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calcitonin gene-related peptide inhibits neuronal apoptosis in heatstroke rats via PKA/p-cREB pathway

chinese Journal of Traumatology 2024年第1期27卷 18-26页

作者： Jie Zhu ya-Hong chen Jing-Jing Ji c.eng-Xiang Lu Zhi-Feng Liu Department of Pediatric General Hospital of Southern Theater Command of PLAGuangzhou510010China Department of Medical Intensive care Unit General Hospital of Southern Theater Command of PLAGuangzhou510010China Department of Intensive care Unit Zhongshan Hospital Xiamen UniversityXiamenFujian province361004China

Purpose:The incidence of heatstroke(HS)is not particularly high;however,once it occurs,the consequences are *** is reported that calcitonin gene-related peptide(cGRP)is protective against brain injury in HS rats,but detailed molecular mechanisms need to be further *** this study,we further explored whether cGRP inhibited neuronal apoptosis in HS rats via protein kinase A(PKA)/p-cAMP response element-binding protein(p-cREB)***:We established a HS rat model in a pre-warmed artificial climate chamber with a temperature of(35.5±0.5)℃and a relative humidity of 60%±5%.Heatstress was stopped once core body temperature reaches above 41℃.A total of 25 rats were randomly divided into 5 groups with 5 animals each:control group,HS group,HS+cGRP group,HS+cGRP antagonist(cGRP8-37)group,and HS+cGRP+PKA/p-cREB pathway blocker(H89)group.A bolus injection of cGRP was administered to each rat in HS+cGRP group,cGRP8-37(antagonist of cGRP)in HS+cGRP8-37 group,and cGRP with H89 in HS+cGRP+H89 *** were recorded and the serum concentration of S100B,neuron-specific enolase(NSE),neuron apoptosis,activated caspase-3 and cGRP expression,as well as pathological morphology of brain tissue were detected at 2 h,6 h,and 24 h after HSin *** expression of PKA,p-cREB,and Bcl-2 in rat neurons were also detected at 2 h after HSin *** cGRP,cGRP8-37,or H89 were used to determine whether cGRP plays a protective role in brain injury via PKA/p-cREB *** unpairedt-test was used between the 2 samples,and the mean±SD was used for multiple ***-tailedpconsidered statistically ***:Electroencephalogram showed significant alteration ofθ(54.50±11.51vs.31.30±8.71,F=6.790,p=0.005)andαwave(16.60±3.21vs.35.40±11.28,F=4.549,p=0.020)in HS group compared to the control group 2 h after *** results of triphosphate gap terminal labeling(TUNEL)showed that the neuronal apoptosis of HS rats was increased in the c

关键词： Heatstroke calcitonin gene-related peptide Brain injury Apoptosis

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Strong-coupling superconductivity with Tc above 70 K in Be-decorated monolayer T-graphene

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Science china(Physics,Mechanics & Astronomy) 2024年第1期67卷 99-105页

作者： Liu yang Peng-Fei Liu Hao-Dong Liu ya-Ping Li Na Jiao Hong-yan Lu Bao-Tian Wang Ping Zhang School of Physics and Physical engineering Qufu Normal UniversityQufu 273165China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science center Dongguan 523803China Institute of Applied Physics and computational Mathematics Beijing 100088China

Using first-principles calculations,we predict a new type of two-dimensional(2D)beryllium(Be)-decorated T-graphene named Bec_(2),where Be atoms are inserted into c–c bonds linking the carbon tetrarings of *** band structure shows that Bec_(2)is metallic,thus,the possible phonon-mediated superconductivity is explored based on the Eliashberg *** calculated electron-phonon coupling(EPc)constantλis up to 4.07,and the corresponding superconducting critical temperature(Tc)is 72.1 K,approaching the liquid nitrogen *** reason for the high Tc is the strong *** it is proved to be an anisotropic single-gap superconductor by analyzing the superconducting gap?kof Bec_(2).The electronic susceptibility calculation shows strong nesting effect in Bec_(2).Since rare 2D superconductors show such a strong EPc constantλwhich originates from the coupling between electrons in c-pzorbital and in-plane vibrations of Be and c atoms,the predicted Bec_(2)provides a new platform for investigating strong EPc 2D superconductor.

