检索结果-南通市图书馆

Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma:New opportunities towards molecularly targeted therapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第3期12卷 1054-1067页

作者： Xu Zhang yuxiang wang Linghua Meng Division of Anti-tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China

Esophageal cancer is one of the most lethal cancers worldwide because of its rapid progression and poor *** squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC)are two major subtypes of esophageal *** predominantly affects African and Asian populations,which is closely related to chronic smoking and alcohol *** typically arises in Barrett’s esophagus with a predilection for Western *** surgical operation and chemoradiotherapy have been applied to combat this deadly cancer,molecularly targeted therapy is still at the early *** the development of large-scale next-generation sequencing,various genomic alterations in ESCC and EAC have been revealed and their potential roles in the initiation and progression of esophageal cancer have been *** therapeutic targets have been identified and novel approaches have been developed to combat esophageal *** this review,we comprehensively analyze the genomic alterations in EAC and ESCC and summarize the potential role of the genetic alterations in the development of esophageal *** in the therapeutics based on the different tissue types and molecular signatures have also been reviewed and discussed.

关键词： Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Next-generation sequencing Genomic alteration Somatic mutation Copy number variation Molecularly targeted therapy

Performance and mechanism of La-Fe metal-organic framework as a highly efficient adsorbent for fluoride removal from mine water

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第5期139卷 245-257页

作者： Chaomin Jia Jianbing wang Huijiao wang Sichao Zhu Xiaohui Zhang yuxiang wang School of Chemical&Environmental Engineering China University of Mining&Technology-BeijingBeijing 100083China Beijing Polytechnic Beijing 100176China Chinese Society for Urban Studies Beijing 100835China

Water fluoride pollution has caused non-negligible harm to the environment and humans,and thus it is crucial to find a suitable treatment *** this study,La-Fe@PTA adsorbent was synthesized for the defluoridation of mine *** results showed that the optimum conditions for defluoridation by La-Fe@PTA were p H close to 7.0,the initial F-concentration of 10 mg/L,the dosage of 0.5 g/L and the adsorption time of 240 *** with SO_4^(2-),Cl^(-),NO_(3)^(-),Ca^(2+)and Mg^(2+),CO_(3)^(2-)and HCO_(3)^(-)presented severer inhibition on fluoride uptake by La-Fe@*** adsorption process fits well with the pseudo-second-order kinetic model and Freundlich model,and the maximum adsorption capacity of Langmuir model was 95 mg/***-bed adsorption results indicated that fluoride in practical fluorinated mine water could be effectively removed from 3.6 mg/L to less than 1.5 mg/L within130 bed volume(BV)by using 1.5 g La-Fe@***,the adsorbent still had good adsorption capacity after regeneration,which confirms the great application potential of La-Fe@PTA as a fluoride ion *** mechanism analysis showed that La-Fe@PTA adsorption of fluorine ions is a physicochemical reaction driven by electrostatic attraction and ion exchange.

关键词： Adsorption La-Fe@PTA Fluoride ion Mine water Mechanism

Lever Arm Compensation of Autonomous Underwater Vehicle for Fast Transfer Alignment

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2019年第4期59卷 105-118页

作者： Qi wang Changsong Yang Shaoen Wu yuxiang wang School of Computer and software Nanjing University of Information Science and TechnologyNanjing210044China Jiangsu Engineering Center of Network Monitoring Nanjing University of Information Science and TechnologyNanjing210044China Department of Computer Science Ball State UniversityMuncie 47306USA

Transfer alignment is used to initialize SINS(Strapdown Inertial Navigation System)in ***-arm effect compensation is studied existing in an AUV(Autonomous Underwater Vehicle)before launched from the mother *** AUV is equipped with SINS,Doppler Velocity Log,depth sensor and other navigation *** lever arm will cause large error on the transfer alignment between master inertial navigation system and slave inertial navigation system,especially in big ship *** paper presents a novel method that can effectively estimate and compensate the flexural lever arm between the main inertial navigation system mounted on the mother ship and the slave inertial navigation system equipped on the *** nonlinear measurement equation of angular rate is derived based on three successive rotations of the body frame of the master inertial navigation *** filter is utilized as the nonlinear estimator for its capability of non-linear *** analysis was conducted on the SINS state vector based on singular value decomposition *** equation of SINS was adopted as the system state *** experiments were conducted and results showed that the proposed method can estimate the flexural lever arm more accurately,the precision of transfer alignment was improved and alignment time was shortened accordingly.

