated the dysfunction in mitochondrial *** addition,EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1αpathway,specifically by reducing pathological Aβdeposition,normalizing energy metabolism,protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins,and downregulating the expression of fission ***,the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by AMPKα1 *** The regulation of hippocampal mitochondrial dynamics and reduction in Aβdeposition via the AMPK/PGC-1αpathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics

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Global existence and large-time behavior for primitive equations with the free boundary

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Science China Mathematics 2024年第10期67卷 2303-2330页

作者： Hai-liang Li Chuangchuang liang School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Academy for Multidisciplinary Studies Capital Normal UniversityBeijing 100048China College of Mathematics and Statistics Chongqing UniversityChongqing 401331China

In the present paper, the primitive equations, which can be used to simulate the large-scale motion of the ocean and atmosphere, are considered in the three-dimensional domain bounded below by a fixed solid boundary and above by a free-moving boundary. The global existence and uniqueness of strong solutions are established, and the long-time convergence to the equilibrium state is shown to be either at an exponential rate for the horizontal periodic domain or at an algebraic rate for the horizontal whole space.

关键词： primitive equations the free boundary value problem global well-posedness large-time behavior

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Sufficient Conditions for Amalgamated 3-Manifolds to be ∂-Irreducible

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 161-172页

作者： Bing FANG Fengchun LEI liang liang School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina School of Mathematics Liaoning Normal UniversityDalian 116029LiaoningChina

In this paper,the authors give some sufficient conditions for an amalgamated 3-manifold along a compact connected surface F with boundary to be ∂-irreducible in terms of distances between some kinds of vertex subsets ... 详细信息

关键词： ∂-Irreducibility Irreducibility Amalgamated 3-manifold Curve complex Arc complex

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Towards net zero carbon buildings:Accounting the building embodied carbon and life cycle-based policy design for Greater Bay Area,China

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Geoscience Frontiers 2024年第3期15卷 284-297页

作者： Hanwei liang Xin Bian liang Dong Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Research Center of Urban Sustainable Development/School of Geographical Sciences Nanjing University of Information Science&Technology(NUIST)Nanjing 210044China Department of Architecture and Civil Engineering Chalmers University of TechnologySE-41296 GothenburgSweden Shenzhen Research Institute(SRI) City University of Hong KongShenzhenChina Department of Public and International Affairs(PIA) City University of Hong Kong999077Hong Kong Special Administrative Region School of Energy and Environment(SEE) City University of Hong Kong999077Hong Kong Special Administrative RegionChina Centre for Public Affairs and Law City University of Hong Kong999077Hong Kong Special Administrative RegionChina

Carbon mitigation of buildings is critical to promote a net-zero *** international society has vigorously promoted‘‘Net Zero Carbon Buildings”across the globe,and accounting for building carbon emissions is critical to support this *** carbon,which represents carbon emissions from the entire lifecycle of the buildings,is fundamental for realizing the idea of zero ***,only limited studies have been conducted so far that take into account the city *** paper aimed to act as a first try to account for the embodied carbon emissions in buildings in 2020 for the Guangdong-Hong Kong Macao Greater Bay Area in China(GBA).We integrated remote sensing techniques such as night-time light data(NLT)and building material flows analysis to calculate and spatialize the newly generated building material stocks(MS).Based on the MS data,we further applied life cycle assessment(LCA)to assess the embodied carbon in the *** results highlighted that over 163 million tons of embodied carbon in buildings of GBA are expected to be generated,from 497 million tons of newly generated building MS in *** embodied carbon in each life cycle stage is valuable for further lifecyclebased policy designs for:(i)supporting the updating of the green building certification system with consideration of the embodied carbon;(ii)promoting the green building material application and certification;and(iii)reducing the embodied carbon intensity from compact urban planning policy,such as the urban agglomeration policies in *** goal of this paper was to shed a light on reducing carbon emissions from the perspective of the entire lifecycle and promote the development of net zero carbon buildings in China and Asia-Pacific.

关键词： Net zero carbon building Embodied carbon Life cycle assessment Life cycle-based policies Greater Bay area

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Reliability Assessment of a New General Matching Composed Network

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China Communications 2024年第2期21卷 245-257页

作者： Zhengyuan liang Junbin liang Guoxuan Zhong Guangxi Key Laboratory of Multimedia Communications and Network Technology School of ComputerElectronics and InformationGuangxi UniversityNanning 530004China Jiangxi Engineering Laboratory of IoT Technologies for Crop Growth Ji’an 343000China

The reliability of a network is an important indicator for maintaining communication and ensuring its stable operation. Therefore, the assessment of reliability in underlying interconnection networks has become an increasingly important research issue. However, at present, the reliability assessment of many interconnected networks is not yet accurate,which inevitably weakens their fault tolerance and diagnostic capabilities. To improve network reliability,researchers have proposed various methods and strategies for precise assessment. This paper introduces a novel family of interconnection networks called general matching composed networks(gMCNs), which is based on the common characteristics of network topology structure. After analyzing the topological properties of gMCNs, we establish a relationship between super connectivity and conditional diagnosability of gMCNs. Furthermore, we assess the reliability of g MCNs, and determine the conditional diagnosability of many interconnection networks.