关键词： two-dimensional carbon-based superconductor electron-phonon coupling strong coupling high superconducting critical temperature

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Succession of bacteria communities during production and application of dairy bedding by membrane-covered aerobic fermentation

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International Journal of Agricultural and Biological engineering 2024年第1期17卷 232-240页

作者： Hongjie Yin Jianfei Zeng chen Fang Xueqin He ya Su Jinpeng Xiong Lujia Han Guangqun Huang college of engineering china Agricultural University Beijing 100083China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China college of Agriculture Guizhou UniversityGuiyang 550025China

The cost of dairy manure treatment and bedding material purchase increases the operating cost of the dairy ***-covered aerobic fermentation system has been widely used for dealing with dairy manure and recycling the final product as bedding ***,the microbial safety in each processing step is still *** better understand the bacterial community dynamics during the whole bedding conversion process,a full-chain and large-scale experiment including 16-day membrane-covered aerobic fermentation and 11-day bedding material application was *** results showed that the pile temperatures in the fermentation stage rapidly increased to 80°c and maintained>50°c for more than 11 days and the use of fermentation product as bedding material provided cows with a stable and comfortable bedding *** chao1 and Shannon index decreased at the end of the fermentation stage and remained stable in the application stage,indicating that membrane-covered aerobic fermentation effectively killed some pathogenic bacteria and guaranteed both the maturity and stability of the final *** dominant bacteria in the fermentation stage were Acinetobacter,Thermus,and Rhodothermus at genus *** common potential pathogens of mastitis(Staphylococcus,Enterococcus,Serratia,Pseudomonas,corynebacterium,Mycobacterium,and Bacillus)were found at the end of fermentation stage but the relative abundance was low(0.0025%-0.2727%).The dominant bacteria in the application stage mainly included Acinetobacter,Pseudomonas,and Flavobacterium at the genus *** relative abundance of Pseudomonas increased in the application stage,which was a reminder to the dairy farm to pay attention to the disinfection and timely replacement of bedding material to prevent the occurrence of dairy *** results of this study contributed deep understanding of the microorganism-driven bedding conversion process and provide practical guidance and cautions for the bedding

关键词： semi-permeable membrane dairy manure aerobic fermentation bedding material bacterial diversity

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The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu Jing yang Wen-Jing Zhang Yi-Ling Zhou Gui-Jun Zhao ya Huang Shu-yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic.engineering and collaborative Innovation center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

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chinese Medicine combined with Adjuvant chemotherapy for Improving Myelosuppression in colorectal cancer Patients:A Systematic Review and Network Meta-Analysis

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chinese Journal of Integrative Medicine 2024年第7期30卷 643-652页

