检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2022年第7期12卷 3103-3112页

作者： Xu-Nian Wu Qian Zhou ya-dan huang Xi Xie Zhe Li Yinuo Wu Hai-Bin Luo School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute School of Pharmaceutical SciencesHainan UniversityHaikou 570228China

Our previous study demonstrated that phosphodiesterase 8(PDE8)could work as a potential target for vascular dementia(Va D)using a chemical probe ***,compound 3a is a chiral compound which was obtained by chiral resolution on HPLC,restricting its usage in ***,a series of non-chiral 9-benzyl-2-chloro-adenine derivatives were discovered as novel PDE8 *** 15 exhibited potent inhibitory activity against PDE8A(IC_(50)=11 nmol/L),high selectivity over other PDEs,and remarkable drug-like properties(worthy to mention is that its bioavailability was up to 100%).Oral administration of 15 significantly improved the c AMP level of the right brain and exhibited dosedependent effects on cognitive improvement in a Va D mouse ***,the X-ray crystal structure of the PDE8A—15 complex showed that the potent affinity and high selectivity of 15 might come from the distinctive interactions with H-pocket including T-shapedπ—πinteractions with Phe785 as well as a unique H-bond network,which have never been observed in other PDE-inhibitor complex before,providing new strategies for the further rational design of novel selective inhibitors against PDE8.

关键词： Phosphodiesterase 8(PDE8) Vascular dementia Structure-based drug design MM-GB/SA Free energy prediction Structure—activity relationship Binding potencies

Structure-based design,synthesis,and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2018年第4期8卷 615-628页

作者： Xu-Nian Wu ya-dan huang Jin-Xuan Li yan-Fa Yu Qian Zhou Chen Zhang Yinuo Wu Hai-Bin Luo School of Pharmaceutical Sciences Sun Yat-sen University Collaborative Innovation Center of High Performance Computing National University of Defense Technology

The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPARγ agonists such as rosiglitazone exhibited remarkable preclinical and clinical treatment effects for these two diseases. In this study, a series of PDE9 inhibitors combining the pharmacophore of rosiglitazone were discovered. All the compounds possessed remarkable affinities towards PDE9 and four of them have the IC_(50) values 5n mol/L. In addition, these four compounds showed low cell toxicity in human SH-SY5Y neuroblastoma *** 11a, the most effective one, gave the IC_(50) of 1.1 nmol/L towards PDE9, which is significantly better than the reference compounds PF-04447943 and BAY 73-6691. The analysis of putative binding patterns and binding free energy of the designed compounds with PDE9 may explain the structure–activity relationships and provide evidence for further structural modifications.

关键词： PDE9 inhibitors Alzheimer’s disease Type 2 diabetes mellitus Rosiglitazone Molecular docking Dynamics simulation

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-Jing Shi Yu Song Xue-Xue Liang Ting Chen huang-Yu Hao Xue Han ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng dan yang Lingxi Qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

基于RNA-Seq的油茶种仁萜类功能组分代谢调控研究

在线全文

学校读者我要写书评

暂无评论

经济林研究 2016年第4期34卷 1-6页

作者：曾艳玲谭晓风颜亚丹黄钟谊杨宇元中南林业科技大学经济林培育与保护省部共建教育部重点实验室湖南长沙410004 中南林业科技大学经济林育种与栽培国家林业局重点实验室湖南长沙410004 中南林业科技大学经济林培育与利用湖南省协同创新中心湖南长沙410004

油茶是我国重要的木本食用油料植物,而茶油不仅不饱和脂肪酸含量高,而且富含微量生物活性物质。为给油茶及其他植物萜类代谢机理的阐述提供理论参考,从而为油茶分子设计育种提供科学依据,以油茶果实膨大期和脂肪酸合成高峰期的种仁为材... 详细信息

