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Anti-wear beam effects on gas-solid hydrodynamics in a circulating fluidized bed

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Particuology 2015年第2期13卷 173-184页

作者： yunfei xia Leming Cheng Chunjiang Yu Linjie Xu Qinhui Wang Mengxiang Fang State Key Laboratory of Clean Energy Utilization Zhejiang University

Anti-wear beams installed on water walls of circulating fluidized bed （CFB） boilers are one of the most effective ways to protect against water-wall erosion. Beam effects from, for example, beam size and superficial gas velocity were investigated on gas-solid hydrodynamics in a CFB test rig using CFD simulations and experimental methods. The downward flow of the wall layer solids is observed to be disrupted by the beam but is then restored some distance further downstream. When falling solids from the wall layer hit the anti-wear beam, the velocity of the falling solids decreases rapidly. A fraction of the solids accumulates on the beam. Below the beams, the falling solids have reduced velocities but upward-moving solids were observed on the wall. The effect of the beam increases with width and superficial gas velocity. Wear occurs mainly above the beam and its variation with width is different above to below the beam. There is an optimum width that, when combined with beam height, results in less erosion.

关键词： Circulating fluidized bed Gas-solid hydrodynamics Anti-wear beam

Void fraction for random loose packing of the cylindrical particles considering filling rate,material and shape

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Particuology 2022年第4期20卷 35-46页

作者： Chengquan Zhang Jun Gao Yukun Xu yunfei xia xiaobin Wei Xing Su Lingjie Zeng School of Mechanical Engineering Tongji UniversityShanghaiChina

Particle packing is widely applied in organic pollutant adsorption,catalytic *** combustion,nuclear cooling,and other *** to the complexity of the shape,the studies on the void fraction of the cylindrical particles are not as thorough as the spherical *** study investigated the influence of the flling rate,material properties and sphericity on the void fraction of cylinders through experiments and ***(discrete element method)was validated by the internal structures of the packing obtained by CT(computed tomography).Based on the logarithmic correlation between the void fraction and flling rate,an ingenious framework for predicting the void fraction of cylindrical particles was presented with two intermediate *** correlating the coefficients with the material property and sphericity,a novel void-fraction prediction model was established with R-squared of *** mechanism of void fraction under random loose packing for cylinders was eventually found in this study.

关键词： Void fraction Random loose packing Cylindrical particles Prediction model DEM

Mannose metabolism and immune regulation:Insights into its therapeutic potential in immunology-related diseases

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BIOCELL 2023年第11期47卷 2535-2546页

作者： QINGPAN BU PING LI yunfei xia XINPEI WEI KAI SONG School of Life Sciences Changchun Normal UniversityChangchun130032China

Mannose,a different isomer of the hydroxyl group at the C-2 position of glucose,shares the same transport carrier protein with glucose to enter cells and participate in the regulation of glucose *** affects cell growth,differentiation,and function and plays an active role in tumor immunity and inflammatory *** paper provides theoretical support for expanding the clinical applications of mannose by exploring its constitution,metabolic pathways,and role in regulating immune cell function and treating immunology-related diseases.

关键词： Mannose Metabolism Immune cell Immune regulation

Characteristic absorption peak of the human blood measured with differential photoacoustic spectroscopy

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Chinese Science Bulletin 2002年第24期47卷 2029-2033页

作者： TANG Zhilie LIU Jinlong xia yunfei SU Yong LIANG Luisheng CHEN Gengsheng Department of Physics South China Normal UniversityGuangzhou 510631China Cancer Center Sun Yat-Sen UniversityGuangzhou510060China

A new highly sensitive spectroscopy technique-differential photoacoustic spectroscopy (PAS) is presented in this paper. The blood samples from 3 healthy persons, patients with leukemia, patients with pregnancy-induced hypertension (PIH), and 40 patients with nasopharyngeal carcinoma were measured by the PAS technique. The normalized, the first order, and the second order differential photo-acoustic spectroscopy of the blood were gained. The results show that ( i) weak absorption peaks or shoulder peaks, which could not be found using conventional photoacoustic spectroscopy, were determined by the first order and the second order differential photoacoustic spectroscopy which significantly improve the sensitivity of detection; and (ii) that two characteristic absorption peaks were found at the wavelength of 637 and 664 nm in all persons’ blood samples by the differential photoacoustic spectroscopy technique. This experiment concludes that the differential photoacoustic spectroscopy technique is superior

关键词： photoacoustic spectroscopy differential spectroscopy characteristic absorption peak.

