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Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research International 2024年第2期31卷 389-400页

作者： Li-ping pan ya-wei Li Fang-guan Tan Yi-chen Chen yang-fan Xu Zhu He Bao-kuan Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and Lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ***–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining *** thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling *** with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically *** results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 *** thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,*** addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the ***,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress

Genetic Variations and Nonalcoholic Fatty Liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence

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Biomedical and Environmental Sciences 2024年第7期37卷 762-773页

作者： yamei Li Xiang Xiao jie Wang Yixu Liu Xiongfeng pan Haibin Yu Jiayou Luo Miyang Luo Department of Epidemiology and Health Statistics School of Public HealthUniversity of South ChinaHengyang 421001HunanChina Department of Maternal and Child Health Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina Supervision and Inspection Department of Shanghai Healthcare Security Bureau Shanghai 200003China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina

Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically ***-analyses of the genetic variants were conducted using at least five data *** epidemiologic credibility of the significant associations was graded using the Venice *** Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing *** identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the *** meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

关键词： Nonalcoholic fatty liver disease Genetic association study Genetic variant Systematic review Meta-analysis

Efficient micrometer-scale thick-film perovskite solar cells with superior stability

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Rare Metals 2024年第4期43卷 1647-1657页

作者： Jian-Fei Hu Gang Chen Shun-Zhang Yu Yue-Xin Lin Kai-Yu Wang Zong-Wei Li Guo-Dong Zhang Teng-Fei pan ya-Jing Li Ming-jie Li Ying-Dong Xia Yi-Fan Lv Yong-Hua Chen Key Laboratory of Flexible Electronics(KLoFE)and Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong999077China Shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhen518057China Optics Valley Laboratory Hubei430074China

It is essential to enhance the thickness of the absorber layer for perovskite solar cells(PSCs)to improve device performance and reduce industry ***,thick perovskite films(>1μm)are difficult to be fabricated by employing traditional solvents,such as N,N-dimethylformamide(DMF),dimethyl sulfoxide(DMSO).Besides,it is a challenge to fabricate thick-film perovskite owing to the deteriorated surface morphology and serious defect ***,a simple method was reported to deposit uniform pinhole-free perovskite films with a thickness of more than 2μm utilizing the methylamine acetate(MAAc)ionic liquid as the *** with methylammonium chloride(MACl)as an additive,thick-film perovskite with~2μm in grain size and few grain boundaries(GBs)was prepared,which dramatically improved the perovskite crystal quality and enhanced carrier transport *** final PSCs exhibited a power conversion efficiency(PCE)of 20.16%.The device showed improved stability with 95%of its initial efficiency in a nitrogen environment over 5000 *** work provides an alternative strategy to produce extremely efficient and stable thick-film *** can be believed that this device has great potential in the application of large areas and laminated PSCs.

关键词： Perovskite solar cells Thick-film Stability Ionic liquid

Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-jie Wei Xin-Yu Wang Hai-Tao Tang Fei-Hu Cui Yun-Qi Wu Ying-Ming pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

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A compact route for efficient production of high-purity β-Ga2O3 powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： Xiao-Wei Zhou Gao-jie Chen Liang Xu Zhi-Jun Shao Cheng yang Yong-pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of Technology Low-Carbon Research Institute Anhui University of Technology

The present study has proposed a compact process for the production of high-purity β-Ga2O3powder by simply using gallium metal and water as the raw materials. The process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product of β-Ga2O3. Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization. X-ray diffractometer（XRD）, scanning electron microscopy（SEM）, thermogravimetryDdifferential scanning calorimetry（TG-DSC） and X-ray photoelectron spectroscopy（XPS） were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH to β-Ga2O3by calcination. Chemical analysis of the final product of β-Ga2O3obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry（ICP-MS）, and the results showed that the contents of the representative impurities such as Ni, Cu, In, Mn, Co, Zn and Cr are obviously lower than the requirement of 5N β-Ga2O3standard, exhibiting excellent application prospect of the proposed process to produce high-purity β-Ga2O3.

