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The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case

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Journal of Pharmaceutical Analysis 2024年第3期14卷 416-426页

作者： Chen Han Zhixin Zhang Zhiyang Feng Chuanjia Zhai Xuejiao Li yulian Shi xiang Li Miao Li Ying Wang Gan Luo Xiaoyan Gao Department of Chinese Medicine Analysis School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China

The comprehensive detection and identification of active ingredients in complex matrices is a crucial *** chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex ***,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 *** are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low *** comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this ***,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine ***,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target ***,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of ***,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly *** on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally *** integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

关键词： Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines

Robust In-Zr Metal-Organic Framework Nanosheets as Ultrathin Interlayer Toward High-Rate and Long-Cycle Lithium-Sulfur Batteries

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CCS Chemistry 2024年第4期6卷 988-998页

作者： Zhibin Cheng Jie Lian Yiyang Chen Yiyang Tang yulian Huang Jindan Zhang Shengchang xiang Zhangjing Zhang Fujian Key Laboratory of Polymer Materials College of Materials Science and EngineeringFujian Normal UniversityFuzhou 350007 State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002

Lithium-sulfur(Li-S)batteries have great potential as the next generation of high-energy-density storage ***,the practical viability of Li-S batteries is largely hampered by undesirable shuttling behavior and sluggish conversion kinetics of ***,a multifunctional separatormodified layer(In/Zr-BTB nanosheets)with the merits of robust structures and efficient catalytic metal sites has been ***/Zr-BTB nanosheets inherit the stable structure from Zr-BTB and strengthen the catalytic performance due to the introduction of highly catalytic species indium via metal-ion *** thickness and areal mass loading of the modified layer are only 260 nm and 0.011 mg/cm2,***,the ultrathin modification layers with efficient catalytic species,compact structures,and uniform pore channels can realize fast Li+transport,effective polysulfide interception,and rapid catalytic ***,the In/Zr-BTB@PP cell with a high sulfur content of 80 wt%could maintain high capacity retention of 85.6%with a low capacity fading rate of 0.048%per cycle after 300 cycles even at a high current rate of 2 *** work opens a new door toward the design of versatile metal-organic framework(MOF)nanosheets and multifunctional separators for high-energy-density Li-S batteries.

关键词： lithium-sulfur batteries metal-organic framework shuttle effect energy storage separator modification

Syntheses and Properties of Lanthanide Hydroxy-meso-tetra(p-chlorophenyl)porphyrin Complexes

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Chemical Research in Chinese Universities 2004年第6期20卷 807-809页

作者： YUMiao yulian-xiang JIANWen-ping YANGWen-sheng LIUGuo-fa CollegeofChemistry JilinUniversityChangchun130023P.R.China

Introduction The syntheses and characterization of porphyrins and metalloporphyrins have been studied extensively[1]. Hemoglobin, myoglobin or cytochrome P450, has been applied as a model compound[2]. Wong C. P. et al... 详细信息

关键词： Hemoglobin Myoglobin Cytochrome Porphyrin Metalloporphyrin Lanthanide porphyrin complex

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铜精矿中低量银的原子吸收光谱法测定

黄金科学技术 2008年第3期16卷 60-62页

作者：向玉莲广东高要河台金矿广东肇庆526127

铜和银都是河台金矿床中重要的伴生元素，银在铜精矿中与铜同步富集到50～60g/t，通过对铜精矿中的银量作原子吸收光谱法测定试验，研究了铜对银在原子吸收光谱法测定中的干扰，并提出了消除干扰的方法。该分析方法准确度与经典方法一... 详细信息

铜和银都是河台金矿床中重要的伴生元素，银在铜精矿中与铜同步富集到50～60g/t，通过对铜精矿中的银量作原子吸收光谱法测定试验，研究了铜对银在原子吸收光谱法测定中的干扰，并提出了消除干扰的方法。该分析方法准确度与经典方法一致，有一定的实践指导意义。

