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中国动脉硬化杂志 2013年第9期21卷 I0074-I0075页

作者： ya-jun duan ling zhang ji-hong han The State Key Laboratory of Medicinal Chemical Biology and the College of Life Sciences Nankai University Tianjin 300071 China

ATP-binding cassette transporter A1 ( ABCA1 ) facilitates cholesterol efflux and thereby inhibits lipid-laden macrophage/foam cell formation and atherosclerosis. ABCA1 expression is transcriptionally regulated by activation of liver X receptor (LXR). Both etopo- side and teniposide are DNA topoisomerase H (Topo 1I ) inhibitors and are chemotherapeutic medications used in the treatment of va- rious cancers. Interestingly, etoposide inhibits atherosclerosis in rabbits by unclear mechanisms. Herein, we report the effects of etoposide and teniposide on macrophage ABCA1 expression and cholesterol efflux. Both etoposide and teniposide increased macro- phage free cholesterol efflux. This increase was associated with increased ABCA1mRNA and protein expression, Etoposide and te- niposide also increased ABCA1 promoter activity in an LXR-dependent manner and formation of the LXRE-LXR/RXR complex indica-ting that transcriptional induction had occurred. Expression of ABCG1 and fatty acid synthase (FAS) , another two LXR-targeted genes, was also induced by etoposide and teniposide. In vivo, administration of mice with either etoposide or teniposide induced mac- rophage ABCA1 expression and enhanced reverse cholesterol transport from macrophages to feces. Taken together, our study indicates that etoposide and teniposide increase macrophage ABCA1 expression and cholesterol efflux that may be attributed to the anti-atherogen- ic properties of etoposide. Our study also describes a new function for TopoⅡinhibitors in addition to their role in anti-tumorigene- sis.

关键词： DNA拓扑异构酶 ABCA1 游离胆固醇巨噬细胞酶抑制剂诱导动脉粥样硬化胆固醇逆转运

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang Lin Gu Qiu-Ying han jia-Qing Xing Ming Zhao Shao-Yi Huang jun-Xi Yi jie Pan Hao hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran zhang Li-Ming Sun Shao-Zhen jiang Dan Luo ling Chen Zheng-jie Wang Yu Yu Tian Xia Xue-Min zhang Ai-ling Li Tao Zhou hong Cai Tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

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Characteristics of Easily Oxidized Soil Carbon Content and Carbon Pool Management Index in Typical Climate Zones in Eastern China

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1729-1736页

作者： Xu, Yi-jun Chen, Xiang-Bi Wang, jun Xie, ling Liu, Wan-Qing zhang, Xiao-Fang duan, Xun Ma, Chong Qiao, hang Hu, ya-jun Nie, San-An College of Resources Hunan Agricultural University Changsha410128 China Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences Changsha410125 China College of Forestry Central South University of Forestry and Technology Changsha410004 China College of Biological and Environmental Engineering Guiyang University Guiyang550005 China University of Chinese Academy of Sciences Beijing100049 China

Climate and land use are important factors affecting the soil carbon pool and organic carbon influx. To explore the characteristics of active organic carbon content and carbon pool management index in farmland soils in typical climate zones,two types of farm land(dry land and paddy fields)and adjacent forest soils in four climate zones(temperate,warm temperate,subtropical,and tropical)in eastern China spanning north to south were selected for study. The permanganate oxidizable carbon(POXC)content in each climate zone was analyzed,and the soil lability of carbon(L),soil lability index(LI),carbon pool index(CPI),and carbon pool management index(CMI)under each land use type were calculated. The following trends were observed across the three land use types:Soil POXC content was generally slightly higher in the north than in the south and consistently higher in paddy fields than in dry lands. L was significantly higher in warm-temperate regions than in the other three climatic regions. This suggests that soils in warm temperate regions(primarily fluvio-aquic soils)and paddy field soils have high organic carbon activity and soil carbon pool quality. However,measures to avoid soil organic carbon(SOC)loss during agricultural use must be crucially implemented. Paddy field soils exhibited higher CPI values than dry land soils across all four climatic regions. Specifically,the CPI of paddy fields was >1 in all regions,whereas dry lands had carbon pool indices of 100. Furthermore,the index was higher in paddy fields than in adjacent dry lands and higher in the north than in the south,suggesting that long-term agricultural use can improve SOC quality,thereby promoting the conversion and supply of soil organic nutrients. Correlation analysis revealed significant positive correlations between POXC and SOC,total nitrogen,pH,and sand and significant negative correlations with clay,silt,mean annual temperature(MAT),and mean annual precipitation(MAP). CMI correlated positively with p

