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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu yu-ya wang Gui-Tao Huo yan-Wei yang Nan Xu Hong wang Yong Wu yu-Fa Miao Rui Fu yu-Wei Zhao Chang-Fa Fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

Laryngopharyngeal reflux disease:Updated examination of mechanisms,pathophysiology,treatment,and association with gastroesophageal reflux disease

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World Journal of Gastroenterology 2024年第16期30卷 2209-2219页

作者： Na Cui Ting Dai yang Liu ya-yu wang Jia-yu Lin Qing-Fan Zheng Dong-Dong Zhu Xue-Wei Zhu Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

Laryngopharyngeal reflux disease(LPRD)is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the *** commonly presents with symptoms such as hoarseness,cough,sore throat,a feeling of throat obstruction,excessive throat *** complex condition is thought to involve both reflux and reflex mechanisms,but a clear understanding of its molecular mechanisms is still ***,there is no standardized diagnosis or treatment *** strategies for LPRD mainly include lifestyle modifications,proton pump inhibitors and endoscopic *** paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms,pathophysiology and treatment of *** also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux Head neck surgery Laryngitis Otolaryngology

Metabolic tuning of a stable microbial community in the surface oligotrophic Indian Ocean revealed by integrated meta-omics

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Marine Life Science & Technology 2022年第2期4卷 277-290页

作者： Zhang-Xian Xie Ke-Qiang yan Ling-Fen Kong Ying-Bao Gai Tao Jin yan-Bin He ya-yu wang Feng Chen Lin Lin Zhi-Long Lin Hong-Kai Xu Zong-Ze Shao Si-Qi Liu Da-Zhi wang State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology Xiamen UniversityXiamen361005China College of Ocean and Earth Sciences Xiamen UniversityXiamen361005China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Sun Yat-Sen UniversityZhuhai519082China BGI-Shenzhen Beishan Industrial Zone 11th BuildingShenzhen518083China BGI Education Center University of Chinese Academy of SciencesShenzhen518083China Key Laboratory of Marine Genetic Resources Third Institute of OceanographyMinistry of Natural Resources of ChinaXiamen361005China State Key Laboratory Breeding Base of Marine Genetic Resources/Fujian Key Laboratory of Marine Genetic Resources Xiamen361005China Institute of Marine and Environmental Technology University of Maryland Center for Environmental ScienceBaltimoreMD21202USA

Understanding the mechanisms,structuring microbial communities in oligotrophic ocean surface waters remains a major ecological *** redundancy and metabolic tuning are two mechanisms that have been proposed to shape microbial response to environmental ***,little is known about their roles in the oligotrophic surface ocean due to less integrative characterization of community taxonomy and ***,we applied an integrated meta-omics-based approach,from genes to proteins,to investigate the microbial community of the oligotrophic northern Indian *** spatial variabilities of both genomic and proteomic compositions indicated a stable microbial community that was dominated by Prochlorococcus,Synechococcus,and ***,fine tuning of some metabolic functions that are mainly driven by salinity and temperature was ***,a tuning divergence occurred between metabolic potential and activity in response to different environmental *** results indicate that metabolic tuning is an important mechanism for sustaining the stability of microbial communities in oligotrophic *** addition,integrated meta-omics provides a powerful tool to comprehensively understand microbial behavior and function in the ocean.

关键词： Microbial community Metabolic tuning Metaproteomics Metagenomics Oligotrophic ocean

不同复垦年限煤矸山土壤微生物群落和酶活性及其影响因子

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生态学杂志 2018年第4期37卷 1120-1126页

作者：于亚军王继萍山西师范大学地理科学学院山西临汾041004

土壤微生物和酶能对土壤生态机制变化和环境胁迫做出反应,对土壤生态功能恢复具有指示意义。为揭示土壤微生物群落及酶活性对煤矸山复垦土壤质量变化的指示作用,以山西省霍州市曹村矿区煤矸山复垦地为研究对象,采集了复垦年限为3、5和7 ... 详细信息

土壤微生物和酶能对土壤生态机制变化和环境胁迫做出反应,对土壤生态功能恢复具有指示意义。为揭示土壤微生物群落及酶活性对煤矸山复垦土壤质量变化的指示作用,以山西省霍州市曹村矿区煤矸山复垦地为研究对象,采集了复垦年限为3、5和7 a果园的0~10和10~20 cm土层土壤,利用磷脂脂肪酸法(PLFA)分析了土壤微生物群落和脲酶(URE)、过氧化氢酶(CAT)、脱氢酶(DH)和碱性磷酸酶(ALP)活性的变化情况,并运用通径分析法分析了土壤理化性质对微生物群落和酶活性的影响。结果表明:(1)3种复垦年限果园土壤有机质、碱解氮和有效磷均随复垦年限的增加而增加,但含水量与黏粒含量仅在复垦7 a果园中增加,与当地原地貌普通果园(CK)相比,3种复垦果园土壤性质均明显较差。(2)3种复垦果园不同群落微生物PLFAs浓度和酶活性随复垦年限的增加均有不同程度的增加,其中细菌、真菌、ALP和URE活性在0~10和10~20 cm土层均表现为随复垦年限的增加而增加的趋势;革兰氏阴性菌(G-)和DH活性在0~10 cm土层、放线菌和CAT活性在10~20 cm土层有显著增加。3种复垦果园土壤不同群落微生物PLFAs浓度和酶活性均低于CK样地。(3)土壤微生物细菌、真菌、放线菌、革兰氏阳性菌(G+)群落PLFAs浓度和CAT、ALP、URE和DH活性对土壤性质变化具有指示作用,可作为煤矸山复垦土壤质量变化的微生物学指标。

