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复合主干融合的图像增强算法

计算机系统应用 2024年第4期33卷 194-201页

作者：万嘉龙况立群曹亚明郭磊熊风光中北大学计算机科学与技术学院太原030051 机器视觉与虚拟现实山西省重点实验室太原030051 山西省视觉信息处理及智能机器人工程研究中心太原030051

基于深度学习的微光图像增强算法所生成的图像普遍存在噪声凸显和细节丢失等问题,而端对端深度学习算法的性能又在很大程度上依赖于骨干网络的提取能力,因此,通过探索更有效的骨干网络结构可以提升微光增强任务的性能收益.本文提出了一... 详细信息

基于深度学习的微光图像增强算法所生成的图像普遍存在噪声凸显和细节丢失等问题,而端对端深度学习算法的性能又在很大程度上依赖于骨干网络的提取能力,因此,通过探索更有效的骨干网络结构可以提升微光增强任务的性能收益.本文提出了一种复合主干网络融合策略的图像增强算法,将不同图像增强算法中的主干网络进行融合,以提高整体网络的特征提取能力.该算法通过逐层融合来自不同主干网络的特征信息,将复合特征引导到解码器中,再充分利用不同的上采样方法,将主干网络融合的特征进行堆叠,最终生成正常光照条件下的图像.通过与现有的主流算法进行定量与定性的对比实验,结果显示,本文方法显著提升了微光图像的亮度,同时保留图像的细节特征,在峰值信噪比和结构相似性客观指标上,在LOL-V2数据集上达到了24.35 dB和0.871,有效解决了图像增强后的噪声凸显和细节丢失问题.

关键词：网络融合图像增强微光复合主干

日本汉方药企业专利布局分析——以株式会社津村为例

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中南药学 2024年第5期22卷 1365-1371页

作者：王铁融刘盼侯媛媛曹雅迪陈宁衡宇鑫刘伟北京中医药大学管理学院北京100029 北京中医药大学图书馆北京100029 北京北中岐黄科技投资管理有限公司北京100029 北京中医药大学成果转化中心北京100029

目的对株式会社津村2000—2022年申请的日本专利和中国专利进行分析,了解其技术研发及专利布局方向,并挖掘其战略处方专利布局,以期对我国中药企业有所启示。方法在Incopat专利检索数据库上检索2000—2022年株式会社津村申请的专利,... 详细信息

目的对株式会社津村2000—2022年申请的日本专利和中国专利进行分析,了解其技术研发及专利布局方向,并挖掘其战略处方专利布局,以期对我国中药企业有所启示。方法在Incopat专利检索数据库上检索2000—2022年株式会社津村申请的专利,对其进行专利标引及专利技术分析。结果株式会社津村围绕汉方制剂产业链上下游技术开展专利布局,专利布局连续且技术主题丰富,对我国中药企业具有潜在威胁,战略处方专利布局具有策略性。结论我国企业要制定灵活的专利布局策略,拓宽中药企业专利布局技术覆盖范围,持续研发投入并做好专利防御,策略性搭建重点中药产品专利网。

关键词：日本汉方药株式会社津村专利布局

Triggering triplet excitons of carbon nanodots through nanospace domain confinement for multicolor phosphorescence in aqueous solution

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Nano Research 2024年第7期17卷 6534-6543页

作者： ya-Chuan Liang Qing cao Yuan Deng Yong Wang Kai-Kai Liu Chong-Xin Shan School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002China Henan Key Laboratory of Diamond Optoelectronic Material and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou 450046China

Easy non-radiative decay property of long-lived triplet excitons in aqueous solution obstructs their applications in aquatic *** reported phosphorescence phenomena in aqueous solution have excited researchers enormously but achieving full-color water-soluble phosphorescent carbon nanodots(CNDs)is still a challenging ***,full-color phosphorescence of water-soluble CNDs has been demonstrated by triggering their triplet excitons through nanospace domain confinement,and Förster energy resonance transfer is used for further tuning phosphorescence *** phosphorescence spans across most of the visible spectrum,ranging from 400 to 700 *** an aqueous solution,the CNDs exhibits blue,green,and red phosphorescence,lasting for approximately 6,10,and 7 s,***,the phosphorescence quantum yields are 11.85%,8.6%and 3.56%,making them readily discernible to the naked eyes and laying a solid foundation for practical ***,phosphorescence flexible optical display and bioimaging have been demonstrated by using the multicolor CNDs-based nanomaterials,showing distinct superiority for accuracy and complete display and imaging in complex emission background.

