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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng yang xiao xiao Hao yan Tian-Lan Lu jun Li Yun-Dan Liao Zhe-wei Kang Li-fang Wang Yue Li Ming Li Bing liu hai-Liang Huang Lu-Xian Lv Yin yao Yun-Long Tan Gerome Breen Ian Everall hong-Xing Wang Zhuo Huang Dai Zhang wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking university Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

Theoretical analysis of the double-differential cross-sections of neutron,proton,deuteron,^(3)He,andαfor the p+^(6) Li reaction

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Nuclear Science and Techniques 2024年第3期35卷 181-197页

作者： fang-Lei Zou xiao-jun Sun Jing-Shang Zhang hai-Rui Guo Yin-Lu Han Rui-Rui Xu Xi Tao Ji-Min Wang xiao-Dong Sun Yuan Tian Tao Ye Yong-Li Xu Chun-Tian Liang college of Physics Guangxi Normal University541004 GuilinChina Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology 541004 GuilinChina China Institute of Atomic Energy P.O.Box 275(41)102413 BeijingChina Institute of Applied Physics and Computational Mathematics 10094 BeijingChina college of Physics and Electronic Shanxi Datong University037009 DatongChina School of Science Tianjin Chengjian University300384 TianjinChina

Based on the unified Hauser–Feshbach and exciton model,which can describe the particle emission processes between discrete energy levels with energy,angular momentum,and parity conservations,a statistical theory of light nucleus reaction(STLN)is developed to calculate the double-differential cross-sections of the outgoing neutron and light charged particles for the proton-induced^(6) Li reaction.A significant difference is observed between the p+^(6) Li and p+^(7) Li reactions owing to the discrepancies in the energy-level structures of the *** reaction channels,including sequential and simultaneous emission processes,are analyzed in *** the double-differential cross-sections of the outgoing proton as an example,the influence of contaminations(such as^(1) H,^(7)Li,^(12)C,and^(16)O)on the target is identified in terms of the kinetic energy of the first emitted *** optical potential parameters of the proton are obtained by fitting the elastic scattering differential *** calculated total double-differential cross-sections of the outgoing proton and deuteron at E_(p)=14 MeV agree well with the experimental data for different outgoing ***,the mixed double differential cross-sections of^(3) He andαare in good agreement with the *** agreement between the measured data and calculated results indicates that the two-body and three-body breakup reactions need to be considered,and the pre-equilibrium reaction mechanism dominates the reaction *** on the STLN model,a PLUNF code for the p+^(6) Li reaction is developed to obtain an ENDF-6-formatted file of the double-differential cross-sections of the nucleon and light composite charged particles.

关键词： Statistical theory of light nucleus reaction p+^(6)Li reaction Light composite charged particle Double-differential cross-sections Two-body breakup Three-body breakup

Azomethine ylide-formation from N-phthaloylglycine by photoinduced decarboxylation:A theoretical study

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中国科学:化学 2012年第10期42卷 1499-1500页

作者： fang Qiu,DING LiNa & fang weihai* college of chemistry,beijing normal university,beijing 100875,China college of chemistry beijing normal university beijing 100875 China

In this work,we report the first CASPT2//CASSCF study of the mechanism of the photodecarboxylation of *** charge transfer excited state SCT(1ππ*) is initially populated upon irradiation at 266 *** a result of a fast internal conversion to the lowest excited singlet state SCT-N(1ππ*),this state becomes a favorable precursor state for proton transfer,which triggers ***,the excited state intramolecular proton transfer(ESIPT) and decarboxylation processes proceed in an asynchronous concerted *** ESIPT process is accomplished in the SCT-N(1ππ*) state,but the CO2 molecule is finally formed in the ground state via the SCT/S0 conical *** ylide is formed in the ground state as a complex with CO2.A barrier of ～15 kcal/mol indicates that azomethine ylide is stable in the ground state,which is consistent with the experimental *** work provides mechanistic details about the formation of azomethine ylide by photoreaction of N-phthaloylglycine.

