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Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 35-42页

作者： li-li Miao Jing-Wen Wang hui-hui liu Shuai Gao Yu-Chen Fan Kai Wang Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Hepatology Shandong UniversityJinan 250012China

Background: Glycine dehydrogenase(GLDC) plays an important role in the initiation and proliferation of several human cancers. In this study, we aimed to detect the methylation status of GLDC promoter and its diagnostic value for hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC). Methods: We enrolled 197 patients, 111 with HBV-HCC, 51 with chronic hepatitis B(CHB), and 35 healthy controls(HCs). The methylation status of GLDC promoter in peripheral mononuclear cells(PBMCs) was identified by methylation specific polymerase chain reaction(MSP). The mRNA expression was examined using real-time quantitative polymerase chain reaction(q PCR). Results: The methylation frequency of the GLDC promoter was significantly lower in HBV-HCC patients(27.0%) compared to that in CHB patients(68.6%) and HCs(74.3%)( P < 0.001). The methylated group had lower alanine aminotransferase level( P = 0.035) and lower rates of tumor node metastasis(TNM) Ⅲ/Ⅳ( P = 0.043) and T3/T4( P = 0.026). TNM stage was identified to be an independent factor for GLDC promoter methylation. GLDC mRNA levels in CHB patients and HCs were significantly lower than those in HBV-HCC patients( P = 0.022 and P < 0.001, respectively). GLDC mRNA levels were significantly higher in HBV-HCC patients with unmethylated GLDC promoters than those with methylated GLDC promoters( P = 0.003). The diagnostic accuracy of alpha-fetoprotein(AFP) combined with GLDC promoter methylation for HBV-HCC was improved compared with that of AFP alone(AUC: 0.782 vs. 0.630, P < 0.001). In addition, GLDC promoter methylation was an independent predictor for overall survival of HBV-HCC patients( P = 0.038). Conclusions: The methylation frequency of GLDC promoter was lower in PBMCs from HBV-HCC patients than that from patients with CHB and HCs. The combination of AFP and GLDC promoter hypomethylation significantly improved the diagnostic accuracy of HBV-HCC.

关键词： Hepatocellular carcinoma Glycine dehydrogenase DNA methylation Peripheral blood mononuclear cells

Clinical study on the relationship between liver cirrhosis,ascites,and hyponatremia

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 751-758页

作者： Xuan-Ji li hui-hui Meng Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430065Hubei ProvinceChina

BACKGROUND Cirrhosis is a common liver disease,and ascites is one of the common clinical ***,the clinical manifestations of ascites combined with hyponatremia as a high-risk condition and its relationship to patient prognosis have not been fully *** To explore the clinical manifestations,prognostic factors,and relationships of ascites with hyponatremia in patients with cirrhosis to provide better diagnostic and treatment *** In this study,we retrospectively analyzed the clinical data of 150 patients diagnosed with cirrhosis and ascites between 2017 and *** were divided into two groups:ascites combined with hyponatremia group and ascites *** compared the general characteristics,degree of hyponatremia,complications,treatment,and prognosis between the two *** In the study results,patients in the ascites combined with hyponatremia group showed an older average age(58.2±8.9 years),64.4%were male,and had a significantly longer hospitalization time(12.7±5.3 d).Hyponatremia was more severe in this group,with a mean serum sodium concentration of 128.5±4.3 mmol/L,which was significantly different from the ascites group of 137.6±2.1 mmol/*** with ascites and hyponatremia were more likely to develop hepatic encephalopathy(56.2%vs 39.0%),renal impairment(45.2%vs 28.6%)and infection(37.0%vs 23.4%).Regarding treatment,this group more frequently used diuretics(80.8%vs 62.3%)and salt supplements(60.3%vs 38.9%).Multiple logistic regression analysis identified older age[Odds ratio(OR)=1.06,P=0.025]and male gender(OR=1.72,P=0.020)as risk factors for hyponatremia combined with ***,patients with ascites and hyponatremia present a clear high-risk status,accompanied by severe complications and poor *** In patients with cirrhosis,ascites with hyponatremia is a high-risk condition that is often associated with severe complications.