关键词： Network performance

Differential expression of plasma extracellular vesicle miRNAs as biomarkers for distinguishing psoriatic arthritis from psoriasis

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中华医学杂志(英文版) 2025年第2期138卷 219-221页

作者： yan Kexiang Zhu jie zhang Mengmeng zhang Fuxin Wang Bing han ling Huang Qiong Tang Yulong Li Yuan yawalkar Nikhil zhang Zhenghua Niu Zhenmin Department of Dermatology Huashan Hospital Fudan University Shanghai China State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and Development School of Life Sciences Human Phenome Institute Fudan University Shanghai China Department of Dermatology Inselspital Bern University Hospital University of Bern Bern CH-Bern Switzerland Department of Genetics Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science &amp Technology (SAST) Shanghai China

Deterministic quantum state and gate teleportation between distant superconducting chips

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Science Bulletin 2025年第3期70卷 351-358页

作者： jiawei Qiu yang Liu ling Hu Yukai Wu jingjing Niu Libo zhang Wenhui Huang Yuanzhen Chen jian Li Song Liu Youpeng Zhong Luming duan Dapeng Yu Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China International Quantum Academy Shenzhen 518048China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084China Department of Physics Southern University of Science and TechnologyShenzhen 518055China

Quantum teleportation is of both fundamental interest and great practical importance in quantum information *** date,quantum teleportation has been implemented in various physical systems,among which superconducting qubits are of particular practical significance as they emerge as a leading system to realize large-scale quantum ***,scaling up the number of superconducting qubits on a single chip becomes increasing challenging because of some emergent technical *** of quantum teleportation and remote computation over qubits on distant superconducting chips is a key quantum communication technology to scaling up the system through a distributed quantum computational ***,this goal has not been realized yet in experiments due to the technical challenges including making a quantum interconnect between distant superconducting chips and the inefficient transfer of flying microwave photons over the lossy *** we demonstrate deterministic teleportation of quantum states and entangling gates between distant superconducting chips connected by a 64-m-long cable bus featuring an ultralow loss of 0.32 dB/km at cryogenic temperatures,where high fidelity remote entanglement is generated via flying microwave *** work demonstrates a prime building block for distributed quantum computation with superconducting qubits,and opens up a new avenue for waveguide quantum electrodynamics and quantum photonics at microwave frequencies.

关键词： Superconducting circuits Quantum network Quantum computing Flying microwave photon

The MON1–CCZ1 complex plays dual roles in autophagic degradation and vacuolar protein transport in rice

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Journal of Integrative Plant Biology 2025年第1期67卷 35-54页

作者： Binglei zhang Yihua Wang Yun Zhu Tian Pan Haigang yan Xin Wang Ruonan jing hongming Wu Fan Wang Yu zhang Xiuhao Bao Yongfei Wang Pengcheng zhang Yu Chen Erchao duan Xiaohang han Gexing Wan Mengyuan yan Xiejun Sun Cailin Lei Zhijun Cheng Zhichao Zhao ling jiang Yiqun Bao Yulong Ren jianmin Wan State Key Laboratory of Crop Gene Resources and Breeding National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China College of Life Sciences Nanjing Agricultural UniversityNanjing 210095China State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Nanjing Agricultural UniversityNanjing 210095China Zhongshan Biological Breeding Laboratory Nanjing 210095China