关键词： N-phthaloylglycine photodecarboxylation excited state intramolecular proton transfer CASPT2//CASSCF method

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-Lin Xiong Xiang-yang Wen Xin-Qiao Li Ce Cai Shuo xiao Qi Luo Wen-Xi Peng Dong-ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao yan-Qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang Jing Duan Chen-wei Wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-yang Li yan-Bing Xu xiao-Hua Liang ya-Qing liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng yang xiao-Jing liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li hong-Mei Zhang Yue Zhu wei Chen Jian-Jian He Zhen Zhang Jin Hou hong-jun Wang yan-Chao Hao Xiang-Yu Wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao xiao-Fei Lan yan-Guo Li Gang Li Xu-fang Li fang-jun Lu hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-wei yang Xue-Juan yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science college China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Spatially explicit reconstruction of cropland cover in Europe from AD 1800 to 2000

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Science China Earth Sciences 2024年第9期67卷 2953-2971页

作者： jun LI Yu YE Xiuqi fang Diyang ZHANG Zhilei WU Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster Ministry of EducationBeijing Normal UniversityBeijing 100875China college of Geographical Science Qinghai Normal UniversityXining 810016China

One of the challenges in global change research is the significant uncertainty in global historical land use and land cover(LUCC)datasets,which are widely used as foundational *** addition to the regional cropland area reconstructions,improving the grid allocation method is another feasible way to raise the reliability of historical LUCC *** this study,an integrated reconstruction of the national cropland areas over the past 200 years was developed for 36 European *** that,the allocation algorithm was built using physiogeographic variables and historical city sites for accounting for land suitability and cultivation preferences,***,cropland data in Europe with a spatial resolution of 5′×5′at five time sections from AD 1800 to 2000 were generated using the optimal allocation algorithm in accordance with the stages of the regional *** results were as follows:(1)The dominant factors governing the distribution of croplands in Europe vary at different agricultural stages,but the results can be merged *** suitability was more optimal for allocation during the modern agricultural stage(AD 1950 and 2000);the priority index combined with land suitability and cultivation preference was more reasonable for allocation during the traditional agricultural stage(AD 1800).The average of the allocations by priority index and the land suitability could be adopted as the allocation results during the transitional stage(AD 1850 and 1900)because the grids for absolute differences within±10 and±20 percentage points between the results obtained from the above two allocations were above 80% and 95%,respectively,which means the two allocation results could be merged.(2)Over the past 200 years,the total cropland area in Europe first increased to a peak in AD 1900 and then ***,the centre of the higher cropland fraction shifted from the western part of Europe in AD 1800 to the eastern part of the continent after AD 1950.(3)

关键词： Land use and land cover change Historical cropland Gridding allocation Europe Past 200 years

THEORETICAL STUDY ON PHOTODECARBONYLATION REACTION OF ACROLEIN

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Chinese Chemical Letters 1993年第3期4卷 215-216页

作者： wei hai fang Ming Bao HUANG De Cai fang Ruo Zhuang liu Department of chemistry,beijing normal university,beijing 100875

Photodecarbonylation reaction of acrolein at 193nm was investigated by ab initio molecular orbital *** result supports photodecarbonylation mechanisms proposed by Fujimoto,and predicts that the reaction should occur i... 详细信息

关键词： THEORETICAL STUDY ON PHOTODECARBONYLATION REACTION OF ACROLEIN

A multi-dimensional microcanonical Monte Carlo study of S_0→T_1 intersystem crossing of isocyanic acid

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Science China chemistry 2009年第11期52卷 1885-1891页

作者： ZHANG Feng1,2,fang weihai1,LUO Yi2 & liu RuoZhuang1 1 college of chemistry,beijing normal university,beijing 100875,China 2 Theoretical chemistry,School of Biotechnology,Royal Institute of Technology,S-10691 Stockholm,Sweden 1. college of chemistry Beijing Normal University Beijing 100875 China 2. Theoretical chemistry School of Biotechnology Royal Institute of Technology S-10691 Stockholm Sweden

