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Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development

Bioactive Materials 2022年第12期7卷 104-115页

作者： Hong Niu Haichang Li ya guan Xin Zhou Zhongguang Li Serana Li Zhao Peng Chen Tao Tan Hua Zhu Valerie Bergdall Xuehong Xu Jianjie Ma Jianjun guan Department of Mechanical Engineering and Materials Science Washington University in St.LouisSt.LouisMO63130USA Institute of Materials Science and Engineering Washington University in St.LouisSt.LouisMO63130USA Department of Surgery Davis Heart and Lung Research InstituteThe Ohio State UniversityColumbusOH43210USA Laboratory of Cell Genetics and Developmental Biology Shaanxi Normal University College of Life SciencesXi’an710062China Department of Veterinary Preventive Medicine University Laboratory Animals ResourcesThe Ohio State UniversityColumbusOH43210USA

MG53 is an essential component of the cell membrane repair machinery,participating in the healing of dermal wounds.Here we develop a novel delivery system using recombinant human MG53(rhMG53)protein and a reactive oxygen species(ROS)-scavenging gel to treat diabetic wounds.Mice with ablation of MG53 display defective hair follicle structure,and topical application of rhMG53 can promote hair growth in the mg53􀀀/􀀀mice.Cell lineage tracing studies reveal a physiological function of MG53 in modulating the proliferation of hair follicle stem cells(HFSCs).We find that rhMG53 protects HFSCs from oxidative stress-induced apoptosis and stimulates differentiation of HSFCs into keratinocytes.The cytoprotective function of MG53 is mediated by STATs and MAPK signaling in HFSCs.The thermosensitive ROS-scavenging gel encapsulated with rhMG53 allows for sustained release of rhMG53 and promotes healing of chronic cutaneous wounds and hair follicle development in the db/db mice.These findings support the potential therapeutic value of using rhMG53 in combination with ROS-scavenging gel to treat diabetic wounds.

关键词： Diabetic wound healing hair follicle stem cell MG53 ROS-Scavenging hydrogel Controlled drug delivery

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立法重复的规则之治——基于450份地方立法规范的分析

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天水行政学院学报（哲学社会科学版） 2024年第1期25卷 99-104页

作者：管亚冰吉林大学法学院吉林长春130015

《中华人民共和国立法法》第八十二条第四款规定,上位法有明确规定的,地方性法规一般不作重复规定,这是一项重要的立法原则,需要进一步明确其内涵。但由于“一般不重复上位法”规定的较为模糊,地方立法规范数量众多,但并没有实现该原则... 详细信息

《中华人民共和国立法法》第八十二条第四款规定,上位法有明确规定的,地方性法规一般不作重复规定,这是一项重要的立法原则,需要进一步明确其内涵。但由于“一般不重复上位法”规定的较为模糊,地方立法规范数量众多,但并没有实现该原则的细化,目前的立法和司法程序也没有对重复立法的情形提供有效的审查和监督机制,导致地方立法对上位法的“复制粘贴”行为层出不穷。这一问题的解决需要总结地方经验,更新立法原则,以地方性法规的方式明晰“合理重复”的内涵和边界,并在立法程序上作出否定性评价。

关键词： “不重复上位法” 不抵触合理重复立法程序

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青海省老年人智能手机使用压力、自我效能感与主观幸福感的现状及关系研究

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青海师范大学学报（自然科学版） 2024年第1期40卷 83-89页

作者：魏凤英关雅欣张婧漪青海师范大学教育学院青海西宁810016 北京师范大学心理学部北京100875

[目的]了解青海省老年人智能手机使用压力、自我效能感与主观幸福感的现状及相关因素.[方法]选取340名青海省60岁以上老年人,使用智能手机使用压力量表、一般自我效能感量表、费城老年中心(PGC)信心量表进行问卷调查,探究青海省老年人... 详细信息