Revalidation of a prognostic score model based on complete blood count for nasopharyngeal carcinoma through a prospective study

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Chinese Journal of Cancer Research 2016年第5期28卷 467-477页

作者： xiaohui Li Hui Chang Yalan Tao xiaohui Wang Jin Gao Wenwen Zhang Chen Chen yunfei xia Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Guangzhou 510060 China Department of Oncology the 421 Hospital of Chinese People's Liberation Army Guangzhou 510318 China Department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei 230001 China

Objective： In our previous work, we incorporated complete blood count （CBC） into TNM stage to develop a new prognostic score model, which was validated to improve prediction efficiency of TNM stage for nasopharyngeal carcinoma （NPC）. The purpose of this study was to revalidate the accuracy of the model, and its superiority to TNM stage, through data from a prospective ***： CBC of 249 eligible patients from the 863 Program No. 2006AA02Z4B4 was evaluated. Prognostic index （PI） of each patient was calculated according to the score model. Then they were divided by the PI into three categories： the low-, intermediate-and high-risk patients. The 5-year disease-specific survival （DSS） of the three categories was compared by a log-rank test. The model and TNM stage （Tth edition） were compared on efficiency for predicting the 5-year DSS, through comparison of the area under curve （AUC） of their receiver-operating characteristic ***： The 5-year DSS of the low-, intermediate- and high-risk patients were 96.0%, 79.1% and 62.2%, respectively. The low- and intermediate-risk patients had better DSS than the high-risk patients （P〈0.001 and P〈0.005, respectively）. And there was a trend of better DSS in the low-risk patients, compared with the intermediate-risk patients （P=0.049）. The AUC of the model was larger than that of TNM stage （0.726 vs. 0.661, P：0.023）. Conclusions： A CBC-based prognostic score model was revalidated to be accurate and superior to TNM stage on predicting 5-year DSS of NPC.

关键词： Complete blood count score model revalidadon disease-specific survival nasopharyngeal carcinoma

Recent advances in high-loading catalysts for low-temperature fuel cells: From nanoparticle to single atom

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SusMat 2021年第4期1卷 569-592页

作者： Lixiao Shen Miao Ma Fengdi Tu Zigang Zhao yunfei xia Kokswee Goh Lei Zhao Zhenbo Wang Guangjie Shao College of Environment and Chemical Engineering State Key Laboratory of Metastable Materials Science and TechnologyHebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource ReuseYanshan UniversityQinhuangdaoP.R.China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Lab of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinP.R.China

Low-temperature fuel cells(LTFCs)are considered to be one of the most promising power sources for widespread application in sustainable and renew-able energy conversion *** remarkable advances have been made in the mass activity of catalysts,mass transport impedance needs to be urgently addressed at a well-designed membrane electrode assembly(MEA)*** the loading of electrocatalysts is conducive to prepare thinner and more efficient MEAs owing to the resulting enhanced reactant permeability,better proton diffusion,and lower electrical ***,recent progress in high-loading(≥40 wt.%)Pt nanoparticle catalysts(NPCs)and high-loading(≥2 wt.%)single-atom catalysts(SACs)for LTFC applications are reviewed.A summary of various synthetic approaches and support materials for high-loading Pt NPCs and SACs is systematically *** influences of high surface area and appropriate surface functionalization for Pt NPCs,as well as coordina-tion environment,spatial confinement effect,and strong metal-support interac-tions(SMSI)for SACs are ***,this review presents some ideas regarding challenges and future opportunities of high-loading catalysts in the application of LTFCs.

关键词： high-loading catalysts low-temperature fuel cells membrane electrode assembly nanoparticle catalysts single-atom catalysts

Target delineation and dose prescription of adaptive replanning intensity-modulated radiotherapy for nasopharyngeal carcinoma

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Cancer Communications 2019年第1期39卷 174-177页

作者： Dehuan Xie Wanqin Cheng Shaowen Lv Rui Zhong Lei Wang Jiang Hu Mingli Wang Shaomin Huang Yong Su yunfei xia Department of Radiation Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in Southern ChinaCollaborative Innovation Center for Cancer Medicine651 Dong Feng Road EastGuangzhou 510060GuangdongP.R.China Department of Oncology Shunde Hospital of Southern Medical UniversityFoshan 528399GuangdongP.R.China Department of Radiation Oncology Hainan General HospitalHaikou 570100HainanP.R.China Department of Radiation Oncology National Cancer Center/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116GuangdongP.R.China

Dear Editor,Intensity-modulated radiotherapy(IMRT)has a distinct advantage of high conformity and is an appropriate tech-nique for treating nasopharyngeal carcinoma(NPC).Pre-vious studies have demonstrated that anatomical changes in the external contour,shape,and location of the target and critical structures are significant and result in dosi-metric changes[1,2].Patients’quality of life and clini-cal outcomes might be improved by IMRT replanning[3].Therefore,replanning strategies should be consid-ered instead of single-planning strategies throughout the entire course of ***,there are sub-stantial controversies on(1)the appropriate time for tar-get redelineation,(2)how to modify the target volumes,and(3)how to evaluate the modified *** present study provides a new perspective in replanning with regard to these three aspects.

