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Differences of Hydrocarbon Enrichment between the Upper and the Lower Structural Layers in the Tazhong Paleouplift

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Acta Geologica Sinica(English Edition) 2010年第5期84卷 1116-1127页

作者： jiang Zhenxue YANG Haijun LI Zhuo PANG Xiongqi HAN Jianfa LI Dongxu HUANG yuyan State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum （Beijing） Beijing 102249 China Basin and Reservoir Research Center China University of Petroleum Beijing 102249 China Tarim Oilfield Company CNPC Korla Xinjiang 841000 China

The Tazhong paleouplift is divided into the upper and the lower structural layers, bounded by the unconformity surface at the top of the Ordovician carbonate rock. The reservoirs in the two layers from different parts vary in number, type and reserves, but the mechanism was rarely researched before. Therefore, an explanation of the mechanism will promote petroleum exploration in Tazhong paleouplift. After studying the evolution and reservoir distribution of the Tazhong paleouplift, it is concluded that the evolution in late Caledonian, late Hercynian and Himalayan periods resulted in the upper and the lower structural layers. It is also defined that in the upper structural layer, structural and stratigraphic overlap reservoirs are developed at the top and the upper part of the paleouplift, which are dominated by oil reservoirs, while for the lower structural layer, lithological reservoirs are developed in the lower part of the paleouplift, which are dominated by gas reservoirs, and more reserves are discovered in the lower structural layer than the upper. Through a comparative analysis of accumulation conditions of the upper and the lower structural layers, the mechanism of enrichment differences is clearly explained. The reservoir and seal conditions of the lower structural layer are better than those of the upper layer, which is the reason why more reservoirs have been found in the former. The differences in the carrier system types, trap types and charging periods between the upper and the lower structural layers lead to differences in the reservoir types and distribution. An accumulation model is established for the Tazhong paleouplift. For the upper structural layer, the structural reservoirs and the stratigraphic overlap reservoirs are formed at the upper part of the paleouplift, while for the lower structural layer, the weathering crust reservoirs are formed at the top, the reef-flat reservoirs are formed on the lateral margin, the karst and inside reservoirs

关键词： the upper and the lower structural layers enrichment difference accumulation model,Tazhong paleouplift

超声引导下肩胛下肌联合胸大肌A型肉毒毒素注射改善偏瘫后肩痛

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温州医科大学学报 2024年第5期54卷 363-370页

作者：潘录录朱含章高立轩林苏进程志清蒋玉燕潘蓉蓉支英豪浙江中医药大学附属温州市中医院康复科3 浙江温州325000

目的:探讨超声引导下肩胛下肌联合胸大肌A型肉毒毒素(BoNT-A)注射对偏瘫后肩痛的影响。方法:选取2023年2月至2024年1月在温州市中医院康复科住院确诊为脑梗死和脑出血的患者为研究对象,采用随机对照原则,将符合纳入标准的36例患者随机... 详细信息

目的:探讨超声引导下肩胛下肌联合胸大肌A型肉毒毒素(BoNT-A)注射对偏瘫后肩痛的影响。方法:选取2023年2月至2024年1月在温州市中医院康复科住院确诊为脑梗死和脑出血的患者为研究对象,采用随机对照原则,将符合纳入标准的36例患者随机分成干预组和对照组,每组18例。干预组在超声引导下向肩胛下肌和胸大肌分别注射100 U(2 mL)的BoNT-A,共200 U(4 mL),对照组则使用等量的0.9%氯化钠溶液。观察治疗后2周、1个月、3个月和6个月偏瘫侧肩部的VAS、无痛被动关节活动范围(pROM)、肌张力(MAS)、上肢功能评分(FMA-UE)和日常生活活动能力评分(MBI)的变化,以及治疗后相关不良反应发生情况。结果:36例患者均顺利完成治疗。两组患者的基线值差异无统计学意义(P>0.05),干预组的VAS和MAS在治疗后2周开始低于对照组(P0.05)。结论:超声引导下肩胛下肌联合胸大肌BoNT-A注射可缓解偏瘫患者的肩痛,减少痉挛,改善肩关节活动度。

关键词：偏瘫后肩痛超声引导 A型肉毒毒素肩胛下肌胸大肌

Challenges and research opportunities for lung cancer screening in China

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Cancer Communications 2018年第1期38卷 366-370页

作者： Zixing Wang yuyan Wang Yao Huang Fang Xue Wei Han Yaoda Hu Lei Wang Wei Song Jingmei jiang Department of Epidemiology&Biostatistics Institute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005P.R.China Radiology Department Cancer HospitalChinese Academy of Medical SciencesBeijing 100021P.R.China Radiology Department Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730P.R.China

Following publication of the results of the National Lung Screening Trial in the United States,a randomized controlled trial in Italy(ITALUNG)and two simulation studies in China reported similar findings in 2017 favoring lung cancer screening with low-dose computed tomography among *** such advances in lung cancer screening,worldwide interest has gradually shifted from evaluating whether refining lung cancer screening protocols is effective in preventing ***,there are several practical problems to be resolved,including the balance of enroll-ment criteria and cost effectiveness,precise measurements to reduce false positive findings,risk-based optimization of screening frequency,challenges associated with cancer heterogeneity,strategies to combine image screening with novel biomarkers,dynamic monitoring of the natural history of cancer,accurate identification and diagnosis of cases among huge populations,and the impact of tobacco control policy and environment *** one in three individuals with lung cancer worldwide resides in China,these questions pose great challenges as well as research opportunities for population screening programs in China.

