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Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma

Cancer Communications 2020年第12期40卷 694-710页

作者： yan yan Jiahao Pan Yonghua Chen Wei Xing Qiang Li Dongyin Wang Xiaoshuang Zhou Jingdun Xie Changhong Miao yunfei Yuan Weian Zeng Dongtai Chen Department of Anesthesiology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China Department of Anesthesiology Huizhou Municipal Central HospitalHuizhouGuangdong 516001P.R.China Department of Anesthesiology Peking University Shenzhen HospitalShenzhenGuangdong 518000P.R.China Department of Anesthesiology Fudan University Zhongshan HospitalShanghai 20032P.R.China Department of Hepatobiliary Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China

Background:Dopamine and dopamine receptor D1(DRD1),a member of the dopamine receptor family,have been indicated to play important roles in cancer progression,but dopamine secretion in hepatocellular carcinoma(HCC)and the effects of DRD1 on HCC remain *** study was designed to explore the contribution of the dopaminergic system to HCC and determine the relationship between DRD1 and prognosis in HCC ***:The dopamine metabolic system was monitored using enzyme-linked immunosorbent assays(ELISAs).The expression of DRD1 was detected by microarray analysis,immunohistochemistry(IHC),and quantitative real-time PCR(qRT-PCR).Stable DRD1 knockout and overexpression cell lines were established for ***,colony formation,and Cell Counting Kit 8(CCK8)assays were performed to assess the malignant behaviors of cancer *** cAMP/PI3K/AKT/cAMP response element-binding(CREB)signaling pathway was evaluated by Western *** pathway,which is agitated by DRD1 in striatal neurons,had been proven to participate in tumor *** HCC tumors were generated for in vivo ***:Dopamine secretion increased locally in HCC due to an imbalance in dopamine metabolism,including the upregulation of dopa decarboxylase(DDC)and the downregulation of monoamine oxidase A(MAOA).Dopamine promoted the proliferation and metastasis of ***1 was highly expressed in HCC tissues and positive DRD1 expression was related to a poor prognosis in HCC *** upregulation of DRD1 agitated malignant activities,including proliferation and metastasis in HCC by regulating the cAMP/PI3K/AKT/CREB pathway,and the downregulation of DRD1 had opposing *** effects of dopamine on HCC was reversed by depleting ***23390,a selective DRD1 antagonist,inhibited the proliferation and metastasis of HCC cells both in vitro and in ***:Dopamine secretion was locally increased in HCC and promoted HCC cell proliferation and ***1

关键词： dopamine dopamine receptor D1 hepatocellular carcinoma prognosis target therapy

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Synchronization and Phase Shaping of Single Photons with High-Efficiency Quantum Memory

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Chinese Physics Letters 2021年第9期38卷 52-57页

作者： Keyu Su yunfei Wang Shanchao Zhang Zhuoping Kong Yi Zhong Jianfeng Li Hui yan Shi-Liang Zhu Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Engineering Technology Research Center for Quantum Precision Measurement South China Normal UniversityGuangzhou 510006China

Time synchronization and phase shaping of single photons both play fundamental roles in quantum information applications that rely on multi-photon quantum *** shaping typically requires separate modulators with extra insertion ***,we develop an all-optical built-in phase modulator for single photons using a quantum *** fast phase modulation of a single photon in both step and linear manner are verified by observing the efficient quantum-memory-assisted Hong-Ou-Mandel interference between two single photons,where the anti-coalescence effect of bosonic photon pairs is *** developed phase modulator may push forward the practical quantum information applications.

关键词： quantum typically verified

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Iron-doped Ag/Ni_(2)(CO_(3))(OH)_(2)hierarchical microtubes for highly efficient water oxidation

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Carbon Energy 2022年第5期4卷 939-949页

作者： Huiwen Zhang Shuxuan Liu Enlai Hu yunfei yang Huimin Zhang Yuting Zhu Lijing yan Xuehui Gao Jing Zhang Zhan Lin Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Department of ChemistryZhejiang Normal UniversityJinhuaChina College of Materials and Chemistry China Jiliang UniversityHangzhouChina Guangzhou Key Laboratory of Clean Transportation Energy Chemistry Guangzhou Higher Education Mega CenterGuangdong University of TechnologyGuangzhouGuangdongChina

Doping of foreign atoms and construction of unique structures are considered as effective approaches to design high-activity and strongdurability ***,we report Fe-doped nickel hydroxide carbonate hierarchical microtubes with Ag nanoparticles(denoted Ag/NiFeHC HMTs)through hydrolysis precipitation *** tests and density functional theory calculations reveal that Fe doping can tune the electron configuration to enhance the conductivity,markedly improve the electrochemical surface area to expose more active sites,and act as reactive centers to lower the free energy of the rate determination *** addition,the unique hierarchical structure can also offer active sites and excellent cycling *** from these advantages,the as-obtained Ag/NiFeHC HMTs show excellent oxygen evolution reaction activity,with an overpotential of 208 mV at 10 mA cm^(−2)in 1.0M ***,it could achieve long-term stability at a current density of 20 mA cm^(−2)for 24 h.

