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Pneumocystis jirovecii diagnosed by next-generation sequencing of bronchoscopic alveolar lavage fluid: A case report and review of literature

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World Journal of Clinical Cases 2023年第4期11卷 866-873页

作者： Qing-Wei Cheng Hong-Li Shen Zhi-Hui Dong Qian-Qian Zhang ya-fen wang Jin yan Yu-Sheng wang Ning-Gang Zhang Department of Oncology The Sixth Division HospitalXinjiang Production and Construction CorpsWujiaqu 831300Xinjiang Uygur Autonomous RegionsChina Department of Gastrointestinal Oncology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina

BACKGROUND The advent of molecular targeted agents and immune checkpoint inhibitors has greatly improved the treatment of advanced renal cell carcinoma(RCC), thus significantly improving patient survival. The incidence of rare drug-related adverse events has gained increased *** SUMMARY We report a patient with advanced RCC treated with multiple lines of molecular targeted agents and immune checkpoint inhibitors, who developed a pulmonary infection after treatment with everolimus in combination with lenvatinib. Determining the pathogenic organism was difficult, but it was eventually identified as Pneumocystis jirovecii by next-generation sequencing(NGS) of bronchoscopic alveolar lavage fluid(BALF) and successfully treated with *** Rare pulmonary infections caused by molecular targeted agents are not uncommon in clinical practice, but their diagnosis is difficult. Evaluating BALF with NGS is a good method for rapid diagnosis of such infections.

关键词： Renal cell carcinoma Everolimus Pneumocystis jirovecii pneumonia Next-generation sequencing Bronchoscopic alveolar lavage fluid Case report

A modified laser-induced choroidal neovascularization animal model with intravitreal oxidized low-density lipoprotein

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1187-1194页

作者： Tong Wu Kuan-Rong Dang ya-fen wang Bao-Zhen Lyu Wen-Qin Xu Guo-Rui Dou Jian Zhou yan-Nian Hui Hong-Jun Du Department of Ophthalmology Xijing HospitalEye Institute of Chinese PLAFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Anatomy and Histology and Embryology Xi’an Health SchoolXi’an 710032Shaanxi ProvinceChina The Orbital Disease Institute of the Third Medical Center of PLA General Hospital Beijing100039China

AIM: To investigate whether intravitreal injection of oxidized low-density lipoprotein(OxLDL) can promote laserinduced choroidal neovascularization(CNV) formation in mice and the mechanism involved, thereby to develop a better animal ***: C57BL6/J mice were randomized into three groups. Immediately after CNV induction with 532 nm laser photocoagulation, 1.0 μL of OxLDL [100 μg/m L in phosphate-buffered saline(PBS)] was intravitreally injected, whereas PBS and the same volume low-density lipoprotein(LDL;100 μg/m L in PBS) were injected into the vitreous as controls. Angiogenic and inflammatory cytokines were measured by quantitative real-time polymerase chain reaction(q RT-PCR) and Western blotting(WB) after 5 d, and CNV severity was analyzed by choroid flat mount and immunofluorescence staining after 1wk. In vitro, retinal pigment epithelial(RPE) cell line(ARPE19) were treated with OxLDL(LDL as control) for 8 h. Angiogenic and inflammatory cytokine levels were measured. A specific inhibitor of lectin-like oxidized low-density lipoprotein receptor 1(LOX1) was used to evaluate the role of LOX1 in this ***: At 7 d after intravitreal injection of 1 μL(100 μg/mL) OxLDL, T15-labeled OxLDL was mainly deposited around the CNV area, and the F4/80-labeled macrophages, the CD31-labeled vascular endothelial cells number and CNV area were increased. Meanwhile, WB and qR T-PCR results showed that vascular endothelial growth factor(VEGF), CC chemokine receptor 2(CCR2), interleukin-6(IL-6), IL-1β, and matrix metalloproteinase 9(MMP9) expressions were increased, which was supported by in vitro experiments in RPE cells. LOX1 inhibitors significantly reduced expressions of inflammatory factors IL-1β and VEGF. CONCLUSION: A modified laser-induced CNV animal model is established with intravitreal injection of 1 μL(100 μg/mL) of OxLDL at 7 d, which at least partially through LOX1. This animal model can be used as a simple model for studying the role of OxLDL in age-

关键词： age-related macular degeneration choroidal neovascularization oxidized low-density lipoprotein animal model

Quality of life and symptom distress after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2022年第32期10卷 11775-11788页

作者： ya-fen wang Ting-yao wang Tzu-Ting Liao Meng-Hung Lin Tzu-Hao Huang Meng-Chiao Hsieh Vincent Chin-Hung Chen Li-Wen Lee Wen-Shih Huang Chao-Yu Chen Cancer Center Chang Gung Memorial HospitalChiayiTaiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayiTaiwan Division of Case Management Cancer CenterChang Gung Memorial HospitalChiayiTaiwan Health Information and Epidemiology Laboratory Chang Gung Memorial HospitalChiayiTaiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayiTaiwan Division of Colorectal Surgery Department of SurgeryChang Gung Memorial HospitalChiayiTaiwan Department of Psychiatry Chang Gung Memorial HospitalChiayi and Chang Gung UniversityTaoyuanTaiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayiTaiwanCollege of MedicineChang Gung UniversityTaoyuanTaiwan Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayiTaiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiungTaiwanDepartment of Early Childhood Care and EducationShu-Zen Junior College of Medicine and ManagementKaohsiungTaiwan

