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Baicalein protects against the development of angiotensin II-induced abdominal aortic aneurysms by blocking JNK and p38 MAPK signaling

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Science China(Life Sciences) 2016年第9期59卷 940-949页

作者： Fang Wang Houzao Chen yunfei yan Yue Liu Shuyang Zhang Depei Liu State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Department of Cardiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

An abdominal aortic aneurysm(AAA) is a permanent, localized dilatation of the abdominal aorta. In western countries, the morbidity of AAA is approximately 8%. Currently, pharmacotherapies for AAA are limited. Here, we demonstrate that baicalein(BAI), the main component of the Chinese traditional drug "Huang Qin", attenuates the incidence and severity of AAA in Apoe儃/儃 mice infused with angiotensin II(AngII). Mechanically, BAI treatment decreases AngII-induced reactive oxygen species(ROS) production in the aortic wall. Moreover, BAI inhibits inflammatory cell accumulation in the aortas of mice infused with AngII. It also inhibits AngII-induced activation of matrix metalloproteinase 2(MMP-2) and MMP-9 to maintain elastin content in vivo. In addition, it blocks AngII cascade by downregulating angiotensin type 1 receptor(AT1R) and inhibiting mitogen-activated protein kinases(MAPKs). Taken together, our findings show that BAI is an effective agent for AAA prevention.

关键词： baicalein abdominal aortic aneurysm oxidative stress vascular inflammation extracellular matrix degradation AT1R MAPKs

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

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BIOCELL 2021年第3期45卷 627-638页

作者： JUNQI GUO YUN yanG WEI ZHAO ZHONGHAI yan XIA yanG yunfei yan RUIMIN HAO JINXIA HU FEI JIAO Department of Biochemistry and Molecular Biology Binzhou Medical UniversityYantai264003China Key Laboratory of Tumor Molecular Biology in Binzhou Medical University Yantai264003China Department of Neurology Columbia UniversityNew York10032USA Department of Cardiology The People’s Hospital of Zhaoyuan CityYantai265400China

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer ***,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well ***,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell *** correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their *** hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter ***,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo ***,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

关键词： miR-16-5p Non–small-cell lung cancer(NSCLC) Fermitin family member 2(FERMT2) Apoptosis Invasion Overall survival(OS)

Quantification constraints on time gap for comagmatic gold deposits:Evidence from chronological statistics

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Chinese Journal Of Geochemistry 2008年第4期27卷 325-334页

作者： TAN Jun WEI Junhao LI Shuiru ZHANG Chunhua LI yanjun GUO Lingli yan yunfei Faculty of Earth Resources China University ofGeosciences Wuhan 430074 China Guangxi Geological Survey Institute Nanning 530023 China China Communications Second Highway Survey Design andResearch Institute Wuhan 430056 China

The time gap between diagenesis and mineralization (TGDM) for comagmatic gold deposits (CGD) plays an important role in confirming the genetic relationship between gold deposits and their related intrusions. With the help of preciously published isotopic ages of some typical gold deposits and their related rocks in China,the authors have discussed and quantified the distribution characteristics and scope of the TGDM. Statistical analyses and Kolmogorov tests showed that mineralizing events are either contemporaneous with or slightly postdate their cognate magma. The TGDM conforms with normal distributions at a 0.05 confidence level and clusters between 0 and 16.0 Ma with a mean of 7.0 Ma. Thus,if the TGDM of CGD is less than 16.0 Ma,it is reasonable to consider,with the aid of other evidence,the possibility of its comagmatic genetic affiliation. The authors also emphasized that to get a precise time gap it is necessary to strengthen the diagenesis-mineralization geological background of the deposits studied,and to pay attention to the study of time gap in combination with trace elements and isotope tracing.