关键词： density functional theory Fe doping Ni2(CO3)(OH)2 hierarchical microtubes water oxidation reaction

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Frequency response of autonomous microgrid based on family-friendly controllable loads

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Chinese Science Bulletin 2013年第7期58卷 693-702页

作者： JIA HongJie QI yan MU yunfei Key Laboratory of Smart Grid of Ministry of Education Tianjin University

Frequency is a key issue for the stable operation of autonomous microgrid(AMG) with a large penetration of intermittent renewable energy *** fast development of demand-side response technology provides a new solution for the frequency control of the *** this paper,a novel decentralized demand control strategy(DDC) for family-friendly controllable refrigerators considering customer comfort level is proposed to regulate the frequency of AMG in coordination with the energy storage system(ESS).The refrigerator under DDC responds to the local frequency signals quickly and adjusts its operation cycle ***,a customer participation degree which is proportional to the frequency deviation is introduced to evaluate the customer comforts when responding to the frequency of ***,a benchmark low voltage AMG is established as a test system to verify the effectiveness of the proposed DDC *** results show that the DDC strategy can not only improve the frequency control effect of AMG effectively but also guarantee the customer comforts as well as reduce the capacity of ESS.

关键词：频率响应家庭电网微型基础负荷可控可再生能源

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一种新的基于SOA的多机器人协作分层体系结构

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机器人 2010年第6期32卷 805-811页

作者：蔡云飞唐振民阎岩南京理工大学模式识别与人工智能研究所江苏南京210094

为了研究高效、通用和松耦合的多机器人协作体系结构,提出一种基于SOA(面向服务的架构)的分层体系结构.在分层结构的基础上,以服务为组成元素,设计规范的多机器人SOA协议与接口,在协作中实现对机器人下层功能组件的透明封装和上层服务... 详细信息

为了研究高效、通用和松耦合的多机器人协作体系结构,提出一种基于SOA(面向服务的架构)的分层体系结构.在分层结构的基础上,以服务为组成元素,设计规范的多机器人SOA协议与接口,在协作中实现对机器人下层功能组件的透明封装和上层服务的灵活调用,可以有效避免异构对协作的影响,有利于系统的构建、扩展、重组和维护.实验结果验证了技术的可行性和实用性.

关键词：面向服务的架构(SOA) 多机器人协作分层体系结构

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动静态力共同作用对电抗器铁心振动影响

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电工技术学报 2023年第4期38卷 1104-1114页

作者：闫荣格程云飞省部共建电工装备可靠性与智能化国家重点实验室(河北工业大学) 天津300130 河北工业大学河北省电磁场与电器可靠性重点实验室天津300130

带气隙结构的并联电抗器铁心在实际运行中,除受到螺杆与夹件施加的静态压紧力外,也会受到磁致伸缩力与铁心饼间麦克斯韦力的动态力作用,动静态力都对铁心的磁性能产生影响,进而影响电抗器铁心振动特性。目前的研究主要集中于静态压紧力... 详细信息

带气隙结构的并联电抗器铁心在实际运行中,除受到螺杆与夹件施加的静态压紧力外,也会受到磁致伸缩力与铁心饼间麦克斯韦力的动态力作用,动静态力都对铁心的磁性能产生影响,进而影响电抗器铁心振动特性。目前的研究主要集中于静态压紧力对硅钢片磁特性以及电抗器铁心振动特性的影响,动态力对其影响的研究未见报道,更没有考虑共同作用的影响。该文首先测量动静态力共同作用下硅钢片的磁特性曲线;其次建立考虑动静态力共同作用的电抗器电磁场-机械场双向耦合模型,对并联电抗器进行电磁振动计算;最后搭建振动测量实验平台,实验结果验证了所建模型的正确性与精准性,为进一步分析电抗器振动问题提供理论支持和分析方法。

关键词：并联电抗器动态力磁特性电磁场-机械场模型

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Early Cretaceous Palynological Assemblage of Jiufengshan Formation in Well yang-3 in Dayangshu Basin

Early Cretaceous Palynological Assemblage of Jiufengshan For...

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中国古生物学会古植物学分会、江苏省古生物学会2021年学术年会

作者： ZHANG yan XUE yunfei WAN Chuanbiao SUN Yuewu Research Center of Paleontology and Stratigraphy Jilin University College of Earth Sciences Jilin University Geological Laboratory Exploration and Development Research Institute of Daqing Oilfield Company Ltd.

