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基于细菌避障策略的无人艇集群自主巡航方法

指挥控制与仿真 2024年第1期46卷 21-29页

作者：郑钰鹏邓科刘昊胡启智珠海云洲智能科技股份有限公司南方海洋科学与工程广东省实验室(珠海) 广东珠海519082 云洲创新科技有限公司深圳研究院广东深圳518106

针对无人艇集群执行巡航任务中的避障问题,提出了一种动态避障算法。首先,获取无人艇周边水域的方形网格轨迹单元态势矩阵;然后,借鉴细菌游走觅食原理,在方形网格轨迹单元集合中,动态匹配最佳避障路径;最后,在动态避障基础上,将无人艇... 详细信息

针对无人艇集群执行巡航任务中的避障问题,提出了一种动态避障算法。首先,获取无人艇周边水域的方形网格轨迹单元态势矩阵;然后,借鉴细菌游走觅食原理,在方形网格轨迹单元集合中,动态匹配最佳避障路径;最后,在动态避障基础上,将无人艇自主巡航过程划分为向目标行进、动态避障、返航补给等阶段,实现无人艇集群对划定水域的常态化巡航。仿真实验结果表明,所提方法对静态点、面障碍以及移动障碍均具有高效的规避能力,在算法基础上,能够实现无人艇集群的常态化无人值守巡航。该算法不仅适合无人艇的避障问题,在其他异构无人装备中也具有广阔的应用前景。

关键词：无人艇动态避障细菌游走方形网格轨迹单元自主巡航

Excellent light-capture capability of trilobal SiNW for ultra-high JSC in single-nanowire solar cells

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光子学研究：英文版 2020年第6期8卷 995-1001页

作者： ZHONGLIANG GAO GUILU Lin yupeng zheng NA SANG YINGFENG LI LEI CHEN MEICHENG LI State Key Laboratory o f Alternate Electrical Power System with Renewable Energy Sources School of Renewable EnergyNorth China Electric Power UniversityBeijing 102206China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China

Single-.nanowire solar cells with a unique light-concentration property are expected to exceed the Shockley-Queisser *** architecture of single nanowire is an important factor to regulate its optical *** designed a trilobal silicon nanowire(SiNW)with two cquivalent scales that possesses superior light-absorption efficiency in the whole wavelength range and shows good tolerance for incident *** electric field distribution in this geometry is concentrated in the blade with small equivalent scale and pivot with large equivalent scale,respectively,in the short wavelength range and long wavelength *** good light absorption of trilobal SiNW in the two wavelength ranges leads to stronger total light absorption capacity than that of cylindrical *** single nanowire solar cells can obtain a short-circuit current density(JSC)of 647 mA·cm^2,which provides a new choice for designing single nanowire with excellent light-capture capability.

关键词： light absorption cylindrical

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多喷嘴水煤浆气化炉运行提质优化操作小结

氮肥技术 2024年第3期45卷 30-31,37页

作者：王玮曹广法张东旭李刚郑玉鹏兖矿新疆煤化工有限公司新疆乌鲁木齐830000 兖矿新疆能化有限公司新疆乌鲁木齐830000

在煤炭深加工利用工艺中,气化系统起着“龙头”作用,其中气化炉的安全稳定、高效运行是龙头中的重心。通过对多喷嘴水煤浆气化炉优化改造措施的分析,指出在生产运行中通过提高多喷嘴水煤浆气化炉的烧嘴使用周期、提升有效产气量、使用... 详细信息

在煤炭深加工利用工艺中,气化系统起着“龙头”作用,其中气化炉的安全稳定、高效运行是龙头中的重心。通过对多喷嘴水煤浆气化炉优化改造措施的分析,指出在生产运行中通过提高多喷嘴水煤浆气化炉的烧嘴使用周期、提升有效产气量、使用更广泛煤种等优化改造措施,取得了良好的经济效益。