关键词： radiotherapy nasopharyngeal prescription

Treatment results and prognostic analysis of 1093 primary nasopharyngeal carcinoma: the experience of a single institution of Guangzhou in the beginning of the 21st century

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The Chinese-German Journal of Clinical Oncology 2008年第4期7卷 187-195页

作者： xiaoqing Liu Wei Luo Mengzhong Liu Ling Ye Ying Sun yunfei xia Department of Radiation Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China

Objective： To analyze the treatment results of primary nasopharyngeal carcinoma （NPC） treated in our institution in the beginning of the 21st century to identify key failures and late effects for refining future treatments. Methods： 1093 patients with primary NPC treated during December 2001 and June 2003 were retrospectively analyzed. The distribution according to the AJCC/UICC （2002 edition） staging system was stage Ⅰ in 5.8%, stage Ⅱ 40.2%, stage Ⅲ 32.7% and stage Ⅳa-b 21.3%. Four different ERT techniques were used： fluoroscopy simulation conventional radiotherapy （CR） in 74.3% of patients, computer tomography simulation conventional radiotherapy （CT-sim CR） 14.2%, three-dimensional conformal radiotherapy （3D-CRT） 6.3%, intensity modulated radiotherapy （IMRT） 5.2%. In the whole series, 46.7% of patients had additional treatment with chemotherapy. Results： The 4-year local failure-free rate （LFFR）, nodal failure-free rate, distant metastasis-free rate, progression-free survival and overall survival （OS） was 89.6%, 96.1%, 85.9%, 73.0% and 82.4%, respectively. The stage was the most important prognostic factor. The 4-year OS and LFFR of patients treated by CR, CT-sim CR, 3D-CRT and IMRT was 80.2%, 89.8%, 89.8%, 92.4% and 87.7%, 96.4%, 91.0%, 96.5%, respectively. The morbidity and degree of xerostomia and trismus were lower in the patients treated by 3D-CRT and IMRT than by CR and CT-sim CR. Conclusion： Treatment results of primary NPC in our institution have been substantially improved. Distant metastasis is the main failure. The CT simulation and conformal radiotherapy can enhance the OS and LFFR, and conformal radiotherapy can reduce the morbidity and degree of late effects.

关键词： nasopharyngeal carcinoma external beam radiation therapy conformal radiotherapy survival pattern of failure

Effectiveness and safety of different amifostine regimens：Preliminary results of a phase Ⅱ multicenter randomized controlled trial

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Chinese Journal of Cancer Research 2018年第3期30卷 307-314页

作者： Hui Chang Wei Yi xiaohui Wang Yalan Tao Xin Yang Chen Chen Wenwen Zhang Shu Zhou Songran Liu xiaohui Li Shirong Ding Jing Li Gong Li Xunfan Shao Yimin Liu Weishu Song yunfei xia Departrnent of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Guangzhou 510060 China Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China Department of Oneology People's Liberation Army 421 Hospital Guangzhou 510318 China Department of Oncology the Main Guangzhou Hospital of the Guangzhou Military Region Guangzhou 510010 China Department of Oneology Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510530 China Department of Radiation Oneology the Affiliated Cancer Hospital of Guangzhou Medical College Guangzhou 510095 China Department of Radiation Ontology the Second Affiliated Hospital Sun Yat-Sen University Guangzhou 510120 China Department of Oneology Guangdong Second People's Hospital Guangzhou 510317 China

Objective：The radioprotective effects of amifostine remain uncertain in patients with nasopharyngeal carcinoma（NPC）,and adverse effects and cost limit generalization of its classical everyday *** phase II multicenter randomized controlled trial aimed to explore whether amifostine could ameliorate the toxicities of NPC patients in the era of intensity-modulated radiotherapy（IMRT）,and to compare different regimens of amifostine on effectiveness and ***：Patients with stage I–IVB NPC were involved prospectively from January 1st,*** patients received radical treatment based on *** a randomization stratified by their stage,these patients were allocated into 3 groups：the group treated without amifostine,the group treated with the everyday regimen of amifostine,and the group treated with the every-other-day *** 3 groups of patients were compared on radiotherapy-related acute toxicities,treatment effects of NPC,and amifostine-related *** trial was registered on the ***（ID：NCT01762514）.Results：Until August 31st,2017,totally 187 patients completed experimental *** amifostine of everyday regimen appeared to reduce the patient proportion of mucositis（79.1%vs.96.8%,P=0.002）.Hypocalcemia was less common in patients treated without amifostine than in those treated with amifostine（22.6%vs.53.4%vs.41.8%,P=0.002）.Neither complete remission rates nor the survivals were affected by ***：Amifostine of everyday regimen could reduce mucositis in NPC patients who received IMRT,though it also had the possibility to cause more hypocalcemia.

关键词： Nasopharyngeal carcinoma amifostine intensity-modulated radiotherapy acute toxicity