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Human chemerin induces eryptosis at concentrations exceeding circulating levels

BIOCELL 2024年第8期48卷 1197-1208页

作者： MARYNA TKACHENKO ANATOLII ONISHCHENKO LILIYA TRYFONYUK DMYTRO BUTOV KATERYNA kot VIKTORIIA NOVIKOVA LIWEI FAN VOLODYMYR PROKOPIUK yurii kot ANTON TKACHENKO Department of Internal Medicine No.2 Clinical Immunology and AllergologyKharkiv National Medical UniversityKharkiv61022Ukraine Research Institute of Experimental and Clinical Medicine Kharkiv National Medical UniversityKharkiv61022Ukraine Institute of Health National University of Water and Environmental EngineeringRivne61022Ukraine Department of Infectious Diseases and Phthisiology Kharkiv National Medical UniversityKharkiv61022Ukraine Biochemistry Department V.N.Karazin Kharkiv National University Ministry of Education and Science of UkraineKharkiv61022Ukraine Department of Chemistry BiochemistryMicrobiology and Food HygieneState Biotechnological UniversityKharkiv61022Ukraine Clinical Research Innovation Lab Floor 26 Block D Qidi Technology Building 8Tsinghua Technology ParkBeijing100084China Department of Cryobiochemistry Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of UkraineKharkiv61015Ukraine

Introduction:Human chemerin is an adipokine that regulates chemotaxis,inflammation,and glucose *** addition,accumulating evidence suggests that chemerin promotes apoptosis,autophagy,and ***,there are no data on its impact on *** current study aimed to analyze the effects of human active Glu^(21)-Ser^(157) chemerin on eryptosis in *** and Methods:Human chemerin 0-2-10-50μg/mL was incubated for 24 h with human erythrocytes(hematocrit 0.4%)obtained from eight healthy *** cytometry-based determination of phospholipid scrambling,reactive oxygen species(ROS)production,and intracellular Ca^(2+)levels was *** supplement data on ROS and Ca^(2+)signaling in chemerin-mediated eryptosis,incubation in the presence or absence of antioxidants vitamin C and N-acetylcysteine and Ca^(2+)-binding agent EGTA was carried out,*** microscopy-based techniques were used to detect reactive nitrogen species(RNS)generation,involvement of caspase-3 and caspase-8,as well as the state of lipid order in cell membranes of erythrocytes exposed to human Glu^(21)-Ser^(157) ***:Our observations suggest that human Glu^(21)-Ser^(157) chemerin had no impact on eryptosis parameters at 2μg/***,chemerin stimulated phosphatidylserine externalization,ROS production,and Ca^(2+)accumulation at higher concentrations suggesting activation of ***^(2+)uptake turned out to be at least partly required for chemerin-mediated ***-mediated erythrotoxicity was additionally mediated by RNS,caspase-3,and ***,Glu^(21)-Ser^(157) chemerin promoted reduction in the liquid-ordered phase of cell membranes in ***:The present study first discloses that human chemerin can induce eryptosis via Ca^(2+)-dependent mechanisms at concentrations noticeably exceeding circulating ***,chemerin-induced eryptosis can hardly contribute to eryptosis-mediated anemia in disease

关键词： Adipokine Cell death Chemerin Oxidative stress Eryptosis

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The micropolar fluid model for blood flow through a tapered artery with a stenosis

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Acta Mechanica Sinica 2008年第6期24卷 637-644页

作者： Kh.S.Mekheimer M.A.El kot Department of Mathematics Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Department of Mathematics Faculty of EducationSuez Canal UniversitySuezEgypt

A micropolar model for axisymmetric blood flow through an axially nonsymmetreic but radially symmetric mild stenosis tapered artery is presented. To estimate the effect of the stenosis shape, a suitable geometry has been considered such that the axial shape of the stenosis can be changed easily just by varying a parameter （referred to as the shape parameter）. The model is also used to study the effect of the taper angle Ф. Flow parameters such as the velocity, the resistance to flow （the resistance impedance）, the wall shear stress distribution in the stenotic region and its magnitude at the maximum height of the stenosis （stenosis throat） have been computed for different values of the shape parameter n, the taper angle Ф, the coupling number N and the micropolar parameter m. It is shown that the resistance to flow decreases with increasing the shape parameter n and the micropolar parameter m while it increases with increasing the coupling number N. So, the magnitude of the resistance impedance is higher for a micropolar fluid than that for a Newtonian fluid model. Finally, the velocity profile, the wall shear stress distribution in the stenotic region and its magnitude at the maximum height of the stenosis are discussed for different values of the parameters involved on the problem.

