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Epidemiological characteristics of seven notifable respiratory infectious diseases in the mainland of China:an analysis of national surveillance data from 2017 to 2021

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Infectious Diseases of Poverty 2023年第6期12卷 96-97页

作者： Le‑le Deng ya‑jun han Zhuo‑wei Li Da‑yan Wang Tao Chen Xiang Ren Guang‑xue He National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Division of Infectious Disease Key Laboratory of Surveillance and Early-Warning On Infectious Disease Chinese Center for Disease Control and Prevention Beijing China

Background Respiratory infectious diseases(RIDs)remain a pressing public health concern,posing a signifcant threat to the well-being and lives of *** study delves into the incidence of seven primary RIDs dur‑ing the period 2017-2021,aiming to gain deeper insights into their epidemiological characteristics for the purpose of enhancing control and prevention *** Data pertaining to seven notifable RIDs,namely,seasonal infuenza,pulmonary tuberculosis(PTB),mumps,scarlet fever,pertussis,rubella and measles,in the mainland of China between 2017 and 2021 were obtained from the National Notifable Disease Reporting System(NNDRS).Joinpoint regression software was utilized to analyze temporal trends,while SaTScan software with a Poisson probability model was used to assess seasonal and spatial *** A total of 11,963,886 cases of the seven RIDs were reported during 2017-2021,and yielding a fve-year aver‑age incidence rate of 170.73 per 100,000 *** these RIDs,seasonal infuenza exhibited the highest aver‑age incidence rate(94.14 per 100,000),followed by PTB(55.52 per 100,000),mumps(15.16 per 100,000),scarlet fever(4.02 per 100,000),pertussis(1.10 per 100,000),rubella(0.59 per 100,000),and measles(0.21 per 100,000).Males experi‑enced higher incidence rates across all seven *** incidence was notably elevated among farmers and individu‑als aged over 65,whereas the other RIDs primarily afected children and students under 15 years of *** inci‑dences of PTB and measles exhibited a declining trend from 2017 to 2021(APC=−7.53%,P=0.009;APC=−40.87%,P=0.02),while the other fve RIDs peaked in *** seasonal and spatial distribution,the seven RIDs displayed distinct characteristics,with variations observed for the same RIDs across diferent *** proportion of laboratory-confrmed cases fuctuated among the seven RIDs from 2017 to 2021,with measles and rubella exhibit‑ing higher proportions and mumps and scarlet fever

关键词： Respiratory infectious diseases Surveillance Epidemiological characteristics Incidence China

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Epidemiological characteristics of imported respiratory infectious diseases in China,2014-2018

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Infectious Diseases of Poverty 2022年第2期11卷 63-71页

作者： Jin-Long Wang Tao Chen Le-Le Deng ya-jun han Da-yan Wang Li-Ping Wang Guang-Xue He National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Division of Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina

Background:With the progress of globalization,international mobility increases,greatly facilitating cross-border transmission of respiratory infectious diseases(RIDs).This study aimed to analyze the epidemiological characteristics and factors influencing imported RIDs,with the goal of providing evidence to support adoption of high-tech,intel-ligent methods to early find imported RIDs and prevent their spread in ***:We obtained data of imported RIDs cases from 2014 to 2018 from the Inbound Sentinel Network of Customs and the National Notifiable Diseases Reporting System in *** analyzed spatial,temporal,and population distribution characteristics of the imported *** developed an index to describe *** correlation coefficients were used to examine associations between independent variables and imported *** analyses and visualizations were conducted with R ***:From a total of 1409265253 inbound travelers,31732(2.25/100000)imported RIDs cases were *** cases were imported from 142 countries and five *** incidence of imported RIDs was nearly 5 times higher in 2018(2.81/100000)than in 2014(0.58/100000).Among foreigners,incidence rates were higher among males(5.32/100000),0–14-year-olds(15.15/100000),and cases originating in Oceania(11.10/100000).The vast majority(90.3%)of imported RIDs were influenza,with seasonality consistent with annual seasonality of *** spatial distribution of imported RIDs was different between Chinese citizens and *** in inbound travel volume and the number of influenza cases in source countries were associated with the number of imported ***:Our study documented importation of RIDs into China from 142 *** travel poses a significant risks bringing important RIDs to *** is urgent to strengthen surveillance at customs of inbound travelers and establish an intelligent surveillance and early warning system to prevent impor

关键词： Imported respiratory infectious disease Influenza Epidemiological characteristics Associated factors China

