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靶向TSPO分子探针^(18)F-FDPA和^(18)F-LW223用于兔腹主动脉粥样硬化易损斑块PET显像的对比研究

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中华核医学与分子影像杂志 2024年第8期44卷 478-483页

作者：李全牟甜甜张颖田毅贠明凯胡标张烨虹解小芬董薇米宏志首都医科大学附属北京安贞医院核医学科北京100029

目的比较靶向相对分子质量1.8×10^(4)转位蛋白(TSPO)的分子探针N,N-二乙基-2-[2-(4-^(18)F-氟苯基)-5,7-二甲基吡唑[1,5-a]并嘧啶-3-基]乙酰胺(^(18)F-FDPA)和^(18)F-(R)-(N-仲丁基)-3-氟甲基-N-甲基-4-苯基喹啉-2-甲酰胺(LW223)用于探测兔腹主动脉粥样硬化易损斑块(VAP)的可行性和效能。方法选取9只健康新西兰大白兔,用完全随机法分为3组(每组3只):正常对照组(A组)、VAP组(B组)和VAP治疗组(C组),分别于造模后第12、16和24周末注射^(18)F-FDPA和^(18)F-LW223,并于注射后40~50 min行活体腹主动脉PET/CT和同机CT血管成像(CTA)。所有显像结束后,处死全部动物,行腹主动脉病理学及免疫荧光检测。采用重复测量方差分析(Bonferroni法)和配对t检验分析数据。结果^(18)F-FDPA在3组不同时间点(第12、16和24周末)PET/CTA同机显像中,靶本比(TBR;腹主动脉病灶/左心室血池)值间差异均有统计学意义(F值:68.09~144.88,均P<0.001)。在第12周末显像中,3组腹主动脉区域均无明显显像剂摄取增高灶。在第16和24周末显像中,B组腹主动脉局部的摄取均高于同期时间点的C组(均P<0.05)和A组(均P<0.001);C组腹主动脉局部的摄取高于同期时间点的A组(均P<0.01)。3组不同时间点PET/CTA图像中,腹主动脉区域均无明显^(18)F-LW223摄取增高灶。在上述3个不同时间点,3组^(18)F-FDPA和^(18)F-LW223的TBR值间差异均有统计学意义(t值:2.88~36.79,均P<0.05)。病理HE、免疫荧光CD68和TSPO染色显示,B组^(18)F-FDPA高摄取易损斑块处巨噬细胞浸润数量多于C组。结论与^(18)F-LW223相比,^(18)F-FDPA可用于早期探测兔腹主动脉易损斑块,并可评估降脂药物干预后易损斑块稳定性的变化。

关键词：斑块动脉粥样硬化主动脉腹受体 FDPA 氟放射性同位素正电子发射断层显像术兔

CZT心脏专用SPECT心肌血流定量技术临床应用中国专家共识

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国际放射医学核医学杂志 2024年第4期48卷 207-214页

作者：余飞李剑明张涵刘海燕武萍何薇尚华肖俊杰贠明凯李殿富张晓丽李思进同济大学核医学研究所同济大学附属第十人民医院核医学科上海200040 泰达国际心血管病医院核医学科天津300457 山西医科大学第一医院核医学科太原030001 复旦大学附属华东医院核医学科上海200040 河北医科大学第二医院核医学科石家庄050000 上海大学心血管研究所上海器官修复工程技术研究中心上海200444 首都医科大学附属北京安贞医院核医学科北京100069 南京医科大学附属第一医院心血管内科南京210029

PET/CT心肌血流量(MBF)定量技术被认为是目前无创评估MBF和心肌血流储备(MFR)的“金标准”,但由于受正电子心肌灌注显像药物获取困难等多种因素的限制,该技术在我国临床实践工作中开展的并不理想。采用全新半导体碲锌镉(CZT)探测器的心... 详细信息

