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Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

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Chinese Journal of Polymer Science 2021年第8期39卷 1020-1028,I0007页

作者： Xiao liu Jian-Wei Guo ya-dong liu Ming liu Hui liu Miao-Miao Han Sheng-Xiang Ji Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein, we prepare an antibacterial composite(TPU-x) through blending medical grade thermoplastic polyurethane(TPU) and the complex(PL-DOSS) of ε-polylysine(ε-PL) and docusate sodium(DOSS). >99% reduction of colony forming unit(CFU) can be obtained in TPU-x composite films even at relatively low content of PL-DOSS, e.g. 0.13% for Methicillin resistant S. aureus(MRSA) and 0.5% for E. coli. The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ~100 nm. TPU-x composite films exhibit long-term stability in saline and good biocompatibility, and retain mechanical properties of TPU.

关键词： Nosocomial infections Antibacterial composite Solution blending Thermoplastic polyurethane Polylysine

Mechanism of Pendulum-type wave phenomenon in deep block rock mass

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Mining Science and Technology 2009年第6期19卷 699-708页

作者： WU Hao FANG Qin ZHANG ya-dong liu Jin-chun GONG Zi-ming Engineering Institute of Engineering Corps PLA University of Science and Technology Nanjing Jiangsu 210007 China

Pendulum-type ( μ wave) wave is a new type of elastic wave propagated with low frequency and low velocity in deep block rock masses. The μ wave is sharply different from the traditional longitudinal and transverse waves propagated in continuum media and is also a phenomenon of the sign-variable reaction of deep block rock masses to dynamic actions, besides the Anomalous Low Friction (ALF) phenomenon. In order to confirm the existence of the μ wave and study the rule of variation of this μ wave experimentally and theoretically, we first carried out one-dimensional low-speed impact experiments on granite and cement mortar blocks and continuum block models with different characteristic dimensions, based on the multipurpose testing system developed by us independently. The effects of model material and dimensions of models on the propagation properties of 1D stress wave in blocks medium are discussed. Based on a comparison and analysis of the propagation properties (acceleration amplitudes and Fourier spectra) of stress wave in these models, we conclude that the fractures in rock mass have considerable effect on the attenuation of the stress wave and retardarce of high frequency waves. We compared our model test data with the data of in-situ measurements from deep mines in Russia and their conclusions. The low-frequency waves occurring in blocks models were validated as Pendulum-type wave. The frequencies corresponding to local maxima of spectral density curves of three-directional acceleration satisfied several canonical sequences with the multiple of 2～(1/2), most of those frequencies satisfied the quantitative expression (2～(1/2))i V p/2△ .

关键词： deep block rock mass Pendulum-type wave cement mortar canonical sequence local maximum frequency

A Facile Strategy to Enhance the Formation of Stereocomplex Crystallites in Poly(L-lactic acid)/Poly(D-lactic acid) Blend with High Molecular Weights

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Chinese Journal of Polymer Science 2023年第7期41卷 1115-1122页

作者： Chan-Na Zhong ya-dong liu Juan Tang Wei-Shuo Chen Shuang-Cheng Li Jun Shao Hao-Qing Hou College of Chemistry&Chemical Engineering and Nanofiber Engineering Center of Jiangxi Province Jiangxi Normal UniversityNanchang330022China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China

Blending of poly(levorotatory-lactic acid) (PLLA) and poly(dextrorotatory-lactic acid) (PDLA) produces the stereocomplex crystallites (PLA SC), which present higher melting temperature and mechanical properties than that of neat PLLA or PDLA. However, in the PLLA/PDLA blends with higher molecular weights, the phase separation occurs and the SC exhibits weak memory after melting, which lead to a small amount of SC together with a large amount of homochiral crystallites (HC) develop during crystallization from the melt. In this study, a small content of graphite oxide was blended with PLLA and PDLA to form ternary blends, and it was exciting to find that the formation of SC was enhanced gradually with the content of graphite oxide. The SC exclusively developed when 2 wt% graphite oxide was incorporated into the PLLA/PDLA, and the crystallinity with ∼50% was received even during fast cooling from the melt (−50 ℃/min). The acceleration formation of SC was speculated due to the interaction between PLA molecular chains and the hydroxyl groups on the surface of graphite oxide and the obstruction of proliferation of graphite oxide.