关键词： liver cirrhosis Ascites Hyponatremia Risk Complications

A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding ya-Wen Wang Qiu-Wen li li-li Zhang Ai-Zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

Constructing a 3D multichannel structure to enhance performance of Ni–Co–Mn hydroxide electrodes for flexible supercapacitors

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Rare Metals 2024年第1期43卷 148-163页

作者： Zhi-hui Xu Shi-Shuai Sun Xue-Lei li Zhi-hui Zhang Hai-Ying li Shuang-Ting Ruan Shou-Gen Yin Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)and Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China College of Science Tianjin University of TechnologyTianjin 300384China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China

The balancing of the electrochemical performance,mechanical stability,and processing technology for applying supercapacitors to flexible and wearable electronics continues to encounter severe ***,we prepare Ni-Co-Mn hydroxide electrodes with a threedimensional multichannel structure via a simple hydrothermal *** are constructed using vertically contiguous nano sheets with a uniform thickness and rough *** electrodes can provide numerous electroactive sites and accelerate the transmission of electrolyte *** relationship between the structure and electrochemical performances is verified by experiments and theoretical ***-dimensional(2D)planar and one-dimensional(1D)fiber electrodes are prepared using a flexible carbon cloth(CC)and carbon fiber(CF),respectively,as *** assembled quasi-solid-state flexible asymmetric supercapacitor(FASC)with a twodimensional sandwich structure using NiCoMn-OH/CC as the electrode achieves a remarkable energy density of73.8 Wh·kg^(-1)at a power density of 1.03 kW·kg^(-1).The quasi-solid-state FASC with a 1D linear structure using NiCoMn-OH/CF as the electrode also attains a high energy density(12.9 Wh·kg^(-1)at a power density of0.75 W·kg^(-1)).Moreover,the electrochemical performances of the NiCoMn/CC//AC/CC and NiCoMn/CF//AC/CF FASCs are not disturbed at different bending angles(0°,45°,90°,135°and 180°),This indicates the superior flexibility of the *** also assemble a self-powered energy-harvesting storage system by integrating FASCs and commercial solar cells to verify its *** displays sustainable development potential for energy storage.

关键词： Supercapacitors Flexible Ni–Co–Mn hydroxide 3D multichannel structure High performances

Effect of forging on the microstructure and texture of a high Nb containing γ-TiAl alloy

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Journal of Central South University 2024年第6期31卷 1763-1773页

作者： TAO hui li hui-zhong WANG li ZHOU Rui CHE Yi-xuan CHEN Yong-hui liANG Xiao-peng School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Key Laboratory of Nonferrous Metal Materials Science and Engineering Central South UniversityChangsha 410083China Department of Materials Science and Engineering City University of Hong KongKowloon 999077Hong KongChina

The effect of forging on the microstructure and texture evolution of a high Nb containing Ti-45Al-7Nb-0.3W(at.%)alloy was investigated by X-ray diffractometer(XRD),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).The results show that the as-cast alloy is mainly composed of α_(2)/γ lamellar colonies with a mean size of 70μm,but the hot-forged pancake displays a near duplex microstructure(DP).Kinking and bending of lamellar colonies,deformation twinning and dynamic recrystallization(DRX)occur during hot ***,dense dislocations in theβphase after forging suggest that the high-temperature β phase with a disordered structure is favorable for improving the hot-workability of the *** the common TiAl casting texture,the solidification process of the investigated as-cast alloy with high Nb content is completely via the β phase region,resulting in the formation of aγ fiber texture where theγ aligns parallel to the heat-flow *** comparison,the relatively strongand weaktexture components in the as-forged alloy are attributed to the deformation *** annealing,static recrystallization occurs at the twin boundary and intersections,which weakens the deformation texture.

关键词： high Nb containingγ-TiAl alloy forging microstructure texture βphase

Erosion-induced recovery CO_(2) sink offset the horizontal soil organic carbon removal at the basin scale

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Science China Earth Sciences 2024年第6期67卷 2019-2033页

作者： lingxia WANG Xiaodong NIE Jiaqi li yaojun liU hui WANG yazhe li Zhongwu li School of Geographic Science Hunan Normal UniversityChangsha 410081China Institute of Interdisciplinary Studies Hunan Normal University and Hunan Provincial Key Laboratory for Eco-environmental Changes and Carbon Sequestration of the Dongting Lake BasinChangsha 410081China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

To improve soil carbon sequestration capacity,the full soil carbon cycle process needs to be understood and *** is essential to evaluate whether water erosion acts as a net source or sink of atmospheric CO_(2)at the basin scale,which encompasses the entire hydrological *** study introduced an approach that combined a spatially distributed sediment delivery model and biogeochemical model to estimate the lateral and vertical carbon fluxes by water erosion at the basin *** this coupling model to the Dongting Lake Basin,the results showed that the annual average amount of soil erosion during 1980-2020 was 1.33×10^(8)t,displaying a decreasing trend followed by a slight *** 12% of the soil organic carbon displacement was ultimately lost in the riverine systems,and the rest was deposited downhill within the *** average lateral soil organic carbon loss induced by erosion was 8.86×10^(11)g C in 1980 and 1.50×10^(11)g C in 2020,with a decline rate of 83%.A net land sink for atmospheric CO_(2)of 5.54×1011g C a^(-1)occurred during erosion,primarily through sediment burial and dynamic ***,ecological restoration projects and tillage practice policies are still significant in reducing erosion,which could improve the capacity of the carbon sink for recovery beyond the rate of horizontal carbon ***,our model enables the spatial explicit simulation of erosion-induced carbon fluxes using costeffective and easily accessible input data across large spatial scales and long ***,it offers a valuable tool for predicting the interactions between carbon dynamics,land use changes,and future climate.