关键词：河台金矿铜精矿原子吸收光谱法银量干扰效应铜元素

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溴酸钠/亚硫酸氢钠体系降解芬太尼

环境化学 2015年第1期34卷 123-128页

作者：徐琳任丽君田兴涛黄志平向玉联王志华北京化工大学化工资源有效利用国家重点实验室北京100029 防化学院北京102205

研究了芬太尼在溴酸钠/亚硫酸氢钠体系中的降解行为,考察了影响芬太尼降解效率的因素.结果显示,溴酸钠与亚硫酸氢钠的物质的量比在1∶0.48至1∶1.26之间,体系的氧化能力强.体系对芬太尼的氧化降解效率与溴酸钠/亚硫酸氢的浓度呈正比,1 ... 详细信息

研究了芬太尼在溴酸钠/亚硫酸氢钠体系中的降解行为,考察了影响芬太尼降解效率的因素.结果显示,溴酸钠与亚硫酸氢钠的物质的量比在1∶0.48至1∶1.26之间,体系的氧化能力强.体系对芬太尼的氧化降解效率与溴酸钠/亚硫酸氢的浓度呈正比,1 mol·L-1的溴酸钠/亚硫酸氢钠、29倍于芬太尼用量可在2 min完全降解芬太尼.有机溶剂具有富集有效氧化成分和芬太尼的作用,有机/水两项体系更利于芬太尼的氧化降解.向完成降解反应后的溴酸钠/亚硫酸氢钠废液中补加亚硫酸氢钠中和剩余氧化剂,可使反应液彻底环境无害化.此外,采用气质联用技术鉴定了芬太尼在溴酸钠/亚硫酸氢体系中的降解产物,探讨了可能的降解机理.

关键词：溴酸钠/亚硫酸氢钠氧化降解芬太尼

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利川市清江河水质监测与分析

中国资源综合利用 2019年第3期37卷 4-6,9页

作者：罗山茅向毓莲黄加昀利川市环境监测站湖北利川445400 武汉理工大学资源与环境工程学院武汉430070

为研究利川市境内最大河流清江河的水质状况,自上游到下游采取四个流域的水样,通过化学和仪器对其温度、pH、氨氮、溶解氧、电导率进行检测分析。结果表明,利川市清江流域总体达到Ⅲ类水体标准,其中部分流域氨氮含量较高。经分析,其主... 详细信息

为研究利川市境内最大河流清江河的水质状况,自上游到下游采取四个流域的水样,通过化学和仪器对其温度、pH、氨氮、溶解氧、电导率进行检测分析。结果表明,利川市清江流域总体达到Ⅲ类水体标准,其中部分流域氨氮含量较高。经分析,其主要原因是城市管网建设不完善,大量生活污水和畜禽养殖废水直接排入水体,导致污染物含量增加。

关键词：清江水质监测水质分析

江苏无锡与青海海东育龄期妇女阴道炎的感染情况及影响因素分析

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热带医学杂志 2024年第5期24卷 748-752页

作者：向湘王妍贾贞马玉莲祁凤仙陆牡丹徐德祥陈道桢安徽医科大学公共卫生学院毒理学系安徽合肥230032 海东市第二人民医院青海海东810600 无锡市妇幼保健院江苏无锡214000

目的探讨江苏省无锡市和青海省海东市两地育龄期妇女阴道炎症感染类型差异及其影响因素,为女性生殖道相关疾病防治提供参考。方法收集2021年5月-2022年6月无锡市妇幼保健院和海东市第二人民医院的妇科门诊病历数据,按照标准共纳入阴道... 详细信息

目的探讨江苏省无锡市和青海省海东市两地育龄期妇女阴道炎症感染类型差异及其影响因素,为女性生殖道相关疾病防治提供参考。方法收集2021年5月-2022年6月无锡市妇幼保健院和海东市第二人民医院的妇科门诊病历数据,按照标准共纳入阴道炎症患者1855例,其中无锡地区1126例,海东地区729例,比较两地区妇女阴道炎症感染类型差异,采用单因素分析影响因素。结果海东地区的滴虫性阴道炎占比高于无锡地区,两地阴道炎的发生率差异有统计学意义(χ^(2)=118.060,P=0.001);无锡地区妇女阴道感染类型在不同年龄和不同季节间差异有统计学意义(χ^(2)=18.484、23.040,P均0.05)。结论无锡和海东两地育龄期妇女阴道炎的感染类型存在差异,职业、季节等因素与阴道炎症相关性较高。

