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Oncology Research 2024年第6期32卷 1109-1118页

作者： ZHIGANG XIA MENGYAO TIAN YUCAI CHENG wenFANG YI ZEFAN DU TIANwen LI yuchen wen LINDI LI YONG LIU CHUN CHEN Pediatric Hematology Laboratory Division of Hematology/OncologyDepartment of PediatricsThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Background:Chimeric antigen receptor T(CAR-T)cell therapy has achieved marked therapeutic success in ameliorating hematological ***,there is an extant void in the clinical guidelines concerning the most effective chemotherapy regimen prior to chimeric antigen receptor T(CAR-T)cell therapy,as well as the optimal timing for CAR-T cell infusion *** and Methods:We employed cell-derived tumor xenograft(CDX)murine models to delineate the optimal pre-conditioning chemotherapy regimen and timing for CAR-T cell ***,transcriptome sequencing was implemented to identify the therapeutic targets and elucidate the underlying mechanisms governing the treatment ***:Our preclinical in vivo evaluation determined that a combination of cyclophosphamide and fludarabine,followed by the infusion of CD19 CAR-T cells five days subsequent to the chemotherapy,exerts the most efficacious therapeutic effect in B-cell hematological ***,RNA-seq data indicated that the therapeutic efficacy predominantly perturbs tumor cell metabolism,primarily through the inhibition of key mitochondrial targets,such as C-Jun Kinase enzyme(C-JUN).Conclusion:In summary,the present study offers critical clinical guidance and serves as an authoritative reference for the deployment of CD19 CAR-T cell therapy in the treatment of B-cell hematological malignancies.

关键词： CD19 CAR-T B-cell hematologic malignancies Metabolism In vivo

基于YOLO v8n-seg-FCA-BiFPN的奶牛身体分割方法

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农业机械学报 2024年第3期55卷 282-289,391页

作者：张姝瑾许兴时邓洪兴温毓晨宋怀波西北农林科技大学机械与电子工程学院陕西杨凌712100 农业农村部农业物联网重点实验室陕西杨凌712100

奶牛身体部位的精准分割广泛应用于奶牛体况评分、姿态检测、行为分析及体尺测量等领域。受奶牛表面污渍和遮挡等因素的影响,现有奶牛部位精准分割方法实用性较差。本研究在YOLO v8n-seg模型的基础上,加入多尺度融合模块与双向跨尺度加... 详细信息

奶牛身体部位的精准分割广泛应用于奶牛体况评分、姿态检测、行为分析及体尺测量等领域。受奶牛表面污渍和遮挡等因素的影响,现有奶牛部位精准分割方法实用性较差。本研究在YOLO v8n-seg模型的基础上,加入多尺度融合模块与双向跨尺度加权特征金字塔结构,提出了YOLO v8n-seg-FCA-BiFPN奶牛身体部位分割模型。其中,多尺度融合模块使模型更好地提取小目标几何特征信息,双向跨尺度加权特征金字塔结构实现了更高层次的特征融合。首先在奶牛运动通道处采集奶牛侧面图像作为数据集,为保证数据集质量,采用结构相似性算法剔除相似图像,共得到1 452幅图像。然后对目标奶牛的前肢、后肢、乳房、尾部、腹部、头部、颈部和躯干8个部位进行标注并输入模型训练。测试结果表明,模型精确率为96.6%,召回率为94.6%,平均精度均值为97.1%,参数量为3.3×10^(6),检测速度为6.2 f/s。各部位精确率在90.3%~98.2%之间,平均精度均值为96.3%。与原始YOLO v8n-seg相比,YOLO v8n-seg-FCA-BiFPN的精确率提高3.2个百分点,召回率提高2.6个百分点,平均精度均值提高3.1个百分点,改进后的模型在参数量基本保持不变的情况下具有更强的鲁棒性。遮挡情况下该模型检测结果表明,精确率为93.8%,召回率为91.67%,平均精度均值为93.15%。结果表明,YOLO v8n-seg-FCA-BiFPN网络可以准确、快速地实现奶牛身体部位精准分割。