作者： LI Rui ZHANG Tong yaN Shao-hua yaN Yun-zi DING ya-cong WANG yan-song yaNG Yu-fei Department of Oncology China Academy of Chinese Medical SciencesXiyuan HospitalBeijing100091China Department of Oncology Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To assess the effectiveness of chinese herbal medicine(cHM)combined with adjuvant chemotherapy on myelosuppression for colorectal cancer(cRc)patients using network meta-analysis(NMA).Methods Literature searches in both international(PubMed,Embase,Web of Science,and cochrane Library)and chinese(china Science and Technology Journal Database,Wanfang Data,china National Knowledge Infrastructure)databases for relevant randomized controlled trials(RcTs)were conducted from inception until October 10,*** included RcTs of patients who received cHM combined with chemotherapy,including FOLFOX,XELOX,FOLFIRI,and other relevant regimens in the cHM treatment *** outcomes included the incidence of myelosuppression,leukopenia,hemoglobin reduction,and *** reviewers independently screened the databases,extracted the data,and assessed the risk of bias and credibility of *** 5.4.1 software and STATA 14.0 were used to perform the *** A total of 31 RcTs were included,published from 2008 to 2021 in *** these,2,314 participants comparing the following 9 cHMs were identified:Shengbai Recipe(SBR),Bazhen Decoction(BZD),Jianpi Jiedu Recipe(JJR),Jianpi Recipe(JR),compound cantharis capsule(ccc),Zaofan Pill(ZFP),Guilu Erxian Gel(GL),Buzhong Tiaogan Decoction(BZ),and Qiamagu capsule(QM).The results of NMA found an indirect *** on the surface under the cumulative ranking curve(SUcRA),the ZFP+chemotherapy group had the lowest incidence of myelosuppression,with an odds ratio(OR)of 0.08[95%confidence interval(cI):0.01,0.76],whereas the GL+chemotherapy group had the lowest incidence of leukopenia,hemoglobin reduction,and thrombocytopenia,with an OR of 5.25(95%cI:2.41,11.43),4.66(95%cI:2.23,9.72),and 0.27(95%cI:0.13,0.54),***,BZD+chemotherapy could alleviate leukopenia,hemoglobin reduction,and thrombocytopenia(Pcomparison showed that there was no difference in the efficacy among the 8 cHMs+c

关键词： chinese herbal medicine colorectal cancer network meta-analysis systematic review myelosuppression chemotherapy

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Activation and polarization of striatal microglia and astrocytes are involved in bradykinesia and allodynia in early-stage parkinsonian mice

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Fundamental Research 2024年第4期4卷 806-819页

作者： Xue Zhang Zi-Lin Shen ya-Wei Ji cui Yin c.eng Xiao chunyi Zhou Jiangsu Province Key Laboratory of Anesthesiology School of AnesthesiologyXuzhou Medical UniversityXuzhou 221004China Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology Xuzhou Medical UniversityXuzhou 221004China NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs School of AnesthesiologyXuzhou Medical UniversityXuzhou 221004China

In addition to the cardinal motor symptoms,pain is a major non-motor symptom of Parkinson's disease(PD).Neuroinflammation in the substantia nigra pars compacta and dorsal striatum is involved in neurodegeneration in *** the polarization of microglia and astrocytes in the dorsal striatum and their contribution to motor deficits and hyperalgesia in PD have not been *** the present study,we observed that hemiparkinsonian mice established by unilateral 6-OHDA injection in the medial forebrain bundle exhibited motor deficits and mechanical *** these mice,both microglia and astrocytes in the dorsal striatum were activated and polarized to M1/M2 microglia and A1/A2 astrocytes as genes specific to these cells were *** effects peaked 7 days after 6-OHDA ***,striatal astrocytes in parkinsonian mice also displayed hyperpolarized membrane potentials,enhanced voltage-gated potassium currents,and dysfunction in inwardly rectifying potassium channels and glutamate *** administration of minocycline,a microglia inhibitor,attenuated the expression of genes specific to M1 microglia and A1 astrocytes in the dorsal striatum(but not those specific to M2 microglia and A2 astrocytes),attenuated the damage in the nigrostriatal dopaminergic system,and alleviated the motor deficits and mechanical allodynia in parkinsonian *** contrast,local administration of minocycline into the dorsal striatum of parkinsonian mice mitigated only *** study suggests that M1 microglia and A1 astrocytes in the dorsal striatum may play important roles in the development of pathophysiology underlying hyperalgesia in the early stages of PD.