油茶是我国重要的木本食用油料植物,而茶油不仅不饱和脂肪酸含量高,而且富含微量生物活性物质。为给油茶及其他植物萜类代谢机理的阐述提供理论参考,从而为油茶分子设计育种提供科学依据,以油茶果实膨大期和脂肪酸合成高峰期的种仁为材料,采用高通量RNA-Seq技术对油茶种仁萜类功能组分代谢的2个不同时期转录组进行了比较分析。结果表明:涉及油茶种仁萜类功能组分代谢调控的基因序列共有68条,包含13类关键酶基因,但是大部分基因在果实膨大期和脂肪酸合成高峰期的差异不显著。文中根据分析结果绘制了油茶种仁萜类物质代谢途径,揭示了调控油茶种仁萜类功能组分代谢过程中的基因作用规律。

关键词：油茶转录组萜类组分代谢基因表达

Systemic thrombosis with prothrombin Belgrade mutation in a Chinese patient:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第10期13卷 35-39页

作者： yan-Feng Wu yan huang Bao-Hui Weng Shan Deng Li-ya Pan Zhen Li Department of Neurology Liuzhou Worker’s HospitalLiuzhou 545007Guangxi Zhuang Autonomous RegionChina Department of Neurology Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Thrombophilia contributes to a significant increased risk of venous thromboembolism and can be either inherited or *** thrombophilia may arise from various gene mutations,some of which have not even been adequately reported or poorly *** studies reported a rare and novel missense mutation in the prothrombin gene(***596Gln),known as prothrombin *** mechanisms and therapeutic strategies associated with prothrombin Belgrade mutation have not been fully *** SUMMARY We present the case of a 26-year-old woman with recurrent systemic thrombosis induced by prothrombin Belgrade *** patient suffered from cerebral venous sinus thrombosis that rapidly progressed to systemic thrombosis,alongside a family history of cerebral thrombosis,and no traditional risk factors or abnormal coagulation ***-genome sequencing detected a novel and rare heterozygous prothrombin missense mutation,c.1787G>T(***596Gln),which was responsible for the major etiology of the systemic *** This case strengthens our understanding about hereditary basis of thrombophilia and provokes considerations for therapeutic options on prothrombin Belgrade mutation.

关键词： Arg596Gln Belgrade mutation Thrombophilia Prothrombin Case report

Evaluation of social network conservation in historical areas of mountainous towns in Chongqing, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2020年第7期17卷 1763-1775页

作者： SHI ya-ling huang Yong HU Dong-yang WAN dan Faculty of Architecture and Urban Planning Chongqing UniversityChongqing400030China The Bartlett School of Construction and Project Management University College London1-19 Torrington PlaceLondonWC1E 7HBUK Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing400030China Chongqing University Planning&Design Institute Co. LtdChongqing400044China

Over recent decades,historical areas conservation has become an important strategy to improve urban competitiveness in the global *** shown in existing studies that the conservation of historical areas mainly focused on the physical environment,there is still room for the non-physical study,and researches on the social network conservation in mountainous historical areas are particularly ***,this paper aims to establish an evaluation system which is helpful for the social network conservation of historical *** evaluation system is based on social network analysis and the information of social relationships gathered in field surveys using a specifically designed questionnaire method in four mountainous towns in Chongqing,*** it was analyzed from three perspectives,i.e.,by the basic statistical properties,condensate subgroup,and *** five analysis indicators were conceived,including density,lambda set,k-core,degree centrality,and betweenness *** analysis results demonstrate that the social networks of the four towns show different indicators,which are respectively relevant to completeness degree,edgerelatedness level,local stability,structural balance,and concentrated trend of social *** from SNA modeling indicate that neighborhood residents of historical areas who have more stable and healthier social relationships are relatively not easily be *** results also illustrate that the social networks structure is influenced by the terrain,form,and function of historical areas,and the change of historical areas is caused by"individual-family-society".Finally,the strategies guiding the social network conservation are put forward from two *** findings suggest that the conservation and management of social network and aborigines in historical areas should be emphasized to increase the collective benefits and vitality.

