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Extensive myocardial calcification in critically ill patients receiving extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4214-4219页

作者： Ming-Liang Sui Chang-Jiang Wu ya-di yang Da-Mei Xia Tian-Jie Xu Wei-Bing Tang Department of Critical Care Medicine Suzhou Kowloon HospitalShanghai Jiaotong University School of MedicineSuzhou 215028Jiangsu ProvinceChina

BACKGROUND Myocardial calcification is a rare complication in critically ill *** prognosis of myocardial calcifications in critically ill patients is very poor if not treated in a timely *** describe a rare case of acute extensive myocardial calcifications due to acute myocarditis after receiving extracorporeal membrane oxygenation(ECMO)*** SUMMARY We report a 17-year-old male patient who developed extensive myocardial calcifications while receiving prolonged ECMO support for severe myocarditis and cardiogenic *** myocardial calcifications were confirmed by chest computed tomography(CT).Myocardial calcifications were observed in the left ventricle walls on CT examination 10 days after *** patient was then discharged with heart function class II on the NYHA *** years later,the patient was still alive with adequate quality of *** then included this patient and 7 other cases retrieved from the PubMed,Cochrane Library,EMBASE,and MEDLINE databases in our study,in order to provide a reference for the clinical diagnosis and treatment of this *** Multiple causes including prolonged hemodynamic failure,profound acidosis,high vasopressor doses,and acute renal failure may jointly lead to extensive myocardial *** precise role of ECMO support in the timing and frequency of acute myocardial calcifications deserves further investigation.

关键词： Cardiogenic shock Cardiac calcification Extracorporeal membrane oxygenation Case report

Novel self-assembled porous yolk-shell NiO nanospheres with excellent electrochromic performance for smart windows

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Particuology 2024年第1期84卷 72-80页

作者： Baoshun Wang ya Huang Siming Zhao Run Li di Gao Hairong Jiang Rufan Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing100084China

With the rapid development of optoelectronics,electrochromic(EC)materials(ECMs)with the advan-tages of low power consumption,easy viewing,high contrast ratio,etc have attached more and more attention from the fields of smart windows,electronic billboards,emerging wearable and portable electronics,and other next-generation *** oxide(NiO)is a promising candidate for high-performance ECMs because of its neutral-colored states and low ***,NiO-based ECMs still face the problem of slow switching speed due to their low electrical conductivity and small lattice ***-organic frameworks(MOFs)are promising candidates to fabricate hollow and porous transition metal oxides(TMOs)with high ion transport efficiency,excellent specific capacitance,and electrochemical *** this work,porous yolk-shell NiO nanospheres(PYS-NiO NSs)were syn-thesized via a solvothermal and subsequent calcination process of Ni-MOF,which exhibited outstanding EC *** the large specific surface areas and hollow porous nanostructures were conducive to ionic transport,PYS-NiO NSs exhibited a fast coloring/bleaching speed(3.6/3.9 s per one coloring/bleaching cycle)and excellent cycling stability(82%of capacity retention after 3000 cycles).These superior EC properties indicated that the PYS-NiO NSs was a promising candidate for high-performance EC *** work provides a new and feasible strategy for the efficient preparation of TMOs ECMs with good EC performance,especially fast switching speed.

关键词： Electrochromic Nickel oxide Metal-organic frameworks Hollow structure Smart windows

Reduction on OFF-responses of Electroretinogram in Monkeys with Long-term High Intraocular Pressure

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Chinese Medical Journal 2017年第22期130卷 2713-2719页

作者： Ke-Gao Liu Xiao-yan Peng Zheng Zhang Hua Sun di-ya yang Ning-Li Wang Department of Ophthalmology Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key Lab Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Tongren Eye Center Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background： There are ON- and OFF-pathways in the normal vertebrate retina. Short- and long-flash electroretinogram （ERG） are suitable methods to observe the function of ON- and OFF-pathways in vivo, respectively. It is clear that high intraocular pressure （IOP） might cause dysfunction of cone-dominated photopic negative response （PhNR） in monkeys with high lOP in ON-pathway. However, whether cone-dominated OFF-responses are also affected is less known. The aim of this study was to observe photopic OFF-responses of ERG in monkeys with high lOP. Methods： Nine monkeys were involved in the experiment from January 2006 to December 2016. High IOP was induced in the right eye by laser coagulation of the mid-trabecular meshwork in five monkeys. Six years after the laser coagulation, both short- and long-flash of the photopic ERG were recorded. Stimulus light was red flashes superimposed on a blue background. Four normal monkeys were examined under the same ERG protocols as controls. Paired t-test was used to compare the difference of each ERG parameter between the lasered eye and the fellow eye. Analysis of variance （ANOVA） with Tukey adjustment was adopted to calculate the differences among the lasered eye, the fellow eye, and the eyes of normal monkeys. Results： The mean amplitude of a-wave （11.73 ± 2.05） and PhNR （8.67 ± 2.44） in lasered eyes was significantly lower than that of a-wave （21.47 ±3.15） and PhNR （22.05 ± 3.42） in fellow eyes （P = 0.03 and P 0.01, respectively） in response to short flash. The mean amplitude old-wave （ 1.60 ± 0.59） and/-wave （3.13± 0.64） was significantly reduced in the lasered eyes than that of d-wave （4.01 ± 0.56） and/-wave （8.79 ± 1.75） in the fellow eyes （P =0.02 and P = 0.02, respectively） in response to long flash. Conclusions： Reduced OFF-responses are recorded in monkeys with high IOP when dysfunction ofphotoreceptor is involved. The reduced OFF-responses to long-flash stimulus show evidence of anomalous retinal circuitry in glaucomat