关键词：黄金沉积时间间隙统计分析测试

MicroRNA-181a is elevated by 10-hydroxycamptothecin and represses lung carcinoma progression by downregulating FOXP1

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BIOCELL 2022年第2期46卷 417-431页

作者： LI PAN WENTING YI DONGMIN LIANG YULONG ZHAO RANRAN WANG PINGYU WANG YOUJIE LI JIAXUAN XIN yunfei yan SHUyanG XIE Department of Biochemistry and Molecular Biology Binzhou Medical UniversityYantai264003China Department of Medical Laboratory Yantai Affiliated Hospital of Binzhou Medical UniversityYantai264100China

Tumor progression is usually characterized by proliferation,migration,and angiogenesis,which is essential for supplying both nutrients and oxygen to the tumor ***,targeting angiogenesis has been considered a promising therapeutic strategy for cancer prevention and *** the present study,we demonstrated that in addition to suppressing lung cancer cell proliferation and migration in vitro,10-hydroxycamptothecin(10-HCPT)is also capable of inhibiting angiogenesis in vivo with a miR-181a-dependent ***,by upregulating miR-181a,which in turn downregulating FOXP1,10-HCPT can inhibit the PI3K/Akt/ERK signaling pathwaymediated ***,reduced levels of miR-181a have been found in both lung cancer cell lines and xenograft with concurrently elevated levels of FOXP1,VEGF,bFGF,and *** with the findings from the in vitro experiments,miR-181a impairs neovascularization in our xenograft *** summary,our findings have not only established the anti-oncogenic role of miR-181a in lung cancer angiogenesis but also suggest that 10-HCPT could be a potential therapeutic reagent for lung cancer treatment.

关键词： microRNA-181a 10-hydroxycamptothecin Angiogenesis Lung carcinoma

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甲烷临氧耦合CO_2重整特性的热力学分析

中国电机工程学报 2014年第2期34卷 279-287页

作者：闫云飞王鑫张力低品位能源利用技术及系统教育部重点实验室(重庆大学) 重庆市沙坪坝区400030

从理论上分析了甲烷临氧耦合CO2重整特性的影响因素,并与无氧体系进行了对比。结果表明:温度升高,甲烷和CO2转化率都升高,且整个反应在温度为1100K已表现出良好效果,甲烷及CO2转化率分别达到96.63%和91.73%;氧碳比α增加,甲烷转化率上升... 详细信息

从理论上分析了甲烷临氧耦合CO2重整特性的影响因素,并与无氧体系进行了对比。结果表明:温度升高,甲烷和CO2转化率都升高,且整个反应在温度为1100K已表现出良好效果,甲烷及CO2转化率分别达到96.63%和91.73%;氧碳比α增加,甲烷转化率上升,CO2转化率下降,α=0.5时,甲烷和CO2转化率分别为99.38%和77.35%;CO2甲烷比β增加时,甲烷和CO2转化率呈现出相反的变化趋势,H2和CO收率分别在β为0.7和0.9时出现极大值;α和β对H2/CO比例都会起到重要的调节作用,α的调节范围较窄,α调节范围较宽;与无氧体系相比,甲烷转化率会高于相同工况下无氧体系的转化率(如950K时有氧体系甲烷转化率为72.58%,已高于1000K时无氧系统时甲烷转化率71.07%),α增加时,CO2转化率与甲烷转化率变化趋势相反,且对于H2/CO调节作用也有较大差异。

关键词：组分变化平衡常数法甲烷临氧 H2 CO比

压力和温度对用于燃料电池的微型反应器内甲烷自热重整特性的影响

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中国电机工程学报 2012年第26期32卷 65-71,148页

作者：闫云飞刘科张力低品位能源利用技术及系统教育部重点实验室(重庆大学) 重庆市沙坪坝区400044

采用CHEMKIN化学反应动力学软件及计算流体力学软件CFD等数值方法详细探讨了在微尺度内甲烷自热重整反应中温度和压力对出口组分摩尔分数的影响和催化壁面总积碳量的影响.结果表明,当温度超过873 K,会促进水煤气转化反应的发生,导致氢... 详细信息

