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Quantitative prediction model for the depth limit of oil accumulation in the deep carbonate rocks:A case study of Lower Ordovician in Tazhong area of Tarim Basin

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Petroleum Science 2024年第1期21卷 115-124页

作者： Wen-yang wang Xiong-Qi Pang ya-ping wang Zhang-Xin Chen Fu-Jie Jiang Ying Chen State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Exploration and Development PetroChina Southwest Oil&Gas Field CompanyChengdu610041SichuanChina Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryT2N 1N4Canada

With continuous hydrocarbon exploration extending to deeper basins,the deepest industrial oil accumulation was discovered below 8,200 m,revealing a new exploration ***,the extent to which oil exploration can be extended,and the prediction of the depth limit of oil accumulation(DLOA),are issues that have attracted significant attention in petroleum *** it is difficult to characterize the evolution of the physical properties of the marine carbonate reservoir with burial depth,and the deepest drilling still cannot reach the ***,the DLOA cannot be predicted by directly establishing the relationship between the ratio of drilling to the dry layer and the *** this study,by establishing the relationships between the porosity and the depth and dry layer ratio of the carbonate reservoir,the relationships between the depth and dry layer ratio were obtained *** depth corresponding to a dry layer ratio of 100%is the *** on this,a quantitative prediction model for the DLOA was finally *** results indicate that the porosity of the carbonate reservoir,Lower Ordovician in Tazhong area of Tarim Basin,tends to decrease with burial depth,and manifests as an overall low porosity reservoir in deep *** critical porosity of the DLOA was 1.8%,which is the critical geological condition corresponding to a 100%dry layer ratio encountered in the *** depth of the DLOA was 9,000 *** study provides a new method for DLOA prediction that is beneficial for a deeper understanding of oil accumulation,and is of great importance for scientific guidance on deep oil drilling.

关键词： Deep layer Tarim Basin Hydrocarbon accumulation Depth limit of oil accumulation Prediction model

Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

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World Journal of Stem Cells 2024年第4期16卷 444-458页

作者： Cheng-Jin Ai Ling-Juan Chen Li-Xuan Guo ya-ping wang Zi-Yi Zhao Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Ophthalmology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Central Laboratory Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina

BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against conventional *** acetic acid(GAA),which is extracted from the seeds of cotton plants,exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting *** To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact *** In this study,LSCs were magnetically sorted from AML cell lines and the CD34+CD38-population was *** expression of leucine-rich pentatricopeptide repeat-containing protein(LRPPRC)and forkhead box M1(FOXM1)was evaluated in LSCs,and the effects of GAA on malignancies and mitochondrial RESULTS LRPPRC was found to be upregulated,and GAA inhibited cell proliferation by degrading *** induced LRPPRC degradation and inhibited the activation of interleukin 6(IL-6)/janus kinase(JAK)1/signal transducer and activator of transcription(STAT)3 signaling,enhancing chemosensitivity in LSCs against conventional chemotherapies,including L-Asparaginase,Dexamethasone,and *** was also found to downregulate FOXM1 indirectly by regulating ***,GAA induced reactive oxygen species accumulation,disturbed mitochondrial homeostasis,and caused mitochondrial *** inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC,GAA resulted in the elimination of ***,GAA induced oxidative stress and subsequent cell damage by causing mitochondrial *** Taken together,the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML.

关键词： Leukemia stem cells Gossypol acetic acid Reactive oxygen species Mitochondrial dysfunction Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling

Charge regulation by ferromagnetic metal/LiF spin-polarized interface for high-performance Li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-yang Feng Shuang Zhou Yi-Fang Zhang ya-ping wang Chun-yan Fu Jian-Wen Li Yuan-Lang Wan Zhi-Jia Zhang Yong Jiang An-Qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the Li metal anode(LMA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/LiF heterogeneous films(T^(M)-LiF-CC)as the substrate for LMA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-LiF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/LiF *** and LiF play individual roles in redistributing electrons and Li^(+)to promote homogeneous Li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while LiF,with low surface diffusion barriers,ensures fast transportation of Li^(+).The Co-LiF-CC@Li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： Lithium metal anode Interfacial charge Ferromagnetic metal Lithium fluoride Spin polarization

Xiao Tan San Jie Fang Hampers the Growth of Colon Cancer Stem Cells through the Wnt/β-catenin Signaling Pathway

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 171-179页

作者： Yu-Qi Zhou Jun-Fei Yuan Hong-Shi Shen ya-ping wang Han-Fei Shi De-Jian Pan Min Ye Department of Hematology and Oncology The 904^(th) Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Clinical Laboratory The 904^(th)Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical UniversityShanghaiChina