BACKGROUND Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy(CRS/HIPEC)for peritoneal surface malignancy can effectively control the disease,however it is also associated with adverse effects which may affect quality of life(QoL).AIM To investigate early perioperative QoL after CRS/HIPEC,which has not been discussed in *** This single institution,observational cohort study enrolled patients who received CRS/*** assessed QoL using the Taiwan residents version of the MD Anderson Symptom Inventory(MDASI-T)and European Organization Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ-C30).Participants completed the questionnaires before CRS/HIPEC(S1),at the first outpatient follow-up(S2),and 3 mo after CRS/HIPEC(S3).RESULTS Fifty-eight patients were *** was no significant perioperative difference in global health *** changes in physical and role functioning scores decreased at S2,and fatigue and pain scores increased at S2 but returned to baseline at *** regression analysis showed that age and performance status were significantly correlated with *** the MDASI-T questionnaire,distress/feeling upset and lack of appetite had the highest scores at S1,compared to fatigue and distress/feeling upset at S2,and fatigue and lack of appetite at *** leading interference items were working at S1 and S2 and activity at ***-T scores were significantly negatively correlated with the EORTC QLQ-C30 *** QoL and symptom severity improved or returned to baseline in most categories within 3 mo after CRS/*** findings can help with preoperative consultation and perioperative care.

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis Quality of life Symptom distress Perioperative care

Kinsenoside:A Promising Bioactive Compound from Anoectochilus Species

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 11-18页

作者： Chang-xing QI Qun ZHOU Yuan ZHOU Zeng-wei LUO Chong DAI Hu-cheng ZHU Chun-mei CHEN Yong-bo XUE Jian-ping wang ya-fen wang ya-ping LIU Ming XIANG Wei-guang SUN Jin-wen ZHANG Yong-hui ZHANG Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 China

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus,and exhibits many biological activities and pharmacological effects,including hepatoprotective,anti-hyperglycemic,anti-hyperliposis,anti-inflammatory,vascular protective and anti-osteoporosis effects and so on,which is contributing to its promising potency in disease *** review aims to recapitulate the pharmacological functions of kinsenoside,as well as its source,extraction,identification,quantitative analysis,pharmacokinetics,synthesis and patent *** data reported in this work can confirm the therapeutic potential of kinsenoside and provide useful information for further new drug development.

关键词： Anoectochilus roxburghii kinsenoside bioactivity synthesis review

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Bi Modified Bi2MoO6 Microspheres by Photo-reduction With Enhanced Visible Light Photocatalytic Activity for Degradation of NOx

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Bi Modified Bi2MoO6 Microspheres by Photo-reduction With Enh...

Nitrogen-doped Carbon Quantum Dots Decorated Zn Sn（OH）6 Nanocomposite with Enhanced Visible Light Photocatalytic Oxidation Activity for NO Removal

第十八届中国科协年会——分12 大气雾霾及PM2.5控制先进技术研讨会

作者： Huichi CHUANG Shengjie YOU ya fen wang Yu HUANG Junji CAO Qian ZHANG DepartmentofenvironmentalEngineering ChungYuanChristianUniversity KeyLaboratoryofAerosolChemistryandPhysics InstituteofEarthEnvironmentChineseAcademyofSciences

The problem of environmental pollution and energy shortage has become the two major problems faced by the sustainable development of human beings. Therefore, the development of friendly new energy has

关键词： Photo-reduction NOx Bi2MoO6

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Nitrogen-doped Carbon Quantum Dots Decorated Zn Sn（OH）6 Na...

骨髓间充质干细胞外泌体中miRNA在视网膜新生血管形成中的作用及机制

第十八届中国科协年会——分12 大气雾霾及PM2.5控制先进技术研讨会

作者： Jinjie HE Shengjie YOU ya fen wang Yu HUANG Junji CAO yanfeng LU DepartmentofenvironmentalEngineering ChungYuanChristianUniversity KeyLaboratoryofAerosolChemistryandPhysics InstituteofEarthEnvironmentChineseAcademyofSciences

Indoor nitrogen oxides can enter the body through breathing, and it cause irritation of the respiratory tract, lungs, and the corrosion damage of organs. So, it is importance to remove these pollutant

关键词： NO removal N-CQDs doped photocatalyst ZnSn(OH)6

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国际眼科杂志 2022年第6期22卷 936-940页

作者：张璐王雅芬叶亚婷白倩郭长梅空军军医大学西京医院眼科全军眼科研究所中国陕西省西安市710032

视网膜血管疾病如早产儿视网膜病变、糖尿病视网膜病变和视网膜静脉阻塞等以异常增生的视网膜新生血管为主要病理表现。骨髓间充质干细胞来源外泌体通过旁分泌作用传递生物活性分子介导细胞间的物质与信息交换。其中,miRNA等内容物在传... 详细信息

视网膜血管疾病如早产儿视网膜病变、糖尿病视网膜病变和视网膜静脉阻塞等以异常增生的视网膜新生血管为主要病理表现。骨髓间充质干细胞来源外泌体通过旁分泌作用传递生物活性分子介导细胞间的物质与信息交换。其中,miRNA等内容物在传递信息中起关键作用,可调控缺血缺氧环境下内皮细胞的增殖、管腔形成和新生血管的形成。并且能够通过血视网膜屏障而不引起免疫、炎症反应,在眼科疾病治疗中极具潜力。本文总结骨髓间充质干细胞衍生外泌体中miRNA在视网膜新生血管形成中的作用和可能的作用机制,以期为外泌体在眼科疾病诊治中的应用拓宽新思路。

关键词：骨髓间充质干细胞外泌体 miRNA 视网膜新生血管

维普期刊数据库

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： fen wang Lu-Yu Liu Sha-Sha Cui Ting-Ting Li Xiao-Meng yang Zhijuan Liu yanyong wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia Li Wenwu Liu Shiji Da Lingbin Kong fen Ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management