关键词： Micropolar fluid Blood flow Tapered artery

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Supplementation of a lacto-fermented rapeseed-seaweed blend promotes gut microbial-and gut immune-modulation in weaner piglets

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Journal of Animal Science and Biotechnology 2022年第1期13卷 138-151页

作者： Yan Hui Paulina Tamez-Hidalgo Tomasz Cieplak Gizaw Dabessa Satessa Witold kot Søren Kjærulff Mette Olaf Nielsen Dennis Sandris Nielsen Lukasz Krych Department of Food Science Faculty of ScienceUniversity of CopenhagenRolighedsvej 26DK-1958 Frederiksberg CDenmark Fermentationexperts A/S.Vorbassevej 12 DK-6622 BaekkeDenmark Department of Veterinary and Animal Sciences Faculty of Health and Medical SciencesUniversity of CopenhagenGrønnegårdsvej 3DK-1870 Frederiksberg CDenmark Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenRolighedsvej 26DK-1958 Frederiksberg CDenmark Department of Animal Science Faculty of Technical SciencesAarhus UniversityBlichers Alle 20DK-8830 TjeleDenmark

Background:The direct use of medical zinc oxide in feed will be abandoned after 2022 in Europe,leaving an urgent need for substitutes to prevent post-weaning ***:This study investigated the effect of using rapeseed-seaweed blend(rapeseed meal added two brown macroalgae species Ascophylum nodosum and Saccharina latissima)fermented by lactobacilli(FRS)as feed ingredients in piglet *** d 28 of life to d 85,the piglets were fed one of three different feeding regimens(n=230 each)with inclusion of 0%,2.5% and 5% *** this period,no significant difference of piglet performance was found among the three *** a subset of piglets(n=10 from each treatment),blood samples for hematology,biochemistry and immunoglobulin analysis,colon digesta for microbiome analysis,and jejunum and colon tissues for histopathological analyses were *** piglets fed with 2.5% FRS manifested alleviated intraepithelial and stromal lymphocytes infiltration in the gut,enhanced colon mucosa barrier relative to the 0% FRS *** colon microbiota composition was determined using V3 and V1-V8 region 16S rRNA gene amplicon sequencing by Illumina NextSeq and Oxford Nanopore MinION,*** two amplicon sequencing strategies showed high consistency between the detected *** sequencing strategies indicated that inclusion of FRS reshaped the colon microbiome of weaned piglets with increased Shannon *** stercorea was verified by both methods to be more abundant in the piglets supplied with FRS feed,and its abundance was positively correlated with colonic mucosa thickness but negatively correlated with blood concentrations of leucocytes and ***:FRS supplementation relieved the gut lymphocyte infiltration of the weaned piglets,improved the colon mucosa barrier with altered microbiota *** the dietary inclusion of FRS from 2.5% to 5% did not lead to further improvements.

关键词： Amplicon sequencing Colon microbiota Fermented feed Gut barrier

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Influence of magnetic field and Hall currents on blood flow through a stenotic artery

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Applied Mathematics and Mechanics(English Edition) 2008年第8期29卷 1093-1104页

作者： Kh.S.Mekheimer M.A.El kot Department of Mathematics Faculty of ScienceAl-Azhar University Nasr City 11884CairoEgypt Department of Mathematics Faculty of EducationSuez Canal UniversitySuezEgypt

A micropolar model for blood simulating magnetohydrodynamic flow through a horizontally nonsymmetric but vertically symmetric artery with a mild stenosis is presented. To estimate the effect of the stenosis shape, a suitable geometry has been considered such that the horizontal shape of the stenosis can easily be changed just by varying a parameter referred to as the shape parameter. Flow parameters, such as velocity, the resistance to flow （the resistance impedance）, the wall shear stress distribution in the stenotic region, and its magnitude at the maximum height of the stenosis （stenosis throat）, have been computed for different shape parameters, the Hartmann number and the Hall parameter. This shows that the resistance to flow decreases with the increasing values of the parameter determining the stenosis shape and the Hail parameter, while it increases with the increasing Hartmann number. The wall shear stress and the shearing stress on the wall at the maximum height of the stenosis possess an inverse characteristic to the resistance to flow with respect to any given value of the Hartmann number and the Hall parameter. Finally, the effect of the Hartmann number and the Hall parameter on the horizontal velocity is examined.

