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Micro-slurry jet for surface processing of dental ceramics

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Biosurface and Biotribology 2019年第1期5卷 8-12页

作者： Takashi Baba yuta Nakashima Shohei Takahashi Tohru Matsubara Ling Yin Yoshitaka Nakanishi Graduate School of Science and Technology Kumamoto UniversityKumamotoJapan Faculty of Advanced Science and Technology Kumamoto UniversityKumamotoJapan Aishi Dental Laboratory Co. Ltd.KumamotoJapan Palmeso Co. Ltd.NiigataJapan School of Mechanical Engineering The University of AdelaideAdelaideAustralia

A micro-slurry jet(MSJ)was used for removing microscopic cracks and microstructural defects on surfaces of dental ceramics,in which the MSJ functioned as a wet blasting machine using mixed alumina particles and water to spray workpiece surfaces by a compressed *** specimens made from a composite resin ceramic(CERASMART 270)and a zirconia ceramic(KZR-CAD Zr)were prepared using a dental computer-aided manufacturing *** results indicate that the MSJ processing has removed the microscopic cracks and defects on surfaces of the composite resin ceramic,and improved the material bending *** comparison,the MSJ processing created spraying patterns on zirconia surfaces due to the movement of the MSJ injection *** bending strength of the MSJ processed zirconia was slightly deteriorated because of the MSJ-induced patterns which might have led to stress concentrations on the ceramic surfaces.

关键词： ceramic ceramics bending

Cronkhite-Canada syndrome associated with myelodysplastic syndrome

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World Journal of Gastroenterology 2009年第46期15卷 5871-5874页

作者： Rei Suzuki Atsushi Irisawa Takuto Hikichi yuta Takahashi Hiroko Kobayashi Hiromi Kumakawa Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University Internal Medicine Soma Public Hospital

We report a case of Cronkhite-Canada syndrome(CCS)associated with myelodysplastic syndrome(MDS).A 54-year-old woman,diagnosed as MDS the prior year after evaluation of anemia,visited our hospital with the chief complaint of epigastric *** also had dysgeusia,alopecia,atrophic nail change,and pigmentation of the palm,all of which began several months *** tests revealed severe ***(CS)showed numerous,dense,red polyps throughout the colon and *** specimens showed stromal edema,infi ltration of lymphocytes,and cystic dilatation of the *** clinical manifestations and histology were consistent with *** prescribed corticosteroids,which dramatically improved her physical findings,laboratory data,and endoscopic fi *** is the first report of CCS in a patient with MDS.

关键词： Cronkhite-Canada syndrome Myelody-splastic syndrome Polyposis Steroid therapy

Cluster structures in stable and unstable nuclei

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Nuclear Science and Techniques 2015年第2期26卷 71-74页

作者： Yoshiko Kanada-En’yo Masaaki Kimura Fumiharu Kobayashi Tadahiro Suhara Yasutaka Taniguchi yuta Yoshida Department of Physics Kyoto University Department of Physics Hokkaido University Department of Physics Niigata University Matsue College of Technology Nihon Institute of Medical Science Moroyama-machiIruma-gunSaitama 350-0435Japan

Cluster structures in light unstable nuclei are discussed. The structures of neutron-rich Be isotopes are theoretically investigated and the molecular orbital bond structure and its role in the vanishing of the neutron magic number N = 8 are discussed. The two-body cluster resonances in highly excited states of neutron-rich Li, Be and B isotopes are predicted theoretically.

