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MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder

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General Psychiatry 2024年第1期37卷 151-162页

作者： Panpan Hu Qiuchen Cao Hu Feng yun liu Yan Chen Jingfan Xu Weixi Feng Huaiqing Sun Huachen Ding Chun Wang Junying Gao Ming Xiao Jiangsu Key Laboratory of Neurodegeneration Nanjing Medical UniversityNanjingJiangsuChina Department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Nanjing Brain Hospital Affliated to Nanjing Medical University NanjingJiangsuChina Functional Brain Imaging Institute of Nanjing Medical University NanjingJiangsuChina

Background Increasing evidence supports the role of microRNAs(miRNAs)in major depressive disorder(MDD),but the pathophysiological mechanism remains *** To explore the mechanism of microRNA-451a(miR-451a)in the pathology and behaviours of *** Abnormal miRNAs such as miR-451a reported previously in the serum of patients with MDD were screened and then confirmed in a mouse model of depression induced by chronic restraint stress(CRS).Eight-week-old male C57BL/6 mice had miR-451a overexpression in the medial prefrontal cortex(mPFC)via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451a-GFP fusion protein followed by behavioural and pathological ***,molecular biological experiments were conducted to investigate the potential mechanism of miR-451a against *** The serum levels of miRNA-451awere significantly lower in patients with MDD,with a negative correlation with the Hamilton Depression Scale ***,a negative association between serum miR-451a and behavioural despair or anhedonia was observed in CRS ***,miR-451a expression was significantly downregulated in the mPFC of CRS-susceptible *** miR-451a in the mPFC reversed the loss of dendritic spines and the depression-like phenotype of CRS ***,miR-451a could inhibit CRS-induced corticotropin-releasing factor receptor 1 expression via targeting transcription factor 2,subsequently protecting dendritic spine *** Together,these results highlighted miR-451a as a candidate biomarker and therapeutic target for MDD.

关键词： therapeutic medial behaviour

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单元教学视域下高中历史情境链的设计思路

教学与管理 2024年第22期 47-51页

作者：刘运浙江大学附属中学杭州310007

单元教学是高中历史常用的教学方法,自统编教材投入使用以来,单元教学更是成为教学大势,但在单元教学实施过程中存在情境设计与运用缺乏整体性的问题,易导致学生知识与思维的断层。而历史情境链具有整体性、渐进性、问题性等特征,可将... 详细信息

单元教学是高中历史常用的教学方法,自统编教材投入使用以来,单元教学更是成为教学大势,但在单元教学实施过程中存在情境设计与运用缺乏整体性的问题,易导致学生知识与思维的断层。而历史情境链具有整体性、渐进性、问题性等特征,可将不同的历史教学情境有逻辑地串联起来,促进单元知识的整合与贯通,发展学生历史思维,从而提升单元教学效果。在单元教学视域下合理设计历史情境链,需要厘清单元逻辑,明确情境链设计的方向;把握单元关键问题,抓住情境链设计的重心;挖掘单元立意,彰显情境链设计的价值。

关键词：单元教学高中历史情境链设计历史教学

Risk factors and risk prediction model for mucocutaneous separation in enterostomy patients:A single center experience

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World Journal of Clinical Cases 2024年第33期12卷 6620-6628页

作者： yun liu Hong Li Jin-Jing Wu Jian-Hong Ye Department of Reconstructive Hand and Plastic SurgeryZhejiang Chinese Medical UniversityLishui Central Hospital289 Kuocang RoadLiandu DistrictLishui 323000Zhejiang ProvinceChina Department of Operation Room Zhejiang Chinese Medical UniversityLishui Central Hospital289 Kuocang RoadLiandu DistrictLishui 323000Zhejiang ProvinceChina