关键词：气化炉烧嘴煤浆提浓有效气

Confidence Estimation Transformer for Long-Term Renewable Energy Forecasting in Reinforcement Learning-based Power Grid Dispatching

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1502-1513页

作者： Xinhang Li Nan Yang Zihao Li yupeng Huang zheng Yuan Xuri Song Lei Li Lin Zhang Beijing University of Posts and Telecommunications Beijing 100876China Beijing Key Laboratory of Research and System Evaluation of Power Dispatching Automation Technology

Expansion of renewable energy could help realize the goals of peaking carbon dioxide emissions and carbon *** existing grid dispatching methods integrating short-term renewable energy prediction and reinforcement learning(RL)have been proven to alleviate the adverse impact of energy fluctuations ***,these methods omit long-term output prediction,which leads to stability and security problems on optimal power *** paper proposes a confidence estimation Transformer for long-term renewable energy forecasting in reinforcement learning-based power grid dispatching(Conformer-RLpatching).Conformer-RLpatching predicts long-term active output of each renewable energy generator with an enhanced Transformer to ensure stable operation of the hybrid energy grid and improve the utilization rate of renewable energy,thus boosting dispatching ***,a confidence estimation method is proposed to reduce the prediction error of renewable ***,a dispatching necessity evaluation mechanism is put forward to decide whether the active output of a generator needs to be *** carried out on the SG-126 power grid simulator show that Conformer-RLpatching achieves great improvement over the second best algorithm DDPG in security score by 25.8%and achieves a better total reward compared with the golden medal team in the power grid dispatching competition sponsored by State Grid Corporation of China under the same simulation *** are outsourced in https://***/BUPT-ANTlab/Conformer-RLpatching.

关键词： Conformer-RLpatching optimal power flow reinforcement learning renewable energy prediction

High-speed GeSn resonance cavity enhanced photodetectors for a 50 Gbps Si-based 2 μm band communication system

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Photonics Research 2024年第4期12卷 767-773页

作者： JINLAI CUI JUN zheng yupeng ZHU XIANGQUAN LIU YIYANG WU QINXING HUANG YAZHOU YANG ZHIPENG LIU ZHI LIU YUHUA ZUO BUWEN CHENG Key Laboratory of Optoelectronic Materials and Devices Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Expanding the optical communication band is one of the most effective methods of overcoming the nonlinear Shannon capacity limit of single *** this study,GeSn resonance cavity enhanced(RCE)photodetectors(PDs)with an active layer Sn component of 9%–10.8%were designed and fabricated on an SOI *** GeSn RCE PDs present a responsivity of 0.49 A/W at 2μm and a 3-dB bandwidth of approximately 40 GHz at 2μ***,Si-based 2μm band optical communication with a transmission rate of 50 Gbps was demonstrated by using a GeSn RCE *** work demonstrates the considerable potential of the Si-based 2μm band photonics in future high-speed and high-capacity optical communication.

关键词： resonance system approximate

Efficacy and safety of low-dose cyclophosphamide combined with lenvatinib, pembrolizumab and TACE for unresectable hepatocellular carcinoma:A single-center, prospective,single-arm clinical trial

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Chinese Journal of Cancer Research 2024年第2期36卷 114-123页