关键词：阴道炎症育龄期妇女滴虫性阴道炎

Detecting protein complexes from DPINs by density based clustering with Pigeon-Inspired Optimization Algorithm

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Science China(Information Sciences) 2016年第7期59卷 30-43页

作者： Xiujuan LEI yulian DING Fang-xiang WU School of Computer Science Shaanxi Normal University School of Mathematical Sciences Nankai University Division of Biomedical Engineering University of Saskatchewan

Detecting protein complexes is crucial to understand principles of cellular organization. Plenty evidences have indicated that sub-graphs with high density in protein-protein interaction(PPI) network, especially dynamic PPI network(DPIN), usually correspond to protein complexes. As a well-known density-based clustering algorithm, Density-Based Spatial Clustering of Applications with Noise(DBSCAN) has been used in many areas due to its simplicity and the ability to detect clusters of different sizes and shapes. However, one of its limitations is that the performance of DBSCAN depends on two specified parameters ε and Min Pts, where εrepresents the maximum radius of a neighborhood from an observing point while Min Pts means the minimum number of data points contained in such a neighborhood. In this article, we develop a new method named as P-DBSCAN to detect protein complexes in DPIN by using Pigeon-Inspired Optimization(PIO) Algorithm to optimize the parameters ε and Min Pts in DBSCAN. The experiments on DIP and MIPS datasets show that P-DBSCAN outperforms the state-of-the-art methods for protein complex detection in terms of several criteria such as precision, recall and f-measure.

关键词： dynamic protein-protein interaction network(DPIN) pigeon-inspired optimization(PIO) protein complex density based clustering gene expression

社区老年人静脉血栓栓塞症认知水平的调查研究

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中华介入放射学电子杂志 2024年第1期12卷 75-81页

作者：李兰向华莫伟胡琴李琴吴雅琴李玉莲彭小蓉湖南省人民医院(湖南师范大学附属第一医院)介入血管外科湖南长沙410000 湖南师范大学附属第一医院湖南长沙410000

目的调查分析社区老年人静脉血栓栓塞症(venous thromboembolism,VTE)认知水平现状及其影响因素,为后期制定社区老年人VTE的预防策略提供依据。方法采用分层随机抽样法,共抽取湖南省5个地区中910名社区老年人(年龄≥60岁)为研究对象。... 详细信息

目的调查分析社区老年人静脉血栓栓塞症(venous thromboembolism,VTE)认知水平现状及其影响因素,为后期制定社区老年人VTE的预防策略提供依据。方法采用分层随机抽样法,共抽取湖南省5个地区中910名社区老年人(年龄≥60岁)为研究对象。采用一般资料调查问卷、VTE认知水平调查问卷、培训意愿问卷以及Padua血栓风险评估表进行现况调查。采用多重线性回归分析VTE认知水平的影响因素。结果研究对象VTE高风险人群占7.96%,VTE知晓率为16.59%,有接受培训意愿的占64.38%。不同年龄、文化程度、VTE病史、培训意愿、体质量指数(body mass index,BMI)的研究对象认知水平得分存在差异,差异有统计学意义(P<0.05)。多重线性回归分析结果显示:文化程度、BMI、培训意愿是社区老年人VTE认知水平的主要影响因素(P<0.05)。结论社区老年人VTE高风险人群比例高,疾病认知水平低,有较强的培训意愿。文化程度低、BMI高,其VTE认知水平较低;培训意愿强,其VTE认知水平较高。亟须采取系列措施提高社区老年人VTE认知水平,并积极开展社区老年人VTE的高危筛查、推进早期预防。

关键词：社区老年人静脉血栓栓塞症认知水平影响因素