关键词： Calcination Hydrothermal synthesis Purity Reaction mechanism β-Ga2O3

Correcting Climate Model Sea Surface Temperature Simulations with Generative Adversarial Networks:Climatology,Interannual Variability,and Extremes

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Advances in Atmospheric Sciences 2024年第7期41卷 1299-1312页

作者： ya WANG Gang HUANG Baoxiang pan Pengfei LIN Niklas BOERS Weichen TAO Yutong CHEN BO LIU Haijie LI State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Earth System Modelling School of Engineering and DesignTechnical University of MunichOttobrunn 85521Germany Potsdam Institute for Climate Impact Research Potsdam 14412Germany Department of Mathematics and Global Systems Institute University of ExeterExeter EX44QEUK CMA Earth System Modeling and Prediction Centre(CEMC) Chinese Academy of Meteorological SciencesBeijing 100081China

Climate models are vital for understanding and projecting global climate change and its associated ***,these models suffer from biases that limit their accuracy in historical simulations and the trustworthiness of future *** these challenges requires addressing internal variability,hindering the direct alignment between model simulations and observations,and thwarting conventional supervised learning ***,we employ an unsupervised Cycle-consistent Generative Adversarial Network(CycleGAN),to correct daily Sea Surface Temperature(SST)simulations from the Community Earth System Model 2(CESM2).Our results reveal that the CycleGAN not only corrects climatological biases but also improves the simulation of major dynamic modes including the El Niño-Southern Oscillation(ENSO)and the Indian Ocean Dipole mode,as well as SST ***,it substantially corrects climatological SST biases,decreasing the globally averaged Root-Mean-Square Error(RMSE)by 58%.Intriguingly,the CycleGAN effectively addresses the well-known excessive westward bias in ENSO SST anomalies,a common issue in climate models that traditional methods,like quantile mapping,struggle to ***,it substantially improves the simulation of SST extremes,raising the pattern correlation coefficient(PCC)from 0.56 to 0.88 and lowering the RMSE from 0.5 to *** enhancement is attributed to better representations of interannual,intraseasonal,and synoptic scales *** study offers a novel approach to correct global SST simulations and underscores its effectiveness across different time scales and primary dynamical modes.

关键词： generative adversarial networks model bias deep learning El Niño-Southern Oscillation marine heatwaves

TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways

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Hepatobiliary & pancreatic Diseases International 2024年第2期23卷 195-209页

作者： yan Zhang Zhen-Zhen Wang An-Qi Han Ming-ya yang Li-Xin Zhu Fa-Ming pan Yong Wang Department of General Surgery The Second Hospital of Anhui Medical UniversityHefei 230601China Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China The Key Laboratory of Major Autoimmune Diseases Anhui Medical UniversityHefei 230032China

Background:As reported,γ-tubulin(TuBG1)is related to the occurrence and development of various types of malignant ***,its role in hepatocellular cancer(HCC)is not *** present study was to investigate the relationship between TuBG1 and clinical parameters and survival in HCC ***:The correlation between TuBG1 and clinical parameters and survival in HCC patients was ex-plored by bioinformatics *** was used for the *** molecular function of TuBG1 was measured using colony formation,scratch assay,trans-well assay and flow *** set enrichment analysis(GSEA)was used to pick up the enriched pathways,followed by investigating the target pathways using Western *** tumor-immune system interactions and drug bank database(TISIDB)was used to evaluate TuBG1 and *** on the TuBG1-related immune genes,a prognostic model was constructed and was further validated internally and ***:The bioinformatic analysis found high expressed TuBG1 in HCC tissue,which was confirmed us-ing immunohistochemistry and Western *** silencing the TuBG1 in HCC cell lines,more G1 arrested cells were found,cell proliferation and invasion were inhibited,and apoptosis was ***,the silence of TuBG1 increased the expressions of Ataxia-Telangiectasia and Rad-3(ATR),phospho-P38 mitogen-activated protein kinase(P-P38MAPK),phospho-P53(P-P53),B-cell lymphoma-2 associated X protein(Bax),cleaved caspase 3 and P21;decreased the expressions of B-cell lymphoma-2(Bcl-2),cyclin D1,cyclin E2,cyclin-dependent kinase 2(CDK2)and *** correlation analysis of immunohistochemistry and clinical parameters and survival data revealed that TuBG1 was negatively corre-lated with the overall *** constructed immune prognosis model could effectively evaluate the ***:The increased expression of TuBG1 in HCC is associated with poor prognosis,which might be involved in the oc