关键词： Poly(lactic acid)stereocomplex Graphite oxide Crystallization behavior Melt memory

Melatonin for the treatment of spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1685-1692页

作者： yan Zhang Wen-Xiu Zhang yan-Jun Zhang ya-dong liu Zong-Jian liu Qi-Chao Wu Yun Guan Xue-Ming Chen Central Laboratory Beijing Luhe HospitalCapital Medical University Department of Orthopedics Beijing Luhe HospitalCapital Medical University Department of Anesthesiology and Critical Care Medicine Johns Hopkins University Department of Neurological Surgery Johns Hopkins University

Spinal cord injury（SCI） from trauma or disease severely impairs sensory and motor function. Neurorehabilitation after SCI is a complex medical process that focuses on improving neurologic function and repairing damaged connections in the central nervous system. An increasing number of preclinical studies suggest that melatonin may be useful for the treatment of SCI. Melatonin is an indolamine that is primarily secreted by the pineal gland and known to be regulated by photoperiodicity. However, it is also a versatile hormone with antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties. Here, we review the neuroprotective properties of melatonin and the potential mechanisms by which it might be beneficial in the treatment of SCI. We also describe therapies that combine melatonin with exercise, oxytetracycline, and dexamethasone to attenuate the secondary injury after SCI and limit potential side effects. Finally, we discuss how injury at different spinal levels may differentially affect the secretion of melatonin.

关键词： spinal cord injury melatonin secondary damage neuroprotection antioxidative antiapoptotic anti-inflammatory synergistic effects neural regeneration

Enhanced rate capability and cycle stability of Ti2C MXene for sodium storage through an aniline molecules welding strategy

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Tungsten 2025年第1期7卷 161-171页

作者： Hao Chen ya-Qin Wang dong-Ting Zhang Bei Zhao Min-Peng Li Chen-yang Li Tian-Peng Xu Mao-Cheng liu State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology School of Computer and Communication Technology Lanzhou University of Technology

MXenes obtained significant attention in the field of energy storage devices due to their characteristic layered structure,modifiable surface functional groups,large electrochemically active surface,and regulable interlayer ***,the self-restacking and sluggish ions diffusion kinetics performance of MXenes during the alkali metal ions insertion/extraction process severely impedes their cycle stability and rate *** paper proposes an aniline molecule welding strategy for welding p-phenylenediamine（PPDA） into the interlayers of Ti2C through a dehydration condensation *** welded PPDA molecules can contribute pillar effect to the layered structure of *** pillar effect effectively maintains the structural stability during the sodium ions insertion/extraction process and effectively expands the interlayer spacing of Ti2C from 1.16 to 1.38 nm,thereby enhancing ions diffusion kinetics performance and improving the long-term cycle *** Ti2C-PPDA demonstrates outstanding Na+storage capability,exhibiting a specific capacity of 100.2 mAh·g-1at a current density of 0.1 A·g-1over 960 cycles and delivering a remarkable rate capability 81.2 mAh·g-1at a current density of 5 A·*** study demonstrates that expanding interlayer spacing is a promising strategy to enhance the Na+storage capacity and improve long-term cycling stability,which provides significant guidance for the design of two-dimensional Na+storage materials with high-rate capability and cycle stability.

关键词： Diffusion kinetics Expanding interlayer spacing Rate capability Sodium ions storage Ti2C

Effect of low-level laser irradiation(LLLI)combined with ferulic acid on the osteoblast differentiation and maturation as well as osteogenesis signaling pathway expression

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Journal of Hainan Medical University 2017年第18期23卷 1-4页

作者： Cheng-Xiao Huang Hua-Long Yu Chao Gao ya-dong liu Department of Orthopaedics III Dongfeng HospitalHubei University of MedicineShiyan CityHubei Province442008