Objective: The purpose of this research was to examine the potential anticancer properties of Xiao Tan San Jie Fang(XTSJF) and its potential mechanism of action against colorectal cancer. Materials and Methods: HCT116 cells were induced into HCT116 spheres in DMEM/F12 medium by treatment with epidermal growth factor + fibroblast growth factor + leukemia inhibitory factor + B27. The proliferation ability and stemness of HCT116 spheres was examined. Various concentrations of XTSJF were used to treat HCT116 spheres to observe the impact on proliferation, apoptosis, and expression of stem cell markers. Next, Wnt/β-catenin pathway-related factor proteins were detected. Results: The findings revealed that XTSJF suppressed cell growth and induced cell death in HCT116 cells in a dosage-dependent manner. Similarly, XTSJF promotes apoptosis, inhibits cell proliferation, prolongs survival, and maintains the expression of stem cells through the Wnt/-catenin/TCF4 axis. XTSJF also inhibits AKT activity and subsequently activates glycogen synthesis kinase-3β expression, inhibiting Wnt/beta-catenin pathway activity and downstream target gene transcript expression. The Wnt/β-catenin signaling pathway is inhibited by the XTSJF, leading to the suppression of colon cancer stem cell proliferation. Conclusion: Xiaotan Sanjie Prescription inhibited colon cancer stem cell growth through Wnt/β-catenin signaling pathway.

关键词： Apoptosis colorectal cancer proliferation traditional Chinese medicine Wnt/β-catenin signaling

Gamma/Hadron Separation Method for the HADAR Experiment

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Research in Astronomy and Astrophysics 2024年第3期24卷 70-74页

作者： yang-Zhao Ren Tian-Lu Chen You-Liang Feng Dan-Zeng Luo-Bu Yi-Qing Guo Cheng Liu Qi Gao Mao-Yuan Liu Xiang-Li Qian ya-ping wang Zi-Hao Zhang Xin-Long Li Qing-Yuan Hou Heng-Jiao Liu Qing-Qian Zhou Shan-Jie Shu The Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Intelligent Engineering Shandong Management University

Ground-based arrays of imaging atmospheric Cherenkov telescopes(IACTs)are the most sensitiveγ-ray detectors for energies of approximately 100 Ge V and *** such IACT is the High Altitude Detection of Astronomical Radiation(HADAR)experiment,which uses a large aperture refractive water lens system to capture atmospheric Cherenkov photons(i.e.,the imaging atmospheric Cherenkov technique).The telescope array has a low threshold energy and large field of view,and can continuously scan the area of the sky being observed,which is conducive to monitoring and promptly responding to transient *** process ofγ-hadron separation is essential in very-high-energy(>30 Ge V)γ-ray astronomy and is a key factor for the successful utilization of *** this study,Monte Carlo simulations were carried out to model the response of cosmic rays within the HADAR *** analyzing the Hillas parameters and the distance between the event core and the telescope,the distinction between air showers initiated byγ-rays and those initiated by cosmic rays was ***,a Quality Factor was introduced to assess the telescope’s ability to suppress the background and to provide a more effective characterization of its performance.

关键词： astroparticle physics-telescopes-methods data analysis

Construction of Orthogonal Arrays without Interaction Columns

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Acta Mathematicae Applicatae Sinica 2022年第1期38卷 159-168页

作者： Shan-qi PANG ya-ping wang Ming-yao AI School of Mathematics and Information Science Henan Engineering Laboratory for Big Data Statistical Analysis and Optimal ControlHenan Normal UniversityXinxiang 453007China KLATASDS-MOE School of StatisticsEast China Normal UniversityShanghai 200062China LMAM School of Mathematical Sciences and Center for Statistical SciencePeking UniversityBeijing 100871China

In this paper a new class of orthogonal arrays(OAs),i.e.,OAs without interaction columns,are proposed which are applicable in factor screening,interaction detection and other *** the tools of difference matrices,we present some general recursive methods for constructing OAs of such *** families of OAs with high percent saturation are *** particular,for any integerλ≥3,such a two-level OA of run 4λcan always be obtained if the corresponding Hadamard matrix exists.