关键词：团簇结构不稳定原子核铍同位素丰中子分子轨道高激发态理论预测

Comment on: Long-term hemodialysis improved and stabilized diabetic macular edema: two case reports

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1891-1892页

作者： Yusuke Kameda yuta Suzuki Megumi Sugai Karin Ishinabe Nichika Fukuoka Yotsuya-sanchome Ekimae Eye Clinic Tokyo 160-0004Japan

Dear Editor,With great excitement, we read the article titled “Longterm hemodialysis improved and stabilized diabetic macular edema: two case reports” by Fan and Yuan[1];a case series study which provided interestin... 详细信息

关键词： edema hemodialysis diabetic

Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma

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World Journal of Gastroenterology 2009年第10期15卷 1267-1272页

作者： Takayuki Kogure Yoshiyuki Ueno Satoshi Sekiguchi Kazuyuki Ishida Takehiko Igarashi yuta Wakui Takao Iwasaki Tooru Shimosegawa Division of Gastroenterology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan Division of Advanced Surgical Science and Technology Graduate School of MedicineTohoku University Sendai 980-8574Japan Department of Pathology Tohoku University HospitalSendai 980-8574Japan Division of Gastroenterology Osaki Citizen Hospital Furukawa 989-6183Japan

A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral *** diagnostics showed the typical findings of liver cell adenoma(LCA).Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed *** tumor was found to contain fat on magnetic resonance imaging.A benign fat containing liver tumor was ***,radiological findings altered,which caused us to suspect that a welldifferentiated hepatocellular carcinoma(HCC)containing fat was becoming *** hepatectomy was performed and the pathological findings showed the typical findings of *** case was an extremely rare LCA,which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.

关键词： Liver cell adenoma Hepatocellularcarcinoma Diagnosis Hepatectomy

Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

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Bone Research 2019年第1期7卷 66-75页

作者： yuta Nakai Kazuo Okamoto Asuka Terashima Shogo Ehata Jun Nishida Takeshi Imamura Takashi Ono Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityYushima 1-5-45Bunkyo-kuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Pathology Graduate School of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Medicine for Pathogenesis Ehime University Graduate School of MedicineShitsukawaToonEhimeJapan

Bone is one of the preferred sites for the metastasis of malignant tumours,such as breast cancer,lung cancer and malignant *** cells colonizing bone have the capacity to induce the expression of receptor activator of nuclear factor-κB ligand(RANKL),which promotes osteoclast differentiation and ***-induced osteoclastic bone resorption leads to a vicious cycle between tumours and bone cells that fuels osteolytic tumour growth,causing bone pain and ***,RANKL contributes to bone metastasis by acting as a chemoattractant to bone for tumour cells that express its receptor,*** inhibition of the RANKL–RANK pathway is a promising treatment for bone metastasis,and a human monoclonal anti-RANKL antibody,denosumab,has been used in the ***,orally available drugs targeting RANKL must be developed to increase the therapeutic benefits to *** we report the efficacy of the small-molecule RANKL inhibitor AS2676293 in treating bone metastasis using mouse *** administration of AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced ***2676293 suppressed RANKLmediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10,which is known not to trigger osteoclast *** on the results from this study,RANKL inhibition with a small-molecule compound constitutes a promising therapeutic strategy for treating bone metastasis by inhibiting both osteoclastic bone resorption and tumour migration to bone.

关键词： Bone tumours metastasis

Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio

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International Journal of Oral Science 2017年第4期9卷 200-209页

作者： nanami yamamoto koji kawaguchi hisako fujihara mitsuhiko hasebe yuta kishi masaaki yasukawa kenichi kumagai yoshiki hamada department of oral and maxillofacial surgery school of dental medicinetsurumi universityYokohamaJapan department of oral hygiene tsurumi junior collegeYokohamaJapan

The autofluorescence visualization method （AVM） uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss （FVL）. In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Seventy-nine tongue specimens clinically suspected to have leukoplakia or squamous cell carcinoma （SCC） were analyzed. First, the AVM was subjectively performed using the Visually Enhanced Lesion scope （VELscope）, and the iodine-staining method was then performed. After biopsy, the histopathological results and the luminance ratio between the lesion and healthy tissue were compared, and a receiver operating characteristic curve was created. The cutoff value for the objective AVM was determined; the lesion was considered FVL-positive or -negative when the luminance ratio was higher or lower than the cutoff value, respectively. The histopathological diagnoses among the 79 specimens were SCC （n = 30）, leukoplakia with dysplasia （n = 34）, and leukoplakia without dysplasia （n= 15）. The cutoff value of the luminance ratio was 1.62, resulting in 66 FVL-positive and 13 FVL-negative specimens. The luminance ratio was significantly higher in the epithelial dysplasia-positive than -negative group （P〈O.O00 1）. The objective AVM showed much higher consistency between histopathological results than did the two methods （kappa statistic = 0.656）. In conclusion, objective autofluorescence visualization has a potential as an auxiliary method for diagnosis of epithelial dysplasia.