关键词： Electroretinogram OFF-responses Monkey liatraocular Pressure Retinal Pathway

Reproducibility of Perfusion Parameters of Optic disc and Macula in Rhesus Monkeys by Optical Coherence Tomography Angiography

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Chinese Medical Journal 2016年第9期129卷 1087-1090页

作者： Jing Li Yi-Quan yang di-ya yang Xiang-Xiang Liu Yun-Xiao Sun Shi-Fei Wei Ning-LiWang Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing 100730 China Beijing Institute of Ophthalmology Beijing Tongren Hospitai Capital Medical University Beijing 100005 China

Background： Optical coherence tomography （OCT） angiography is a novel technique by which we can detect the local perfusion of fundus directly. The aim of this study was to evaluate the reproducibility of optic disc and macular flow perfusion parameters in rhesus monkeys using OCT angiography. Methods： Eighteen healthy monkeys （18 eyes） were subjected to optic disc and macula flow index measurements via a high-speed and high-resolution spectral-domain OCT XR Avanti with a split-spectrum amplitude de-correlation angiography algorithm. Right eye was imaged 3 times during the first examination and once during each of the two following examinations. The intra-visit and inter-visit intraclass correlation coefficients （ICCs） were both determined. Results： The average flow indices of the four optic disc area layers were 0.171 ± 0.009 （optic nerve head）, 0.015 ± 0.004 （vitreous）, 0.052 ±0.009 （radial peripapillary capillary）, and 0.167 ± 0.011 （choroid）. Average flow indices of the four macula area layers were 0,044 ± 0.011 （superficial retina）, 0.036 ± 0.011 （deep retina）, 0.016 ± 0.009 （outer retina）, and 0.155 ± 0.013 （choroid）. Intra-visit （1CC value： 0.821-0.954） and inter-visit （ICC value： 0.844±0.899） repeatability were both high. Conclusions： The study is about the reproducibility of optic disc and macular perfusion parameters as measured by OCT angiography in healthy rhesus monkeys. Flow index measurement reproducibility is high for both the optic disc and macula of normal monkey eyes. OCT angiography might be a useful technique to assess changes when examining monkeys with experimental ocular diseases.

关键词： Flow Index Macula Optic disc Optical Coherence Tomography Angiography

Bifurcations and Spatiotemporal Patterns in the diffusive Nutrient-Microorganism Model

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Acta Mathematicae Applicatae Sinica 2024年

作者： ya-di WANG Hai-long YUAN yan-ling LI School of Mathematics and Information Science Shaanxi Normal University School of Arts and Sciences Shaanxi University of Science and Technology School of Mathematics and Statistics Xi'an Jiaotong University

In this paper, the diffusive nutrient-microorganism model subject to Neumann boundary conditions is considered. The Hopf bifurcations and steady state bifurcations which bifurcate from the positive constant equilibrium of the system are investigated in details. In addition, the formulae to determine the direction of Hopf and steady state bifurcations are derived. Our results show the existence of spatially homogeneous/nonhomogeneous periodic orbits and steady state solutions, which indicates the spatiotemporal dynamics of the system. Some numerical simulations are also presented to support the analytical results.

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SnS_(2) nanosheets decorated SnO_(2) hollow multishelled nanostructures for enhanced sensing of triethylamine gas

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Rare Metals 2024年第5期43卷 2339-2348页

作者： Wen-di Liu ya Xiong Ao Shen Xin-Zhen Wang Xiao Chang Wen-Bo Lu Jian Tian School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China College of Physics Qingdao UniversityQingdao 266071China Zernike Institute for Advanced Materials University of Groningen9747 AG GroningenThe Netherlands

Highly sensitive,fast and low-temperature detection of triethylamine(TEA)gas based on SnO_(2) is attractive yet remains ***,SnS_(2) nanosheets(NSs)/SnO_(2) hollow multishelled structures(HoMSs)-based sensors are designed by the synthesis of SnO_(2) HoMSs,followed by in situ sulfuration with *** varying the thioacetamide levels,Sn S_(2)/SnO_(2) heterostructures with different SnS_(2) contents were obtained and their TEA gas sensing performances were investigated.

