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Journal of dermatologic science and cosmetic technology 2024年第1期1卷 13-20页

作者： Silu Zhang Shan Lu yun wang Jiayi Ni Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering Co.Ltd.Shenzhen 518116China Department of Dermatology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Sprim(China)Consulting Co.Ltd. Shanghai 201201China

Background:Oxidative stress is a significant factor in skin aging and pigmentation,which can be precipitated by various *** and tyrosinase inhibitors,such as carotenoids,yeast extract(glutathione),sodium hyaluronate,astaxanthin,and niacin,can individually protect the skin against aging through distinct *** mechanisms potentially enhance the skin barrier and improve signs of aging and ***,the synergistic effects of these compounds,as found in a golden tomato extract formulation,have been scarcely ***:To evaluate the effects of an orally administered formulation on the skin aging and *** and Methods:In this study,a randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLAB?Tomato Niacinamide *** of all participants,62 volunteers completed the experiment and were included in the statistical ***:The results indicated that after eight weeks of consuming the research product,there were no significant changes in the skin indicators within the placebo *** contrast,the treatment group receiving the sample formulation exhibited a 35.63%increase in stratum corneum hydration and a 29.39%reduction in transepidermal water loss(TEWL),suggesting enhanced skin *** assessments revealed improvements in skin color and gloss index by 15.03%and 11.41%,respectively,in the treatment ***,the skin gloss and individual typology angle(ITA)value increased by 18.59%and 6.36%,respectively,leading to a lighter skin *** enhancements were also observed in skin pigmentation,color uniformity,and *** eight weeks of intervention with the sample,blood levels of superoxide dismutase(SOD)and glutathione peroxidase(GPx)increased,while malondialdehyde(MDA)levels ***:These findings confirm that continuous intake of the tomato extract formulation over eight weeks effectively improved the volunteers'skin w

关键词： Skin whitening Skin aging Antioxidant Gold tomato extracts Combination effect

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Thermal management by manipulating electromagnetic parameters

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Chinese Physics B 2024年第5期33卷 21-27页

作者：王云梁迪飞韩天成邓龙江 National Engineering Research Center of Electromagnetic Radiation Control Materials University of Electronic Science and Technology of ChinaChengdu 611731China Key Laboratory of Multi-spectral Absorbing Materials and Structures of Ministry of Education University of Electronic Science and Technology of ChinaChengdu 611731China

Electromagnetic absorbing materials may convert electromagnetic energy into heat energy and dissipate ***,in a high-power electromagnetic radiation environment,the temperature of the absorbing material rises significantly and even *** becomes critical to ensure electromagnetic absorption performance while minimizing temperature ***,we systematically study the coupling mechanism between the electromagnetic field and the temperature field when the absorbing material is irradiated by electromagnetic *** find out the influence of the constitutive parameters of the absorbing materials(including uniform and non-uniform)on the temperature ***,through a smart design,we achieve better absorption and lower temperature *** accuracy of the model is affirmed as simulation results aligned with theoretical *** work provides a new avenue to control the temperature distribution of absorbing materials.

关键词： multi-physics field electromagnetic-thermal coupling microwave absorption high power application

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The potential role of Gegen Qinlian decoction in the treatment of coronavirus disease 2019 based on network pharmacology and validation of lipopolysaccharide-induced macrophages

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Integrative Medicine Discovery 2024年第24期8卷 1-8页

作者： Lei wang Ling-yun wang Li Zhong Jian-Feng Shi Xiao-Ming Yao Wan-Wei Yang Department of Clinical Laboratory Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese medicineJiangsu Province Academy of Traditional Chinese MedicineNanjing 210028China

Background:Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2,which has led to deaths and currently lacks an efficient *** studies suggesting the potential of the Gegen Qinlian decoction(GQD)in preventing COVID-19,comprehensive analyses of its anti-COVID-19 potential are still ***:GQD treatment was evaluated for its efficacy in ameliorating the early stage(24 hours)of lipopolysaccharide(LPS)-induced cytokine storm in ***,target genes of GQD were co-analyzed with COVID-19 signature genes to identify key ingredients and their *** was also conducted using an LPS-induced macrophage ***:GQD treatment effectively ameliorated the early stage of LPS-induced cytokine storm in *** ingredients such as quercetin were found to be involved in multiple pathways,including inflammation,immunity,oxidative stress,cell proliferation,and apoptosis,through the AGE-RAGE signaling pathway and IL-17 signaling *** the LPS-induced macrophage model,quercetin inhibited macrophage polarization(M1)and the secretion of inflammatory factors(IL-6,TNF-α,IL-17A).Conclusions:Our results indicate that GQD can be utilized in the treatment of cytokine storm induced by COVID-19 and has the potential to treat COVID-19 by suppressing the COVID-19 signature genes and macrophage polarization.