Objective: To study the effect of low-level laser irradiation (LLLI) combined with ferulic acid on the osteoblast differentiation and maturation as well as osteogenesis signaling pathway expression. Methods: The cranium was collected from the SD rats born within 24 h, osteoblasts were separated, cultured and then divided into control group, ferulic acid group, LLLI group, ferulic acid + LLLI group, and the expression osteoblast differentiation markers, proliferation molecules and signaling pathway molecules were detected after continuous treatment with different conditions for three days. Results: 3 d after treatment, the Bax and Bid mRNA expression in ferulic acid group, LLLI group and ferulic acid + LLLI group of cells were significantly lower than those in control group while Bcl-2, CyclinD1, E2F, Col-I, OC and ALP mRNA expression as well as Wnt, β-catenin, Runx2, cAMP and PKA protein expression were significantly higher than those in control group;Bax and Bid mRNA expression in ferulic acid + LLLI group of cells were significantly lower than those in ferulic acid group and LLLI group while Bcl-2, CyclinD1, E2F, Col-I, OC and ALP mRNA expression as well as Wnt, β-catenin, Runx2, cAMP and PKA protein expression were significantly higher than those in ferulic acid group and LLLI group;Col-I, OC, ALP, Bax, Bid, Bcl-2, CyclinD1 and E2F mRNA expression as well as Wnt, β-catenin, Runx2, cAMP and PKA protein expression were not significantly different between ferulic acid group and LLLI group. Conclusion: Low-level laser irradiation (LLLI) combined with ferulic acid can promote osteoblast differentiation and maturation and activate osteogenesis signaling pathway.

关键词： Low-level laser irradiation Ferulic acid Differentiation Proliferation Signaling pathway

中央孔型ICL V4c植入术矫正中高度近视的稳定性及高阶像差分析

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国际眼科杂志 2019年第4期19卷 644-648页

作者：杨云刘亚东郑州大学第二附属医院眼科中国河南省郑州市450000

目的:探讨中央孔型ICL V4c植入术矫正中高度近视的稳定性及对高阶像差的影响。方法:观察采用ICL V4c人工晶状体植入术(研究组17例34眼)和全飞秒小切口基质透镜取出术(SMILE)(对照组18例34眼)治疗的高度近视患者术前、术后1d,1wk,1、3mo ... 详细信息

目的:探讨中央孔型ICL V4c植入术矫正中高度近视的稳定性及对高阶像差的影响。方法:观察采用ICL V4c人工晶状体植入术(研究组17例34眼)和全飞秒小切口基质透镜取出术(SMILE)(对照组18例34眼)治疗的高度近视患者术前、术后1d,1wk,1、3mo UCVA、BCVA、球镜(SE)、柱镜(CE)、IOP、角膜内皮细胞计数、总高阶像差(RMS)、球差、垂直彗差、水平彗差、彗差的差异。结果:术后1、3mo研究组SE、CE高于对照组(P<0.05),术后1wk,1、3mo RMS、彗差低于对照组(P<0.05),术后3mo球差、水平彗差低于对照组(P<0.05)。结论:ICL V4c植入术矫正中高度近视眼具有良好稳定性,对术眼高阶像差影响小。

关键词： ICL V4c 中高度近视高阶像差稳定性

HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

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Oncology Research 2025年第1期33卷 83-102页

作者： YUEZHOU ZHANG ZHAO ZHANG JINXIN dong CHANGAN liu Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China

Background:Aberrant expression of RNA-binding proteins(RBPs)has been linked to a variety of diseases,including hematological disorders,cardiovascular diseases,and multiple types of *** nuclear ribonucleoprotein C(HNRNPC),a member belonging to the heterogeneous nuclear ribonucleoprotein(hnRNP)family,plays a pivotal role in nucleic acid *** studies have underscored the significance of HNRNPC in tumorigenesis;however,its specific role in malignant tumor progression remains inadequately ***:We leveraged publicly available databases,including The Cancer Genome Atlas(TCGA),to explore the potential involvement of HNRNPC across various ***,we performed experimental validation studies focused on liver ***:Our analysis revealed that HNRNPC is overexpressed in a wide range of common malignancies,including liver and lung cancers,and is strongly linked to unfavorable ***,HNRNPC was observed to be closely linked to tumor *** immune checkpoint analysis and immune cell infiltration assessment,HNRNPC emerged as a potential target for modulating tumor ***,silencing of HNRNPC markedly inhibited the proliferation,metastasis,and infiltration of liver cancer ***:In summary,our findings highlight HNRNPC as a prognostic marker in various cancers,including liver cancer,and suggest its involvement in shaping the tumor immune *** insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression,particularly through immunotherapeutic strategies.

关键词： Heterogeneous nuclear ribonucleoprotein C(HNRNPC) Pan-cancer analysis Tumor immunity Prognostic biomarker Immunotherapeutic target Hepatocellular carcinoma

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein