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Treatment outcomes of chemotherapy between unresectable and recurrent biliary tract cancer

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World Journal of Gastroenterology 2014年第48期20卷 18452-18457页

作者： Takashi Sasaki Hiroyuki Isayama Yousuke Nakai yukiko Ito Ichiro Yasuda Nobuo Toda Hiroshi Yagioka Saburo Matsubara Keiji Hanada Hiroyuki Maguchi Hideki Kamada Osamu Hasebe Tsuyoshi Mukai Yoshihiro Okabe Iruru Maetani Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine the University of Tokyo Tokyo 113-8655 Japan Department of Gastroenterology Japanese Red Cross Medical Center Tokyo 150-8935 Japan First Department of Internal Medicine Gifu University Hospital Gifu 501-1194 Japan Department of Gastroenterology Mitsui MemorialHospital Tokyo 101-8643 Japan Department of Gastroenterology JR Tokyo General Hospital Tokyo 151-8528 Japan Department of Gastroenterology Kanto Central Hospital Tokyo 158-8531 Japan Center for Gastroendoscopy Onomichi General Hospital Hiroshima 722-8508 Japan Center for Gastroenterology Teine-Keijinkai Hospital Hokkaido 006-8555 Japan Department of Gastroenterology and Neurology Faculty of Medicine Kagawa University Kagawa 761-0793 Japan Department of Gastroenterology Nagano Municipal Hospital Nagano 381-8551 Japan Department of Gastroenterology Gifu Municipal Hospital Gifu 500-8513 Japan Department of Gastroenterology Osaka Red Cross Hospital Osaka 543-8555 Japan Division of Gastroenterology Department ofInternal Medicine Toho University Ohashi Medical CenterTokyo 153-8515 Japan

AIM: To evaluate the differences in the treatment outcomes between the unresectable and recurrent biliary tract cancer patients who received chemotherapy.

关键词： Biliary tract cancer Unresectable Recurrent Pooled analysis Chemotherapy

Measurements of the Lower Uterine Segment at Term in Women with Previous Cesarean Delivery

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Open Journal of Obstetrics and Gynecology 2016年第1期6卷 1-7页

作者： Tadatsugu Kinjo Hitoshi Masamoto Keiko Mekaru Yusuke Taira yukiko Chinen Hayase Nitta Yoichi Aoki Department of Obstetrics and Gynecology Graduate School of Medicine University of the Ryukyus Nishihara Okinawa Japan

Purpose: To evaluate the accuracy of sonographic measurements of the lower uterine segment (LUS) thickness at term in predicting uterine scar defects in women with previous Cesarean delivery (CD). Methods: Eighty-nine pregnant women who underwent CD between 37 and 41 weeks of gestation from 2013 to 2015 were enrolled in this study and divided into two groups. Group A consisted of women with previous CD, and Group B consisted of women with previous vaginal deliveries. We performed an ultrasound evaluation of the myometrial and full thickness of LUS (mLUS and fLUS) transvaginally before a CD and evaluated the appearance of LUS during surgery, which was defined as follows: grade I, well-developed;grade II, thin without visible content;grade III, translucent with visible content;and grade IV, either dehiscence or rupture. Results: The median mLUS and fLUS were 1.50 and 4.07 mm in the group A, and 2.75 and 5.37 mm in the group B. We observed significant differences in the median mLUS and fLUS between grades I/II (2.07 and 4.37 mm) and grades III/IV (0.67 and 2.52 mm). Both mLUS and fLUS were predictive factors for grades III/IV and cutoff values were 0.97 mm of mLUS and 3.13 mm of fLUS, having a sensitivity of 87.5% and 75.0%, and a specificity of 87.7% and 91.4% in mLUS and fLUS measurement, respectively. Conclusion: Sonographic measurements of LUS at term may be a feasible and reliable method to predict uterine rupture or uterine dehiscence in women with prior CD.

关键词： Lower Uterine Segment Sonographic Measurement Previous Cesarean Uterine Rupture Uterine Dehiscence

Hemoglobin Level Stability after a Switch from Darbepoetin Alfa to Epoetin Beta Pegol for the Treatment of Renal Anemia in Hemodialysis Patients

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International Journal of Clinical Medicine 2015年第9期6卷 652-660页

作者： Sayaka Takahashi Yoshiko Tanaka Mari Takano Keiko Suzuki Mio Ueda yukiko Shimamoto Kosaku Nitta Department of Nephrology Shinjuku Ishikawa Clinic Tokyo Japan Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan

Background: New erythropoiesis-stimulating agents (ESAs) with a longer half-life have been developed for the treatment of anemia as a complication of patients with end-stage renal disease. Objectives: The objective of the present study was to assess the hemoglobin (Hb) stability of a Japanese cohort of hemodialysis (HD) patients who were simultaneously switched from darbepoetin alfa (DA) to epoetin beta pegol (CERA). Methods: This was an observational, prospective study of HD patients 20 years of age or more who were switched from intravenous (IV) DA to IV CERA and continued on HD for at least 3 months. The dose was adjusted to maintain the Hb level to within 1.0 g/dl of the baseline value. Results: A total of 68 HD patients (75.0% male, median age 63.0 years) were enrolled. The patients’ mean Hb levels were 10.8 ± (0.6) g/dl at Month 0, 10.9 ± 0.7 at Month 1, 10.8 ± 0.7 at Month 2, and 10.9 ± 0.8 at Month 3, and the differences from the level at Month 0 were not significant. After the switch, the ESA dose decreased significantly (P P < 0.0001). Conclusion: Switching from DA to CERA was associated with approximate 89% reduction of the required dose in Japanese HD patients being treated with an ESA and showed a favorable impact on the treatment of renal anemia, including the need for less frequent injections and a reduction of the ESA dose.