Autophagy is a highly conserved cellular program in eukaryotic cells which mediates the degradation of cytoplasmic components through the lysosome,also named the vacuole in ***,the molecular mechanisms underlying the fusion of autophagosomes with the vacuole remain ***,we report the functional characterization of a rice(Oryza sativa)mutant with defects in storage protein transport in endosperm cells and accumulation of numerous autophagosomes in root *** and immunocytochemical experiments showed that this mutant exhibits a defect in the fusion between autophagosomes and *** mutant harbors a loss-of-function mutation in the rice homolog of Arabidopsis thaliana MONENSIN SENSITIVITY1(MON1).Biochemical and genetic evidence revealed a synergistic interaction between rice MON1 and AUTOPHAGY-RELATED 8a in maintaining normal growth and *** addition,the rice mon1 mutant disrupted storage protein sorting to protein storage ***,quantitative proteomics verified that the loss of MON1 function influenced diverse biological pathways including autophagy and vacuolar transport,thus decreasing the transport of autophagic and vacuolar cargoes to ***,our findings establish a molecular link between autophagy and vacuolar protein transport,and offer insights into the dual functions of the MON1–CCZ1(CAFFEINE ZINC SENSITIVITY1)complex in plants.

关键词： autophagic degradation MON1–CCZ1 Rab7 rice vacuolar trafficking

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng yang Song Xie Zi-Meng han Hao-Cheng Liu Chong-han Yin Wen-Bin Sun zhang-Chi ling Huai-Bin yang De-han Li Qing-Fang Guan Shu-hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

Carbon interconnected microsized Si film toward high energy room temperature solid-state lithium-ion batteries

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Chinese Chemical Letters 2025年第2期36卷 531-535页

作者： Xin Li ling zhang Yunyan Fan Shaojing Lin Yong Lin Yongsheng Ying Meijiao Hu Haiying Gao Xianri Xu Zhongbiao Xia Xinchuan Lin junjie Lu Xiang han School of Information Engineering Fujian Business University College of Artificial Intelligence Yango University College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University

Solid-state batteries （SSBs） with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potential high energy ***,Si suffers from poor electrical conductivity and huge volume change and particles fracture during lithiaiotn and delithiation,which induces low practical energy *** addition,the SSBs are often operated at high temperature due to the poor physical contact and huge resistance between Si and solid-state electrolyte （SSE）.To improve the bulk electronic/ionic conductivity of Si and its interfacial compatibility with SSE,herein,a binder free and self-supporting Si/C film was *** monolithic carbon not only enhance the electric conductivity but also release huge stress during lithiation and *** addition,paired with the flexible and soft poly（vinylidene fluoride）-co-hexafluoropropylene （PVDF-HFP） and Li1.3Al0.3Ti1.7（PO4）3（LATP） solid-state electrolyte,a LiF-rich and electrochemical stable solid-electrolyte interphase （SEI） layer is in-situ *** fast bulk and interfacial ionic transportation as well as the mechanical integrity of MSi enable high performance SSBs at room *** a result,high specific capacity of 2137 m Ah/g with an initial Coulombic efficiency of 83.2%is obtained at a rate of 0.5 A/*** at a high rate of 3 A/g,the specific capacity is1793 m Ah/*** a rate of 1 A/g,the Si/C anode delivers a long cycling performance over 500 cycles while maintains a capacity of 1135 mAh/*** work provides a new strategy that combines charge transfer kinetics and interfacial chemistry design toward high energy density Si-based SSBs.

