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德行与德性:思政工作贯穿创业教育全过程的两个维度

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黑龙江高教研究 2018年第10期36卷 146-150页

作者：朱亚宾朱庆峰王耀彬南京信息工程大学江苏南京210044

基于道德哲学视域,以道德行为和道德品质为基本维度来解构创业教育,突出创业教育的道德主体内涵、道德能动性内涵、利益相关性内涵和道德责任内涵等;彰显创业教育的诚实守信、遵纪守法以及团结合作等品质。在当前创业教育道德缺失问题... 详细信息

基于道德哲学视域,以道德行为和道德品质为基本维度来解构创业教育,突出创业教育的道德主体内涵、道德能动性内涵、利益相关性内涵和道德责任内涵等;彰显创业教育的诚实守信、遵纪守法以及团结合作等品质。在当前创业教育道德缺失问题导向下,建构思政工作贯穿全过程的创业教育内涵发展路径,包括坚定社会主义核心价值观德性体系的价值引导、注重培养大学生创业的道德主体能动性、完善创业教育与创业实践道德情境和建立高校创业教育的道德评价机制。

关键词：思政工作创业教育道德行为道德品质

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo bin feng Min Liu Fan Zheng Shuang Huang yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo ya-Qing feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Effect of mold electromagnetic stirring on solidification structure and solute segregation in continuous casting bloom

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Journal of Iron and Steel Research International 2022年第1期29卷 124-131页

作者： Dong-bin Jiang Li-feng Zhang ya-dong Wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China State Key Lab of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina

The effect of mold electromagnetic stirring(M-EMS)on the solidification structure and solute segregation in the continuous casting bloom of U78CrV steel is *** solute distribution in the macroscale is analyzed using a carbon–sulfur analyzer and that in the microscale is measured with an electron probe *** Image-J software is applied to analyze the number density and area ratio of segregation *** results show that the segregation spots are mainly located in the columnar to equiaxed transition zone and the equiaxed zone,which are enriched with C,Cr,and Mn *** the M-EMS applied,the columnar grain inclines to the upstream *** the current intensity increases,the deflecting angle of columnar grain rises,especially with the current intensity larger than 300 ***,the center segregation shows a declining trend and the area fraction of the equiaxed zone rises ***,it is found that the area ratio and number density of segregation spots increase with the higher current intensity of M-EMS.

关键词： Solidification structure Macrosegregation Mesosegregation Segregation spot Mold electromagnetic stirring

我国职业教育产教融合政策话语聚焦与变迁研究

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黑龙江高教研究 2025年第1期43卷 155-160页

作者：宋亚峰汪萌天津大学天津300350

全面深化产教融合是新时代推动职业教育高质量发展的关键所在。为厘清我国职业教育产教融合政策话语聚焦与变迁之图景,以2000一2022年教育部及教育部职业教育与成人教育司《工作要点》为研究对象,采用文本分析法构建了我国职业教育“产... 详细信息

全面深化产教融合是新时代推动职业教育高质量发展的关键所在。为厘清我国职业教育产教融合政策话语聚焦与变迁之图景,以2000一2022年教育部及教育部职业教育与成人教育司《工作要点》为研究对象,采用文本分析法构建了我国职业教育“产教融合”政策关注的五大维度二十二要素分析框架。研究发现,2000一2022年间我国职业教育产教融合政策主要聚焦培养模式创新、办学体制改革、办学条件建设、教育教学改革、相关制度建设等五大核心议题。基于各要素频次统计分析所得出的结果,结合产教融合相关政策可知,这一时期我国产教融合政策变迁从原先教育端的“单向奔赴”,到产教系统的“双向对接”,再到当前的政行企校协同、产教深度融合。未来我国职业教育产教融合政策仍需进一步提升科学性、实效性与系统性,推进政策真正落地生根。

关键词：职业教育产教融合政策话语文本分析

Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment

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World Journal of Clinical Cases 2022年第31期10卷 11299-11312页

作者： ya-ya Qin Song feng Xiao-Dong Zhang bin Peng Department of Neurology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Basic Medicine North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Ribonucleotide reductase(RR)is a key enzyme in tumor proliferation,especially its *** there are multiple therapeutics for tumors,they all have certain *** their advantages,traditional Chinese medicine(TCM)monomers have become an important source of anti-tumor ***,screening and analysis of TCM monomers with RRM2 inhibition can provide a reference for further anti-tumor drug *** To screen and analyze potential anti-tumor TCM monomers with a good binding capacity to *** The Gene Expression Profiling Interactive Analysis database was used to analyze the level of RRM2 gene expression in normal and tumor tissues as well as RRM2's effect on the overall survival rate of tumor *** monomers that potentially act on RRM2 were screened via literature *** AutoDock software,the screened monomers were docked with the RRM2 *** The expression of RRM2 mRNA in multiple tumor tissues was significantly higher than that in normal tissues,and it was negatively correlated with the overall survival rate of patients with the majority of tumor *** literature mining,we discovered that berberine,ursolic acid,gambogic acid,cinobufagin,quercetin,daphnetin,and osalmide have inhibitory effects on *** results of molecular docking identified that the above TCM monomers have a strong binding capacity with RRM2 protein,which mainly interacted through hydrogen bonds and hydrophobic *** main binding sites were Arg330,Tyr323,Ser263,and *** RRM2 is an important tumor therapeutic *** TCM monomers screened have a good binding capacity with the RRM2 protein.