关键词： Lung cancer Low-dose CT Screening

Chlorine-substituted chiral 2D perovskite microwires with enhanced lattice rigidity for sensitive circularly polarized light detection

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Science China Chemistry 2023年第12期66卷 3602-3610页

作者： Meng Yuan Yuchen Qiu Yingjie Zhao yuyan Zhao Hui Li Xiao Wei Gaosong Chen jiangang Feng Hanfei Gao Jinjin Zhao Jiahui Zhao Lei jiang Yuchen Wu Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China College of Chemistry Zhengzhou UniversityZhengzhou 450001China College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Special Functional Materials of Ministry of Education National and Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologyCollaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117585Singapore Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China Ji Hua Laboratory Foshan 528000China Department of Physics Shanxi Datong UniversityDatong 037009China

Chiral two-dimensional(2D) perovskites offer numerous attractive features for optoelectronics owing to their soft, deformable lattices and a high degree of chemical tunability. While tremendous advances have been made in perovskite-based direct circularly polarized light(CPL) detection, the low circular polarization anisotropy factor and sensitivity of those photodetectors arising from large lattice distortion still limit practical applications. Herein, chiral 2D perovskite-based single-crystalline microwire arrays with enhanced circular dichroism(CD) absorption are fabricated with the synergy of the capillary-bridgeconfined assembly method and chlorine-substituted phenethylamine(Cl-MBA). Compared with phenethylamine(MBA)-inserted perovskites, the smaller lattice distortion and increased halogen–halogen interaction within Cl–MBA-inserted perovskites strengthen lattice rigidity and weaken electron–phonon coupling to improve carrier transport and thermal stability, resulting in high-performance CPL photodetectors with an anisotropy factor of 0.25, responsivity exceeding 95.7±9.3 A W^(-1)and detectivity exceeding(3.05±0.30)×10^(13)Jones. This work opens a new perspective to modulate circular polarization sensitivity and will be helpful to realize promising implementations in quantum computation and communication.

关键词： chiral perovskites microwire arrays lattice rigidity circular polarization photodetectors

Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators

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Acta Pharmaceutica Sinica B 2020年第2期10卷 313-326页

作者： jianglin Wang Xueyan jiang Lixin Zhao Shengjia Zuo Xiantong Chen Lingmin Zhang Zhongxiao Lin Xiaoya Zhao yuyan Qin Xinke Zhou Xi-Yong Yu Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China

Overexpression of exogenous lineage-determining factors succeeds in directly reprogramming fibroblasts to various cell *** studies have reported reprogramming of fibroblasts into induced cardiac progenitor cells(iCPCs).CRISPR/Cas9-mediated gene activation is a potential approach for cellular reprogramming due to its high precision and multiplexing *** we show lineage reprogramming to iCPCs through a dead Cas9(dCas9)-based transcription activation *** and robust activation of endogenous cardiac factors,including GATA4,HAND2,MEF2 C and TBX5(G,H,M and T;GHMT),can reprogram human fibroblasts toward *** iCPCs show potentials to differentiate into cardiomyocytes,smooth muscle cells and endothelial cells in *** of MEIS1 to GHMT induces cell cycle arrest in G2/M and facilitates cardiac *** reprogramming of human fibroblasts into iCPCs provides a promising cellular resource for disease modeling,drug discovery and individualized cardiac cell therapy.

关键词： Lineage reprogramming Human foreskin fibroblasts Induced cardiac progenitor cells CRISPR/Cas9 SAM Cardiac transcription factors

Realizing methanol synthesis from CO and water via the synergistic effect of Cu^(0)/Cu^(+)over Cu/ZrO_(2) catalyst

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Journal of Energy Chemistry 2024年第6期93卷 126-134,I0004页

作者： Yuan Fang Fan Wang Yang Chen Qian Lv Kun jiang Hua Yang Huibo Zhao Peng Wang yuyan Gan Lizhi Wu Yu Tang Xinhua Gao Li Tan Institute of Molecular Catalysis and In Situ/Operando Studies Fujian Key Laboratory of Electrochemical Energy Storage MaterialsState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108FujianChina Leibniz-Institut für Katalyse e.V.an der Universität Rostock Albert-Einstein Strasse 9118059 RostockGermany Department of Chemistry Tsinghua UniversityBeijing 100084China State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021Ningxi1China

The optimizing utilization of ca rbon resources has drawn wide attention all over the world,while exploiting the high-efficiency catalytic routes remains a ***,a direct methanol synthesis route is realized from pure CO and H_(2)O over 10%Cu/t-ZrO_(2) catalyst,where the time yield of methanol is144.43 mmol mol_(Cu)^(-1)h^(-1)and the methanol selectivity in hydrocarbons is 100%,The Cu species highly dispersed in the t-ZrO_(2) support lead parts of them in the cationic *** Cu^(+)sites contribute to the dissociation of H_(2)O,providing the H*source for methanol synthesis,while the formed Cu^(0) sites promote the absorption and transfer of H*during the ***,the H_(2)O is even a better H resource than H_(2) due to its better dissociation effectivity in this catalytic *** present work offers a new approach for methanol synthesis from CO and new insight into the process of supplying H donor.

