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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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制造业工匠型人才创新绩效的形成过程与验证——基于自组织目标理论的扎根研究

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华东经济管理 2025年第1期39卷 41-51页

作者：李群王雨欣常州大学商学院江苏常州213159

文章结合自组织目标理论,以制造业工匠型人才为研究对象,通过扎根理论挖掘和分析工匠型人才创新绩效的形成过程。结果表明,工匠型人才的创新绩效产生于心理目标系统建构和实现的循环过程,由“心理目标触发—心理目标建构—行动过程—行... 详细信息

文章结合自组织目标理论,以制造业工匠型人才为研究对象,通过扎根理论挖掘和分析工匠型人才创新绩效的形成过程。结果表明,工匠型人才的创新绩效产生于心理目标系统建构和实现的循环过程,由“心理目标触发—心理目标建构—行动过程—行动结果”构成,心流状态贯穿其中;工匠型人才的创新绩效体现在国家、组织和个体三个层面上,三个层面互为基础、不可分割;创新绩效经由结果反馈再一次作用于心理目标触发,产生新的心理目标,从而进入下一轮循环。在此基础上,通过词频分析进一步验证结论。

关键词：自组织目标理论工匠型人才心流创新绩效扎根理论

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少数民族特色饮食与心血管疾病的关系:基于西南区域少数民族聚集地世居自然人群队列研究

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中国全科医学 2025年第6期28卷 688-696页

作者：王媛肖斐张宇馨周恩慧钟建琴胡宇欣洪峰贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵州省贵阳市561113

背景心血管疾病(CVD)是引起死亡及致残的主要慢病之一,是我国重要的公共卫生问题,目前鲜见少数民族特色饮食对CVD影响的研究。目的分析贵州省少数民族CVD的流行现状,探讨民族特色饮食与CVD患病风险的关系。方法本研究数据来源于“西南... 详细信息

背景心血管疾病(CVD)是引起死亡及致残的主要慢病之一,是我国重要的公共卫生问题,目前鲜见少数民族特色饮食对CVD影响的研究。目的分析贵州省少数民族CVD的流行现状,探讨民族特色饮食与CVD患病风险的关系。方法本研究数据来源于“西南区域少数民族聚集地世居自然人群队列研究”流行病学调查数据库,2018年7月—2019年8月,采用多阶段分层抽样,对贵州省黔东南苗族侗族自治州和黔南布依族苗族自治州的18790名30~79岁世居三代的侗族、苗族、布依族居民进行基线调查,最终共有17085人纳入分析,根据调查对象是否患有CVD将其分为两组:CVD组(530名)和非CVD组(16555名)。由专业调查员使用该项目组开发的专用电子问卷进行面对面访谈,包括基本情况、生活习惯、疾病史、饮食情况等调查。根据少数民族饮食文化研究可知,要求调查对象回忆过去1年中吃腌制蔬菜、糯米及其制品、腌制鱼/肉类、腊/熏肉、白酸汤、红酸汤、牛/羊瘪菜、紫血肉、鱼腥草、蕨菜、油茶这11种食物的频次(次/月)。采用非条件Logistic回归模型和限制性立方样条分析民族特色饮食与CVD的关系。结果贵州省少数民族CVD总患病率为3.20%(530/17085),各民族CVD患病率为侗族3.14%(207/6599)、苗族3.13%(158/5043)、布依族3.03%(165/5443),男性患病率(3.68%)高于女性(2.80%)。多因素Logistic回归分析结果显示,在总人群中,糯米及其制品1~3次/月(OR=0.720,95%CI=0.553~0.937,P=0.015)是CVD的保护因素。在侗族人群中,蕨菜≤1次/月(OR=2.172,95%CI=1.162~4.059,P=0.015)是CVD的危险因素;在苗族人群中,糯米及其制品1次/月(OR=0.442,95%CI=0.202~0.967,P=0.041)是CVD的保护因素;在布依族人群中,牛/羊瘪菜≤1次/月(OR=1.935,95%CI=1.046~3.579,P=0.035)是CVD的危险因素。亚组分析结果显示:在男性人群中,糯米及其制品1~3次/月(OR=0.639,95%CI=0.427~0.957,P=0.030)可降低CVD的患病风险;在1次/月(OR=1.655,95%CI=1.011~2.709,P=0.045)可增加CVD的患病风险;在体质量正常的人群中,糯米及其制品1次/月(OR=7.507,95%CI=1.324~42.556,P=0.023)可增加CVD的患病风险,而油茶>1次/月(OR=0.319,95%CI=0.103~0.990,P=0.048)可降低CVD的患病风险;在不饮酒人群中,糯米及其制品1~3次/月(OR=0.710,95%CI=0.531~0.948,P=0.020)、红酸汤1~3次/月(OR=0.775,95%CI=0.613~0.980,P=0.033)均可降低CVD的患病风险,而腊/熏肉1~3次/月(OR=1.400,95%CI=1.040~1.884,P=0.027)可增加CVD的患病风险。糯米及其制品、腌制鱼/肉类和紫血肉与CVD的患病风险均存在非线性量效关系(P<0.05,P_(非线性)<0.05)。结论贵州省少数民族人群CVD的患病率较低。糯米及其制品、油茶、鱼腥草、紫血肉、红酸汤、牛/羊瘪菜、腊/熏肉的食用频次可能会影响CVD的患病风险。应对少数民族特色饮食的摄入频率知识进行宣传,从饮食方面对贵州省少数民族人群CVD进行防控干预。