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双液滴同时垂直撞击壁面的数值研究

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物理学报 2017年第2期66卷 229-238页

作者：高亚军姜汉桥李俊键赵玉云胡锦川常元昊中国石油大学(北京)石油工程教育部重点实验室北京102249

采用质量守恒的level set方法对双液滴同时垂直撞击干壁面后的流动过程进行了模拟研究,主要讨论了韦伯数(We)、壁面接触角(θ)以及双液滴水平间距(S)等物理参数对相界面流动过程的影响,分析了不同参数下射流高度和水平铺展半长随时间的... 详细信息

采用质量守恒的level set方法对双液滴同时垂直撞击干壁面后的流动过程进行了模拟研究,主要讨论了韦伯数(We)、壁面接触角(θ)以及双液滴水平间距(S)等物理参数对相界面流动过程的影响,分析了不同参数下射流高度和水平铺展半长随时间的变化规律.研究表明:We数较大时,中心射流液柱将产生二次液滴,随后液柱反弹至空中,且We数越大,中心射流产生的二次液滴次数越多,最大无量纲射流高度和最大无量纲铺展半长越大;随壁面接触角的增大,中心射流液柱出现反弹现象,水平铺展液流出现断裂的时间越早,最大无量纲射流高度和最大无量纲铺展半长越小;最大无量纲射流高度值与液滴水平间距的相关性不单调,铺展半长随水平间距的增大而增大.

关键词： Level Set方法双液滴撞击射流高度铺展半长

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan yang han Jia Tuo Liu Yuzhen yang jun yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu han jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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不同注视性质的远视性弱视儿童黄斑区视网膜厚度分析

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国际眼科杂志 2020年第3期20卷 509-512页

作者：高鸽石晶谭小波韩雅军郝佳颖许雪妹承德医学院河北省承德市067000 承德医学院附属医院眼科河北省承德市067000

目的:通过对4~8岁远视性屈光不正性弱视患儿注视性质、黄斑各分区视网膜厚度的测量、眼轴长度的检查,探讨远视性弱视儿童注视性质与其黄斑各分区视网膜厚度间的相关性;并进行远视性弱视儿童视网膜厚度及其相关因素的研究。方法:前瞻性... 详细信息

目的:通过对4~8岁远视性屈光不正性弱视患儿注视性质、黄斑各分区视网膜厚度的测量、眼轴长度的检查,探讨远视性弱视儿童注视性质与其黄斑各分区视网膜厚度间的相关性;并进行远视性弱视儿童视网膜厚度及其相关因素的研究。方法:前瞻性非随机同期对照研究试验。将2018-09/12首次就诊且之前未进行过任何弱视训练的患儿共计44例57眼纳入该研究。选取屈光不正性远视性弱视儿童36眼作为远视性弱视组,视力正常儿童21眼作为正常对照组,两组均利用光学相干断层扫描技术(OCT)进行黄斑各分区视网膜厚度测量;同时将入组患儿在直接眼底镜检查下分为黄斑中心注视组32眼,旁中心注视组25眼,进行黄斑各分区视网膜厚度测量;用SPSS19.0统计软件分别分析两组间视网膜厚度及差异。结果:黄斑中心注视组在黄斑中心凹、黄斑内环鼻侧处视网膜厚度均小于旁中心注视组(P0.05)。远视性弱视组的黄斑中心凹、黄斑内环鼻侧、黄斑内环下方及黄斑外环上方处视网膜厚度均大于正常对照组(P0.05)。远视性弱视组眼轴长度较正常对照组短(P<0.05)。结论:黄斑中心注视儿童在黄斑区中心凹、内环鼻侧处视网膜厚度增加;远视性弱视儿童在黄斑区中心凹、内环鼻侧、内环下方、外环上方处视网膜厚度增加;远视性弱视儿童眼轴长度变短。

关键词：注视性质黄斑区视网膜厚度弱视眼轴光学相干断层扫描

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双光子湮灭吸收截面和吸收系数

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天文学报 2002年第3期43卷 272-283页

作者：凌家杰刘当波陈磊许亚娣尤峻汉上海交通大学物理系空间与天体物理研究所上海200030

双光子湮灭造成的γ射线吸收是γ射线天文学辐射转移理论的一个重要内容.通过相对论变换,将目前QED理论给出的仅在动量中心参考系中表示的双光子湮灭截面推广到实验室系(观侧者系),并用湮灭前两光子的能量hω,hω＇及夹角θ表示此截面,... 详细信息