关键词： conditional diagnosability interconnection networks network reliability super connectivity

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Efficacy of scleral buckling for the treatment of rhegmatogenous retinal detachment using a novel foldable capsular buckle

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 558-563页

作者： Fang-Fang Fan Chang Xiao liang Wang Xin-Ting Wang Dan-Dan Liu Xing Ge ya-Lu Liu Su-yan Li The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University Xuzhou 221000Jiangsu ProvinceChina Department of Ophthalmology Xuzhou First People’s HospitalXuzhou 221116Jiangsu ProvinceChina Eye Disease Prevention and Treatment Institute of Xuzhou Xuzhou 221116Jiangsu ProvinceChina The Affiliated Shuyang Hospital of Xuzhou Medical University Shuyang 223600Jiangsu ProvinceChina

●AIM:To evaluate the effectiveness and safety of scleral buckling for the treatment of rhegmatogenous retinal detachment(RRD)using a novel foldable capsular buckle(FCB).●METHODS:This was a series of case observation *** patients(18 eyes)who visited our ophthalmology department between August 2020 and August 2022 and were treated for RRD with scleral buckling using FCB were *** procedure was similar to conventional scleral buckling,while a balloon-like FCB was placed onto the retinal break with balanced salt solution filling for a broad,external indentation instead of the silicone *** retinal reattachment rate,best corrected visual acuity(BCVA),intraocular pressure(IOP),refractive dioptre and astigmatism degree,and complications were evaluated and recorded.●RESULTS:There were 7 males and 11 females aged *** average time course of RRD was 12d,ranging from *** retinal break was located in the superior quadrants in 8 eyes and in the inferior quadrants in 10 eyes,with macula-off detachments in 12 *** patients were followed-up for at least *** final retinal reattachment rate was 100%.The BCVA was significantly improved compared with the baseline(P0.05).Three patients had transiently high IOPs within one week after *** diplopia occurred in 5 patients after surgery and then disappeared after the balloon fluid was removed.●CONCLUSION:The success rate of FCB scleral buckling for RRD is *** procedure can be expected to be applied in new,uncomplicated cases of RRD.

关键词： rhegmatogenous retinal detachment scleral buckling foldable capsular buckle

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Baicalin Prevents Colon Cancer by Suppressing CDKN2A Protein Expression

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1007-1017页

作者： LI Gang-gang CHU Xiu-feng XING ya-min XUE Xia Ihtisham Bukhari liang Xin-feng XU Ji-xuan MI yang ZHENG Peng-yuan Henan Key Laboratory of Helicobacter pylori Microbiota and Gastrointestinal Cancers Marshall Medical Research Center Fifth Affiliated Hospital of Zhengzhou University

Objective:To observe the therapeutic effects and underlying mechanism of baicalin against colon ***:The effects of baicalin on the proliferation and growth of colon cancer cells MC38 and *** were observed and predicted potential molecular targets of baicalin for colon cancer therapy were studied by network ***,molecular docking and drug affinity responsive target stability（DARTS）analysis were performed to confirm the interaction between potential targets and ***,the mechanisms predicted by in silico analyses were experimentally verified in-vitro and ***:Baicalin significantly inhibited proliferation,invasion,migration,and induced apoptosis in MC38 and CT26 cells（all P<0.01）.Additionally,baicalin caused cell cycle arrest at the S phase,while the G0/G1phase was detected in the tiny portion of the *** network pharmacology analysis identified 6 therapeutic targets associated with baicalin,which potentially affect various pathways including 39 biological processes and 99 sugnaling *** addition,molecular docking and DARTS predicted the potential binding of baicalin with cyclin dependent kinase inhibitor 2A（CDKN2A）,protein kinase B（AKT）,caspase 3,and mitogen-activated protein kinase（MAPK）.In vitro,the expressions of CDKN2A,MAPK,and p-AKT were suppressed by baicalin in MC38 and CT26 *** vivo,baicalin significantly reduced the tumor size and weight（all P<0.01） in the colon cancer mouse model via inactivating p-AKT,CDKN2A,cyclin dependent kinase 4,cyclin dependent kinase 2,interleukin-1,tumor necrosis factor α,and activating caspase 3 and mouse double minute 2 homolog signaling（all P<0.05）.Conclusion:Baicalin suppressed the CDKN2A protein level to prevent colon cancer and could be used as a therapeutic target for colon cancer.