关键词：心血管疾病少数民族特色饮食贵州 Logistic模型队列研究

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Statics, vibration, and buckling of sandwich plates with metamaterial cores characterized by negative thermal expansion and negative Poisson's ratio

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Applied Mathematics and Mechanics(English Edition) 2023年第9期44卷 1457-1486页

作者： Qiao ZHANG yuxin SUN National Key Laboratory of Strength and Structural Integrity School of Aeronautic Science and EngineeringBeihang UniversityBeijing 100191China

This paper proposes a three-dimensional(3D)Maltese cross metamaterial with negative Poisson’s ratio(NPR)and negative thermal expansion(NTE)adopted as the core layers in sandwich plates,and aims to explore the relations between the mechanical responses of sandwich composites and the NPR or NTE of the ***,the NPR and NTE of the metamaterial are derived analytically based on energy *** effective elastic modulus and mass density of the 3D metamaterial are obtained and validated by the finite element method(FEM).Subsequently,the general governing equation of the 3D sandwich plate under thermal environments is established based on Hamilton’s principle with the consideration of the von Kármán *** differential quadrature(DQ)FEM(DQFEM)is utilized to obtain the numerical *** is shown that NPR and NTE can enhance the global stiffness of sandwich *** geometric parameters of the Maltese cross metamaterial significantly affect the responses of the thermal stress,natural frequency,and critical buckling load.

关键词： negative Poisson's ratio(NPR) negative thermal expansion(NTE) sand-wich plate vibration buckling

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Simulation of 3D parachute fluid–structure interaction based on nonlinear finite element method and preconditioning finite volume method

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Chinese Journal of Aeronautics 2014年第6期27卷 1373-1383页

作者： Fan yuxin Xia Jian College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics

A fluid–structure interaction method combining a nonlinear finite element algorithm with a preconditioning finite volume method is proposed in this paper to simulate parachute transient dynamics. This method uses a three-dimensional membrane–cable fabric model to represent a parachute system at a highly folded configuration. The large shape change during parachute inflation is computed by the nonlinear Newton–Raphson iteration and the linear system equation is solved by the generalized minimal residual（GMRES） method. A membrane wrinkling algorithm is also utilized to evaluate the special uniaxial tension state of membrane elements on the parachute canopy. In order to avoid large time expenses during structural nonlinear iteration, the implicit Hilber–Hughes–Taylor（HHT） time integration method is employed. For the fluid dynamic simulations, the Roe and HLLC（Harten–Lax–van Leer contact） scheme has been modified and extended to compute flow problems at all speeds. The lower–upper symmetric Gauss–Seidel（LUSGS） approximate factorization is applied to accelerate the numerical convergence speed. Finally,the test model of a highly folded C-9 parachute is simulated at a prescribed speed and the results show similar characteristics compared with experimental results and previous literature.

关键词： Flow fields analysis Fluid–structure interaction Nonlinear structural dynam-ics Numerical analysis Parachute inflation

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A fast algorithm for calculating surface electric field of converter valve shield system by multipole boundary element method

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Science China(Technological Sciences) 2018年第11期61卷 1745-1754页

作者： SHI yuxin WANG ZeZhong Beijing Key Laboratory of High Voltage & EMC North China Electric Power University

The surface electric field analysis of the converter valve shield system is a large-scale electrostatic field problem, which is difficult to analyse. The fast multipole boundary element method(FMBEM), which is suitable for solving large-scale problems,can accelerate the computation speed and conserve memory. However, the coefficient matrix implicitly formed by using the FMBEM is sometimes ill-conditioned, especially for large-scale problems; thus, the convergence of iteration is poor. In this paper, a fast solver is proposed to improve efficiency. First, an adaptive GMRES(m) with variant restart parameter is adjusted for the Galerkin FMBEM. In addition, the sparse approximate inverse preconditioner is improved, and a new sparsity pattern is proposed for the multiscale problem derived from the converter valve shield system. The numerical results show that the accuracy can meet the engineering requirements compared with the finite element method. Compared with other solvers and preconditioners, the algorithm can achieve a satisfactory convergence rate and reduce the computation time. In addition, a single bridge shield system of ±160 kV converter valve is successfully analysed using the proposed method.