关键词： Tumor Ribonucleotide reductase M2 inhibitor Traditional Chinese medicine Monomer Molecular docking Literature mining

A Novel Self-adaptive Circuit Design Technique Based on Evolvable Hardware

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International Journal of Automation and computing 2020年第5期17卷 744-751页

作者： Jun-bin Zhang Jin-yan Cai ya-feng Meng Tian-Zhen Meng Department of Electronic and Optical Engineering Mechanical Engineering CollegeShijiazhuang 050003China

Since traditional fault tolerance methods of electronic systems are based on redundant fault tolerance technique,and their structures are fixed when circuits are designed,the self-adaptive ability is *** order to solve these problems,a novel circuit self-adaptive design technique based on evolvable hardware(EHW)is *** features robustness,self-organization and *** can be adapted to a complex environment through dynamic configuration of the *** this paper,the proposed technique *** consumption of hardware resources and the number of convergence iterations *** effectiveness and superiority of the proposed technique are *** designed circuit has the ability of resistible redundant-state interference(RRSI).The proposed technique has a broad application prospect,and it has great significance.

关键词： Circuit design self-adaptive design redundant fault tolerance technique evolvable hardware(EHW) evolutionary algorithms(EA)

Facile and One-step Direct Synthesis of Poly(valine)as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

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Chinese Journal of Polymer Science 2022年第9期40卷 1016-1027页

作者： ya-bin Meng Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China

Synthetic poly(amino acid)s with good biodegradable and biocompatible properties have attracted increased attention as carriers in biomedical applications in recent years,their synthesis and purification procedures are usually complicated and some by-products would occur *** this,polypeptide with good biodegradable and biocompatible properties is prepared and optimized by one-step and direct synthesis strategy and poly(valine)(PVal)is selected here as a model polypeptide in this *** newly generated PVal can self-assemble into poly(valine)nanoparticles(PVal-NPs)with a high drug-loading capacity(>20 wt%)of doxorubicin(DOX)and shows strong cytotoxicity against 4T1 *** cellular internalization,the release of DOX could be accelerated by the endosomal acidic environment which leads to enhanced anticancer *** results in vivo show that DOX@PVal-NPs have a long blood circulation time,high cancer accumulation and penetration,and good therapeutic performance in 4T1 tumor-bearing mice without causing obvious adverse effect on main *** these combined advantages,these PVal-based nanoplatform would provide an effective drug delivery tool for clinical breast cancer therapy.

关键词： Poly(amino acid) Nanoparticle Drug carrier Doxorubicin Breast cancer

Modeling and Experimental Validation of the Electron Beam Selective Melting Process

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Engineering 2017年第5期3卷 701-707页

作者： Wentao yan ya Qian Weixin Ma bin Zhou Yongxing Shen feng Lin Department of Mechanical Engineering Tsinghua University Beijing 100084 China Department of Mechanical Engineering Northwestern University Evanston IL 60201 USA State Key Lab of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China

Electron beam selective melting （EBSM） is a promising additive manufacturing （AM） technology. The EBSM process consists of three major procedures：（1） spreading a powder layer, （2） preheating to slightly sinter the powder, and （3） selectively melting the powder bed. The highly transient multi-physics phenomena involved in these procedures pose a significant challenge for in situ experimental observation and measurement. To advance the understanding of the physical mechanisms in each procedure, we leverage high- fidelity modeling and post-process experiments. The models resemble the actual fabrication procedures, including （1） a powder-spreading model using the discrete element method （DEM）, （2） a phase field （PF） model of powder sintering （solid-state sintering）, and （3） a powder-melting （liquid-state sintering） model using the finite volume method （FVM）. Comprehensive insights into all the major procedures are provided, which have rarely been reported. Preliminary simulation results （including powder particle packing within the powder bed, sintering neck formation between particles, and single-track defects） agree qualitatively with experiments, demonstrating the ability to understand the mechanisms and to guide the design and optimization of the experimental setup and manufacturing process.

关键词： Modeling Electron beam Additive manufacturing Powder scale