关键词： Parkinson's disease Dopaminergic system Striatum Microglia Astrocytes Substantia nigra pars compacta

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Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

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engineering 2024年第7期38卷 144-154页

作者： Jun-Su Zhou Long c.eng Yuan Gao Zhan-Peng Ge Bin Zhou Jing-ya Li Jin-Xin Zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-c(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E-G(compounds 5-7)-were isolated from Trigonostemon *** 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical *** 3 is an unprecedented phenylpropanoid-norditerpenoid adduct with a new dimerization ***(+)-and(-)-4 are the first example of S-shaped 1,4-dioxane-fused norditerpenoid *** by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and(-)-8 and(+)-and(-)-9,*** structures were characterized using a combined ***,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase(AcLY)inhibition with a halfmaximal inhibition concentration(Ic50)value of(0.46±0.11)lmol·L^(-1),as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound 7 and AcLY.

关键词： Norditerpenoid heterodimer Trigonostemon fragilis Euphorbiaceae Trigofragiloid Structural revision Adenosine triphosphate-citrate lyase(AcLY) inhibitory activity

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Self-fertilization in a gonochoristic fish yellow catfish

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Aquaculture and Fisheries 2024年第2期9卷 234-244页

作者： Yue Yu Ziyi Lu Min chen ya Liu yang Ding chenhao Hu Zhigang Shen college of Fisheries Key Lab of Freshwater Animal BreedingMinistry of Agriculture and Rural AffairsWuhan430070China Key Lab of Agricultural Animal Genetics Breeding and Reproduction of Ministry of EducationWuhan430070China engineering Technology Research center for Fish Breeding and culture in Hubei Province Wuhan430070China engineering Research center of Green Development for conventional Aquatic Biological Industry in the yangtze River Economic Belt of Ministry of Education Huazhong Agricultural UniversityWuhan430070China Hubei Huangyouyuan Fishery Development Limited company Wuhan430070China

Sex control techniques are in great demand for aquaculture because of the huge benefits of mono-sex *** a previous study on yellow catfish(Tachysurus fulvidraco),intersex individuals were produced by administrating 17α-methyltestosterone(MT)or aromatase inhibitor letrozole(LZ).The ovarian and testicular portions of intersexual gonads developed well and were completely separated,arousing our interest in producing self-fertilizable fish and clone-like fish *** this study,yellow catfish fry were treated with a combination of MT and LZ at a low dose(5 mg kg^(-1)MT,300 mg kg^(-1)LZ)at a low water temperature(27.0℃,mixed sex-producing temperature,LL group)and a high temperature(33.5◦c,male-producing temperature,HL group),and with a high dose(10 mg kg^(-1) MT,600 mg kg^(-1) LZ)at a low water temperature(LH group),during 12-65 days post-hatching,the critical period of sex *** XX and XY intersex were produced with different percentages at the same time through co-treatment with MT and LZ,with or without the help of male-producing *** highest percentage of XY intersex(53%in XY,36%in XX and XY)and XX intersex(47%in XX,25%in XX and XY)was produced in LH and HL groups,*** of gonadal morphology,histology,and sperm dynamic analysis indicate that some XX and XY intersex individuals were capable of self-fertilization through artificial *** reproductive performance of these intersex individuals was then investigated by injecting spawning agents,dissecting gonads,and artificially fertilizing eggs with their own *** XX,XY,and YY genotypic individuals were produced by the self-fertilization of XY intersex *** present study successfully produced high percentages of XX and XY intersex and conducted self-fertilization by mating the eggs and sperm of a single intersex ***-fertilization in fish will show great potential in aquaculture genetics and breeding,for example,generating high

关键词： Sex differentiation Self-fertilization Sex reversal Mono-sex clone

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RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201

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mLife 2024年第1期3卷 74-86页

作者： ya-Wen He Zi-Jing Jin Ying cui Kai Song Bo chen Lian Zhou State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSJTU-NLBP Joint R&D Centre for Biopesticides and BiofertilizersSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Zhiyuan Innovative Research centre Student Innovation CentreZhiyuan CollegeShanghai Jiao Tong UniversityShanghaiChina