关键词： converter valve electrostatic field fast multipole boundary element method (FMBEM) GMRES preconditioner

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High order sub-cell finite volume schemes for solving hyperbolic conservation laws I: basic formulation and one-dimensional analysis

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Science China(Physics,Mechanics & Astronomy) 2017年第8期60卷 60-75页

作者： JianHua Pan yuxin Ren School of Aerospace Engineering Tsinghua University

In this paper, a family of sub-cell finite volume schemes for solving the hyperbolic conservation laws is proposed and analyzed in one-dimensional cases. The basic idea of this method is to subdivide a control volume(main cell) into several sub-cells and the finite volume discretization is applied to each of the sub-cells. The averaged values on the sub-cells of current and face neighboring main cells are used to reconstruct the polynomial distributions of the dependent variables. This method can achieve arbitrarily high order of accuracy using a compact stencil. It is similar to the spectral volume method incorporating with PNPM technique but with fundamental differences. An elaborate utilization of these differences overcomes some shortcomings of the spectral volume method and results in a family of accurate and robust schemes for solving the hyperbolic conservation laws. In this paper, the basic formulation of the proposed method is presented. The Fourier analysis is performed to study the properties of the one-dimensional schemes. A WENO limiter based on the secondary reconstruction is constructed.

关键词： compact high order method sub-cell finite volume method unstructured grid

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Oxygen-penetration-induced large hardness enhancement in nanoscale Nb/Ti multilayers

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Acta Metallurgica Sinica(English Letters) 2012年第2期25卷 141-152页

作者： yuxin ZHAO Wensheng LAI Advanced Material Laboratory Department of Materials Science&EngineeringTsinghua UniversityBeijing 100084China

Nb/Ti multilayers with different modulation periods were prepared by magnetron sputtering deposition. Microstructure and mechanical properties were investigated by XRD, SEM and Nanoindentation. It turns out that hardness of samples increases with decreasing modulation wavelength （A） and then dropped at small A. Through scrutinizing other results in literature, we found that the coherent stress rather than modulus mismatch played more important role for hardness enhancement with de- creasing A of the bcc-hcp multilayers. Annealing of samples in low （or high） vacuum at 400 ~C for 30 min led to large （or medium） enhancement of hardness, while the modulated structure was still maintained. It was found that annealing in low vac- uum resulted in oxygen penetration into the multilayers as revealed by auger electron spectroscopy, but hardly changed metallic sheet resistivity. XRD results suggested that some niobium oxides were formed in Nb layers and oxygen distributed intersti- tially in Ti layers. The large hardness enhancement after annealing is mainly due to the strengthening effect from dispersive distribution of nano-scale niobium oxides and interstitial oxygen in the multilayers. In addition, interfaces between adjacent layers were more distinct after annealing which indicated good thermal stability of laminated structure.

关键词： Nb/Ti multilayer Hardness Microstructure Annealing Nanoindentation

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Generalized Maximum Principles and Stochastic Completeness for Pseudo-Hermitian Manifolds

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Chinese Annals of Mathematics,Series B 2022年第6期43卷 949-976页

作者： yuxin DONG Weike YU School of Mathematical Sciences Fudan UniversityShanghai 200433China Corresponding author.School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China

In this paper,the authors establish a generalized maximum principle for pseudo-Hermitian *** corollaries,Omori-Yau type maximum principles for pseudo-Hermitian manifolds are ***,they prove that the stochastic completeness for the heat semigroup generated by the sub-Laplacian is equivalent to the validity of a weak form of the generalized maximum ***,they give some applications of these generalized maximum principles.

关键词： Pseudo-Hermitian manifold Omori-Yau type maximum principles Stochastic completeness

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A Comparative Study on Heat Transfer Performance of Typical Petrochemical Reactors

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China Petroleum Processing & Petrochemical Technology 2016年第4期18卷 61-70页

作者： Li yuxin refining process department sinopec engineering incorporationBeijing100101

The performance of heat transfer is a key issue for reactor design in petrochemical industry. Since the heat transfer in reactors is a complicated process and depends on multiple parameters, the evaluation of the heat transfer performance is usually challenging, and few previous studies gave an overall view of heat exchange performance of different types of reactors. In this review, heat transfer coefficients of two types of petrochemical reactors, including the packed bed and the fluidized bed, were systematically analyzed and compared based on a number of reported correlations. The relationship between heat transfer coefficients and fluid flow velocity in different reactors has been well established, which clearly demonstrates the varying range of their heat transfer coefficients. Heat transfer coefficients of gas-phase packed bed can exceed 200 W/m^2·K, rather than the suggested values(17—89 W/m^2·K) mentioned in the literature. The fluidized bed shows better performance for both two-phase and three-phase beds as compared to the packed bed. Systems with liquid phase also show better heat transfer performance than other phases because of the larger heat capacity of liquid. Thus the industrial three-phase fluidized beds have the best heat transfer performance with an overall heat transfer coefficient of greater than 1 000 W/m^2·K. The heat transfer results provided by this review can afford not only new insights into the heat transfer in typical reactors, but also the basis and guidelines for reactor design and selection.

关键词： heat transfer packed bed fluidized bed loop reactor transfer coefficient

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