关键词： H_(2)O CO Methanol Cu-based catalysts t-ZrO_(2)

Modification on the Performance of the Hemihydrate Gypsum with the Plant Source Polymer of Dry Matcha Powder

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Journal of Wuhan University of Technology(Materials Science) 2018年第6期33卷 1452-1458页

作者： LI Haoxin WANG Yanwei Key Laboratory of Advanced Civil Engineering Materials Ministry of Education Tongji University China Railway No.9 Engineering Testing Co. Ltd

The objective of this study was to assess the feasibility of using the plant-source polymer of the matcha powder as a composite admixture for hemihydrate gypsum. Hemihydrate gypsum was mixed with different contents of matcha powder, and then the water requirement for the normal consistency, setting times, density, strength, hydration and microstructure of the hardened mixture were evaluated. The experimental results showed that it increased the water requirement for the normal consistency, and it regulated the setting times and reduced the density. Hemihydrate gypsum with more matcha powder had the higher water requirement, longer setting times and lower density. Less than 1% matcha powder had slight impact on the strength of hardened paste, but more than 1% matcha powder had a remarkable one. Matcha powder changed the hydration process and prolonged the induction and acceleration period. Small needlelike crystals were transformed into longer, larger and thicker ones as more matcha powder was mixed. This case is closely related to the prolongation of the induction and acceleration period. Besides, more and larger pores were observed in the hardened paste with more matcha powder. It is attributed to the appearances of the tea polyphenol in matcha powder and the larger and longer crystal morphology in hardened paste as well as the high water requirement for the normal consistency. These results are important to the application of matcha powder as a composite admixture for the hemihydrate gypsum as well as the prosperity and development of the tea industry.

关键词： matcha powder hemihydrate gypsum strength hydration property microstructure

Reliability Assessment of Nuclear Power Plant Digital Instrumentation and Control System I: Challenges and Research Status of Reliability Assessment Methodology

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Reliability Assessment of Nuclear Power Plant Digital Instru...

Low-depth whole genome sequencing reveals copy number variations associated with higher pathologic grading and more aggressive subtypes of lung non-mucinous adenocarcinoma

第26届中国控制与决策会议

作者： Zhou Shiliang jiang Ruitao Liu yuyan School of Nuclear Science and Engineering North China Electric Power University School of Control and Computer Engineering North China Electric Power University

ISBN: (纸本)9781479937097

Considering characteristics of nuclear power plant digital instrumentation and control system, challenges of reliability assessment of digital instrumentation and control system are pointed out. As for its dynamic behavior and multi-states failure mode, limitation of traditional methods, research status and applicability of dynamic flowgraph methodology and other advance dynamic reliability assessment approach were introduced and compered. It’s concluded that Dynamic flowgraph methodology maybe the dominant one in future after simplify its model procedure and reduction computational cost of its deductive analysis.

关键词： Nuclear power plant Digital instrumentation and control system Dynamic reliability Research status

来源： cnki会议 cnki会议评论

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Chinese Journal of Cancer Research 2020年第3期32卷 334-346页

作者： Zheng Wang Lin Zhang Lei He Di Cui Chenglong Liu Liangyu Yin Min Zhang Lei jiang yuyan Gong Wang Wu Bi Liu Xiaoyu Li David S Cram Dongge Liu Departm ent of Pathology Beijing HospitalNational Center of GerontologyBeijing 100730China Departm ent of Radiology Beijing HospitalNational Center of GerontologyBeijing 100730China Berry Genomics Corporation Beijing 102206China

Objective:Histology grade,subtypes and TNM stage of lung adenocarcinomas are useful predictors of prognosis and *** aim of the study was to investigate the relationship between chromosomal instability,morphological subtypes and the grading system used in lung non-mucinous adenocarcinoma(LNMA).Methods:We developed a whole genome copy number variation(WGCNV)scoring system and applied next generation sequencing to evaluate CNVs present in 91 LNMA tumor ***:Higher histological grades,aggressive subtypes and more advanced TNM staging were associated with an increased WGCNV score,particularly in CNV regions enriched for tumor suppressor genes and *** addition,we demonstrate that 24-chromosome CNV profiling can be performed reliably from specific cell types(<100 cells)isolated by sample laser capture ***:Our findings suggest that the WGCNV scoring system we developed may have potential value as an adjunct test for predicting the prognosis of patients diagnosed with LNMA.

关键词： Lung adenocarcinoma lung non-mucinous adenocarcinoma(LNMA) histological grading TNM staging copy number variations(CNVs) whole genome copy number variation(WGCNV)score