关键词： stenotic artery Hall currents blood flow

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Mitigation of floor heave in West Kentucky Coal Mine

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International Journal of Mining Science and Technology 2016年第3期26卷 521-525页

作者： Perry Kyle Bradley Joel Unrug kot Klimek Mark Mining Engineering Department University of Kentucky Alliance Resource Partners

A West Kentucky mine operation in No. 11 seam encountered floor heave, due to the localized increase in the thickness of the fireclay mine floor. Floor heave has overridden seals installed in two mined out panels. The third seal's location was planned for isolating that area from the Mains. A plan of support has been developed to prevent repetition of the floor heave and related problems outby the seals. The applied ground control measures were successful. An attempt of a 3D numerical modeling was made; thus, it would match the observed behavior of the mine floor and could be used as a design tool in similar conditions. The paper describes sequence of events, an applied mitigation ground control system, and the first stage of numerical modeling.

关键词：底鼓煤矿塔基三维数值模拟地面控制系统底板厚度密封件设计工具

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Chemical characteristics of aerosols at coastal station in Hong Kong.Ⅱ. Environmental behavior of trace elements during the April 1995 to April 1996

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Journal of Environmental Sciences 2004年第2期16卷 212-221页

作者： K.S.Lam Z.L.Cheng S.C.kot C.W.Tsang Department of Civil and Structural Engineering the Hong Kong Polytechnic UniversityResearch Center for Eco-Environmental Sciences Chinese Academy of SciencesDepartment of Mechanical Engineering The Hong Kong University of Science & Technology Clear Water BayDepartment of Applied Biology and Chemical Technology the Hong Kong Polytechnic University Hung Hom Hong Kong ChinaBeijing 100085 ChinaHong Kong ChinaHung Hom Hong Kong China

An one-year of sampling aerosol program was carried out during the period of April 1995 to April 1996 at coastal region, Cape D′Aguilar, in Hong Kong. The trace element composition of aerosol particles(TSP and PM 10 ) were measured and analyzed by using the Instrumental Neutron Activation Analysis(INAA) and Inductive Couple Plasma-Mass Spectrometry(ICP-MS) techniques. The results showed that the polluted elements such as: V, Zn, As, Pb, Cd, Sb, I, Se, Bi, with high enrichment factor(E.F) values, are derived from anthropogenic sources, while Sc, Al, Fe, Mn, Sm, La, Sr are less than 10 in E.F, these elements are related the crust and soil. The concentration of the trace elements are present seasonal variation i.e. summer low and winter high, whereas the V or noncrustal V(V *) present summer high and winter low, this phenomenon might be explained by local or regional oil combustion sources. Use three type of elemental ratio, e.g. La/Sm, Mn */V * and Bi/Al indicate that both TSP and PM 10 of La/Sm ratios are mainly related to soil and dust, Mn */V * are probably represent fossil combustion and Bi/Al are possibly associated with refuse incineration, ferromanganese alloys and aluminum production. The varimax rotation factor analysis for trace elements was performed. By means of the absolute principal component analysis(APCA) and multiple regression, the contribution of trace elements to possible sources and overall means of trace elements were estimated. The results showed that the present station is impacted by the anthropogenic species, although the quantities are different during the summertime and wintertime.

关键词： TSP PM 10 trace elements enhancement factor element ratios seasonal variation factor analysis

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On the Variability and Correlation of Surface Ozone and Carbon Monoxide Observed in Hong Kong Using Trajectory and Regression Analyses

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Advances in Atmospheric Sciences 2004年第1期21卷 141-152页

作者：王体健 K.S.LAM C.W.TSANG S.C.kot Department of Atmospheric Sciences Nanjing University Nanjing 210093 Environmental Engineering Unit Department of Civil & Structural Engineering The Hong Kong Polytechnic University Hong Kong Environmental Engineering Unit Department of Civil & Structural Engineering The Hong Kong Polytechnic University Hong Kong Department of Mechanical Engineering Hong Kong University of Science & Technology Hong Kong

This paper investigates, the variability and correlation of surface ozone (Os) and carbon monoxide (CO) observed at Cape D'Aguilar in Hong Kong from 1 January 1994 to 31 December 1995. Statistical analysis shows that the average O3 and CO mixing ratios during the two years are 32±17ppbv and 305±191 ppbv, respectively. The O3/CO ratio ranges from 0.05 to 0.6 ppbv/ppbv with its frequency peaking at 0.15. The raw dataset is divided into six groups using backward trajectory and cluster analyses. For data assigned to the same trajectory type, three groups are further sorted out based on CO and NOX mixing ratios. The correlation coefficients and slopes of O3/CO for the 18 groups are calculated using linear regression analysis. Finally, five kinds of air masses with different chemical features are identified: continental background (CB), marine background (MB), regional polluted continental (RPC), perturbed marine (P*M), and local polluted (LP) air masses. Further studies indicate that O3 and CO in the continental and marine background air masses (CB and MB) are positively correlated for the reason that they are well mixed over the long range transport before arriving at the site. The negative correlation between O3 and CO in air mass LP is believed to be associated with heavy anthropogenic influence, which results from the enhancement by local sources as indicated by high CO and NOx and depletion of O3 when mixed with fresh emissions. The positive correlation in the perturbed marine air mass P*M favors the low photochemical production of O3. The negative correlation found in the regional polluted continental air mass RPC is different from the observations at Oki Island in Japan due to the more complex O3 chemistry at Cape D'Aguilar.