BACKGROUND Mucocutaneous separation(MCS)is a common postoperative complication in enterostomy patients,potentially leading to significant *** identification of risk factors is crucial for preventing this ***,predictive models for MCS remain *** To construct a risk prediction model for MCS in enterostomy patients and assess its clinical predictive *** A total of 492 patients who underwent enterostomy from January 2019 to March 2023 were included in the *** were divided into two groups,the MCS group(n=110),and the non-MCS(n=382)based on the occurrence of MCS within the first 3 weeks after *** and multivariate analyses were used to identify the independent predictive factors of MCS and the model *** operating characteristic curve analysis was used to assess the model’s *** The postoperative MCS incidence rate was 22.4%.Suture dislodgement(P<0.0001),serum albumin level(P<0.0001),body mass index(BMI)(P=0.0006),hemoglobin level(P=0.0409),intestinal rapture(P=0.0043),incision infection(P<0.0001),neoadjuvant therapy(P=0.0432),stoma site(P=0.0028)and elevated intra-abdominal pressure(P=0.0395)were potential predictive factors of *** dislodgement[P<0.0001,OR:28.007595%CI:(11.0901-82.1751)],serum albumin level(P=0.0008,OR:0.3504,95%CI:[0.1902-0.6485]),BMI[P=0.0045,OR:2.1361,95%CI:(1.2660-3.6235)],hemoglobin level[P=0.0269,OR:0.5164,95%CI:(0.2881-0.9324)],intestinal rapture[P=0.0351,OR:3.0694,95%CI:(1.0482-8.5558)],incision infection[P=0.0179,OR:0.2885,95%CI:(0.0950-0.7624)]and neoadjuvant therapy[P=0.0112,OR:1.9769,95%CI:(1.1718-3.3690)]were independent predictive factors and included in the *** model had an area under the curve of 0.827 and good clinical utility on decision curve *** The mucocutaneous separation prediction model constructed in this study has good predictive performance and can provide a reference for early warning of mu

关键词： Enterostomy Mucocutaneous separation Risk assessment model Performance validation

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净水厂气浮单元的系统性工艺优化及技术改造

中国给水排水 2024年第16期40卷 101-105页

作者：刘云奎上海市政工程设计研究总院<集团>有限公司上海200092

山东省M水厂设计规模为10×10^(4) m^(3)/d,原水为水库水。2003年增设气浮单元,包括静态管道混合器、穿孔旋流池和气浮池。针对气浮单元实际运行期间出现的问题,采取了相应改进措施:将现状管道混合、穿孔旋流工艺优化为机械混合和机械... 详细信息

山东省M水厂设计规模为10×10^(4) m^(3)/d,原水为水库水。2003年增设气浮单元,包括静态管道混合器、穿孔旋流池和气浮池。针对气浮单元实际运行期间出现的问题,采取了相应改进措施:将现状管道混合、穿孔旋流工艺优化为机械混合和机械絮凝工艺;采用高速气浮技术,将液面负荷由原设计的5.6 m^(3)/(m^(2)·h)增至12.1 m^(3)/(m^(2)·h),由此将分离区长度缩短至8.0 m,节省的空间改造为直板絮凝区和气浮出水区;优化了溶气罐布置,缩短了溶气水管长度;采用集水更均匀且与高速气浮技术耦合的大阻力配水板,改进了气浮集水方式;气浮刮渣水位控制方式由电动调节阀改为即时联动更快捷的电动堰门,操作更加直观便利。

关键词：高速气浮液面负荷大阻力配水板

Tandem asymmetric dearomatized functionalization reaction of phenols with Evans-ynamides enabled by divergent electrophiles

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Science China Chemistry 2024年

作者： Ying-Qi Zhang Gan-Lu Qian yun liu Jia-Hui Li Xin Hong Zhou Xu Bo Zhou Long-Wu Ye State Key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering Xiamen University Center of Chemistry for Frontier Technologies Department of Chemistry State Key Laboratory of Clean Energy Utilization Zhejiang University Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of Pharmacy Xuzhou Medical University State Key Laboratory of Elemento-Organic Chemistry Nankai University State Key Laboratory of Organometallic Chemistry Chinese Academy of Sciences

Herein, we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic enones. Besides, the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high efficiency. Moreover, the enantioselectivities of these products can be perfectly induced by Evans auxiliaries (99%ees). Significantly, this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives, but also constitutes the first asymmetric halogenation/selenation of ynamides. Theoretical calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

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Bidirectional relationship between diabetes mellitus and depression:Mechanisms and epidemiology

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World Journal of Psychiatry 2024年第10期14卷 1429-1436页

作者： yun liu Shi-Yan Huang De-Le liu Xin-Xing Zeng Xiao-Rui Pan Jie Peng Department of Psychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNumber 43Shangfang RoadNanchang 330029China The Second Clinical Medical College Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Psychosomatic Medicine Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina

Diabetes mellitus and depression exhibit a complex bidirectional relationship that profoundly impacts patient health and quality of *** review explores the physiological mechanisms,including inflammation,oxidative stress,and neu-roendocrine dysregulation,that link these *** factors such as social support and lifestyle choices also contribute *** insights reveal a higher prevalence of depression among diabetics and an in-creased risk of diabetes in depressed individuals,influenced by demographic *** management strategies combining mental health asse-ssments and personalized treatments are *** research should focus on longitudinal and multi-omics studies to deepen understanding and improve therapeutic outcomes.