关键词：奶牛身体部位分割语义分割 FCABasicBlock BiFPN YOLO v8n

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乌拉特刺绣的技艺特点及创新应用

染整技术 2024年第7期46卷 122-124页

作者：温宇辰河套学院艺术系内蒙古巴彦淖尔015000

乌拉特刺绣是蒙古族民间手工艺之一,集手工、绘画、刺染等工艺为一体,近年来备受社会各界关注。对此,有必要了解乌拉特刺绣的历史沿革、技艺特点和文化内涵,深入剖析当前乌拉特刺绣技艺在传承和创新中面临的问题,如此方能厘清乌拉特刺... 详细信息

乌拉特刺绣是蒙古族民间手工艺之一,集手工、绘画、刺染等工艺为一体,近年来备受社会各界关注。对此,有必要了解乌拉特刺绣的历史沿革、技艺特点和文化内涵,深入剖析当前乌拉特刺绣技艺在传承和创新中面临的问题,如此方能厘清乌拉特刺绣的创新应用路径,推动该技艺的发展。

关键词：乌拉特刺绣技艺特点创新应用

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纳米流体提高采收率机理研究现状

特种油气藏 2024年第3期31卷 1-10页

作者：郝龙侯吉瑞梁拓闻宇晨屈鸣中国石油大学(北京) 北京102249 西安石油大学陕西西安213164 东北石油大学三亚海洋油气研究院海南三亚572024

与传统的表面活性剂和聚合物溶液相比,纳米流体驱油是一项新的提高采收率技术,但目前机理研究成果较为分散,缺少系统性。因此,结合国内外纳米流体研究情况,总结纳米流体主要提高采收率机理,指出了纳米流体目前所面临的研究难点,展望了... 详细信息

与传统的表面活性剂和聚合物溶液相比,纳米流体驱油是一项新的提高采收率技术,但目前机理研究成果较为分散,缺少系统性。因此,结合国内外纳米流体研究情况,总结纳米流体主要提高采收率机理,指出了纳米流体目前所面临的研究难点,展望了纳米材料在今后的攻关方向。研究表明:纳米流体提高采收率机理包括降低油水界面张力,在油水固三相区形成楔形膜,产生结构分离压力,改善流度比扩大波及体积,改变岩石润湿性,增强泡沫稳定性,降低注入压力和选择性调堵孔道;今后可从提高纳米流体稳定性、降低纳米流体成本、提高采收率机理协同性研究以及开发高效纳米驱油体系等方面进行深入探索。该研究为大规模推广纳米流体在提高采收率方面的应用提供了理论基础和实验依据。

关键词：纳米流体提高采收率界面张力结构分离压力润湿性

基于视频分析的规模化奶牛智能监测技术研究进展

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华南农业大学学报 2024年第5期45卷 649-660页

作者：宋怀波王云飞邓洪兴许兴时温毓晨张姝瑾农业农村部农业物联网重点实验室/西北农林科技大学机械与电子工程学院陕西杨凌712100

奶牛智能监测是规模化奶牛养殖的重要环节,视频分析技术具备无接触、低成本及智能分析优势,已成为当前规模化奶牛智能监测技术研究的热点。奶牛目标检测、目标跟踪以及个体和行为识别技术对规模化奶牛监管具有重要意义,复杂养殖环境中... 详细信息

奶牛智能监测是规模化奶牛养殖的重要环节,视频分析技术具备无接触、低成本及智能分析优势,已成为当前规模化奶牛智能监测技术研究的热点。奶牛目标检测、目标跟踪以及个体和行为识别技术对规模化奶牛监管具有重要意义,复杂养殖环境中的光照、昼夜交替变化、围栏遮挡以及牛群数量繁多导致的相互遮挡是影响规模化奶牛智能监测的重要因素。本文对基于视频分析的奶牛智能监测技术研究中常用的深度模型及应用情况进行综述,提出了当前研究中面临的问题与挑战。分析发现,注意力机制、混合卷积等技术是提高模型识别准确率的有效方法,轻量化模块有利于减少模型的复杂度与计算量;计算复杂度、普适性、准确性等是影响该技术推广应用的因素;具体应用时,需要针对奶牛养殖环境、奶牛状况等进行具体分析以不断满足规模化养殖的需求。