关键词： Historical areas Social network analysis Physical environment Evaluation Conservation Mountainous towns

TRAF7 negatively regulates the RLR signaling pathway by facilitating the K48-linked ubiquitination of TBK1

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2023年第3期38卷 419-428页

作者： Jing-Ping huang ya-Xian yang Tian Chen dan-dan Wang Jing Li Liang-Guo Xu College of Life Science Jiangxi Normal UniversityNanchang330022China

TANK-binding kinase 1(TBK1)is a nodal protein involved in multiple signal transduction *** RNA virus-mediated innate immunity,TBK1 is recruited to the prion-like platform formed by MAVS and subsequently activates the transcription factors IRF3/7 and NF-κB to produce type I interferon(IFN)and proinflammatory cytokines for the signaling *** this study,TRAF7 was identified as a negative regulator of innate immune ***7 interacts with TBK1 and promotes K48-linked polyubiquitination and degradation of TBK1 through its RING domain,impairing the activation of IRF3 and the production of IFN-β.In addition,we found that the conserved cysteine residues at position 131 of TRAF7 are necessary for its function toward *** of TRAF7 could facilitate the activation of IRF3 and increase the transcript levels of downstream antiviral *** data suggest that TRAF7 negatively regulates innate antiviral immunity by promoting the K48-linked ubiquitination of TBK1.

关键词： TANK-Binding kinase 1(TBK1) Type I interferon TRAF7 Ubiquitination Innate immunity

Synthesis,Structure and Optical Properties of Cerium(Ⅲ) Triphosphate CeP_3O_9

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2007年第3期26卷 338-346页

作者： TONG Hua-Nan ZHANG Hao CHENG Wen-dan WU Dong-Sheng GONG ya-Jing ZHU Jing huang Shu-Ping ZHAO dan State Key Laboratory of Structural Chemistry Fujian Institute of Research on theStructure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

The single crystal and crystallized powder of triphosphate CeP3O9 have been synthesized, and the space group of CeP3O9has been determined to be C2221 with the cell parameters ofa = 8.6059, b = 11.2437, c = 7.3518 A, V= 711.4（3） A^3, Z= 4, D,. = 3.520 g/cm^3, F（000） = 700, R = 0.0377 and wR = 0.0930. The absorption and emission spectra have been measured, for which the strongest absorption and emission peaks are located at 280 and 320 nm, respectively. The density of state （DOS） and dielectric function have been calculated by the DFT method. The crystal is transparent provided the wavelength is larger than 341 nm, and the observed ultraviolet cut-off edge is at about 350 nm for a polycrystalline power sample. It is possible that the triphosphate CeP3O9 will become an ultraviolet emission material.

关键词： crystal structure phosphate optical properties density of states

Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第48期26卷 7593-7602页

作者： Xiong Sun yao huang ya-Li Zhang dan Qiao yan-Cheng Dai Department of Gastroenterology Shanghai PuTuo District People's Hospital Affiliated to Tongji UniversityTongji University School of MedicineShanghai 200060China Department of Digestive Diseases Jing'an District Central HospitalFudan UniversityShanghai 200040China Institute of Digestive Diseases LongHua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China

Ulcerative colitis(UC)is a chronic relapsed intestinal disease with an increasing incidence around the *** pathophysiology of UC remains ***,the role of the interaction between the enteric nervous system and the immune system in the pathogenesis of UC has been the focus of attention and has become a research *** intestinal peptide(VIP)is a kind of endogenous neuropeptide with regulatory activity on intestinal *** has been shown to regulate immune disorders in animal and human experiments and has become an effective anti-inflammatory and immune modulator that affects the innate immune system and adaptive immune *** B cells(Bregs)are a new group of B cells that negatively regulate the immunity and have received extensive attention in immune *** can regulate immune tolerance by producing interleukin(IL)-10,IL-35,and transforming growth factor-β,suppressing autoimmune diseases or excessive inflammatory *** secretion of IL-10 by Bregs induces the development of T helper(Th)0 and Th2 *** also induces Th2 cytokines and inhibits Th1 cytokines,thereby inhibiting Th1 cells and the Th1/Th2 *** further clarity on the mechanism of the regulation of IL-10 expression by VIP in Bregs in colitis patients,we believe that Bregs can provide a novel strategy for the clinical treatment of ***,we aim to review the current literature on this evolving topic.

关键词： Vasoactive intestinal peptide Ulcerative colitis Interleukin-10 Bregs Pathogenesis