关键词： carbon nanodots triplet excitons multicolor aqueous solution

Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients

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World Journal of Gastroenterology 2014年第38期20卷 13956-13965页

作者： ya-Li cao Zhi-Gang Tian Fang Wang Wen-Ge Li Dan-Ying Cheng yan-Fang yang Hong-Mei Gao Department of Nephrology China-Japan Friendship Hospital Department of Surgery Beijing Luhe Hospital Department of Gastroenterology China-Japan Friendship Hospital Department of Hepatology Beijing Ditan HospitalCapital Medical University

AIM: To determine the clinicopathological characteristics of nonsteroidal anti-inflammatory drug (NSAID)-induced acute hepato-nephrotoxicity among Chinese patients.

关键词： Nonsteroidal anti-inflammatory drug Hepato-nephrotoxicity Acute interstitial nephritis Acute hepatitis Cholestasis

不同诱导周期对人白色前脂肪细胞分化水平的影响研究

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环境卫生学杂志 2024年第5期14卷 378-383,399页

作者：苗轲高旭曹亚强石莹顾雯杨辉陈圆圆唐宋中国疾病预防控制中心环境与人群健康重点实验室/中国疾病预防控制中心环境与健康相关产品安全所北京100021 南通市疾病预防控制中心国家食品安全风险评估中心南京医科大学全球健康中心

目的通过诱导人白色前脂肪细胞(human white adipose tissue stromal vascular fraction,hWAT-SVF)分化为成熟脂肪细胞,检测不同分化周期中hWAT-SVF细胞成脂标志物的表达水平,为完善和优化人前脂肪细胞分化模型提供数据支持。方法将hWAT... 详细信息

目的通过诱导人白色前脂肪细胞(human white adipose tissue stromal vascular fraction,hWAT-SVF)分化为成熟脂肪细胞,检测不同分化周期中hWAT-SVF细胞成脂标志物的表达水平,为完善和优化人前脂肪细胞分化模型提供数据支持。方法将hWAT-SVF细胞培养6天至融合状态,采用3-异丁基-1-甲基黄嘌呤、地塞米松、胰岛素等诱导细胞分化,在分化的第0、3、6、9、12天收集细胞,观察细胞大小和形态等变化,检测脂滴、中性脂质和甘油三酯(triglyceride,TG)的生成情况,以及脂肪生成相关基因和蛋白[过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)、脂肪酸结合蛋白4(fatty acid binding protein 4,FABP4)和脂滴包被蛋白1(perilipin 1,PLIN1)]等的表达水平。结果经诱导分化后,hWAT-SVF细胞形态明显变大变圆,脂滴和TG含量显著升高,成脂标志物如PPARγ、FABP4、PLIN1等的表达水平显著上调,表明成功将hWAT-SVF细胞诱导为成熟脂肪细胞。分化第3天PPARγ;以及分化第9天成熟脂肪细胞标志物(FABP4和PLIN1)蛋白表达水平分别显著升高1.8、21、14.3倍。结论在分化第9天,hWAT-SVF细胞已具备成熟脂肪细胞的特征。本研究成功缩短了人源前脂肪细胞分化模型的构建周期,为研究脂肪生成效应及机制提供了一种有效的细胞模型。

关键词：白色脂肪细胞脂肪细胞分化成脂标志物

Targeting the signaling in Epstein-Barr virus-associated diseases: mechanism, regulation, and clinical study

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Signal Transduction and Targeted Therapy 2021年第2期6卷 339-371页

作者： ya cao Longlong Xie Feng Shi Min Tang Yueshuo Li Jianmin Hu Lin Zha Luqing Zhao Xinfang Yu Xiangjian Luo Weihua Liao Ann MBode Key Laboratory of Carcinogenesis and Invasion Chinese Ministry of EducationDepartment of RadiologyXiangya HospitalCentral South University410078 ChangshaChina Cancer Research Institute and School of Basic Medical Science Xiangya School of MedicineCentral South University410078 ChangshaChina Key Laboratory of Carcinogenesis Chinese Ministry of Health410078 ChangshaChina Research Center for Technologies of Nucleic Acid Based Dlagnostics and Therapeutics Hunan Province 410078 ChangshaChina Molecular Imaging Research Center of Central South University.410008 Changsha HunanChina National Joint Engineering Research Center for Genetic Diagnostics of Ifectious Diseases and Cancer 410078 ChangshaChina Department of Radiology Xiangya HospitalCentral South University410078 Changsha China The Hormel Institute Universty of MinnesotaAustinMN 55912.USA