关键词： Carbon coating Interphase Lithium-ion battery Silicon anode Solid-state electrolyte

High-Magnetic-Field-Induced First-Order Magnetic Transition and Tricritical Phenomenon in Antiferromagnetic Semimetal NdSb

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Chinese Physics Letters 2025年第2期42卷 125-131页

作者： jun Zhao Azizur Rahman Wei Liu Langsheng ling Yuyan han Chuanying Xi Li Pi Zhe Qu Hao Gao Lei zhang School of Mechanical and Electrical Engineering Sanming UniversitySanming 365004China Anhui Key Laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Department of Physics Lab of Low-dimensional Magnetism and Spintronic DevicesSchool of PhysicsHefei University of TechnologyHefei 230009China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Hefei National Research Center for Physical Sciences at Microscale University of Science and Technology of ChinaHefei 230026China

The antiferromagnetic(AFM)semimetal NdSb is well known for the interplay between its exotic magnetism and topological ***,its magnetism remains poorly *** this study,we thoroughly investigated the magnetization of NdSb single crystals with a high magnetic field(H)of up to 30T applied in various *** found that the AFM phase is suppressed by a magnetic field of 9.41T when H‖[100]and 11.25T when H‖[110],whereas the suppression field ranges from 9.41 to 10.67T with a hysteresis of 1.26T when H‖[111].The magnetization of H‖[100],which is an easy direction with a typical magnetic transition,was studied in *** AFM phase with H‖[100]was suppressed at lower temperatures,disappearing at approximately 6.25 *** critical exponents β=0.234(3),γ=0.824(6),and δ=4.90(6)were obtained for H‖[100],and aligned with a tricritical mean-field *** of the critical behavior suggests a fieldinduced tricritical phenomenon for H‖[100].An H-T phase diagram for an NdSb single crystal was constructed for H‖[100],revealing a field-induced first-order transition and a tricritical point(TCP)at T_(tr)=6.25K and H_(tr)=9.41 *** clarification of the multiple magnetic phases and transitions in NdSb provides crucial insights into the correlation between its magnetism and topology.

关键词： critical magnetization Transition

Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients

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World Journal of Diabetes 2025年第2期16卷 103-113页

作者： Fang Lv Xiao-ling Cai Xiu-Ying zhang Xiang-Hai Zhou Xue-yao han Yu-Feng Li Li-Nong ji Department of Endocrinology and Metabolism Peking University People's HospitalBeijing 100044China Department of Endocrinology Beijing Friendship Hospital Pinggu CampusBeijing 101200China

BACKGROUND The association between body mass index(BMI)and bone mineral density(BMD)has shown inconsistent results,varying by sex and skeletal *** normal or elevated bone mass,individuals with type 2 diabetes have an increased risk of hip and vertebral *** To assess lumbar spine trabecular volumetric BMD(vBMD)across different BMI categories in individuals with and without *** This cross-sectional study included 966 men over 50 years old and 1001 postmenopausal women from the Pinggu Metabolic Disease *** vBMD of lumbar vertebrae 2 through 4 was measured using quantitative computed *** adipose tissue,subcutaneous adipose tissue(SAT),visceral adipose tissue(VAT),and lumbar skeletal muscle area were also *** In men with obesity(P=0.038)and overweight(P=0.032),vBMD was significantly higher in the diabetes group compared to non-diabetic *** adjusting for age and sex,no significant saturation effect between BMI and BMD was found in participants with diabetes or in women without ***,a BMI threshold of 22.33 kg/m²indicated a saturation point for vBMD in nondiabetic *** predictors of vBMD in men included age(r=-0.387,P<0.001),BMI(r=0.130,P=0.004),and VAT(r=-0.145,P=0.001).For women,significant predictors were age(r=-0.594,P<0.001),BMI(r=0.157,P=0.004),VAT(r=-0.112,P=0.001),and SAT(r=-0.068,P=0.035).CONCLUSION The relationship between BMI and trabecular vBMD differs in individuals with and without *** and obese men with diabetes exhibit higher vBMD.

关键词： Obesity and overweight Body mass index Diabetes Lumbar spine volumetric bone mineral density Quantitative computed tomography