关键词： Gegen Qinlian decoction coronavirus disease 2019 network pharmacology macrophage polarization

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Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women

Journal of dermatologic science and cosmetic technology

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Journal of dermatologic science and cosmetic technology 2024年第2期1卷 26-37页

作者： Shan Lu Silu Zhang yun wang Jiayi Ni Tiantian Zhao Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering CoLtd.Shenzhen 518116China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural affairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhouGuangdong 510610China Department of Dermatology Shanghai Ninth People‘s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Sprim(China)Consulting Co.Ltd. Shanghai 201201China e Department of Food Science Rutgers UniversityNew BrunswickNJ 08901United States

Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging *** positive results in animal models,the combination effects of CP and EP and the bioavailability of CP in human studies,particularly in young and middle-aged women,remain ***:To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged *** and Methods:A single-center,randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLABR fish collagen tripeptide *** consumed the drink over an 8-week ***:Compared to the placebo group,the collagen drink group showed significant improvements in skin hydration(39.19%increase),transepidermal water loss(33.45%decrease),skin elasticity(25.37%increase),dermal collagen content(21.64%increase),pore size(7.94%decrease),wrinkle length(18.09%decrease),skin smoothness(2.85%improvement),and skin roughness(15.32%decrease).Overall pore volume decreased by 60%,and visual assessments indicated a decrease in skin luminosity by 15.20%and smoothness index by 22.55%.Mass spectrometry demonstrated a significant increase in collagen efficacy components,including blood pH and GPH levels(P<0.05).Conclusion:The study confirmed the combination nourishing and anti-skin aging effects of EP and CP on the skin of young and middle-aged women,demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides.

关键词： Collagen tripeptides Elastin peptides Anti-aging Skin protection Peptide absorption

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在历史的主动选择中塑造中华民族共同体——《中华民族共同体概论》的共同体叙事逻辑

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民族教育研究 2024年第2期35卷 9-12页

作者：王云芳中央民族大学马克思主义学院北京100081

《中华民族共同体概论》以中华民族共同体形成、发展、巩固的历史进程为根基,以铸牢中华民族共同体意识为主线,围绕中华民族共同体发展中的若干问题链条,用有形有感有效的大量鲜活历史史料让学生认识到,在历史的主动选择过程中,狭隘的... 详细信息

《中华民族共同体概论》以中华民族共同体形成、发展、巩固的历史进程为根基,以铸牢中华民族共同体意识为主线,围绕中华民族共同体发展中的若干问题链条,用有形有感有效的大量鲜活历史史料让学生认识到,在历史的主动选择过程中,狭隘的民族观一步步被抵制和消解,最终从统治者到民众产生了更为集中、统一的中华民族共同体观念。这种历史主动选择的共同体叙事逻辑不仅科学揭示了中华民族形成和发展的道理、学理和哲理,夯实了中华民族共同体理念,而且大力宣介了中华民族共同体意识,强化了正确的中华民族历史观。

关键词：中华民族共同体《中华民族共同体概论》共同体叙事逻辑中华民族历史观

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基于共生体系的成长式儿童课桌椅创新设计研究

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家具与室内装饰 2024年第8期31卷 10-16页

作者：王昀陈枫中国美术学院工业设计学院浙江杭州310009 中国美术学院文创中心浙江杭州310009

研究旨在设计一款基于共生体系的可成长式人体工学课桌椅,通过构建该模型验证设计的可行性和创新性。研究采用了一系列系统化的设计方法和理论分析工具。首先,运用KJ法对用户需求进行详细归类和分析,以确保设计过程中充分考虑到用户的... 详细信息

研究旨在设计一款基于共生体系的可成长式人体工学课桌椅,通过构建该模型验证设计的可行性和创新性。研究采用了一系列系统化的设计方法和理论分析工具。首先,运用KJ法对用户需求进行详细归类和分析,以确保设计过程中充分考虑到用户的多元化需求。随后,采用FAHP和QFD集成模型深入构建用户需求与设计要求之间的相关性关系。FAHP方法用于确定不同用户需求的权重,从而辨识出核心需求。QFD方法则转化这些需求为设计要求,确保设计解决方案的目标一致性和重点聚焦。面对设计过程中出现的技术矛盾和挑战,本研究进一步应用TRIZ理论提出了创新性解决策略,有效解决了设计中的关键技术难题。基于共生体系构建的成长式人体工学课桌椅不仅满足了用户对于舒适性、可调节性和美观性的需求,而且在环境适应性、可持续性和创新性方面展现出显著优势。通过整合KJ法、FAHP/QFD集成模型和TRIZ理论,本研究提出了一种全新的设计思路和方法论,不仅为可成长式家具的设计提供了有效的指导,也为未来家具设计创新提供了有益的参考。

关键词：可持续家具设计可成长式模糊层次分析法质量功能展开共生体系

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高阶矩风险与市场收益:来自中国期权市场的证据

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管理科学学报 2024年第5期27卷 122-140页

作者：周倜王云奇南方科技大学商学院金融系深圳518055 深圳证券交易所博士后工作站深圳518038

基于上证50ETF期权隐含的方差和高阶矩的期限结构,本研究使用偏最小二乘回归的降维方法构造了与中国股票市场收益相关的方差-高阶矩风险因子.实证结果显示,在2015年到2020年的样本期内,该风险因子显著地预测未来1个月以及2周至8周的市... 详细信息