Epstein-Barr virus-associated diseases are important global health *** a group I carcinogen,EBV accounts for 1.5%of human malignances,including both epithelial-and lymphatic-originated ***,EBV plays an etiological and pathogenic role in a number of non-neoplastic diseases,and is even involved in multiple autoimmune diseases(SADs).In this review,we summarize and discuss some recent exciting discoveries in EBV research area,which including DNA methylation alterations,metabolic reprogramming,the changes of mitochondria and ubiquitin-proteasome system(UPS),oxidative stress and EBV lytic reactivation,variations in non-coding RNA(ncRNA),radiochemotherapy and *** and learning from this advancement will further confrm the far-reaching and future value of therapeutic strategies in EBV-associated diseases.

关键词： diseases alterations originated

Polo-like kinase 1 protects intestinal epithelial cells from apoptosis during sepsis via the nuclear factor-κB pathway

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Chinese Medical Journal 2020年第15期133卷 1886-1888页

作者： Ying-ya cao Zhen Wang Lin-Ming Lu Zeng-Xiang Xu Jia-Jia Li Xiao-Gan Jiang Wei-Hua Lu Department of Intensive Care Unit Yijishan HospitalFirst Affiliated Hospital of Wannan Medical CollegeWuhuAnhui 241001China Department of Pathology Yijishan HospitalFirst Affiliated Hospital of Wannan Medical CollegeWuhuAnhui 241001China

To the Editor:Sepsis is defined as the life-threatening organ dysfunction caused by dysregulated host response to infection,eventually leading to multiple organ dysfunction *** gut,which is considered to play a signif... 详细信息

关键词： sepsis eventually infection

Activation of the Ig la I promoter by the transcription factor Ets-1 triggers Ig lal-Cal germline transcription in epithelial cancer cells

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Cellular & Molecular Immunology 2014年第2期11卷 197-205页

作者： Zhi Duan Hui Zheng San Xu Yiqun Jiang Haidan Liu Ming Li Duosha Hu Wei Li Ann M. Bode Zigang Dong ya cao Laboratory of Tumor Molecular Biology Cancer Research Institute Central South University Changsha China Key Laboratory of Carcinogenesis andCancer Invasion Ministry of Education Changsha China Key Laboratory of Carcinogenesis Ministry of Health Changsha China Center of Clinical Gene rDiagnosis and Theralav Department of Cardiothoracic Surgery The Second Xian~:ya Hospital Central South University Changsha China Department ofimmunology Xiangya Medical College Central South University Changsha China The Hormel Institute University of Minnesota Austin MN USACorrespondence: Dr Y Cao Laboratory of Tumor Molecular Biology Cancer Research Institute Central South University Changsha 410078 China.

Immunoglobulins （Igs） are known to be synthesized and secreted only by B lymphocytes. Class switch recombination （CSR） is a key event that enables B cells to express Igs, and one of the crucial steps for CSR initiation is the germline transcription of Iggenes. Surprisingly, recent studies have demonstrated that the Iggenes are also expressed in some epithelial cancer cells; however, the mechanisms underlying how cancer cells initiate CSR and express Igs are still unknown. In this study, we confirmed that the Ig la I promoter in cancer cell lines was activated by the Ets- 1 transcription factor, and the activity of the Ig la I promoter and ig lal-C^l germiine transcription were attenuated after knockdown of Ets-1 by specific small interfering RNAs （siRNA）. Furthermore, the expression of Ets-1 and Iga heavy chain in cancer cells was dose dependently upregulated by TGF-I^I. These results indicate that activation of the Ig lal promoter by the transcriotion factor Ets-1 is a critical Dathwav and orovides a novel mechanism for le exoression in non-B cell cancers.

关键词： epithelial cancer cells Ets-1 Ig I^1 promoter

L-Arg Mediated cellular and humoral immune function by TLR9 in DCs during the Early and Latter Stages of Plasmodium yoelii 17XL Infection in DBA/2 Mice

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L-Arg Mediated cellular and humoral immune function by TLR9 ...