Pseudomonas aeruginosa is a ubiquitous and metabolically versatile microorganism naturally found in soil and *** is also an opportunistic pathogen in plants,insects,animals,and *** response to increasing cell density,*** uses two acylhomoserine lactone(AHL)quorum-sensing(QS)signals(i.e.,N-3-oxo-dodecanoyl homoserine lactone[3-oxo-c12-HSL]and Nbutanoyl-homoserine lactone[c4-HsL]),which regulate the expression of hundreds of ***,how the biosynthesis of these two QS signals is coordinated remains *** studied the regulation of these two QS signals in the rhizosphere strain ***1201 sequentially produced 3-oxo-c12-HSL and c4-HSL at the early and late growth stages,*** highest 3-oxo-c12-HSL-dependent elastase activity was observed at the early stage,while the highest c4-HSL-dependent rhamnolipid production was observed at the late *** atypical regulator RsaL played a pivotal role in coordinating 3-oxo-c12-HSL and c4-HSL biosynthesis and QS-associated *** repressed las/transcription by binding the-10 and-35 boxes of the lasl *** contrast,RsaL activated rhll transcription by binding the region encoding the 5'-untranslated region of the rhll ***,RsaL repressed its own expression by binding a nucleotide motif located in the-35 box of the rsaL ***,RsaL acts as a molecular switch that coordinates the sequential biosynthesis of AHL QS signals and differential virulence in ***,c4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal(PQS)QS signaling ***,we propose a new model of the QS regulatory network in PA1201,in which RsaL represents a superior player acting at the top of the hierarchy.

关键词： N-3-oxo-dodecanoyl homoserine lactone N-butanoyl-homoserine lactone Pseudomonas aeruginosa quorum sensing RsaL

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Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma:A prospective multicenter cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 249-256页

作者： Ming-Da Wang chen Yuan Ke-chun Wang Nan-ya Wang Ying-Jian Liang Hong Zhu Xiang-Min Tong Tian yang Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Naval Medical University)Shanghai 200438China Department of clinical Laboratory Laboratory Medicine CenterZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310000China Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Medical Oncology First Affiliated Hospital of Soochow UniversitySuzhou 215006China fDepartment of central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhou 310006China

Background:cancer-related fatigue(cRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor *** study aimed to evaluate the efficacy and safety of Renshenguben(RSGB)oral solution,a ginseng-based traditional chinese medicine,in alleviating cRF in patients with advanced hepatocellular carcinoma(Hcc)receiving antitumor ***:In this prospective,open-label,controlled,multicenter study,patients with advanced Hcc at BcLc stage c and a brief fatigue inventory(BFI)score of≥4 were *** were assigned to the RSGB group(RSGB,10 mL twice daily)or the control group(with supportive care).Primary and secondary endpoints were the change in multidimensional fatigue inventory(MFI)score,and BFI and functional assessment of cancer therapy-hepatobiliary(FAcT-Hep)scores at weeks 4 and 8 after *** events(AEs)and toxicities were ***:A total of 409 participants were enrolled,with 206 assigned to the RSGB *** week 4,there was a trend towards improvement,but the differences were not statistically *** week 8,the RSGB group exhibited a significantly lower MFI score(Pcompared to the control group,indicating improved fatigue ***,the RSGB group showed significantly greater decrease in BFI and FAcT-Hep scores at week 8(Pceiving various antitumor treatments showed similar *** linear regression analyses revealed that the RSGB group experienced a significantly substantial decrease in MFI,BFI,and FAcT-Hep scores at week *** serious drug-related AEs or toxicities were ***:RSGB oral solution effectively reduced cRF in patients with advanced Hcc undergoing antitumor therapy over an eight-week period,with no discernible *** findings support the potential of RSGB oral solution as an adjunctive treatment for managing cRF in this patient population.

关键词： cancer-related fatigue Hepatocellular carcinoma Renshenguben oral solution Efficacy Safety Ginseng

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