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World Journal of Pediatrics 2024年第4期20卷 404-412页

作者： Xin‑Nan Zong Hui Li ya‑qin zhang Department of Growth and Development Capital Institute of PediatricsBeijing 100020China

Background A more comprehensive assessment of growth and nutrition in children is required in China due to rapid socioeconomic *** aimed to investigate height and body mass index(BMI)trajectories from 1975 to 2015 and the prevalence of stunting and obesity in 2016 among children in Chinese *** A total of 904,263 children from birth to 6.9 years were collected from a series of nationally representative surveys in *** and BMI trajectories and prevalence of stunting,underweight,overweight and obesity were *** The average height level of Chinese urban children under 7 years presented a positive secular trend from 1975 to 2015;however,a slowing tendency occurred in 2005‒*** apparent increase was observed at the 5th,50th and 95th percentiles of BMI in urban children aged 3 years and older,with a more prominent increase at the 95th *** total prevalence of stunting and underweight under 7 years was 1.4%and 2.0%,*** total prevalence of overweight and obesity under 7 years was 12.6%and 4.3%,respectively,with 12.7%and 4.9%for boys,12.6%and 3.6%for girls,12.1%and 4.0%in urban areas and 13.1%and 4.5%in suburban rural *** The average height level of Chinese urban children has reached World Health Organization child growth standards since 2005 and presented a slowing tendency in secular trend in 2005‒*** attention and efforts and public health interventions should be urgently made to combat overweight and obesity among preschool children.

关键词： Body mass index Children Height Obesity Stunting

Comparison of updated birth weight,length and head circumference charts by gestational age in China with the INTERGROWTH-21 st NCSS charts:a population-based study

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World Journal of Pediatrics 2023年第1期19卷 96-105页

作者： ya-qin zhang Hui Li Xin-Nan Zong Hua-Hong Wu Department of Growth and Development Capital Institute of PediatricsNo.2Ya Bao RoadChaoyang DistrictBeijingChina

Background INTERGROWTH-21 st Newborn Cross-Sectional Study(NCSS)charts were established and recommended for global ***,whether one international reference is appropriate for all populations is still *** aim to compare the updated Chinese birth size charts by gestational age with INTERGROWTH-21st NCSS *** A cross-sectional survey was carried out,and the birth weight,length and head circumference of 24,375 infants born after uncomplicated pregnancies at gestational age ranging from 24+0 to 42+6 weeks were measured in 13 cities in China from 2015 to *** charts were *** measurements of all these infants were evaluated by the methods of calculating their Z scores using the INTERGROWTH-21 st *** prevalence of small for gestational age(SGA)and large for gestational age(LGA)based on birth weight was analyzed using Chinese charts and INTERGROWTH-21st *** The mean Z scores were 0.10 for birth weight,0.35 for length and-0.02 for head *** to the INTERGROWTH-21st charts,the Chinese birth weight percentile curves were higher except for the 90th percentile at 29-37 weeks gestational age,and the length percentile curves were higher after 33 weeks gestational age,while the 10th percentile of the head circumference was lower and the other percentiles were *** prevalence of SGA was 10.1%[95%confidence interval(CI)=9.7%-10.5%]using the Chinese birth weight chart and 6.5%(95%CI=6.2%-6.8%)using the INTERGROWTH-21 st birth weight *** prevalence of LGA was 9.9%(95%CI=9.5%-10.2%)and 8.2%(95%CI=7.9%-8.6%)using the Chinese and INTERGROWTH-21st birth weight charts,*** Chinese birth size charts based on infants born after uncomplicated pregnancies were different from the INTER-GROWTH-21st *** in the classification of newborns by the two charts should receive attention,and whether the application of INTERGROWTH-21st in Chinese newborns will lead to miscl

关键词： Birth length Birth weight Growth charts Head circumference Newborns

Numerical study on the blocking effect of skin on Flash-Ball Impact and damage assessment

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Defence Technology（防务技术） 2024年第3期33卷 532-545页