关键词： ozone carbon monoxide trajectory

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Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

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Journal of Geriatric Cardiology 2022年第9期19卷 705-711页

作者： Danish Iltaf Satti Yan Hiu Athena Lee Keith Sai Kit Leung Jeremy Man Ho Hui Thompson Ka Ming kot Arslan Babar Gauranga Mahalwar Abraham KC Wai Tong Liu Leonardo Roever Gary Tse Jeffrey Shi Kai Chan International Health Informatics Study(IHIS)Network Cardiovascular Analytics Group Hong KongChina-UK Collaboration Emergency Medicine Unit Li Ka Shing Fac-ulty of MedicineThe University of Hong KongHong KongChina Aston Medical School Faculty of Health&Life SciencesAston UniversityBirminghamUnited Kingdom Li Ka Shing Faculty of Medicine The University of Hong KongHong KongChina Department of Anaesthesia and Pain Service Princess Margaret HospitalLai Chi KokKowloonHong KongChina Department of Medicine Cleveland Clinic FoundationClevelandUSA Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardi-ologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Clinical Research Federal Uni-versity of UberlândiaUberlândiaBrazil Kent and Medway Medical School CanterburyKentUnited Kingdom 不详

OBJECTIVES To assess the effect of vasopressin,steroid and epinephrine(VSE)combination therapy on return of spontan-eous circulation(ROSC)after in-hospital cardiac arrest(IHCA),and test the conclusiveness of evidence using trial sequential ana-lysis(TSA).METHODS The systematic search included PubMed,EMBASE,Scopus,and Cochrane Central Register of Controlled *** controlled trials(RCTs)that included adult patients with IHCA,with at least one group receiving combined VSE therapy were *** was extracted independently by two *** main outcome of interest was *** out-comes included survival to hospital discharge or survival to 30 and 90 days,with good neurological *** We included a total of three RCTs(n=869).Results showed that VSE combination therapy increased ROSC(risk ra-tio=1.41;95%CI:1.25-1.59)as compared to *** demonstrated that the existing evidence is *** was also validated by the alpha-spending adjusted relative risk(1.32[1.16,1.49],P<0.0001).Other outcomes could not be meta-analysed due to differences in timeframe in the included *** VSE combination therapy administered in cardiopulmonary resuscitation led to improved rates of ***-ture trials of VSE therapy should evaluate survival to hospital discharge,neurological function and long-term survival.

关键词： resuscitation analysis return

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The Teahouse Revival

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China International Business 2005年第8期 42-44页

作者： JAN kot

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一种新的加密方法及在数字数据版权保护中应用(英文)

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软件学报 2002年第3期13卷 330-334页

作者：马建峰 Chiam Teechye kot Chichung Alex 西安电子科技大学计算机学院南洋理工大学电气电子工程学院新加坡639798

提出了一种新的具有多个私钥的加密方法.这种加密方法的安全性有赖于有限域上分组码译码问题的困难性.根据所提的加密算法,给出了一种适用于数字数据版权盗版跟踪方案.对于每一个数字数据的合法拷贝,给出的跟踪方案都分配一个分组码的... 详细信息

提出了一种新的具有多个私钥的加密方法.这种加密方法的安全性有赖于有限域上分组码译码问题的困难性.根据所提的加密算法,给出了一种适用于数字数据版权盗版跟踪方案.对于每一个数字数据的合法拷贝,给出的跟踪方案都分配一个分组码的码字与该拷贝的解密软件或者相关装置相对应.所提的方案能够有效地提取与解密软件或者装置相对应的码字,并进而利用所用分组码的译码算法找到所有参与非法拷贝制作的合法授权用户,其中,假设参与数字数据非法拷贝的合法用户数不超过所用码的纠错能力.与其他已有方案相比,所提方案具有更好的性能,并且容易实现.所提加密方案的潜在应用领域包括计算机软件、视频/音频等产品的数字数据版权保护方面.

关键词：线性码版权保护盗版跟踪方案公钥加密译码加密方法数字数据版权保护

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