PET/CT心肌血流量(MBF)定量技术被认为是目前无创评估MBF和心肌血流储备(MFR)的“金标准”,但由于受正电子心肌灌注显像药物获取困难等多种因素的限制,该技术在我国临床实践工作中开展的并不理想。采用全新半导体碲锌镉(CZT)探测器的心脏专用SPECT定量技术近些年在国内逐步开展,可实现定量评估MBF和MFR。本专家共识介绍了CZT心脏专用SPECT MBF定量技术的相关药物准备、具体步骤及其在临床应用中所提供的诊断与预后价值,希望有助于进一步规范和推广该技术在国内的应用。

关键词：体层摄影术,发射型计算机,单光子心肌灌注显像碲锌镉心肌血流量心肌血流储备

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Multi-time Collaborative Restoration for Integrated Electrical-gas Distribution Systems Based on Rolling Optimization

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 660-671页

作者： Jingyang yun Zheng Yan yun Zhou Peichao Zhang Weidong Hu Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong University

This paper proposes a multi-time collaborative restoration model for integrated electricity-gas distribution sys-tems(IEGDSs)considering multiple resources after extreme weather *** on the linearized power flow constraints of the unbalanced electrical distribution system(EDS)and gas distribution system(GDS),this problem can be formulated as a mixed-integer linear programming(MILP)*** improve the efficiency and veracity of the solution,a rolling optimiza-tion based two-stage method is developed with the first stage solved by a linear approximation model,and the second stage solved by real-time updated rolling *** solving the MILP problem using rolling optimization,the proposed model and solution method achieve efficient and reliable collaborative restoration of IEGDS considering multiple resources and unbal-anced operation characteristics of *** effectiveness of the proposed model and method is validated by using an IEGDS made of a 37-bus unbalanced EDS and 11-node *** Terms-Electricity-gas system,mix-integer linear programming,power system restoration.

关键词： Electricity-gas system mix-integer linear programming power system restoration

Effect of the vortical structures on the hydrodynamic performance of a pitching hydrofoil

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Journal of Hydrodynamics 2024年第2期36卷 406-420页

作者： Rui Yuan Hui-yun Hao Qin Wu yun-qing Liu Biao Huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

The objective is to study the vortical structural behaviors of a transient pitching hydrofoil and their effects on the hydrodynamic performance. The pitching motion of the hydrofoil is set to pitch up with an almost constant rate from 5° to 15° and then back to 5°, with the Reynolds number 4.4×10^(5) and the frequency 2 Hz. The results show that the main coherent structures around the pitching hydrofoil include small-scale laminar separation bubble (LSB), large-scale second vortex (SV) and trailing edge vortex (TEV) which are all vortical. The relationship between the vortical structure and the lift is investigated with the finite-domain impulse theory. It indicates that the major part of the lift is contributed by the LSB, whereas the shedding and the formation of the SV and TEV cause the fluctuation of the lift. The proper orthogonal decomposition (POD) method is applied to capture the most energetic modes, revealing that the LSB mode occupies a large amount of energy in the flow field. The dynamic mode decomposition (DMD) method accurately extracts the dominant frequency and modal characteristics, with the first mode corresponding to the mean flow, the second mode corresponding to the LSB structure and the third and fourth modes corresponding to the vortex shedding.

关键词： Hydrodynamics vortical structures finite-domain impulse theory proper orthogonal decomposition(POD) dynamic mode decomposition(DMD) Pitching hydrofoil

Value Iteration-Based Cooperative Adaptive Optimal Control for Multi-Player Differential Games With Incomplete Information

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 690-697页

作者： yun Zhang Lulu Zhang yunze Cai the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China

This paper presents a novel cooperative value iteration(VI)-based adaptive dynamic programming method for multi-player differential game models with a convergence *** players are divided into two groups in the learning process and adapt their policies *** method removes the dependence of admissible initial policies,which is one of the main drawbacks of the PI-based ***,this algorithm enables the players to adapt their control policies without full knowledge of others’ system parameters or control *** efficacy of our method is illustrated by three examples.