作者： Dihua Ouyang Chunwei qin Xiaowen qin Qiantao zhang Xingyu Liu Xi'an University of Architecture and Technology Xi'an 710055China Analysis and Testing Center Xi'an University of Architecture and TechnologyXi'an 710055China Engineering University of PAP Xi'an 710086China

To explore the response law of non-lethal large-size kinetic energy projectiles to blunt attack on skin tissue,and to evaluate the skin injury characteristics of the attacked personnel and the use safety of kinetic energy *** on the LS-DYNA simulation software,a three-layer skin simulation model and a Flash-Ball rubber bullet model are established,and the force-time and deformation-time biomechanical corridors of the Flash-Ball rubber bullet impacting human skin tissue are *** corridor curve and the energy transfer and diffusion are analyzed and *** safety evaluation of the damage caused by the rubber bullet shooting a human body at different distances is carried out using the empirical formula of the penetration ***,the safe shooting distance is *** results show that the model used in the simulation has a good correlation with the experimental data,its biomechanical corridor characteristics are different from those of conventional vehicle impact and smallsize projectile response *** energy transfer and action time of medium and low-speed impact may cause greater *** fat layer is the largest energy absorption *** minimum safe shooting distance to ensure skin tissue from penetrating damage is 15.8 m,and the limit specific kinetic energy of skin damage is 7.88 J/cm^(2).This study can be extended to the study of biomechanical response law and safety evaluation under the impact of the same type of large kinetic energy projectile,which provides an important theoretical reference for the police to use large kinetic energy projectiles to conduct safe shooting in peacekeeping operations.

关键词： KIPs Blunt strike Biomechanical response Damage analysis

SHARP POINTWISE-IN-TIME ERROR ESTIMATE OF L1 SCHEME FOR NONLINEAR SUBDIFFUSION EQUATIONS

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Journal of Computational Mathematics 2024年第3期42卷 662-678页

作者： Dongfang Li Hongyu qin Jiwei zhang School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China School of Mathematics and Statistics Wuhan UniversityWuhan 430072China

An essential feature of the subdiffusion equations with theα-order time fractional derivative is the weak singularity at the initial *** weak regularity of the solution is usually characterized by a regularity parameterσ∈(0,1)∪(1,2).Under this general regularity assumption,we present a rigorous analysis for the truncation errors and develop a new tool to obtain the stability results,i.e.,a refined discrete fractional-type Grönwall inequality(DFGI).After that,we obtain the pointwise-in-time error estimate of the widely used L1 scheme for nonlinear subdiffusion *** present results fill the gap on some interesting convergence results of L1 scheme onσ∈(0,α)∪(α,1)∪(1,2].Numerical experiments are provided to demonstrate the effectiveness of our theoretical analysis.

关键词： Sharp pointwise-in-time error estimate Ll scheme Nonlinear subdiffusion equations Non-smooth solutions

Changes of feeding patterns in Chinese city children under 2 years from 1985 to 2015: results from a series of national cross-sectional surveys

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World Journal of Pediatrics 2019年第2期15卷 176-181页

作者： Hua-Hong Wu ya-qin zhang Xin-Nan Zong Hui Li Department of Growth and Development Capital Institute of PediatricsYaBao RoadChaoYang DistrictBeijing 100020China

Background In China,as the social transformation and economic development from 1985 to 2015,children's feeding pattern has undergone some *** we aimed to analyze the secular trend on feeding patterns of city children in *** All data were from a series of national survey which implemented once every 10 years in China from 1985 to *** use same indexes to evaluate the feeding pattern of children in these four *** From 1985 to 2005,the exclusive breastfeeding rates in infants under 6 months of age decreased,especially in suburban areas decreased by 17.7%;the continuous breastfeeding rate of 1-year-old children in suburban area decreased from 60.1 to 27.6%.However,from 2005 to 2015,the exclusive breastfeeding rates under 6 months of age increased by 16.0% in urban areas and 5.9% in suburban areas;the continuous breastfeeding rate of 1-year-old children in urban increased from 17.0 to 36.0%.The overall feeding rate of complementary food in infants under 6 months of age declined from 1985 to 2015;the average age at introduction of all complementary foods was around 6 months of age in *** There is an obvious trend on feeding pattern of Chinese *** 1985 to 2005,the breastfeeding rate decreased,the duration time of breastfeeding was shortened and the age at introduction of complementary food was *** 2005 to 2015,the breastfeeding rate increased,the duration time of breastfeeding was prolonged,and the age at introduction of complementary food was postponed.