关键词：植被恢复微生物群落结构酶活性土壤质量煤矸山

Combined therapy with methylprednisolone and ulinastatin in experimental autoimmune encephalomyelitis

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Chinese Medical Journal 2013年第18期126卷 3439-3445页

作者： SHU ya-qing yaNG yu wang yu-ge DAI Yong-qiang XIAO Li QIU Wei LU Zheng-qi WU Ai-ming RUAN Heng-fang HU Xue-qiang Multiple Sclerosis Center Department of Neurology the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Our previous study had demonstrated that ulinastatin （UTI） had a neuroprotective effect in experimental autoimmune encephalomyelitis （EAE）. Methylprednisolone has been recommended to be a standard drug in multiple sclerosis （MS） therapies. The present study was to investigate the protective effects of UTI combined methylprednisolone in EAE. Methods Mice were divided into a UTI treatment group, a methylprednisolone treatment group, a combined treatment group with UTI and methylprednisolone, a normal saline treatment group, and a normal control group. EAE mice were induced in groups receiving different combined treatments, or respective monotherapies. Demyelination was evaluated by Solochrome cyanin staining. 2＇,3＇-cyclic nucleotide 3＇- phosphodiesterase （CNP）/myelin basic protein （MBP）/the precursor form of nerve growth factor （proNGF）/p75/inducible nitric oxide synthase （iNOS） proteins in cerebral cortex of EAE were detected by Western blotting. Results The combined treatment group had a lower clinical score （0.61±0.06） and demyelinating score （1.33±0.33） than the groups with normal saline （clinical score： 1.39±0.08, P 〈0.001; demyelinating score： 2.75±0.49, P 〈0.05） or monotheraphies. Compared with the saline treated EAE group, UTI combined methylprednisolone significantly increased expressions of CNP （1.14±0.06 vs. 0.65±0.04, P 〈0.001）, MBP （1.28±0.14 vs. 0.44±0.17, P 〈0.001）, and decreased expressions of proNGF （1.08±0.10 vs. 2.32±0.12, P 〈0.001）, p75 （1.13±0.13 vs. 2.33±0.17, P 〈0.001）, and iNOS （1.05±0.31 vs. 2.17±0.13, P 〈0.001） proteins in EAE. Furthermore, UTI combined methylprednisolone could significantly upregulate MBP （1.28±0.14 vs. 1.01±0.15, P 〈0.05） expression and downregulate iNOS （1.05±0.31 vs. 1.35±0.14, P 〈0.05） expression compared to methylprednisolone treatment EAE group. And proNGF expression was significantly lower in combined treatment （1.08±0.10） than that in UTI （1.51±0.24, P 〈0.05） or methylprednisolone （1.31±0.04, P 〈0.05） trea

关键词： ulinastatin methylprednisolone combined therapy experimental autoimmune encephalomyelitis neuroprotection

Gate Tunable Supercurrent in Josephson Junctions Based on Bi_(2)Te_(3) Topological Insulator Thin Films

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Chinese Physics Letters 2021年第3期38卷 89-94页

作者： Wei-Xiong Wu yang Feng yun-He Bai yu-Ying Jiang Zong-Wei Gao yuan-Zhao Li Jian-Li Luan Heng-An Zhou Wan-Jun Jiang Xiao Feng Jin-Song Zhang Hao Zhang Ke He Xu-Cun Ma Qi-Kun Xue ya-yu wang State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200438China Frontier Science Center for Quantum Information Beijing 100084China Beijing Academy for Quantum Information Sciences Beijing 100084China

We report transport measurements on Josephson junctions consisting of Bi_(2)Te_(3) topological insulator(TI)thin films contacted by superconducting Nb *** a device with junction length L=134 nm,the critical supercurrent Ic can be modulated by an electrical gate which tunes the carrier type and density of the TI *** can reach a minimum when the TI is near the charge neutrality regime with the Fermi energy lying close to the Dirac point of the surface *** the p-type regime the Josephson current can be well described by a short ballistic junction *** the n-type regime the junction is ballistic at 0.7 K

关键词： state. film. Josephson

Synthesis, and crystal structure of a novel tetra-nuclear Nickel(Ⅱ) complex derived from pyridine-2-carboxaldehyde bearing an intramolecular acetato bridge

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Synthesis, and crystal structure of a novel tetra-nuclear Ni...

Silk damping in scalar-induced gravitational waves: a novel probe for new physics

中国化学会2008年中西部地区无机化学、化工学术交流会

作者： Feng Xun wang Li-ya~* wang yu-Fang College of Chemistry and Chemical Engineering, Luoyang Normal University,Luoyang 471022, China

Recently, intense interest has been focused on studies of cubane-like poly-nuclear complexes due to their relevance to multi-electron transfer centers systems, and to their interesting properties1-3]. Tetranuclear cub... 详细信息

关键词： and crystal structure of a novel tetra-nuclear Nickel Synthesis complex derived from pyridine-2-carboxaldehyde bearing an intramolecular acetato bridge

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： yan-Heng yu Sai wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun wang Shuai wang yan Li Libo Chen Handong Jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density