关键词： Transfer alignment SINS lever-arm effect AUV observability analysis

Hybrid Hydrogels Assembled from Phenylalanine Derivatives and Agarose with Enhanced Mechanical Strength

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2016年第5期32卷 872-876页

作者： YU Ye wang yuxiang FENG Chuanliang State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China

A roadblock for supramolecular hydrogels is their poor mechanical properties. Herein, to enhance the mechanical strength of supramolecular hydrogels, agarose（AG） was incorporated into the low molecular weight hy- drogelator（G1）. The results of scanning electron microscopy（SEM）, circular dichroism（CD） and Fourier transform infrared spectroscopy（FTIR） prove that G1 gelators can self-assemble into cross-linked network together with AG. The mechanical properties of the gels are characterized by a rotary rheometer and the mechanical properties of the hybrid hydrogels（Hgel） can be significantly improved and may be further tuned by changing the ratio of the two components. For example, the elastic modulus of Hgel II[m（G1）：m（AG）=7：3] is about 2 times higher than that of G1 hydrogel. The results demonstrate that the mechanical property of hybrid supramolecular hydrogels can be adjusted through the formation of a cross-linked network.

关键词： Supramolecular gelator Hybrid hydrogel Mechanical strength Self-assembly

Augmentation-based discriminative meta-learning for cross-machine few-shot fault diagnosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2023年第6期66卷 1698-1716页

作者： XIA PengCheng HUANG YiXiang wang yuxiang LIU ChengLiang LIU Jie State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China MoE Key Lab of Artificial Intelligence AI InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical and Aerospace Engineering Carleton UniversityOttawa ON K1S 5B6Canada

Deep learning methods have demonstrated promising performance in fault diagnosis *** the scarcity of data in industrial scenarios limits the practical application of such methods,transfer learning effectively tackles this issue through crossmachine knowledge ***,the cross-machine few-shot problem,which is a more general industrial scenario,has been rarely *** studies have not considered the cross-machine domain shift problem,which results in poor testing *** paper proposes an augmentation-based discriminative meta-learning method to address this *** the meta-training process,signal transformation is proposed to increase the meta-task diversity for more robust feature learning,and multi-scale learning is combined for more adaptive feature *** the meta-testing process,limited labeled fault information is used to promote model generalization in the target domain through quasi-meta-training based on data ***,a novel hyperbolic prototypical loss is proposed for more discriminative feature representation and separable category prototypes by designing a hyperbolic decision ***-machine few-shot diagnosis experiments were conducted using three datasets from different machines,namely,the bearing,motor,and gear *** effectiveness of the proposed method was verified through ablation and comparison studies.

关键词： fault diagnosis few-shot learning meta-learning data augmentation cross-machine discriminative loss

同方期刊数据库

A Dynamic and Deadline-Oriented Road Pricing Mechanism for Urban Traffic Management

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2022年第1期27卷 91-102页

作者： Jiahui Jin Xiaoxuan Zhu Biwei Wu Jinghui Zhang yuxiang wang the School of Computer Science and Engineering Southeast UniversityNanjing 211189China the Department of Computer Science and Engineering Hangzhou Dianzi UniversityHangzhou 310018China

Road pricing is an urban traffic management mechanism to reduce traffic ***,most of the road pricing systems based on predefined charging tolls fail to consider the dynamics of urban traffic flows and travelers’demands on the arrival *** this paper,we propose a method to dynamically adjust online road toll based on traffic conditions and travelers’demands to resolve the above-mentioned *** method,based on deep reinforcement learning,automatically allocates the optimal toll for each road during peak hours and guides vehicles to roads with lower toll ***,it further considers travelers’demands to ensure that more vehicles arrive at their destinations before their estimated arrival *** method can increase the traffic volume effectively,as compared to the existing static mechanisms.