关键词： Diabetes Depression Mechanisms Epidemiology Bidirectional relationship

Macrophage polarization disorder in the endometrial immune microenvironment may contribute to recurrent implantation failure

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Reproductive and Developmental Medicine 2024年第3期8卷 162-168页

作者： yun liu Xian-Ming Tan Tian-Tian He Department of Obstetrics and Gynecology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Department of Obstetrics The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000China

Objective:To investigate the role and mechanisms by which macrophages(MΦ)contribute to the immune environment of the endometrium in cases of recurrent implantation failure(RIF).Methods:Endometrial transcriptome data from women with and without RIF(control group)were *** CIBERSORT software was used to determine the abundance of immune cells within the endometrial tissue based on expression *** gene co-expression network analysis was used to identify crucial regulatory genes and ***:Application of CIBERSORT confirmed significant infiltration of macrophages in the RIF ***6,TTC21A,KLHL31,NFIA,TNNT1,TPM1,CPVL,FUS,PEX5,and SLC43A3 were all closely correlated with M2 and M0 *** and DisNor analyses revealed that these genes contribute to the regulation of macrophage polarization via the Wnt signaling ***:This study identified dysregulation of macrophage polarization within the immune microenvironment of the endometrium in patients with RIF.A comprehensive analysis was conducted to investigate the potential mechanisms underlying this *** of macrophage polarization in the endometrium of patients with RIF is strongly associated with the Wnt signaling pathway.

关键词： Macrophage Polarization disorder Immune microenvironment Recurrent implantation failure Assisted reproductive technology

带有摩擦耗能组件的可更换钢梁柱拼接节点抗震性能试验

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吉林大学学报（工学版） 2024年第6期54卷 1643-1656页

作者：刁延松任义建杨元强赵凌云刘秀丽刘芸青岛理工大学土木工程学院山东青岛266525

基于可恢复功能的抗震设计理念,提出了一种带有摩擦耗能组件的可更换钢梁柱拼接节点。该节点同时利用屈服和摩擦两种机制进行耗能,具有延性好、损伤可控及损伤后可更换等优点。设计制作了缩尺比为1∶1.5的2个可更换钢梁柱拼接节点和1个... 详细信息

基于可恢复功能的抗震设计理念,提出了一种带有摩擦耗能组件的可更换钢梁柱拼接节点。该节点同时利用屈服和摩擦两种机制进行耗能,具有延性好、损伤可控及损伤后可更换等优点。设计制作了缩尺比为1∶1.5的2个可更换钢梁柱拼接节点和1个悬臂段螺栓连接钢梁柱节点试验模型,分别对其进行拟静力试验。对破坏后的2个可更换钢梁柱拼接节点试件进行修复,并进行二次加载,得到了节点试件在低周往复荷载作用下的滞回曲线、骨架曲线、刚度退化曲线、应变和位移曲线、延性及耗能等抗震性能指标。结果表明:提出的可更换钢梁柱拼接节点的延性及耗能能力均优于悬臂段螺栓连接钢梁柱节点;可更换钢梁柱拼接节点的塑性损伤主要集中在可更换构件上,而主体构件基本保持在弹性工作范围内;修复后的节点几乎完全恢复了抗震性能,满足可更换性的要求。

关键词：结构工程可恢复功能可更换钢梁柱拼接节点抗震性能摩擦耗能拟静力试验

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微无创与人工智能融合在盆底疾病诊治中的应用及展望

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中国实用妇科与产科杂志 2024年第9期40卷 882-886页

作者：刘萍刘云鹭南方医科大学南方医院妇产科广东广州510515 深圳市人民医院(暨南大学第二临床医学院南方科技大学第一附属医院)妇科广东深圳518020

盆底功能障碍是一类严重影响女性生活质量的疾病,全面、准确地评估盆底疾病与治疗方案的制定及相应疗效密切相关。近年来,在原有检查手段的基础之上,应用人工智能技术对盆底疾病进行诊治初见成效,尤其是微无创作为近代医学的发展趋势,... 详细信息

盆底功能障碍是一类严重影响女性生活质量的疾病,全面、准确地评估盆底疾病与治疗方案的制定及相应疗效密切相关。近年来,在原有检查手段的基础之上,应用人工智能技术对盆底疾病进行诊治初见成效,尤其是微无创作为近代医学的发展趋势,其与人工智能相融合,将给这一领域的发展注入新的活力。文章就微无创及人工智能技术在盆底疾病诊治中的应用及相关问题进行讨论,并且对未来的发展方向进行展望。

关键词：盆底功能障碍微无创人工智能