关键词： complex aliasing difference matrix Hadamard matrix Kronecker sum symmetric array

Event plane determination from the zero degree calorimeter at the cooling storage ring external-target experiment

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Nuclear Science and Techniques 2023年第7期34卷 113-121页

作者： Li-Ke Liu Hua Pei ya-ping wang Biao Zhang Nu Xu Shu-Su Shi Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China

The Cooling Storage Ring external-target experiment(CEE)spectrometer is used to study the nuclear matter created in heavy-ion collisions at√sNN=2.1-2.4 GeV with the aim to reveal the quantum chromodynamics phase structure in the high-baryon-density *** flow is considered an effective probe for evaluating the properties of media during high-energy nuclear *** of the main functions of the zero-degree calorimeter(ZDC),a subdetector system in the CEE,is to determine the reaction plane in heavy-ion *** step is crucial for measuring the collective flow and other reaction-plane-related *** this paper,we illustrate the procedures for event plane determination using the ***,isospin-dependent quantum molecular dynamics model-based predictions of the rapidity dependence of the directed and elliptical flows for p,d,t,3He,and 4He,produced in 2.1 GeV U+U collisions,are presented.

关键词： QCD phase structure Heavy-ion collisions Collective flow Reaction plane Zero-degree calorimeter

Classifier for centrality determination with zero-degree calorimeter at the cooling-storage-ring external-target experiment

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Nuclear Science and Techniques 2023年第11期34卷 168-173页

作者： Biao Zhang Li‑Ke Liu Hua Pei Shu‑Su Shi Nu Xu ya‑ping wang Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China

The zero-degree calorimeter(ZDC)plays a crucial role toward determining the centrality in the Cooling-Storage-Ring External-target Experiment(CEE)at the Heavy Ion Research Facility in Lanzhou.A boosted decision tree(BDT)multi-classification algorithm was employed to classify the centrality of the collision events based on the raw features from ZDC such as the number of fired channels and deposited *** data from simulated^(238)U+^(238)U collisions at 500 MeV∕u,generated by the IQMD event generator and subsequently modeled using the GEANT4 package,were employed to train and test the BDT *** results showed the high accuracy of the multi-classification model adopted in ZDC for centrality determination,which is robust against variations in different factors of detector geometry and *** study demon-strates the good performance of CEE-ZDC in determining the centrality in nucleus-nucleus collisions.

关键词： ZDC Boosted decision trees Multi-classification IQMD Centrality determination

Hydrocarbon expulsion model and resource potential evaluation of high-maturity marine source rocks in deep basins:Example from the Ediacaran microbial dolomite in the Sichuan Basin,China

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Petroleum Science 2022年第6期19卷 2618-2630页

作者： Wen-yang wang Xiong-Qi Pang ya-ping wang Zhang-Xin Chen Chang-Rong Li Xin-Hua Ma State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research Institute of Exploration and Development Petro China Southwest Oil&Gas Field CompanyChengduSichuan 610041China Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgary T2N 1N4Canada School of Earth and Space Sciences Peking UniversityBeijing 100871China Research Institute of Petroleum Exploration and Development(RIPED) Petro ChinaBeijing 100083China

Hydrocarbon expulsion features and resource potential evaluation of source rocks are crucial for the petroleum ***-maturity marine source rocks have not exhibited a hydrocarbon expulsion mode owing to the lack of low-maturity source rocks in deep petroliferous *** considered the Ediacaran microbial dolomite in the Sichuan Basin,the largest high-maturity marine gas layer in China,to exhibit a method that quantitatively characterizes the hydrocarbon expulsion of high-maturity marine source *** experiment of fluid inclusion,rock pyrolysis,and vitrinite reflectance(Ro)of 119 microbial dolomite core samples obtained from the Dengying Formation were performed.A hydrocarbon expulsion model of high-maturity source rock was established,and its resource potential was *** results showed that the Ediacaran microbial dolomite in the Sichuan Basin is a good source rock showing vast resource *** hydrocarbon expulsion threshold is determined to be vitrinite reflectance at 0.92%.The hydrocarbon expulsion intensities in the geologic history is high with maximum of 1.6×10^(7)t/km^(2).The Ediacaran microbial dolomite expelled approximately 1.008×10^(12)t of hydrocarbons,and the recoverable resource was 1.5×10^(12)m^(3).The region can be categorized into areasⅠ,Ⅱ,Ⅲ,andⅣ,in decreasing order of hydrocarbon expulsion *** with a higher hydrocarbon expulsion intensity have a lower drilling risk and should be prioritized for exploration in the orderⅠ>Ⅱ>Ⅲ>Ⅳ.Two areas,northern and central parts of Ediacaran in the Sichuan Basin,were selected as prospects which had the drilling priority in the future gas *** production data of 55 drilled wells verified the high reliability of this *** model in this study does not require low-maturity samples and can be used for evaluating high-maturity marine source rocks,which has broad applicability in deep basins worldwide.

关键词： Deep petroliferous basin Overmatured source rocks Hydrocarbon expulsion model Resource evaluation Sichuan basin