关键词： road pricing traffic congestion al eviation deep reinforcement learning

Effect of Y and Ce Micro-alloying on Microstructure and Hot Tearing of As-Cast Al-Cu-Mg Alloy

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 939-952页

作者： Chunyu Yue Bowen Zheng Ming Su yuxiang wang Xiaojiao Zuo Yinxiao wang Xiaoguang Yuan School of Materials Science and Engineering Shenyang University of TechnologyShenyang110870China Institute of Metal Research Chinese Academy of SciencesShenyang110016China

In this work,the Al-Cu-Mg alloy with different Y(0-0.2 wt%)and Ce(0.5-1.5 wt%)are *** effect of mixed addition of Y and Ce on the grain structure and hot tearing for Al-4.4Cu-1.5Mg-0.15Zr alloy was investigated using"cross"hot tearing *** results indicate that as rare earth Y and Ce increases,the grain size becomes finer,the grain morphology changes from dendrite to equiaxed grain,and effectively reduce the hot tearing sensitivity coefficient(HTS1)and crack susceptibility coefficient(CSC)of the *** the increase of Ce element(0.5-1.5 wt%),the hot tearing susceptibility of the alloy decreases first and then *** the increase of Y element(0-0.2 wt%),the hot tearing sensitivity of the alloy *** the content of rare earth is 0.2 wt%Y+1.0 wt%Ce,the minimum HTS1 value and CSC value of the alloy are 68 and 0.53,*** earth Ce refines the alloy microstructure,shortens the feeding channel,and reduces the hot tearing ***,the rare earth Y can form Al6Cu6Y phase at the grain boundary,improve the feeding capacity of the ***,appropriate addition of rare earth Y and Ce can effectively reduce the hot tearing tendency of the alloy.

关键词： Al-Cu-Mg alloy Y and Ce Microstructure Thermal analysis Hot tearing sensitivity

Study on Local Resistance of non-Newtonian Power Law Fluid in Elbow Pipes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2016年第3期25卷 287-291页

作者： ZHANG Hao XU Tiantian ZHANG Xinxin wang yuxiang wang Yuancheng LIU Xueting School of Thermal Energy Engineering Shandong Jianzhu University Key Laboratory of Renewable Energy Utilization Technologies in Buildings Ministry of Education Department of Thermal Engineering University of Science and Technology Beijing

This paper focuses on the flow characteristic and local resistance of non-Newtonian power law fluid in a curved 90° bend pipe with circular cross-sections, which are widely used in industrial applications. By employing nu- merical simulation and theoretical analysis the properties of the flow and local resistance of power law fluid under different working conditions are obtained. To explore the change rule the experiment is carried out by changing the Reynolds number, the wall roughness and differcnt diameter ratio of elbow pipe. The variation of the local resistance coefficient with the Reynolds number, the diameter ratio and the wall roughness is presented comprehensively in the paper. The results show that the local resistance force coefficient hardly changes with Reynolds number of the power law fluid; the wall roughness has a significant impact on the local resistance coefficicnt. As the pipe wall roughness increasing, the coefficient of local resistance force will increase. The main reason of the influence of the roughness on the local resistance coefficient is the increase of the eddy current region in the power law fluid flow, which increases the kinetic energy dissipation of the main flow. This paper provides theoretical and numerical methods to understand the local resistance property of non-Newtonian power law fluid in elbow pipes.

关键词： non-Newtonian fluid Local resistance coefficient Reynolds number Bend diameter ratio Roughness

Infuence of Liquid Film Characteristics on Hot Cracking Initiation in Al–Cu Alloys at the End of Solidifcation

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2023年第1期36卷 103-117页

作者： Ming Su Xiaoguang Yuan Chunyu Yue Wentao Zheng yuxiang wang Jian Kang School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

In this study,Al–4Cu alloy specimens with spherical grains and liquid flms were obtained by isothermal reheating *** hot cracking of the solidifcation process was determined using a modifed constrained rod casting experimental apparatus,and the efect of liquid flm characteristics at the end of solidifcation on hot cracking initiation of Al–4Cu alloys was systematically investigated by combining molecular dynamics simulations and other *** the extension of soaking time,the liquid fraction(liquid flm fraction at the end of solidifcation)and grain shape factor increased with higher isothermal reheating ***,the widened flling channel decreased the hot cracking initiation temperature and the critical hot cracking shrinkage stress was found to increase,thus reducing the hot cracking severity in Al–4Cu *** dynamics simulations revealed that with the extension of soaking time,the composition of the liquid flm changed at diferent isothermal reheating temperatures,but the short-range structure and atomic ordering of the liquid flm remained the *** activity of the liquid flm increased in equilibrium,leading to a decrease in viscosity and an increase in fuidity,which contributed to the flling *** isothermal reheating at 640℃for 60 min,the liquid fraction reached the maximum,and the viscosity of the liquid flm was the *** addition,almost no hot cracks were found.

关键词： Al-4Cu alloy Liquid flm characteristics Isothermal reheating Molecular dynamics simulation Hot cracking initiation mechanism