作者： yupeng Ren Yuxuan Li Mingbo Cao Yongchang Tang Feng Yuan Gaoyuan Yang Zhiwei He zheng Shi Xiaorui Su Zhicheng Yao Meihai Deng Department of Hepatobiliary Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of General Surgery Qilu HospitalShandong UniversityJinan 250012China Department of Hepatobiliary Surgery the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Hepatobiliary and Pancreatic Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenvatinib, pembrolizumab and transarterial chemoembolization(TACE) for the treatment of ***: From February 2022 to November 2023, a total of 40 patients diagnosed with uHCC were enrolled in this small-dose, single-center, single-arm, prospective study. They received a combined treatment of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE. Study endpoints included progression-free survival(PFS), objective response rate(ORR), and safety assessment. Tumor response was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST), while survival analysis was conducted through KaplanMeier curve analysis for overall survival(OS) and PFS. Adverse events(AEs) were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 5.0).Results: A total of 34 patients were included in the study. The median follow-up duration was 11.2 [95% confidence interval(95% CI), 5.3-14.6] months, and the median PFS(mPFS) was 15.5(95% CI, 5.4-NA) *** OS(mOS) was not attained during the study period. The ORR was 55.9%, and the disease control rate(DCR) was 70.6%. AEs were reported in 27(79.4%) patients. The most frequently reported AEs(with an incidence rate >10%) included abnormal liver function(52.9%), abdominal pain(44.1%), abdominal distension and constipation(29.4%), hypertension(20.6%), leukopenia(17.6%), constipation(17.6%), ascites(14.7%), and insomnia(14.7%). Abnormal liver function(14.7%) had the most common grade 3 or higher ***: A combination of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE is safe and effective for u HCC, showcasing a promising therapeutic strategy for managing uHCC.

关键词： Hepatocellular carcinoma lenvatinib low-dose cyclophosphamide pembrolizumab transarterial chemoembolization

Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing Shanshan Yang Lingling Geng yupeng Yan Fangshuo zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

HCCDB v2.0:Decompose Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 131-142页

作者： Ziming Jiang Yanhong Wu Yuxin Miao Kaige Deng Fan Yang Shuhuan Xu yupeng Wang Renke You Lei Zhang Yuhan Fan Wenbo Guo Qiuyu Lian Lei Chen Xuegong Zhang Yongchang zheng Jin Gu Eight-Year Program of Clinical Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100006China MOE Key Laboratory of Bioinformatics BNRIST Bioinformatics DivisionInstitute for Precision Medicine&Department of AutomationTsinghua UniversityBeijing 100084China Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Fuzhou Institute for Data Technology Fuzhou 350207China University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438China National Center for Liver Cancer Shanghai 201805China

Large-scale transcriptomic data are crucial for understanding the molecular features of hepatocellular carcinoma(HCC).Integrated 15 transcriptomic datasets of HCC clinical samples,the first version of HCC database(HCCDB v1.0)was released in *** the meta-analysis of differentially expressed genes and prognosis-related genes across multiple datasets,it provides a systematic view of the altered biological processes and the inter-patient heterogeneities of HCC with high reproducibility and *** four years having passed,the database now needs integration of recently published ***,the latest single-cell and spatial transcriptomics have provided a great opportunity to decipher complex gene expression variations at the cellular level with spatial ***,we present HCCDB v2.0,an updated version that combines bulk,single-cell,and spatial transcriptomic data of HCC clinical *** dramatically expands the bulk sample size by adding 1656 new samples from 11 datasets to the existing 3917 samples,thereby enhancing the reliability of transcriptomic meta-analysis.A total of 182,832 cells and 69,352 spatial spots are added to the single-cell and spatial transcriptomics sections,respectively.A novel single-cell level and 2-dimension(sc-2D)metric is proposed as well to summarize cell type-specific and dysregulated gene expression *** are all graphically visualized in our online portal,allowing users to easily retrieve data through a user-friendly interface and navigate between different *** extensive clinical phenotypes and transcriptomic data in the database,we show two applications for identifying prognosis-associated cells and tumor *** v2.0 is available at http://***/database/hccdb2.

关键词： Hepatocellular carcinoma Database Integrative analysis Single-cell RNA sequencing Spatial transcriptomics

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高速公路沥青路面裂缝养护与防治技术研究

山西建筑 2018年第15期44卷 143-144页

作者：郑宇鹏山西交通控股集团有限公司运城北高速公路分公司山西运城044000

对高速公路沥青路面裂缝的养护技术进行了介绍,针对高速公路沥青路面裂缝的成因,从合理选择施工材料、提高路面平整度、合理设置封层等方面,提出了防治对策,可为高速公路日常养护提供技术参考。

关键词：高速公路沥青路面裂缝养护技术