关键词： Breastfeeding Complementary feeding Infant and young children Secular change

METTL5 promotes gastric cancer progression via sphingomyelin metabolism

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： ya-Qiong zhang Jian Li Zhe qin De-Ming Li Fang-Zhou Ye Song-Hua Bei Xiao-Hong zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of GC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of GC via sphin

关键词： Gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

Automatic detection of small bowel lesions with different bleeding risks based on deep learning models

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World Journal of Gastroenterology 2024年第2期30卷 170-183页

作者： Rui-ya zhang Peng-Peng Qiang Ling-Jun Cai Tao Li yan qin Yu zhang Yi-qing Zhao Jun-Ping Wang Department of Gastroenterology The Fifth Clinical Medical College of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina School of Computer and Information Technology Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina School of Life Sciences and Technology Mudanjiang Normal UniversityMudanjiang 157011Heilongjiang ProvinceChina

BACKGROUND Deep learning provides an efficient automatic image recognition method for small bowel(SB)capsule endoscopy(CE)that can assist physicians in ***,the existing deep learning models present some unresolved *** To propose a novel and effective classification and detection model to automatically identify various SB lesions and their bleeding risks,and label the lesions accurately so as to enhance the diagnostic efficiency of physicians and the ability to identify high-risk bleeding *** The proposed model represents a two-stage method that combined image classification with object ***,we utilized the improved ResNet-50 classification model to classify endoscopic images into SB lesion images,normal SB mucosa images,and invalid ***,the improved YOLO-V5 detection model was utilized to detect the type of lesion and its risk of bleeding,and the location of the lesion was *** constructed training and testing sets and compared model-assisted reading with physician *** The accuracy of the model constructed in this study reached 98.96%,which was higher than the accuracy of other systems using only a single *** sensitivity,specificity,and accuracy of the model-assisted reading detection of all images were 99.17%,99.92%,and 99.86%,which were significantly higher than those of the endoscopists’*** image processing time of the model was 48 ms/image,and the image processing time of the physicians was 0.40±0.24 s/image(P<0.001).CONCLUSION The deep learning model of image classification combined with object detection exhibits a satisfactory diagnostic effect on a variety of SB lesions and their bleeding risks in CE images,which enhances the diagnostic efficiency of physicians and improves the ability of physicians to identify high-risk bleeding groups.

关键词： Artificial intelligence Deep learning Capsule endoscopy Image classification Object detection Bleeding risk

Cobalt(Ⅲ)hydride HAT mediated enantioselective intramolecular hydroamination access to chiral pyrrolidines

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Science China Chemistry 2024年第6期67卷 2002-2008页

作者： Qi Meng Tao qin Huanran Miao Ge zhang Qian zhang Jilin Province Key Laboratory of Organic Functional Molecular Design&Synthesis Department of ChemistryNortheast Normal UniversityChangchun130024China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China

Enantioenriched pyrrolidines and derivatives are ubiquitous substructures in compounds of importance to medicinal and biological ***,we report an efficient cobalt-catalyzed intramolecular asymmetric hydroamination reaction that produces chiral pyrrolidines with good to excellent yield and *** with previously reported radicalinvolved methodologies for enantioenriched pyrrolidines,these conditions feature two elegant versatilities,enabling(1)the use of cobalt-catalyzed hydrogen atom transfer(HAT)to generate organocobalt intermediates that bring radical reaction to organometallic chemistry,and(2)enantioselective intramolecular C-N bond forging through an S_(N)2-like displacement involving dynamic kinetic resolution(DKR).This approach provides a new alternative and efficient methodology for enantioselective radical-involved C-N bond construction that can be used in the synthesis of both chiral pyrrolidines and homologous nitrogen heterocycles.