[目的]了解青海省老年人智能手机使用压力、自我效能感与主观幸福感的现状及相关因素.[方法]选取340名青海省60岁以上老年人,使用智能手机使用压力量表、一般自我效能感量表、费城老年中心(PGC)信心量表进行问卷调查,探究青海省老年人智能手机使用压力、自我效能感和主观幸福感现状及三者之间的关系,并对三者现状进行影响因素分析.[结果]青海省老年人(n=340)存在一定程度的智能手机使用压力;自我效能感与国际成人常模相比较差[(28.6±5.2)vs(22.64±5.61)];主观幸福感及其中因子与先前研究常模相比较差[(17.9±3.95)vs(12.58±5.71)].多元线性回归分析显示,青海省老年人年龄与智能手机使用压力总分正向关联(β=0.24),受教育程度、智能手机的使用频率与智能手机使用压力总分负向关联(β=-0.72、-0.54);青海省老年人性别、智能手机使用压力与自我效能感总分负向关联(β=-2.06、-0.74);青海省老年人月收入、自我效能感与主观幸福感总分正向关联(β=0.84、0.22).

关键词：老年人智能手机使用压力主观幸福感自我效能感现状研究

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Chinese Medicine Plaster as A New Treatment for Surgical Site Infection in Patients with Cesarean Delivery:A Randomized,Double-Blind,Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第6期29卷 483-489页

作者： HAN guan-ya WU Xiao-li LI Dong-mei CAI Hai-rui ZHOU Jun-jun HE Xiao-bo Department of Obstetrics Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China Department of Medical Intensive Care Unit Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China

Objective To evaluate the efficacy of Chinese plaster containing rhubarb and mirabilite on surgical site infection(SSI)in patients with cesarean delivery(CD)by performing a randomized controlled trial.Methods This randomized controlled trial included 560 patients with CD due to fetal head descent enrolled at a tertiary teaching center between December 31,2018 and October 31,2021.Eligible patients were randomly assigned to a Chinese medicine(CM)group(280 cases)or a placebo group(280 cases)by a random number table,and were treated with CM plaster(made by rhubarb and mirabilite)or a placebo plaster,respectively.Both courses of treatment lasted from the day 1 of CD,followed day 2 until discharge.The primary outcome was the total number of patients with superficial,deep and organ/space SSI.The secondary outcome was duration of postoperative hospital stay,antibiotic intake,and unplanned readmission or reoperation due to SSI.All reported efficacy and safety outcomes were confirmed by a central adjudication committee that was unaware of the study-group assignments.Results During the recovery process after CD,the rates of localized swelling,redness and heat were significantly lower in the CM group than in the placebo group[7.55%(20/265)vs.17.21%(47/274),P<0.01].The durution of postoperative antibiotic intake was shorter in the CM group than in the placebo group(P<0.01).The duration of postoperative hospital stay was significantly shorter in the CM group than in the placebo group(5.49±2.68 days vs.8.96±2.35 days,P<0.01).The rate of postoperative C-reactive protein elevation(≽100 mg/L)was lower in the CM group than in the placebo group[27.6%(73/265)vs.43.8%(120/274),P<0.01].However,there was no difference in purulent drainage rate from incision and superficial opening of incision between the two groups.No intestinal reactions and skin allergies were found in the CM group.Conclusions CM plaster containing rhubarb and mirabilite had an effect on SSI.It is safe for mothers and imposes lower economic and mental burdens on patie

关键词： Chinese medicine plaster rhubarb and mirabilite surgical site infection cesarean delivery randomizedcontrolledtrial

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施氮磷肥对黄土丘陵区典型草地优势种光谱特征的影响

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草地学报 2024年第4期32卷 1094-1104页

作者：管雅君王绍妍陈志飞罗杨周俊杰简春霞许培丹牟英坤徐炳成西北农林科技大学草业与草原学院陕西杨凌712100 西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100 贵州大学生命科学学院贵州贵阳550025 中国科学院水利部水土保持研究所陕西杨凌712100

探讨施肥后草地群落优势种光谱特征响应和差异,对准确评价草地施肥效应有重要意义。以黄土丘陵区6个典型优势种[白羊草(Bothriochloa ischaemum)、长芒草(Stipa bungeana)、达乌里胡枝子(Lespedeza davurica)、菊叶委陵菜(Potentilla ta... 详细信息

探讨施肥后草地群落优势种光谱特征响应和差异,对准确评价草地施肥效应有重要意义。以黄土丘陵区6个典型优势种[白羊草(Bothriochloa ischaemum)、长芒草(Stipa bungeana)、达乌里胡枝子(Lespedeza davurica)、菊叶委陵菜(Potentilla tanacetifolia)、蒙古蒿(Artemisia mongolica)和铁杆蒿(Artemisia sacrorum)]为对象,测定并提取了不同施氮磷处理下的7个光谱特征参数。结果表明:相比未施肥,单施氮或磷均降低6个优势种在“蓝谷”、“绿峰”和“红谷”处的光谱反射率;氮磷配施后,各优势种的红边幅值(AMP)和红边面积(S red)呈增加趋势,白羊草、达乌里胡枝子、菊叶委陵菜和铁杆蒿的差值植被指数(DVI)均增大。结果表明,光谱特征参数可有效反映黄土丘陵区草地优势种的氮磷施肥效应,植被指数DVI,NDVI和GNDVI相比RVI更适合于评价草地群落优势种对施氮磷肥的响应和差异。

关键词：红边参数植被指数光谱特征草地群落黄土高原

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Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity

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Science China(Life Sciences) 2021年第7期64卷 1077-1086页

作者： ya-Na guan Yue Li Moom Roosan Qing Jing Shanghai Jiao Tong University School of Medicine(SJTUSM)&CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of Sciences(CAS)Shanghai 200031China Chapman University IrvineCA 92618USA

Mural cells(MCs)wrap around the endothelium,and participate in the development and homeostasis of vasculature.MCs have been reported as heterogeneous population morphologically and functionally.However,the transcriptional heterogeneity of MCs was rarely studied.In this study,we illustrated the transcriptional heterogeneity of MCs with different perspectives by using publicly available single-cell dataset GSE109774.Specifically,MCs are transcriptionally different from other cell types,and ligand-receptor interactions of different cells with MCs vary.Re-clustering of MCs identified five distinct subclusters.The heterogeneity of MCs in tissues was reflected by MC coverage,various distribution of MC subclusters,and ligand-receptor interactions of MCs and parenchymal cells.The transcriptomic diversity of MCs revealed in this article will help facilitate further research into MCs.

关键词： mural cells single-cell analysis heterogeneity

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Seed priming with chitosan improves maize germination and seedling growth in relation to physiological changes under low temperature stress

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第6期10卷 427-433页

作者： ya-jing guan Jin HU Xian-ju WANG Chen-xia SHAO Seed Science Center College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China Yuan Longping High-Tech Agriculture Co. Ltd. Changsha 410001 China

低温度应力在萌芽和早幼苗生长期间是玉米的全球生产的重要限制。有 0.25% ， 0.50% ，和 0.75% 的种子 priming (w/v ) 的效果在生长和生理的变化上的 15 ° C 的 chitosan 答案用二玉米(Zea mays L.) 被调查生来的线， HuangC (寒心容... 详细信息

低温度应力在萌芽和早幼苗生长期间是玉米的全球生产的重要限制。有 0.25% ， 0.50% ，和 0.75% 的种子 priming (w/v ) 的效果在生长和生理的变化上的 15 ° C 的 chitosan 答案用二玉米(Zea mays L.) 被调查生来的线， HuangC (寒心容忍) 并且 Mo17 (寒心敏感) 。当有 chitosan 的种子 priming 没在低温度应力下面在萌芽百分比上有重要效果时，它提高了萌芽索引，减少了吝啬的萌芽时间(MGT ) ，并且增加了射击高度，根长度，和射击和根在两根玉米线的干燥重量。 malondialdehyde ( MDA )的衰落内容和血浆膜的相对渗透和可溶的糖和脯氨酸的集中的增加， peroxidase (邮政部门)活动，并且过氧化氢酶(猫)活动与 chitosan 的三集中在 priming 以后在寒心敏感、寒心容忍的玉米幼苗两个都被检测。HuangC 对对 chitosan 的不同集中作出回应不太敏感。有为大约 60 ∼64 h 的 0.50% chitosan 的 Priming 似乎有最好的效果。因此，它建议有 chitosan 的种子 priming 可以在低温度应力下面为幼苗生长改进玉米种子和利益的萌芽的速度。