关键词：奶牛智能监测技术目标检测深度学习机器视觉畜牧养殖

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负电性高效聚合物降解剂研究及矿场先导试验

特种油气藏 2024年第3期31卷 167-174页

作者：闻宇晨侯吉瑞娄泽洋潘以诺屈鸣中国石油大学(北京)提高采收率研究院北京102249 中国石油青海油田分公司青海海西816400 东北石油大学三亚海洋油气研究院海南三亚572024

针对聚合物驱过程中长期注聚合物导致的聚合物堵塞问题,研发了一种负电性高效聚合物降解剂。采用电子显微镜、Zeta电位仪和多重光散射仪等仪器,研究了降解剂的微观形貌特征、体系稳定性、降解性能和降黏性能,评价了降解剂在多孔介质中... 详细信息

针对聚合物驱过程中长期注聚合物导致的聚合物堵塞问题,研发了一种负电性高效聚合物降解剂。采用电子显微镜、Zeta电位仪和多重光散射仪等仪器,研究了降解剂的微观形貌特征、体系稳定性、降解性能和降黏性能,评价了降解剂在多孔介质中的动态降解效果。结果表明:降解剂的最佳用量为质量分数为1.0%,该用量下聚合物降黏率和降解率均能达到95%以上,对聚合物及聚合物胶团的降解能力强,解堵效果明显。该降解剂腐蚀性弱,对井筒和管道损害小。在锦州9-3油田W4-4井开展了注聚合物井解堵矿场试验,验证了负电性高效聚合物降解剂的矿场解堵效果。该聚合物降解剂能够为聚合物驱高效开发提供技术支持。

关键词：聚合物驱聚合物降解剂堵塞降黏率降解率提高采收率

Imbibition mechanisms of high temperature resistant microemulsion system in ultra-low permeability and tight reservoirs

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Petroleum Exploration and Development 2022年第6期49卷 1398-1410页

作者： XIAO Lixiao HOU Jirui wen yuchen QU Ming WANG Weiju WU Weipeng LIANG Tuo Unconventional Petroleum Science and Technology Research Institute China University of Petroleum(Beijing)Beijing 102249China Key Laboratory of Petroleum Engineering Education MinistryChina University of Petroleum(Beijing)Beijing 102249China

Lower-phase microemulsions with core-shell structure were prepared by microemulsion dilution *** high temperature resistant systems were screened and the performance evaluation experiments were conducted to clarify the spontaneous imbibition mechanisms in ultra-low permeability and tight oil reservoirs,and to direct the field microfracture huff and puff test of oil *** microemulsion system(O-ME)with cationic-nonionic surfactant as hydrophilic shell,No.3 white oil as oil phase core has the highest imbibition recovery;its spontaneous imbibition mechanisms include:the ultra-low interfacial tension and wettability reversal significantly reduce oil adhesion work to improve oil displacement efficiency,the nanoscale“core-shell structure”formed can easily enter micro-nano pores and throats to expand the swept volume,in addition,the remarkable effect of dispersing and solubilizing crude oil can improve the mobility of crude *** on the experimental results,a microfracture huff and puff test of O-ME was carried out in Well YBD43-X506 of Shengli *** being treated,the well had a significant increase of daily fluid production to 5 tons from 1.4 tons,and an increase of daily oil production to 2.7 tons from 1.0 ton before treatment.