关键词： TuBG1 Hepatocellular carcinoma Apoptosis Cell cycling Immunomodulators

A state-of-the-art review on delayed expansion of cemented paste backfill materials

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Rare Metals 2024年第8期43卷 3475-3500页

作者： Meng-Yuan Li Li-jie Guo Yue Zhao Lei Zhang Kai yang Xiao-Peng Peng Andrew pan BGRIMM Technology Group Beijing 100160China National Centre for International Research On Green Metal Mining Beijing102628China Department of Civil and Mineral Engineering University of TorontoTorontoON M5S 1A4Canada

Utilizing delayed expansion cemented paste backfill materials(DECPB) in mine backfill operations offers an effective solution to the challenge of achieving proper contact between the in-situ cemented backfill mass and the roof in mined-out areas(backfill-roof contact).This article presents recent progress in both theoretical and experimental research concerning *** types and mechanisms of expansive additives,including expansive agents,foaming agents,and expansive mineral materials relevant to DECPB,are explained,along with their impact on the expansive properties and mechanical characteristics of *** composition,material characteristics,preparation methods,and controlled release mechanisms of microcapsules are *** methods for measuring the volume change rate of paste backfill slurries are *** indicates that an appropriate content of expansive additives not only enhances the expansive properties of cemented paste backfill materials but also contributes to improving their mechanical *** foaming agents and bentonite are found to be more suitable for preparing DECPB compared to expansive *** delayed expansion of cemented paste backfill material is influenced by microcapsules,with their wall materials,preparation parameters,and the alkaline slurry environment affecting their controlled release *** and optimizing precise measurement devices and methods forfor the volume change rate of cemented paste backfill materials is essential requirement for studying the performance of *** delayed expansion technology with retarding techniques in cemented paste backfill materials can provide a reliable solution for achieving proper backfill-roof contact in the future.

关键词： Paste backfill Delayed expansion Mining with backfill Expansive additives Tailings

A perspective on the key factors of safety for rechargeable magnesium batteries

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Journal of Energy Chemistry 2024年第7期94卷 656-676页

作者： Shuangshuang Tan jie Xu Rongrui Deng Qiannan Zhao Chaohe Xu Guangsheng Huang Jingfeng Wang Fusheng pan National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China National Innovation Center for Industry-Education Integration of Energy Storage Technology College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Chongqing Institute of New Energy Storage Materials and Equipment Chongqing 401135China

Rechargeable Mg batteries(RMBs)have become one of the best subsitutes for lithium-ion batteries due to the high volumetric capacity,abundant resources,and uniform plating behavior of Mg metal ***,the safety hazard induced by the formation of high-modulue Mg dendrites under a high current density(10 mA cm^(-1))was still revealed in recent *** has forced researchers to re-examine the safety of *** this review,the intrinsic safety factors of key components in RMBs,such as uneven plating,pitting and flammability of Mg anode,heat release and crystalline water decomposition of cathode,strong corrosion,low oxidition stability and flammability of electrolytes,and soforth,are systematacially *** origins,formation mechanisms,and possible safety hazards are deeply *** develop high-performance Mg anode,current strategies including designing artificial SEI,three-dimensional substrates,and Mg alloys are *** practical electrolytes,the configurations of boron-centered anions and simple Mg salts and the functionalized solvent with high boiling point and low flammability are suggested to comprehensively *** addition,the future study should more focus on the investigation on the thermal runaway and decomposition of cathode materials and *** review aims to provide fundamental insights into the relationship between electrochemistry and safety,further promoting the sustainable development of RMBs.

关键词： Rechargeable Mg batteries Battery safety Mg dendrites Electrolyte decomposition Intrinsic safety issues