关键词： asymmetric catalysis radical hydroamination cobalt catalysis hydrogen atom transfer

Heterogeneous MXene-based films with graded electrical conductivity towards highly efficient EMI shielding and electrothermal heating

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Nano Research 2024年第8期17卷 7264-7274页

作者： Yu zhang Guangcheng zhang Zhonglei Ma Jianbin qin Xi Shen Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Research Institute for Sports Science and Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

The increasing need for electromagnetic interference(EMI)shielding of electronics in cold environments such as those in aircraft,space exploration,and wearable heaters to avoid hazardous icing conditions or hypothermia requires the development of thin and lightweight EMI shielding materials preferably by absorbing rather than reflecting electromagnetic(EM)waves while also generating heat through energy-efficient electrothermal ***,it is challenging to achieve absorption-dominant EMI shielding and energy-efficient electrothermal heating simultaneously in a thin and lightweight ***,we develop a heterogeneous composite film comprising a porous multi-walled carbon nanotubes(MWCNTs)/bacterial cellulose(BC)film and an aligned MXene/Ag nanowires(NWs)backing via a sequential vacuum filtration *** porous film contains random conductive networks of MWCNTs with moderate conductivity while the aligned MXene sheets atop Ag NWs network affords high conductivity in the backing,giving rise to graded electrical conductivity for absorption-dominant EMI *** increasing Ag NW coverage leads to significantly increased electrical conductivity without increasing the EM wave reflection as well as the density and thickness of the film,yielding excellent specific EMI shielding effectiveness(>8500 dB/(g·cm^(2))),low driving voltage for energy-efficient electrothermal heating(163℃at 2.5 V),and fast response time(60 s)at a low areal density of 0.015 mg/cm^(2).Combining EMI shielding and electrothermal heating,the heterogeneous film developed here are promising contenders for the protection of electronic equipment in low-temperature environment.

关键词： heterogenous composite film MXene electromagnetic interference(EMI)shielding thermal management

Kinetic model of vibration screening for granular materials based on biological neural network

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Particuology 2024年第5期88卷 98-106页

作者： Zhan Zhao yan zhang Fang qin Mingzhi Jin School of Agricultural Engineering Jiangsu UniversityZhenjiang212013China Shandong Academy of Agricultural Machinery Sciences Ji'nan250100China

The kinetic model is the theoretical basis for optimizing the structure and operation performance of vibration screening *** this paper,a biological neurodynamic equation and neural connections were established according to the motion and interaction properties of the material under vibration *** material feeding to the screen and the material passing through apertures were considered as excitatory and inhibitory inputs,respectively,and the generated stable neural activity landscape was used to describe the material distribution on the 2D screen *** dynamic process of material vibration screening was simulated using discrete element method(DEM).By comparing the similarity between the material distribution established using biological neural network(BNN)and that obtained using DEM simulation,the optimum coefficients of BNN model under a certain screening parameter were determined,that is,one relationship between the BNN model coefficients and the screening operation parameters was *** screening parameters were randomly selected,and the corresponding relationships were established as a ***,with straw/grain ratio,aperture diameter,inclination angle,vibration strength in normal and tangential directions as inputs,five independent adaptive neuro-fuzzy inference systems(ANFIS)were established to predict the optimum BNN model coefficients,*** training results indicated that ANFIS models had good stability and *** flexibility and adaptability of the proposed BNN method was demonstrated by modeling material distribution under complex feeding conditions such as multiple regions and non-uniform rate.

关键词： Kinetic model Material distribution Vibration screening Biological neural network DEM simulation Adaptive neuro-fuzzy inference systems