关键词： autofluorescence epithelial dysplasia oral cancer Visually Enhanced Lesion scope

Patellar dislocation following distal femoral replacement after extraarticular knee resection for bone sarcoma:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3561-3572页

作者： yuta Kubota Kazuhiro Tanaka Masashi Hirakawa Tatsuya Iwasaki Masanori Kawano Ichiro Itonaga Hiroshi Tsumura Orthopaedic Surgery Oita UniversityYufu City 879-5593OitaJapan

BACKGROUND For the treatment of bone sarcoma in the distal femur,wide-margin resection and knee reconstruction with tumor endoprosthesis are standard *** knee resection is required in cases of tumor invasion of the knee joint;however,the incidence of complications,such as aseptic loosening,prosthesis infection,and implant failure,is higher than that following intra-articular knee *** the best of our knowledge,there are three reports of patellar dislocations after replacement of a tumor *** SUMMARY A 36-year-old man with no significant past medical history was admitted to our institution with continuous pain in his left knee for 4 *** open biopsy was performed,and the patient was diagnosed with a left distal femoral malignant bone ***-articular knee resection and knee reconstruction with a tumor endoprosthesis were *** the alignment of the tumor prosthesis was acceptable,knee instability was noticed *** axial radiographic view of the patellar and computed tomography showed lateral patellar dislocation at 4 wk *** patient had to undergo a lateral release and proximal *** could perform his daily activities at 9 mo *** revealed no patellar *** Proximal realignment may be considered during primary surgery if there is an imbalance in the forces controlling the patellar tracking.

关键词： Bone tumor Distal femoral replacement Lateral release Patellar dislocation Proximal realignment Case report

Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis

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World Journal of Clinical Cases 2017年第7期5卷 280-285页

作者： Akira Yamamiya Katsuya Kitamura Yu Ishii yuta Mitsui Tomohiro Nomoto Hitoshi Yoshida Division of Gastro- enterology Department of MedicineShowa University School of Medicine

AIM To investigate the feasibility of initial endoscopic common bile duct(CBD) stone removal in patients with acute cholangitis(AC).METHODS A single-center,retrospective study was conducted between April 2013 and December 2014 and was approved by the Medical Ethics Committee at our *** informed consent was obtained from each patient prior to the *** cohort comprised 31 AC patients with CBD stones who underwent endoscopic biliary drainage(EBD) for na?ve papilla within 48 h after AC *** retrospectively divided the participants into two groups: 19 patients with initial endoscopic CBD stone removal(initial group) and 12 patients with delayed endoscopic CBD stone removal(delayed group).We evaluated the feasibility of initial endoscopic CBD stone removal in patients with *** We observed no significant differences between the groups regarding patient *** to the assessments based on the Tokyo Guidelines,the AC severity of patients with initial endoscopic CBD stone removal was mild to *** use of antithrombotic agents before EBD was less frequent in the initial group than in the delayed group(11% vs 58%,respectively; P = 0.004).All the patients underwent successful endoscopic CBD stone removaland adverse events did not differ significantly between the *** number of endoscopic retrograde cholangiopancreatography procedures was significantly lower in the initial group than in the delayed group [median(interquartile range) 1(1-1) vs 2(2-2),respectively; P < 0.001].The length of hospital stay was significantly shorter for the initial group than for the delayed group [10(9-15) vs 17(14-20),respectively; P = 0.010].CONCLUSION Initial endoscopic CBD stone removal in patients with AC may be feasible when AC severity and the use of antithrombotic agents are carefully considered.

关键词： Acute cholangitis Common bile duct stone Feasibility Initial endoscopic common bile stone removal Endoscopic retrograde cholangiopancreatography