关键词： Water erosion Sediment transfer Lateral soil carbon loss Land-atmosphere CO_(2) flux Dongting Lake Basin

Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： li Jie CHEN ya-feng GAO Lei li Yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(EliSA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(Plity,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

A hybrid nickel/iron-pyromellitic acid electrocatalyst for oxygen evolution reaction

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Nano Research 2024年第4期17卷 2481-2491页

作者： Guoqi li lin li Wenlong li Fusheng li Chunze Yuan Nian Zhang hui Zhang Tsu-Chien Weng School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China State Key Lab of Fine Chemicals Institute of Artificial PhotosynthesisDUT-KTH Joint Education and Research Center on Molecular DevicesDalian University of Technology(DUT)Dalian 116024China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

The migration of protons during the oxygen evolution reaction(OER)is a key factor that affects the performance of OER *** enhance proton transportation,we designed a catalyst based on nickel/iron-pyromellitic acid(NiFe-PMA)prepared by the electrochemical deposition *** catalyst exhibited a low overpotential of 188 mV at a current density of 10 mA·cm^(-2),a Tafel slope of 28.2 mV·dec^(-1),and long-term stability for 30 days with a current of 50 mA·cm^(-2).We characterized the NiFe-PMA catalyst using various techniques,including Fourier transform infrared(FTIR)spectroscopy,Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),X-ray absorption spectroscopy(XAS),transmission electron microscopy(TEM),scanning electron microscopy(SEM),and inductively coupled plasma-optical emission spectrometry(ICP-OES).Our results showed that NiFe-PMA contains nickel,iron atoms,and both coordinated and uncoordinated carboxylate ***,XPS data confirmed that carboxylate ligands could adjust the outer electronic structure of metal ions,resulting in the high valence state of Ni in *** result of XAS indicated that the nickel atoms present in the catalyst might be easier to maintain a higher chemical *** investigations using kinetic isotope effects(KIEs)and proton inventory revealed that the uncoordinated carboxylic protons played a crucial role in receiving protons during the OER,which promoted the proton transfer of the rate-determining step of the *** novel electrocatalysts provide a new strategy for designing more active and cost-effective catalysts for the OER.

关键词： nickel/iron-pyromellitic acid oxygen evolution reaction kinetic isotope effects

Resistance to salt stresses by aerobic granular sludge:sludge property and microbial community

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 107-116页

作者： Xiao Wu hui li Meili Wang Tianying Zhang Jiawei li Yongdi liu Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission School of Chemistry and EnvironmentSouthwest Minzu UniversityChengdu 610041China Institute for Environmental Pollution and Health School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China School of life Sciences Southwest UniversityChongqing 400715China State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resources and Environmental EngineeringEast China University of Science and TechnologyShanghai 200237China Institute of Qinghai-Tibetan Plateau Southwest Minzu UniversityChengdu 610041China

Saline wastewater is regarded as a challenge for wastewater treatment plants because high-salinity conditions negatively affect on traditional biological *** granular sludge(AGS)has gained attention as a promising technology for saline wastewater treatment because of its compact structure and the ability to withstand toxic ***,this study investigated the saltresistance performance,sludge properties and microbial community of AGS under low-salinity and high-salinity conditions,with the saline concentrations ranging from 0 to 50 g/*** results showed that AGS could withstand long-term saline stresses,and the maximum salinity reached 50 g/L within 113 *** salinities of 10,30,and 50 g/L,the chemical oxygen demand(COD)removal efficiencies were 90.3%,88.0%and 78.0%,*** also its maintained strength and aggregation at salinities of 10 and 30 g/*** of extracellular polymeric substances(EPS)by non-halophilic bacteria that enhanced sludge *** compact structure that ensured the microorganisms bioactivity helped to remove organic matters under salinities of 10 and 30 g/*** a salinity of 50 g/L,moderately halophilic bacteria,including Salinicola,Thioclava,Idiomarina and Albirhodobacter,prevailed in the *** dominant microbial communities shifted to moderately halophilic bacteria,which could maintain aerobic granular stabilization and remove organic matters under 50 g/L *** results in this study provide a further explanation for the long-term operation of AGS for treating saline wastewater at different *** is hoped that this work could bring some clues for the mystery of salt-resistance mechanisms.

关键词： Aerobic granular sludge Long-term saline stresses Performance Sludge property Microbial community