双光子湮灭造成的γ射线吸收是γ射线天文学辐射转移理论的一个重要内容.通过相对论变换,将目前QED理论给出的仅在动量中心参考系中表示的双光子湮灭截面推广到实验室系(观侧者系),并用湮灭前两光子的能量hω,hω＇及夹角θ表示此截面,便于γ射线在天文学中的实际应用.进一步,在各向同性周边辐射场的一般前提下,求出方向平均的简化截面公式σ(ω,ω＇),得出方向平均的湮灭阈值条件和湮灭概率最大时两个光子能量的匹配条件.进一步确认在γ射线天文学中,双光子湮灭截面和γ光子-电子的康普顿散射截面确有可比性.最后完成了天体物理中几种常见低频辐射场如热韧致辐射场、黑体辐射场以及非热的幂律场中双光子湮灭吸收系数kγγ(hω)～hω的计算曲线,并给出较详细的物理讨论.

关键词：双光子湮灭吸收截面吸收系数 QED理论 γ射线天文学相对论变换

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儿童隐匿性高度近视脉络膜厚度变化及其影响因素研究进展

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国际眼科杂志 2021年第5期21卷 836-839页

作者：韩雅军石晶谭小波荆刘一杨洁许雪妹承德医学院中国河北省承德市067000 承德医学院附属医院眼科中国河北省承德市067000

高度近视是一种严重危害儿童视功能的眼病,因其对眼底造成的不可逆性改变。高度近视需要早发现、早诊断、早治疗,如不及时干预可引起近视进一步加重,甚至失明。但近视的筛查经常遇到患儿近视度数不高,进一步检查发现已有高度近视眼底改... 详细信息

高度近视是一种严重危害儿童视功能的眼病,因其对眼底造成的不可逆性改变。高度近视需要早发现、早诊断、早治疗,如不及时干预可引起近视进一步加重,甚至失明。但近视的筛查经常遇到患儿近视度数不高,进一步检查发现已有高度近视眼底改变,这种隐匿性的高度近视改变在诊疗过程中极容易被忽视。本文旨在总结近视儿童脉络膜厚度变化及其影响因素文献,为隐匿性高度近视儿童临床研究提供相关证据。

关键词：隐匿性高度近视脉络膜厚度儿童频域相干光断层扫描的深度增强成像技术

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儿童隐匿性高度近视黄斑区视网膜厚度分析

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国际眼科杂志 2021年第6期21卷 1107-1111页

作者：韩雅军石晶谭小波杨洁许雪妹荆刘一承德医学院附属医院眼科中国河北省承德市067000

目的:观察分析隐匿性高度近视儿童黄斑区视网膜厚度变化及其相关因素。方法:前瞻性非随机对照研究。选取2019-09/2020-09在承德医学院附属医院眼科门诊首次就诊且未进行过任何近视矫正训练的儿童56例110眼纳入研究,根据儿童近视的临床... 详细信息

目的:观察分析隐匿性高度近视儿童黄斑区视网膜厚度变化及其相关因素。方法:前瞻性非随机对照研究。选取2019-09/2020-09在承德医学院附属医院眼科门诊首次就诊且未进行过任何近视矫正训练的儿童56例110眼纳入研究,根据儿童近视的临床表现分为隐匿性高度近视组(27例52眼)和对照组(29例58眼,普通近视儿童)。比较两组儿童黄斑各分区视网膜厚度情况,分析隐匿性高度近视儿童黄斑中心凹平均视网膜厚度与基线资料的相关性。结果:隐匿性高度近视儿童黄斑区视网膜厚度以黄斑中心凹最薄,内环区上方最厚。隐匿性高度近视组儿童黄斑9个分区平均视网膜厚度均较对照组变薄,其中黄斑中心凹、外环区下方和颞侧处视网膜厚度有显著差异(均P0.05)。Pearson相关分析结果显示,隐匿性高度近视儿童黄斑中心凹平均视网膜厚度与性别、年龄、眼轴、眼压、角膜曲率均无相关性(P>0.05),与屈光度呈负相关性(r=-0.201,P<0.05)。结论:隐匿性高度近视儿童黄斑视网膜厚度以黄斑中心凹最薄,内环区上方最厚,黄斑各分区平均视网膜厚度较相应屈光度数近视儿童薄。隐匿性高度近视儿童黄斑中心凹平均视网膜厚度与屈光度呈负相关。

关键词：隐匿性高度近视儿童黄斑中心凹视网膜厚度频域相干光断层扫描成像技术

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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