关键词： SnS attractive sheets

The effect of increased intra-abdominal pressure on orbital subarachnoid space width and intraocular pressure

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Neural Regeneration Research 2018年第2期13卷 353-359页

作者： Su-meng Liu Ning-li Wang Zhen-tao Zuo Wei-wei Chen di-ya yang Zhen Li Yi-wen Cao Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Department of Neurology Xuanwu Hospital Capital Medical University

In accordance with the trans-lamina cribrosa pressure difference theory, decreasing the trans-lamina cribrosa pressure difference can re- lieve glaucomatous optic neuropathy. Increased intracranial pressure can also reduce optic nerve damage in glaucoma patients, and a safe, effective and noninvasive way to achieve this is by increasing the intra-abdominal pressure. The purpose of this study was to observe the changes in orbital subarachnoid space width and intraocular pressure at elevated intra-abdominal pressure. An inflatable abdominal belt was tied to each of 15 healthy volunteers, aged 22-30 years （12 females and 3 males）, at the navel level, without applying pressure to the abdomen, before they laid in the magnetic resonance imaging machine. The baseline orbital subarachnoid space width around the optic nerve was measured by magnetic resonance imaging at 1, 3, 9, and 15 mm behind the globe. The abdominal belt was inflated to increase the pressure to 40 mmHg （1 mmHg = 0.133 kPa）, then the orbital subarachnoid space width was measured every 10 minutes for 2 hours. After removal of the pressure, the measurement was repeated 10 and 20 minutes later. In a separate trial, the intraocular pressure was measured for all the subjects at the same time points, before, during and after elevated intra-abdominal pressure. Results showed that the baseline mean orbital subarachnoid space width was 0.88 ＋ 0.1 mm （range： 0.77-1.05 mm）, 0.77 ＋ 0.11 mm （range： 0.60-0.94 mm）, 0.70 ＋ 0.08 mm （range： 0.62-0.80 ram）, and 0.68 _＋ 0.08 mm （range： 0.57-0.77 mm） at 1, 3, 9, and 15 mm behind the globe, respectively. During the elevated intra-abdominal pressure, the orbital subarachnoid space width increased from the baseline and dilation of the optic nerve sheath was significant at 1, 3 and 9 mm behind the globe. After decompression of the abdominal pressure, the orbital subarachnoid space width normalized and returned to the baseline value. There was no significant difference in the intra

关键词： nerve regeneration intraocular pressure intra-abdominal pressure intracranial pressure trans-lamina cribrosa pressure difference orbital subarachnoid space width magnetic resonance imaging optic nerve sheath glaucoma cerebrospinal fluid pressure subarachnoid space neural regeneration

Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological Research 2024年第3期45卷 520-534页

作者： Lin Liu ya Zhang Meng-di Yuan Dong-Miao Xiao Wei-Hua Xu Qi Zheng Qi-Wei Qin You-Hua Huang Xiao-Hong Huang College of Marine Sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China Nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511464China Southern Marine Science and Engineering Guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SGIV),focusing on the roles of key *** showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SGIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SGIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SGIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(GA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not GA,suppressed SGIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SGIV Alpha-linolenic acid Antiinflammatory

Longitudinal observation of intraocular pressure variations with acute altitude changes

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World Journal of Clinical Cases 2019年第20期7卷 3226-3236页

作者： Yuan Xie Yun-Xiao Sun Ying Han di-ya yang Yi-Quan yang Kai Cao Shu-Ning Li Xue Li Xin-Xin Lu Shi-Zheng Wu Ning-Li Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Ophthalmology University of CaliforniaSan FranciscoCA 94143United States Department of Laboratory Medicine Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Departments of Neurology the Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Higher intraocular pressure(IOP)is a major risk factor for developing glaucoma,and the leading cause of irreversible blindness *** altitude(HA)may be involved in IOP,but the reported results were *** to HA directly by plane from low altitude regions is an acute,effortless ***,the effects of such exposure to different altitudes on IOP have rarely been *** To investigate changes in IOP after rapid effortless exposure to HA in stages and compare it with systemic *** Fifty-eight healthy subjects(116 eyes)were divided into three groups:17 lowaltitude(LA)residents[44 m above sea level(ASL)],22 HA residents(2261 m ASL)and 19 very HA(VHA)residents(3750 m ASL).The LA group flew to HA *** days later,they flew with the HA group to VHA where both groups stayed for 2 ***,the LA group flew back to HA and stayed for 1 d before flying back to 44 ***,oxygen saturation(SpO2)and pulse rate were *** linear mixed model was used to compare repeated *** IOP in the LA group significantly decreased from 18.41±2.40 mmHg at 44 m to 13.60±3.68 mmHg at 2261 m ASL(P<0.001),and then to 11.85±2.48 mmHg at 3750 m ASL(P=0.036 compared to IOP at 2261 m ASL)and partially recovered to 13.47±2.57 mmHg upon return to 44 *** in the LA group at HA and VHA was comparable to that in the local residents(12.2±2.4 mmHg for HA,11.5±1.8 mmHg for VHA).IOP was positively associated with SpO2 while negatively associated with pulse *** IOP in the LA group gradually reduced as altitude elevated in stages and became comparable to IOP in local *** may be associated with IOP,which deserves further study.

关键词： Intraocular pressure High altitude Hypoxia Glaucoma Lowlanders Erythrocyte