The Dayangshu Basin,as a Mesozoic faulted-basin in Northeast China,extends in NNE *** in the southern depression of the basin,the Well yang-3 outcropped the Cretaceous non-marine deposits,named as Longjiang,Jiufengshan and Ganhe formations in ascending *** black mudstone samples were collected from the coal-bearing deposit of the Jiufengshan Formation in the horizon(1 804.46～1 896.99 m in depth) of Well *** palynomorphs were recognized in the samples and named as the Osmundacidites-Baculatisporites-Aequitriradite *** is significant in correlation of the Early Cretaceous strata,especially in the regional biostratigraphic correlation of the Jiufengshan *** assemblage is characterized by;①fern spores are diverse,accounting over 70.00% of the palynomorphs;while gymnosperm pollen account for 30.00% and angiosperm pollen are absent.②among the fern spores,Osmundacidites(11.18%),Baculatisporites(7.06%) and Aequitriradites(5.29%) are richest ***(3.53%) and Uvaesporites(3.53%) are *** important genera including Triporoletes,Cicatricosisporites,Foveotriletes,Lygodiumsporites,Yichangsporites,Hsuisporites,Demoisporites,Foraminisporis,Pilosisporites,Leptolepidites and Fixisporites,*** often seen.③gymnosperm pollen are damaged and difficult to be ***,Paleocoliferus,Protoconiferus are *** assemblage is quite similar to the Trilobosporite-Cicatricosisporite-Cycadopites Assemblage established by Pu Ronggan and du Hongzhang(1985)from the coal seams of the Jiufengshan Formation in the Dayangshu Coal-Mine,however,Cycadopites and Trilobosporites were not found in the present samples of the Well *** species of fern spores such as Triporoletes,Cicalricosisporites,Aequitriradites,Yichangsporites,Hsuisporites,Densoisporites are important indicators of Cretaceous age,while others are wide distributed species during Jurassic and Cretaceous time,for examples,Ster

关键词： the Dayangshu Basin Early Cretaceous Palynological assemblage Jiufengshan Formation

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Efficient 671 nm red light generation in annealed proton-exchanged periodically poled LiNbO3 waveguides

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Chinese Optics Letters 2020年第11期18卷 68-71页

作者： yunfei Niu Lei yang Dongjie Guo yan Chen Xiaoyang Li Gang Zhao Xiaopeng Hu National Laboratory of Solid State Microstructures College of Engineering and Applied Sciencesand School of PhysicsNanjing UniversityNanjing 210093China

We report efficient generation of 671 nm red light based on quasi-phase-matched second harmonic generation of 1342 nm in LiNbO3 waveguides. The design method and fabrication process of the high-quality annealed protonexchanged periodically poled channel waveguides were presented. A continuous-wave 1.71 mW red light was obtained with a single-pass conversion efficiency of 47%·W-1·cm-2, which is 88% that of the theoretical *** for 1 mW quasi-continuous-laser input, the corresponding peak power being 2 W, the conversion efficiency reached up to 60%. Our results indicate that the annealed proton-exchanged periodically poled LiNbO3 waveguide is promising for high-efficiency and low power consumption nonlinear generation of visible light.

关键词： lithium niobate second-harmonic generation optical waveguides proton exchange

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The 50 nm-thick yttrium iron garnet films with perpendicular magnetic anisotropy

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Chinese Physics B 2022年第4期31卷 67-72页

作者： Shuyao Chen yunfei Xie Yucong yang Dong Gao Donghua Liu Lin Qin Wei yan Bi Tan Qiuli Chen Tao Gong En Li Lei Bi Tao Liu Longjiang Deng National Engineering Research Center of Electromagnetic Radiation Control Materials University of Electronic Science and Technology of ChinaChengdu 610054China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Yttrium iron garnet(YIG) films possessing both perpendicular magnetic anisotropy(PMA) and low damping would serve as ideal candidates for high-speed energy-efficient spintronic and magnonic ***,it is still challenging to achieve PMA in YIG films thicker than 20 nm,which is a major bottleneck for their *** this work,we demonstrate that this problem can be solved by using substrates with moderate lattice mismatch with YIG so as to suppress the excessive strain-induced stress release as increasing the YIG *** carefully optimizing the growth and annealing conditions,we have achieved out-of-plane spontaneous magnetization in YIG films grown on sGGG substrates,even when they are as thick as 50 ***,ferromagnetic resonance and spin pumping induced inverse spin Hall effect measurements further verify the good spin transparency at the surface of our YIG films.

关键词： spintronics perpendicular magnetic anisotropy magnetic thin film deposition by sputtering

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How to Increase Farmers' Income in the Poor Mountainous Areas ?

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Asian Agricultural Research 2015年第4期7卷 81-83页

作者： yunfei SONG yan LIU Lin ZENG Shunsheng LU Guotian yanG yan SHAN Guixian WU Lamei yanG Agricultural Technique Extension Station in Longyang District

Using the gray system theory and gray relational analysis method,the relationship between added value of hybrid corn,hogs,Juglans sigillata,Pisum Sativum L.,safflower and that of farmers' net income in Bailongjing Village,Wafang Township,Longyang District,Baoshan City,Yunnan Province was analyzed,and the ways to increase farmers' per capita net income were studied. The results showed that economic income of farmers by structure adjustment of agriculture is Juglans sigillata > Pisum Sativum L. > safflower > hogs > hybrid corn. The study can provide scientific basis for optimizing agricultural industrial structure in Baoshan City,and promoting the rapid growth of farmers' economic income.

关键词： Baoshan City Agriculture Industrial structure Gray

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