关键词： ultra-low permeability reservoir tight oil microemulsion imbibition mechanism oil displacement efficiency EOR

Low-Enthalpy and High-Entropy Polymer Electrolytes for Li-Metal Battery

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Energy & Environmental Materials 2024年第1期7卷 95-103页

作者： Haitao Zhang yuchen Wang Junfeng Huang wen Li Xiankan Zeng Aili Jia Hongzhi Peng Xiong Zhang Weiqing Yang Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Institute of Electrical Engineering Chinese Academy of Sciences

Ionic-conductive solid-state polymer electrolytes are promising for the development of advanced lithium batteries yet a deeper understanding of their underlying ion-transfer mechanism is needed to improve *** we demonstrate the low-enthalpy and high-entropy(LEHE) electrolytes can intrinsically generate remarkably free ions and high mobility,enabling them to efficiently drive lithium-ion storage.

关键词： charge concentration gradient lithium dendrites lithium-metal battery low-enthalpy and high-entropy polymer electrolyte

Wetting front migration model of ion-adsorption rare earth during the multi-hole unsaturated liquid injection

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 483-496页

作者： Yu Wang Xiaojun Wang yuchen Qiu Hao Wang Gang Li Kaijian Hu wen Zhong Zhongqun Guo Bing Li Chunlei Zhang Guangxiang Ye Jiangxi Key Laboratory of Mining Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Resources and Environment Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Civil Engineering and Surveying&Mapping Engineering Jiangxi University of Science and TechnologyGanzhou341000China Ganzhou Nonferrous Metallurgy Research Institute Ganzhou341000China

In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still ***,wetting front migration distance and leaching time are usually required to optimize the leaching *** this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head *** the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were *** the postintersection stage,the intersection accelerated the wetting front *** using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the ***,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was *** analysis results showed that the proposed model can accurately simulate the infiltration process under experimental *** research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.

关键词： Ion-adsorption rare earth ore Multi-hole unsaturated liquid injection In situ leaching Intersection effect Calculation model

Transcriptomic and epigenomic landscapes of muscle growth during the postnatal period of broilers

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Journal of Animal Science and Biotechnology 2024年第05期 1851-1865页

作者： Shuang Gu Qiang Huang yuchen Jie Congjiao Sun Chaoliang wen Ning Yang State Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding China Agricultural University National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics Breeding and Reproduction Ministry of Agriculture and Rural Affairs Department of Animal Genetics and Breeding College of Animal Science and Technology China Agricultural University Sanya Institute of China Agricultural University

Background Broilers stand out as one of the fastest-growing livestock globally, making a substantial contribution to animal meat production. However, the molecular and epigenetic mechanisms underlying the rapid growth and development of broiler chickens are still unclear. This study aims to explore muscle development patterns and regulatory networks during the postnatal rapid growth phase of fast-growing broilers. We measured the growth performance of Cornish(CC) and White Plymouth Rock(RR) over a 42-d period. Pectoral muscle samples from both CC and RR were randomly collected at day 21 after hatching(D21) and D42 for RNA-seq and ATAC-seq library *** The consistent increase in body weight and pectoral muscle weight across both breeds was observed as they matured, with CC outpacing RR in terms of weight at each stage of development. Differential expression analysis identified 398 and 1,129 genes in the two dimensions of breeds and ages, respectively. A total of 75,149 ATAC-seq peaks were annotated in promoter, exon, intron and intergenic regions, with a higher number of peaks in the promoter and intronic regions. The age-biased genes and breed-biased genes of RNA-seq were combined with the ATAC-seq data for subsequent analysis. The results spotlighted the upregulation of ACTC1 and FDPS at D21, which were primarily associated with muscle structure development by gene cluster enrichment. Additionally, a noteworthy upregulation of MUSTN1, FOS and TGFB3 was spotted in broiler chickens at D42, which were involved in cell differentiation and muscle regeneration after injury, suggesting a regulatory role of muscle growth and *** This work provided a regulatory network of postnatal broiler chickens and revealed ACTC1 and MUSTN1 as the key responsible for muscle development and regeneration. Our findings highlight that rapid growth in broiler chickens triggers ongoing muscle damage and subsequent regeneration. These findings provide a foundatio

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