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A differential control method for the proportional directional valve

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 892-902页

作者： Bo JIN ya-guang zhu Wei LI De-sheng ZHANG Lu-lu ZHANG Fei-fei CHEN The State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Ningbo HOYEA Machinery Manufacture Co. Ltd.

For the proportional directional valve controlled by two proportional solenoids, the normal control method(NCM) energizes only one solenoid at a time. The performance of the valve is greatly influenced by the nonlinearity of the proportional solenoid, such as dead zone and low force gain with a small current, and this effect cannot be eliminated by a simple dead-zone current compensation. To avoid this disadvantage, we propose the differential control method(DCM). By employing DCM, the controller outputs differential signals to simultaneously energize both solenoids of the proportional valve, and the operating point is found by analyzing the force output of the two solenoids to make a minimum variation of the current force gain. The comparisons of the valve response characteristics are made between NCM and DCM by nonlinear dynamic simulation and experiments. Simulation and experimental results show that by using DCM, the frequency response of the valve is greatly enhanced, especially when the input is small, which means that the dynamic characteristics of the proportional valve are improved.

关键词： Differential control method Frequency response Proportional directional valve Spool displacement feedback

Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong zhu guang yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

智慧医疗情境下四方主体隐私行为的交互机理及演化趋势研究

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现代情报 2025年第1期45卷 135-149页

作者：朱光吴晗逸刘雯南京信息工程大学风险治理与应急决策研究院江苏南京210044 南京信息工程大学管理工程学院江苏南京210044

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平... 详细信息

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平台和政府四方博弈模型。根据不同参数调节下各方行为策略的收益、成本、损失等计算收益矩阵,求解主体的演化稳定策略,并考虑不同因素对主体行为策略及系统稳定状态的影响。[结果/结论]患者的隐私披露行为与披露隐私后获得的服务收益密切相关,医疗机构的隐私保护投入成本和隐私泄露概率对其隐私保护行为有显著影响,智慧医疗平台的政府奖惩、罚款收益和投入成本是影响其严格管理行为的关键因素,政府的监管行为与奖惩机制等因素密切相关。通过应用本文模型和方法,可以动态调整隐私保护机制,明确各方职责,推动智慧医疗可持续健康发展。

关键词：智慧医疗演化博弈隐私行为患者医疗机构智慧医疗平台政府

Research on the nanometric machining of a single crystal nickel via molecular dynamics simulation

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Science China(Technological Sciences) 2016年第12期59卷 1837-1846页

作者： GONG ya Dong zhu Zong Xiao ZHOU Yun guang SUN yao School of Mechanical Engineering & Automation Northeastern University

Molecular dynamics simulations are employed to study the nanometric machining process of single crystal nickel. Atoms from different machining zones had different atomic crystal structures owing to the differences in the actions of the cutting tool. The stacking fault tetrahedral was formed by a series of dislocation reactions, and it maintained the stable structure after the dislocation reactions. In addition, evidence of crystal transition and recovery was found by analyzing the number variations in different types of atoms in the primary shear zone, amorphous region, and crystalline region. The effects of machining speed on the cutting force, chip and subsurface defects, and temperature of the contact zone between the tool and workpiece were investigated. The results suggest that higher the machining speed, larger is the cutting force. The degree of amorphousness of chip atoms and the depth and extent of subsurface defects increase with the machining speed. The average friction coefficient first decreases and then increases with the machining speed because of the temperature difference between the chip and machining surface.

关键词： molecular dynamics simulation nanometric machining single crystal nickel crystal transition and recovery machining speed

A versatile nanobuilding precursor for the effective architecture of well-defined organic/inorganic hybrid via click chemistry

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Chinese Chemical Letters 2012年第9期23卷 1095-1098页

作者： ya Kun zhu Shan Yi guang Hong yao Xu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials&College of Material Science and Engineering Donghua UniversityChina Shanghai 201620 College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityChina Shanghai 201620

A novel octazido substituted nanobuilding precursor, octakis[dimethy（p-azidomethylene）siloxyl]octasilsesquioxane （ODA）, was prepared by the conventional diazo-transfer reaction of octalds[dimethy（p-chloromethylene）silyl]octasilsesquioxane （ODC） with NAN3, and its structure was characterized by FT-IR, 1H, a3C, 29Si NMR and MALDI-TOF MS, respectively. The structural rearrangement of POSS core in the synthesis strategy of ODA developed in this work was effectively prohibited in comparison with traditionary azidization process. The resultant ODA was not only soluble in common solvents such as CHC13, THF, toluene, DMF and DMSO, but also could effectively serve as a versatile nanobuilding precursor for the architecture of well-defined organic- inorganic hybrids via click chemistry.