关键词： Adaptive dynamic programming incomplete information multi-player differential game value iteration

Synergistically coupling of Ni–Fe LDH arrays with hollow Co–Mo sulfide nanotriangles for highly efficient overall water splitting

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Rare Metals 2024年第2期43卷 522-532页

作者： yun Jae Lee Seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityAnseongGyeonggi-do17546Republic of Korea Department of Intelligent Energy and Industry Chung-Ang University84 Heukseok-ro Dongjak-guSeoul06974Republic of Korea Western Seoul Center Korea Basic Science Institute150 Bugahyeon-roSeodaemun-guSeoul03759Republic of Korea

Developing bifunctional catalysts that can catalyze both oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is pivotal to commercializing large-scale water ***,a novel hollow nanotriangle composed of NiFe LDH-CoMoS_(x) heterojunction(H-CMSx@NiFe LDH)is proposed as a highly efficient bifunctional electrocatalyst for both OER and *** fabricate a heterojunction system,ultra-thin nickel–iron layered double hydroxide(NiFe LDH)nanosheets are uniformly electrodeposited onto a metal–organic framework-derived hollow CoMoS_(x) *** strong coupling of CoMoS_(x) and NiFe LDH catalysts forms the intimate heterojunction interfaces to facilitate interfacial charge transfer,which is favorable to enhance the bifunctional catalytic ***,the large void of CoMoS_(x) nanotriangles and interconnected ultra-thin NiFe LDH nanosheets result in good electrolyte penetration and gas ***,the as-prepared H-CMSx@NiFe LDH on nickel foam(NF)exhibits an impressive catalytic activity and durability for OER and HER activities,delivering a current density of 100 mA·cm^(−2) at the small overpotentials of 214 and 299 mV in OER and HER,***,H-CMSx@NiFe LDH/NF proves to be an effective electrode for an alkaline electrolyzer,as a voltage of only 1.99 V is enough to achieve a current density voltage of only 1.99 V is enough to achieve a current density of 400 mA·cm^(−2) with no degradation in performance over 50 h.

关键词： Overall water splitting Metal-organic framework Molybdenum sulfide Layered double hydroxide Heterojunction

Millimeter-wave PA design techniques in ISSCC 2024

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Journal of Semiconductors 2024年第4期45卷 16-18页

作者： yun Wang Hongtao Xu State Key Laboratory of Integrated Chips and Systems School of MicroelectronicsFudan UniversityShanghai 201203China

Millimeter-wave systems with high integration level have been rapidly developed to enable modern wireless communication,sensing,and *** millimeter-wave power amplifier(PA)is one of the most challenging and critical components in a millimeter-wave transceiver,it is the last active stage in a transmitter amplifying spectrally efficient complex modulation signal for radiation with high output power.

关键词： millimeter Millimeter ISSCC

Rebuilding the theory of isotope fractionation for evaporation of silicate melts under vacuum condition

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Acta Geochimica 2024年第4期43卷 661-676页

作者： Jie Wang yun Liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China CAS Center for Excellence in Comparative Planetology Hefei 230026China

Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion *** on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations of laboratory experiments due to its oversimplified ***,we point out that the Hertz-Knudsen-equation-based theory is incomplete for silicate melt evaporation cases and can only be used for situations where the vaporized species is identical to the one in the *** propose a new model designed for silicate melt evaporation under *** model considers multiple steps including mass transfer,chemical reaction,and *** derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,*** model can eff ectively reproduce most reported KIFFs of laboratory experiments for various elements,i.e.,Mg,Si,K,Rb,Fe,Ca,and ***,the KIFF-mixing model referring that an overall rate of evaporation can be determined by two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and *** addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts by using the fitting slope in ln(−ln f)versus ln(t).Notably,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.

关键词： Evaporation Kinetic isotopic fractionation Chemical kinetics Hertz-Knudsen equation CAIS

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Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： Yu FANG yun Yan YANG College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity