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Neurosyphilis complicated by anti-γ-aminobutyric acid-B receptor encephalitis: A case report

World Journal of Clinical Cases 2024年第11期12卷 1960-1966页

作者： ya-Xiu fang Xiao-Ming Zhou Dong Zheng Guang-Hui Liu Peng-Bo Gao Xiao-Zhen Huang Zhi-Cheng Chen Hui Zhang Lin Chen ya-fang Hu Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing *** cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been *** report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)*** SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local *** was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for *** 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were *** was then transferred to our *** Mini-Mental State Examination(MMSE)crude test results showed only 2 *** magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral ***-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and *** treatment,his mental symptoms were *** impairment was significantly improved,with a MMSE of 8 *** anti-GABABR antibody titer decreased to 1:*** patient received methylprednisolone and penicillin after *** months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:*** This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.

关键词： Anti-γ-aminobutyric acid-B receptor GABABR Neurosyphilis Tissue-based assay Magnetic resonance imaging Mini-mental state examination Case report

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Recent progress of two-dimensional metal-base catalysts in urea oxidation reaction

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Rare Metals 2024年第8期43卷 3607-3633页

作者： Qi-Xiang Huang fang Wang Yong Liu Bi-Ying Zhang fang-ya Guo Zhong-Qiu Jia Hao Wang Tian-Xiang yang Hai-Tao Wu Feng-Zhang Ren Ting-Feng Yi School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471000China School of Environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023China Henan Province International Joint Laboratory of Materials for Solar Energy Conversion and Lithium Sodium Based Battery Luoyang 471023China School of Chemistry and Life Sciences Suzhou University of Science and TechnologySuzhou 215009China School of Materials Science and Engineering Northeastern UniversityShenyang110819China

Urea oxidation reaction(UOR)is an auxiliary water electrolysis hydrogen production technology developed in recent years to replace oxygen evolution reaction and reduce energy consumption,which can produce hydrogen more efficiently by low theoretical potential,reduce the average cost of electrochemical hydrogen production,and is a frontier research hotspot for renewable hydrogen ***-dimensional(2D)nanomaterials as electrocatalysts have many favorable potential,such as it can effectively reduce the resistivity of materials and increase the specific surface area with *** paper reviews the application of 2D materials in UOR in alkaline *** a cross-sectional comparison of various material performance data including overpotential,Tafel slope,electrochemical active surface area(ECSA)and it stability test was conducted,which could illustrate the differences between materials composed of different *** addition,the main challenges hindering the progress of research on 2D materials in urea electrocatalysis processes and promising materials in this field in future are summarized and *** is believed that this review will contribute to designing and analyzing highperformance 2D urea electrocatalysts for water splitting.

关键词： Water splitting Urea oxidation reaction Two-dimensional Transition metal compounds Noble/non-noble metals

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Dynamics of information diffusion and disease transmission in time-varying multiplex networks with asymmetric activity levels

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Chinese Physics B 2024年第3期33卷 690-699页

作者：谢笑笑霍良安董雅芳程英英 Business School University of Shanghai for Science and TechnologyShanghai 200093China School of Intelligent Emergency Management University of Shanghai for Science and TechnologyShanghai 200093China School of Management Henan University of Science and TechnologyLuoyang 471023China

While the interaction between information and disease in static networks has been extensively investigated,many studies have ignored the characteristics of network *** this study,we construct a new two-layer coupling model to explore the interactions between information and *** upper layer describes the diffusion of disease-related information,and the lower layer represents the disease *** then use power-law distributions to examine the influence of asymmetric activity levels on dynamic propagation,revealing a mapping relationship characterizing the interconnected propagation of information and diseases among partial nodes within the ***,we derive the disease outbreak threshold by using the microscopic Markov-chain approach(MMCA).Finally,we perform extensive Monte Carlo(MC)numerical simulations to verify the accuracy of our theoretical *** findings indicate that the activity levels of individuals in the disease transmission layer have a more significant influence on disease transmission compared with the individual activity levels in the information diffusion ***,reducing the damping factor can delay disease outbreaks and suppress disease transmission,while improving individual quarantine measures can contribute positively to disease *** study provides valuable insights into policymakers for developing outbreak prevention and control strategies.

关键词： information diffusion disease transmission asymmetric activity levels quarantine strength

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Molecular Conformational Isomerization:An Efficient Way to Design Novel Emitters with Dual-Thermally Activated Delayed Fluorescence Characteristics and Their Optoelectronic and Bioimaging Applications

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CCS Chemistry 2024年第4期6卷 912-922页

作者： Yi-Zhong Shi ya-fang Xiao Hao Wu Shao-Li Zhang Xiao-Chun Fan Ye Tian Chang-Qing Ye Kai Wang Jia Yu Chun-Sing Lee Xiao-Hong Zhang School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009 Institute of Functional Nano and Soft Materials(FUNSOM) Joint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu Center of Super-Diamond and Advanced Films(COSDAF) Department of ChemistryCity University of Hong KongHong Kong SAR School of Biomedical Engineering The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260 Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow UniversitySuzhou 215123Jiangsu Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123Jiangsu

Single-molecule luminophores with dual-thermally activated delayed fluorescence(TADF)properties are receiving increasing ***,how to achieve these goals requires more in-depth ***,we demonstrate a novel example emitter,10-(5-(2-(pyridin-3-yl)-[4,5′-bipyrimidin]-6-yl)pyridin-2-yl)-10Hphenoxazine(PmPy-PXZ),enabling dual-TADF properties due to its key feature of conformational *** a pyridine bridge can greatly reduce the steric hindrance and facilitate dual-stable conformations in the ground state,where the quasi-axial(QA)forms ***,unlike previously reported TADF molecules with dual confirmations,both theoretical and experimental measurements show that not only the quasi-equatorial(QE)forms but also the QA forms exhibit distinct TADF characteristics,which can be attributed to an additional higher reverse intersystem crossing *** is the first time that dual-TADF properties of single molecules have been achieved based on conformational *** applications in“self-doping”organic light-emitting diode and biomedical imaging have further been *** these results show the good potential of such dual-band TADF emitters based on molecular conformational isomerization.

关键词： dual-thermally activated delayed fluorescence conformational isomerization organic light-emitting diode biomedical imaging self-doping

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Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

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Traditional Medicine Research 2024年第9期9卷 21-31页

作者： Han-Qing Zhang Shuang Wu Xin Chen ya-Xuan fang Qiu-Mei Lan Zi-Jun Zhou yan-Heng Qiao Jie Li yan-Ru Zhao Ming Pei Bo yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

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小学生作业抄袭的诚信心理困境及其教育应对

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教学与管理 2024年第26期 6-10页

作者：方亚军郑航华南师范大学教育科学学院

关注小学生作业抄袭的诚信心理困境对于洞察小学生学习心理品质、建设小学生诚信学习生活具有重要意义。小学生作业抄袭是指小学生对其同伴的作业内容或方法进行模仿、复制、抄写或沿用,制造相同数据的一种学习投机行为。就其诚信心理... 详细信息

关注小学生作业抄袭的诚信心理困境对于洞察小学生学习心理品质、建设小学生诚信学习生活具有重要意义。小学生作业抄袭是指小学生对其同伴的作业内容或方法进行模仿、复制、抄写或沿用,制造相同数据的一种学习投机行为。就其诚信心理困境而言,小学生作业抄袭表征为学习态度的虚伪化、学习情感的隐匿化和学习意志的褪色化,这些诚信心理困境的内在动因源于基于风险逃避的身体本能、基于压力转移的心理应付和基于效率追逐的价值导向。因此,应对小学生作业抄袭的诚信教育需培养小学生基于行事认真的学习习惯,建立小学生基于责任担当的学习信用,塑造小学生基于质量自信的学习价值观。

关键词：小学生作业抄袭学习诚信诚信心理

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国家治理视角下民族事务治理主体关系现代化研究

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山西师大学报（社会科学版） 2024年第1期51卷 78-87页

作者：宁亚芳中国社会科学院民族学与人类学研究所北京100081

民族事务是国家治理的重要内容,民族事务治理主体关系现代化既是民族事务治理体系和治理能力现代化的缩影,也是推动民族事务治理体系和治理能力现代化的动力。立足于中国民族事务治理实践,民族事务治理主体关系现代化是指在中国共产党... 详细信息

民族事务是国家治理的重要内容,民族事务治理主体关系现代化既是民族事务治理体系和治理能力现代化的缩影,也是推动民族事务治理体系和治理能力现代化的动力。立足于中国民族事务治理实践,民族事务治理主体关系现代化是指在中国共产党的领导下,围绕增进中华民族共同性的方向,以强国建设、民族复兴为根本目标,国家权力机构与各类推动中华民族共同体建设的主体结成共商共建共治共享关系格局的进程。中国民族事务治理主体关系现代化吸收了多元主体协作治理的优势,但摒弃了西方治理理论“去中心化”“去国家化”的理念,与西方治理理论强调政府与非政府、公共与私人的二元对立与分离存在根本不同。党的领导、政府的统筹和组织,在构建稳定有序和谐高效的民族事务治理主体关系中发挥着核心引领作用。民族事务治理主体关系现代化对共商共建共治共享理念的强调,为增进中华民族的共同性奠定了思想基础和实践基础。

关键词：国家治理民族事务治理主体关系共同性现代化

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失智症老年人长期照护及其预防干预研究进展

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中国公共卫生 2024年第1期40卷 98-102页

作者：朱培嘉张良文方亚厦门大学公共卫生学院卫生经济政策暨老年健康研究中心厦门361102 厦门大学公共卫生学院卫生技术评估福建省高校重点实验室厦门361102

失智症(又名认知症、痴呆症)是一种进行性中枢神经系统退行性病变,主要表现为慢性、进行性认知功能减退及记忆力和语言能力的丧失,随着病情进展会给患者及其家庭造成巨大的疾病和经济负担。随着全球人口老龄化趋势加剧,失智症发病率逐... 详细信息

失智症(又名认知症、痴呆症)是一种进行性中枢神经系统退行性病变,主要表现为慢性、进行性认知功能减退及记忆力和语言能力的丧失,随着病情进展会给患者及其家庭造成巨大的疾病和经济负担。随着全球人口老龄化趋势加剧,失智症发病率逐年上升,失智症老年人的长期照护呈现刚性需求。以往,我国对失智症老年人长期照护的研究模式多借鉴国外经验,近年来倾向于对失智症老年人群规模、宏观经济负担等预测研究,但缺乏对失智症老年人长期照护成本测算及其研究方法的系统梳理,对于失智症预防干预效果评价研究鲜有涉及。本文在概述国内外失智症老年人长期照护体系现状的同时,系统梳理了国内外失智症老年人长期照护成本及预防干预策略、方式及评价研究,为探索构建新时代失智症老年人长期照护体系提供循证依据。

关键词：失智症老年人长期照护预防干预

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中国老年人慢性病共病模式与肌少症发生风险的关联性研究

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中国慢性病预防与控制 2024年第5期32卷 327-331页

作者：林舒静何凌骁方亚厦门大学公共卫生学院卫生技术评估福建省高校重点实验室福建省厦门361102

目的探讨中国老年人慢性病共病模式与肌少症发生风险的关联,为肌少症的预防与控制提供科学依据。方法数据来源于中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS),选取在2011年及2013年参与初次调查的2... 详细信息

目的探讨中国老年人慢性病共病模式与肌少症发生风险的关联,为肌少症的预防与控制提供科学依据。方法数据来源于中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS),选取在2011年及2013年参与初次调查的2569名≥60岁老年人作为研究对象,对其进行问卷调查和体格检查。以2015年为观测终点,2013—2015年新发肌少症为观测结局。采用SPSS 25.0软件进行t检验、方差分析、χ^(2)检验,采用Cox回归分析不同共病模式与肌少症发病风险的关联。应用Mplus 7.4进行潜在类别分析(LCA)识别老年人共病模式。结果中国老年人慢性病共病的患病率为52.90%,随访期间共发生287例肌少症,肌少症的发病密度为34.0/1000人年。LCA识别出3组慢性病共病模式,分别为呼吸系统疾病组、代谢系统疾病组、关节炎-消化系统疾病组。调整混杂因素后,多因素Cox回归分析结果显示,与未患慢性病组相比,关节炎-消化系统疾病组肌少症的发病风险显著上升(HR=1.606,95%CI:1.176~2.193,P<0.05)。结论关节炎-消化系统疾病模式与肌少症的发生风险密切相关,肌少症的监控应重点关注该人群。

关键词：慢性病共病模式肌少症

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我国公立互联网医院经济效果评估

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中国医院 2024年第9期28卷 23-27页

作者：房亚楠张晓旺天津行政学院天津市300191 天津大学胸科医院天津市300222

目的:探索公立互联网医院的设立对就医经济层面的影响。方法:基于2019年与2020年的公立互联网医院数据以及《中国卫生健康统计年鉴》数据,利用二次指派程序法剖析随着互联网医院数量的增加,其经济效果的展现。结果:互联网医院在2019年... 详细信息

目的:探索公立互联网医院的设立对就医经济层面的影响。方法:基于2019年与2020年的公立互联网医院数据以及《中国卫生健康统计年鉴》数据,利用二次指派程序法剖析随着互联网医院数量的增加,其经济效果的展现。结果:互联网医院在2019年有助于缩小全国门诊费用和住院费用异质性,并且门诊的积极作用保持到了2020年;随着2020年互联网医院数量激增,拉大了住院医疗服务费用异质性。老年人作为医疗服务的弱势群体和主力军,在互联网医院利用方面需要更多关注。结论:应注意增加对住院患者的针对性远程服务供给,并进一步消除老年人使用互联网医院的“数字鸿沟”。

关键词：公立医院互联网医院经济效果评估

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