关键词： Azides POSS Nanoparticles Structural Click chemistry

Synthesis and Crystal Structure of a Ternary Complex:[Ni(phen)_2(pmal)]·8H_2O

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1265-1269页

作者： SNN ya-guang Laboratory of Coordination Chemistry Shenyang Institute of Chemical TechnologyShenyang 110142 China

A new ternary complex [Ni（phen）（pmal）]·8H2O （phen = 1,10-phenanthroline, pmal^2- = phenethyl malonic acid） has been synthesized by the reaction of nickel acetate, phen and phenethyl malonic acid. Elemental analysis, IR spectra and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure. Crystal data for this complex： triclinic system, space group PI^-, a = 10.387（5）, b = 13.112（6）, c = 14.229（6） °A, α= 76.176（7）, β = 83.778（8）, γ = 71.770（6）°, C35H42N4O12Ni, Mr= 769.44, Z = 2, F（000） = 808, V = 1786.1°A^3, Dc = 1.431 g/cm^3,μ= 0.612 mm^-1, the final R = 0.0653 and wR = 0.1033 for 9379 （Rint = 0.0244） independent reflections and 4730 observed reflections （I〉 2σ（I））. Structural analysis shows that the coordination geometry of Ni（Ⅱ） is a distorted octahedron. A novel two-dimensional structure is constructed from （H2O）4 and （H2O）12 water clusters, and the complex forms a 3-D network supramolecular structure by hydrogen bonds and π-π stacking of neighboring phens.

关键词： Ni(Ⅱ) phenethyl malonic acid crystal structure water cluster

Molecular simulation study of the microstructures and properties of pyridinium ionic liquid[HPy][BF_(4)]mixed with acetonitrile

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原子与分子物理学报 2025年第4期42卷 27-32页

作者： XU Jian-Qiang MA Zhao-Peng CHENG Si LIU Zhi-Cong zhu guang-Lai Department of Physics School of Physics and Electronic InformationAnhui Normal UniversityWuhu 241002China

The microstructures and thermodynamic properties of mixed systems comprising pyridinium ionic liquid[HPy][BF_(4)]and acetonitrile at different mole fractions were studied using molecular dynamics simulation in this *** following properties were determined:density,self-diffusion coefficient,excess molar volume,and radial distribution *** results show that with an increase in the mole fraction of[HPy][BF_(4)],the self-diffusion coefficient ***,the excess molar volume initially decreases,reaches a minimum,and then *** rules of radial distribution functions(RDFs)of characteristic atoms are *** increasing the mole fraction of[HPy][BF_(4)],the first peak of the RDFs of HA1-F decreases,while that of CT6-CT6 rises at first and then *** indicates that the solvent molecules affect the polar and non-polar regions of[HPy][BF_(4)]differently.

关键词： Pyridinium ionic liquids Thermodynamic properties Molecular dynamics simulation Radial distribution functions

An Interior-Point Algorithm for Linear Programming with Optimal Selection of Centering Parameter and Step Size

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Journal of the Operations Research Society of China 2021年第3期9卷 659-671页

作者： ya-guang yang Nuclear Regulatory Commission Office of ResearchRockville 20850USA

For interior-point algorithms in linear programming,it is well known that the selection of the centering parameter is crucial for proving polynomiality in theory and for efficiency in ***,the selection of the centering parameter is usually by heuristics and separated from the selection of the line-search step *** heuristics are quite different while developing practically efficient algorithms,such as Mehrotra’s predictor–corrector(MPC)algorithm,and theoretically efficient algorithms,such as short-step path-following *** introduces a dilemma that some algorithms with the best-known polynomial bound are least efficient in practice,and some most efficient algorithms may not be convergent in polynomial ***,in this paper,we propose a systematic way to optimally select the centering parameter and linesearch step size at the same time,and we show that the algorithm based on this strategy has the best-known polynomial bound and may be very efficient in computation for real problems.

关键词： Interior-point method Convergence Polynomial algorithm Linear programming

Sticking-bacteria gel enhancing anti-multidrug-resistant microbial therapy under ultrasound

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Nano Research 2022年第10期15卷 9105-9113页

作者： ya-Qi zhu Wei-Qiang Huang guang Chen Lei Xia Ye-Zi You Yue Yu The Department of Gastroenterology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China

The use of antibiotic could cause severe drug-resistance and the increasing spread of pathogenic drug-resistant bacteria has brought a big threat to human health,hence,some innovative methods inspired,such as sonodynamic therapy,have become increasingly attractive for realizing the antibiotic-free methods against bacterial ***,many pathogens can invade normal healthy cells to establish intracellular replicative niches,which makes it more difficult to kill and remove these ***,inspired by respiratory mucus trapping bacteria to kill them,we developed a novel gel of amorphous TiO_(x) nanofibers dotted with Ti_(2)C(OH)_(2) nanosheets,which could capture and trap bacteria into the gel via a strong binding ability toward bacteria by forming a Ti–O–P bond between phosphate in the bacterial wall and Ti-OH in the gel,thereby,efficiently blocking the invasions of ***,the gel has excellent ability for generating reactive oxygen species(ROS)under ultrasound irradiation,therefore,the bacteria in the gel could be effectively killed by the ROS produced under ultrasound ***,Ti2C(OH)2 in the gel was able to scavenge H_(2)O_(2),and transfer it into O_(2) in the infection environment,providing enough O_(2) for sonodynamic *** experimental results have demonstrated that the functional gel obviously accelerated the healing of multidrug-resistant microorganisms-infected wounds.

关键词： multidrug-resistant bacteria gel ultrasound bacteria-sticking