关键词：壳聚糖溶液玉米自交系低温胁迫幼苗生长种子引发生理变化萌发活性检测

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Effect of the scale of quantitative trait data on the representativeness of a cotton germplasm sub-core collection

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第2期14卷 162-170页

作者： Jian-cheng WANG Jin HU ya-jing guan yan-fang ZHU Seed Science Center College of Agriculture and BiotechnologyZhejiang University Shandong Crop Germplasm Center Shandong Academy of Agricultural Sciences

A cotton germplasm collection with data for 20 quantitative traits was used to investigate the effect of the scale of quantitative trait data on the representativeness of plant sub-core collections.The relationship between the representativeness of a sub-core collection and two influencing factors,the number of traits and the sampling percentage,was studied.A mixed linear model approach was used to eliminate environmental errors and predict genotypic values of accessions.Sub-core collections were constructed using a least distance stepwise sampling(LDSS) method combining standardized Euclidean distance and an unweighted pair-group method with arithmetic means(UPGMA) cluster method.The mean difference percentage(MD),variance difference percentage(VD),coincidence rate of range(CR),and variable rate of coefficient of variation(VR) served as evaluation parameters.Monte Carlo simulation was conducted to study the relationship among the number of traits,the sampling percentage,and the four evaluation parameters.The results showed that the representativeness of a sub-core collection was affected greatly by the number of traits and the sampling percentage,and that these two influencing factors were closely connected.Increasing the number of traits improved the representativeness of a sub-core collection when the data of genotypic values were used.The change in the genetic diversity of sub-core collections with different sampling percentages showed a linear tendency when the number of traits was small,and a logarithmic tendency when the number of traits was large.However,the change in the genetic diversity of sub-core collections with different numbers of traits always showed a strong logarithmic tendency when the sampling percentage was changing.A CR threshold method based on Monte Carlo simulation is proposed to determine the rational number of traits for a relevant sampling percentage of a sub-core collection.

关键词：晶状体上皮细胞蛋白质组分细胞增殖姜黄素

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Evolution exploration and structure prediction of Keggin-type group IVB metal-oxo clusters

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Chinese Chemical Letters 2024年第5期35卷 487-492页

作者： Run-Han Li Tian-Yi Dang Wei guan Jiang Liu ya-Qian Lan Zhong-Min Su School of Chemistry South China Normal UniversityGuangzhou 510006China Institute of Functional Material Chemistry Faculty of ChemistryNortheast Normal UniversityChangchun 130024China Institute of Theoretical Chemistry Jilin UniversityChangchun 130023China

The fascinating chemical structure and broad application prospect of Keggin-type polyoxometalates(POMs)have attracted many chemists to explore and discover continuously.Unlike the traditional Keggin,larger metal atomic radius,higher metal coordinated numbers,lower metal valence states and other features allow the group IVB metal-based Keggin(IVB-Keggin)more space and unknown in terms of structure and performance.Herein,density functional theory(DFT)calculations were performed to explore the influences including cores,shells,caps,and terminal ligands,et al.on IVB-Keggin,and analyze the possibility of novel structure synthesis.From the perspective of multi-layer onion-like clusters,molecular energy level,host-guest interaction energy,surface charge and covalent bond polarity can be further adjusted to achieve the oriented design of functional IVB-Keggin.These insights are expected to provide theoretical support for experimental synthesis,opening a new perspective to understand the growth of Keggin.

关键词： Keggin Metal-oxo clusters Group IVB Onion pattern DFT

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Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research(International) 2024年第2期31卷 389-400页

作者： Li-ping Pan ya-wei Li Fang-guan Tan Yi-chen Chen yang-fan Xu Zhu He Bao-kuan Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and Lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ladle.Alumina–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining technology.The thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling simulation.Combined with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically analyzed.The results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 m.The thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,respectively.The addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the slits.Consequently,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress

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