基于上证50ETF期权隐含的方差和高阶矩的期限结构,本研究使用偏最小二乘回归的降维方法构造了与中国股票市场收益相关的方差-高阶矩风险因子.实证结果显示,在2015年到2020年的样本期内,该风险因子显著地预测未来1个月以及2周至8周的市场收益,月度样本内和样本外R^(2)分别达到了10.08%和6.55%.在控制了常见的经济预测变量和期权变量后,该因子的预测能力仍然保持显著.这表明我国股市收益中包含了对偏度和峰度风险的补偿,与含时变高阶矩的资产定价模型相一致.在经济价值方面,方差-高阶矩因子的预测能力可为投资者在市场择时交易中带来可观的收益.结果表明,中国期权市场提供了高阶矩风险的独特信息,这为理解我国股市风险与收益的权衡关系提供了新的角度.

关键词：上证50ETF期权风险中性高阶矩股票收益率可预测性偏最小二乘回归时变高阶矩CAPM

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基于特征增强和历史帧选择的Transformer视觉跟踪算法

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控制与决策 2024年第10期39卷 3506-3512页

作者：侯志强杨晓麟马素刚王云龙余旺盛王昀琛西安邮电大学计算机学院西安710121 西安邮电大学陕西省网络数据分析与智能处理重点实验室西安710121 空军工程大学信息与导航学院西安710100

为进一步提升跟踪算法在历史帧信息利用和目标特征表达方面的性能,提出基于特征增强和历史帧选择的Transformer视觉跟踪算法(feature enhancement and history frame selection based Transformer visual tracking, FEHST).首先,在骨干网络中引入动态预测模块,通过稀疏化策略提高自注意力机制的计算效率,聚焦目标区域特征;其次,提出特征增强模块,将局部信息与全局信息的优势相结合,提升特征的表达能力;最后,采用自适应历史帧选择策略,提升跟踪器对目标动态信息的关注.在LaSOT、TrackingNet、GOT-10K和OTB100等数据集上进行了大量的实验,实验结果显示,在LaSOT、TrackingNet、OTB100上分别取得70.1%、83.0%和71.6%的成功率,在GOT-10K上取得71.4%的平均重叠度,并能以27 FPS的速度运行.

关键词：计算机视觉视觉跟踪深度学习注意力机制历史帧选择 Transformer

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Clinical features and treatment outcomes of major depressive disorder with genital symptoms

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Chinese Medical Journal 2024年第5期137卷 622-624页

作者： Xiaohui Wu yuncheng Zhu Ping Sun Shuo wang Zhiguo Wu Jia Huang Lan Cao yun wang Yousong Su Zhijian Yao Zuowei wang Fan wang Yong wang Daihui Peng Jun Chen Yiru Fang Department of Clinical Research Center&Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai 200083China Department of Psychiatry Nanjing Medical University Affiliated Brain HospitalNanjingJiangsu 210029China Department of Psychiatry&Affective Disorders Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 200118China

To the Editor:Major depressive disorder(MDD)is a mood disorder characterized by complex patterns of emotional,cognitive,and behavioral symptomology and deficits in daily *** symptoms,including a reduction in libido and menstrual disturbances,have been considered to be a classic symptom of MDD for many *** evidence has reached a broad consensus that the incidence of genital symptoms is higher in patients with MDD than in the general population.A systematic review and meta-analysis found a bidirectional association between MDD and genital symptoms,with patients with MDD showing a 50–70%increased risk of developing genital symptoms,while individuals with genital symptoms had a 130–210%increased risk of developing MDD.^([1])As previously reported,50–70%of people with MDD experience sexual dysfunction.^([2])To date,few studies have focused on the comparison of clinical features between patients with MDD with and without genital symptoms,and the longitudinal prognosis.

关键词： symptoms Clinical features

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配体调控Cp_(2)TiCl_(2)催化合成单、双取代苯并咪唑衍生物的研究

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分子催化（中英文） 2024年第1期38卷 51-62,I0003页

作者：王芸芸陆旭李晓月王涛宁夏师范学院化学化工学院宁夏回族自治区绿色催化材料与技术重点实验室宁夏固原756000

以邻苯二胺和芳香醛为反应起始物,在50℃,乙醇为溶剂,0.02 mmol L-苯丙氨酸为催化剂条件下,催化合成产物为单取代苯并咪唑类化合物,产率可达到70%;而在50℃,以乙醇为溶剂,0.04 mmol L-苯丙氨酸为Brønsted acid配体,0.02 mmol Cp_(2)TiCl... 详细信息

以邻苯二胺和芳香醛为反应起始物,在50℃,乙醇为溶剂,0.02 mmol L-苯丙氨酸为催化剂条件下,催化合成产物为单取代苯并咪唑类化合物,产率可达到70%;而在50℃,以乙醇为溶剂,0.04 mmol L-苯丙氨酸为Brønsted acid配体,0.02 mmol Cp_(2)TiCl_(2)为Lewis acid的条件下,则催化生成1,2-二取代苯并咪唑类化合物,产率可达到97%.底物普适性较好,且后处理简单.同时利用NMR分析对机理进行了初步的研究.

关键词：二氯二茂钛配体调控苯并咪唑类化合物

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