采用CHEMKIN化学反应动力学软件及计算流体力学软件CFD等数值方法详细探讨了在微尺度内甲烷自热重整反应中温度和压力对出口组分摩尔分数的影响和催化壁面总积碳量的影响.结果表明,当温度超过873 K,会促进水煤气转化反应的发生,导致氢气减少、水和一氧化碳增加,用于燃料电池的微型反应器内甲烷自热重整的温度不宜超过1000K,此时重整合成气中氢气的摩尔分数可达54.05%,一氧化碳的摩尔分数为9.98%;从能效、积炭和燃料电池的原料气的要求分析,用于燃料电池的微型反应器内甲烷自热重整的反应压力应低于1.8105Pa;同时在1000K左右,积炭过程和消炭过程可到达一个平衡阶段,有利于催化剂寿命的延长。

关键词：微型反应器燃料电池甲烷自热重整压力温度积炭

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基于幂法则的太阳能热风系统性能研究

太阳能学报 2016年第1期37卷 157-163页

作者：闫云飞代长林张力低品位能源利用技术及系统教育部重点实验室(重庆大学) 重庆400030 重庆大学动力工程学院重庆400030

利用数值模拟方法研究温升、"抽力"与体积流量关系以及集热棚半径、涡轮压降对系统性能参数的影响规律,所得的温升-体积函数关系可为初始设计中系统及设备性能的分析、控制算法的设计提供帮助。结果表明,"抽力"与体积流量间函数以最佳... 详细信息

利用数值模拟方法研究温升、"抽力"与体积流量关系以及集热棚半径、涡轮压降对系统性能参数的影响规律,所得的温升-体积函数关系可为初始设计中系统及设备性能的分析、控制算法的设计提供帮助。结果表明,"抽力"与体积流量间函数以最佳流量为分界点呈不同关系:低于最佳流量时,"抽力"是流量的一次函数;大于最佳流量时,"抽力"是流量的幂函数,其指数m与最佳压降比f_(opt)存在关系f_(opt)=(2-m)/3,通过幂函数求得的系统最大功率、最佳涡轮压降比与实际值的误差均在3.5%内。随着集热棚半径的增大,幂函数指数、一次函数斜率、系统功率、空气温升、蓄热层温升等均表现出增大趋势,最佳压降比、集热棚净效率、单位面积功率及热流密度均呈减小趋势。随涡轮压降增大,空气温升速率增大、"抽力"增大速率逐渐增大,且涡轮压降增大与"抽力"增大的共同作用导致流量随涡轮压降增大而线性减小。

关键词：幂法则最佳压降比集热棚半径抽力

Low Power Consumption Thermo-optical Switch based on DR1/PMMA

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Low Power Consumption Thermo-optical Switch based on DR1/PMM...

全国第15次光纤通信暨第16届集成光学学术会议

作者： Zijian Cao yunfei yan Jie Meng Lin Jin Daming Zhang State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin University

In this paper,a low power consumption thermo-optical switch based on DRl/PMMA materials was *** material is easy to synthesis and has high cost-performance,high thermo-coefficient and the other advantages for electro-optical device. SiO was chosen as substrate material,DRl/PMMA as the core material and PMMA as the cladding *** SiO substrate can make the optical filed distribution near the heater,this structure is good for improve the modulation *** rectangle waveguide based Mach-Zehnder interferometer was chosen for this device.A coplanar waveguide electrode was chosen as figure 1. The coplanar waveguide heater ensured the high frequency response of *** the meanwhile, it is a heat sink can prevent the thermo power *** length of device is 3.5 cm and the length of heater is 1.5 *** test results show the power consumption is 30 mW and the extinction ratio is 19 dB.. The rise time and fall time are less than 0.5 *** work gives important information for design and fabrication of electro-optical and thermo-optical hybrid integrated devices.

关键词： DR1/PMMA Optical Switch Mach-Zehnder

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A QUESTION OF TASTE

The World of Chinese 2020年第1期 48-52页

作者： yan yunfei 不详

Since becoming mass-produced on the mainland in the 1970 s, MSG has been ubiquitous in Chinese cooking—until *** fads and food safety scares are pointing diners to alternative condiments and to rethink what makes foo... 详细信息

关键词： cooking mainland becoming