A general formula for the multi-dimensional Monte Carlo microcanonical nonadiabatic rate constant expressed in configuration space is applied to calculate the rate of intersystem crossing(ISC) between the ground(S0) and first excited triplet(T1) states for isocyanic ***-,two-and three-dimensional potential energy surfaces are constructed by coupled-cluster single-double CCSD calculations,which are used for Monte Carlo *** calculated S0→T1 ISC rate is in good agreement with experimental findings,which gives us a reason to believe that the multi-dimensional Monte Carlo microcanonical nonadiabatic rate theory is a very effective method for calculating nonadiabatic transition rate of a polyatomic molecule.

关键词： multi-dimensional Monte Carlo microcanonical nonadiabatic rate theory intersystem crossing isocyanic acid nonadiabatic transition

地下芽植物芽库密度响应环境干扰的Meta分析

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Journal of Plant Ecology 2024年第3期17卷 28-38页

作者： Tao fang Duo Ye Ju-Juan Gao fang-Li Luo yao-jun Zhu Fei-hai Yu School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China college of Life Sciences Zhejiang Normal UniversityJinhua 321000China Fujian MinJiang River Estuary Wetland National Nature Reserve Administrative Offce Fuzhou 350200China The Key Laboratory of Ecological Protection in the Yellow River Basin of National Forestry and Grassland Administration Beijing 100083China Institute of Ecological Conservation and Restoration Chinese Academy of ForestryBejing 100083China National Positioning Observatory for Mangrove Wetland Ecosystems Zhanjiang 524448China Institute of Wetland Ecology&Clone Ecology/Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation Taizhou UniversityTaizhou 318000China

地下芽库是地下芽植物地下储存器官产生的无性繁殖体的集合,是地下芽植物繁殖的主要方式。地下芽库密度反映了地下芽植物群落的潜在更新能力。然而,不同的扰动和生境类型对地下芽库密度的影响尚缺乏全面的了解;此外,不同类型地下芽库对... 详细信息

地下芽库是地下芽植物地下储存器官产生的无性繁殖体的集合,是地下芽植物繁殖的主要方式。地下芽库密度反映了地下芽植物群落的潜在更新能力。然而,不同的扰动和生境类型对地下芽库密度的影响尚缺乏全面的了解;此外,不同类型地下芽库对不同扰动类型的响应是否存在差异也不明确。本研究通过Meta分析系统收集了环境扰动对地下芽库密度影响的相关文献,计算了不同扰动和生境类型对各地下芽库类型密度影响的累计效应值。结果发现,由于地下芽库对扰动的响应存在相反或波动的特征,整体上环境扰动对地下芽库密度的影响较小,而干旱对芽库密度具有负效应。总体而言,环境扰动降低了根状茎芽的密度,但增加了分蘖芽的密度。环境扰动降低了湿地中的地下芽库密度,但在其它生境类型中并未发现显著影响。因此,地下芽植物的芽库对扰动有着很强的抗性和弹性,地下芽库的密度变化取决于扰动的类型、分布的生境和受扰动的芽库类型。

关键词：无性繁殖体地下芽植物生境类型扰动类型地下发芽器官

The ε-Complexity of the Approximate Solution of Integral Equations with Isotropic Kernels

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Acta Mathematica Sinica,English Series 2002年第4期18卷 679-686页

作者： Wan MA Gen Sun fang college of Mathematics & Information Science of Wenzhou university, Wenzhou 325027, P. R. China Department of Mathematics, beijing normal university, beijing 100875, P. R. China college of Mathematics & Information Science of Wenzhou university Wenzhou 325027 P. R. China Department of Mathematics Beijing Normal University Beijing 100875 P. R. China

The exact order of s-complexity is determined in L_p (2≤p≤∞) spaces for the second kind of Fredholm integral equations with kernels belonging to an isotropic Sobolev class.

关键词： Fredholm equation ε-complexity Sobolev classes