关键词： CDKN2A apoptosis baicalin cell cycle colon cancer network pharmacology

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Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 844-856页

作者： Yu-liang Zhang Zi-Rong Liu Zhi Liu Yi Bai Hao Chi Da-Peng Chen ya-Min Zhang Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of cancers worldwide,ranking fifth among men and seventh among women,resulting in more than 7 million deaths *** the development of medical tech-nology,the 5-year survival rate of HCC patients can be increased to 70%.How-ever,HCC patients are often at increased risk of cardiovascular disease(CVD)death due to exposure to potentially cardiotoxic treatments compared with non-HCC ***,CVD and cancer have become major disease burdens ***,further research is needed to lessen the risk of CVD death in HCC patient *** This study was conducted on the basis of the Surveillance,Epidemiology,and End Results database and included HCC patients with a diagnosis period from 2010 to *** independent risk factors were identified using the Fine-Gray model.A nomograph was constructed to predict the CVM in HCC *** nomograph performance was measured using Harrell’s concordance index(C-index),calibration curve,receiver operating characteristic(ROC)curve,and area under the ROC curve(AUC)***,the net benefit was estimated via decision curve analysis(DCA).RESULTS The study included 21545 HCC patients,of whom 619 died of ***(5 cm:2.090(1.543-2.830),P<0.001],surgery(no)[0.376(0.297-0.476),P<0.001],and chemotherapy(none/unknown)[0.578(0.472-0.709),P<0.001]were independent risk factors for CVD death in HCC *** discrimination and calibration of the nomograph were *** C-index values for the training and validation sets were 0.736 and 0.665,*** AUC values of the ROC curves at 2,4,and 6 years were 0.702,0.725,0.740 in the training set and 0.697,0.710,0.744 in the validation set,*** calibration curves showed that the

关键词： Hepatocellular carcinoma Cardiovascular disease deaths Fine-Gray model Risk factor Nomograph Predict

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Dynamics of information diffusion and disease transmission in time-varying multiplex networks with asymmetric activity levels

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Chinese Physics B 2024年第3期33卷 690-699页

作者：谢笑笑霍良安董雅芳程英英 Business School University of Shanghai for Science and TechnologyShanghai 200093China School of Intelligent Emergency Management University of Shanghai for Science and TechnologyShanghai 200093China School of Management Henan University of Science and TechnologyLuoyang 471023China

While the interaction between information and disease in static networks has been extensively investigated,many studies have ignored the characteristics of network *** this study,we construct a new two-layer coupling model to explore the interactions between information and *** upper layer describes the diffusion of disease-related information,and the lower layer represents the disease *** then use power-law distributions to examine the influence of asymmetric activity levels on dynamic propagation,revealing a mapping relationship characterizing the interconnected propagation of information and diseases among partial nodes within the ***,we derive the disease outbreak threshold by using the microscopic Markov-chain approach(MMCA).Finally,we perform extensive Monte Carlo(MC)numerical simulations to verify the accuracy of our theoretical *** findings indicate that the activity levels of individuals in the disease transmission layer have a more significant influence on disease transmission compared with the individual activity levels in the information diffusion ***,reducing the damping factor can delay disease outbreaks and suppress disease transmission,while improving individual quarantine measures can contribute positively to disease *** study provides valuable insights into policymakers for developing outbreak prevention and control strategies.

关键词： information diffusion disease transmission asymmetric activity levels quarantine strength

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Non-interactive SM2 threshold signature scheme with identifiable abort

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Frontiers of Computer Science 2024年第1期18卷 171-185页

作者： Huiqiang liang Jianhua CHEN School of Mathematics and Statistics Wuhan UniversityWuhan 430072China

A threshold signature is a special digital signature in which the N-signer share the private key x and can construct a valid signature for any subset of the included t-signer,but less than t-signer cannot obtain any *** the breakthrough achievements of threshold ECDSA signature and threshold Schnorr signature,the existing threshold SM2 signature is still limited to two parties or based on the honest majority setting,there is no more effective solution for the multiparty *** make the SM2 signature have more flexible application scenarios,promote the application of the SM2 signature scheme in the blockchain system and secure cryptocurrency *** paper designs a non-interactive threshold SM2signature schemebasedon partially homomorphic encryption and zero-knowledge *** the last round requires the message input,so make our scheme non-interactive,and the pre-signing process takes 2 rounds of communication to complete after the key *** allow arbitrary threshold t

关键词： SM2 signature secure multi-party computation threshold signature UC-secure dishonest majority

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