关键词： Darbepoetin Alfa Epoetin Beta Pegol Hemoglobin ESA Resistance Hemodialysis

Recurrent Ectopic Pregnancy in the Remnant Fallopian Tube Following Ipsilateral Partial Salpingectomy

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Open Journal of Obstetrics and Gynecology 2015年第7期5卷 373-377页

作者： Eijiro Hayata Takehiko Tsuchiya Toshimitsu Maemura yukiko Katagiri Tomonori Hasegawa Mineto Morita Department of Obstetrics and Gynecology Toho University Omori Medical Center Tokyo Japan Department of Social Medicine Toho University School of Medicine Tokyo Japan

A 39-year-old female with a history of partial salpingectomy for tubal pregnancy was diagnosed as having recurrent ectopic pregnancy in the distal portion of the fallopian tube remnant, which was successfully treated by laparoscopic surgery. The patient was multigravida (9 pregnancies) and uniparous. She had undergone right partial salpingectomy by laparotpmy for right isthmic ectopic pregnancy at the age of 31 years. At 6 weeks of the current pregnancy, she was referred to our hospital for suspected ectopic pregnancy. The gestational sac was not observed in the uterus, and a mass was observed in the right adnexal region by transvaginal ultrasonography. Emergency laparoscopic surgery revealed the pregnancy site in the ampulla of the remnant portion of the right fallopian tube;therefore, this portion was resected. Because the proximal portion of the fallopian tube remnant was completely occluded, we concluded that this was a case of ectopic pregnancy resulting from the intraperitoneal migration of a fertilized ovum. With current developments in assisted reproductive technologies, reanastomosis of the fallopian tube is rarely performed. While partial salpingectomy is less likely to contribute to the preservation of fertility, it increases the risk of recurrent ectopic pregnancy. A single-stage total salpingectomy on the affected side should be the first choice of treatment when fallopian tube preservation surgery is not selected.

关键词： Ectopic Pregnancy Laparoscopy Fallopian Tube Remnant

Availability of Circulating MicroRNAs as a Biomarker for Early Diagnosis of Diffuse Large B-Cell Lymphoma

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Open Journal of Blood Diseases 2015年第4期5卷 48-58页

作者： Katsushige Inada Yasushi Okoshi yukiko Cho Hitoaki Saito Tatsuo Iijima Mitsuo Hori Hiroshi Kojima Department of Hematology Ibaraki Prefectural Central Hospital Ibaraki Japan Ibaraki Clinical Education and Training Center University of Tsukuba Hospital Ibaraki Japan Faculty of Medicine University of Tsukuba Ibaraki Japan Department of Medical Oncology Ibaraki Prefectural Central Hospital Ibaraki Japan Department of Pathology Ibaraki Prefectural Central Hospital Ibaraki Japan

Background: MicroRNA (miRNA) regulates post-transcriptional gene expression through binding to complementary sites of target messenger RNA, including that from oncogenes or tumor suppressor genes. This study planned to pursue the possibility that circulating miRNA could be used for the early diagnosis of diffuse large B-cell lymphoma (DLBCL). Materials and Methods: Expression levels of miRNA obtained from serum, exosome-enriched serum, and formalin-fixed paraffin-embedded (FFPE) tissue were evaluated. Samples were collected from patients with newly diagnosed DLBCL (n = 33) or healthy volunteers (n = 22). Based on the results of previous reports, ten miRNAs were selected and expression levels were analyzed by the quantitative real-time PCR. Results: The expression levels of hsa-miR-15a-3p, hsa-miR-21-5p, hsa-miR-181a-5p, and hsa-miR-210-5p differed significantly between DLBCL patients and controls in serum and/or exosome-enriched serum, but not in FFPE tissue. In contrast, expression levels of hsa-miR-155-5p in FFPE tissue were significantly higher in DLBCL patients, as previously reported. Conclusion: We confirmed that some miRNAs were differentially expressed in serum from DLBCL patients as previously reported. Measurement of these miRNA in exosome-enriched serum did not improve the accuracy in the differential diagnosis of DLBCL. In addition, these miRNAs seem to be produced outside of lymphoma tissue.

关键词： DLBCL miRNA Serum Exosome Formalin-Fixed Paraffin-Embedded Tissue

生于Equisetum上的日本新记录种Stamnaria americana(英文)

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菌物学报 2013年第3期32卷 448-456页

作者： Tsuyoshi HOSOYA yukiko SAITO Yukio HARADA Kazuaki TANAKA Yan-Jie ZHAO Makoto KAKISHIMA Department of Botany National Museum of Nature and Science Center for Molecular Biodiversity Research National Museum of Nature and Science Faculty of Agriculture and Life Science Hirosaki University Faculty of Life and Environmental Science Tsukuba University

对日本新记录种Stamnaria americana进行了描述和图示。尽管低温适宜该种子囊孢子的萌发,它在20℃生长最好。DNA序列分析的结果表明,其分类地位应该从柔膜菌科转入锤舌菌科。

关键词：数据库生长温度锤舌菌纲系统发育序列分析

Oocyte quality improvement using a herbal medicine comprising 7 crude drugs

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 195-202页

作者： Taketo Inoue Yoshiyuki Ono yukiko Yonezawa Michinobu Oi Naomi Kobayashi Junji Kishi Nobuyuki Emi Herb Pharmacy Co. Ltd. Kobe Japan Ono Ladies Clinic Hyogo Japan

Maternal age is a significant factor in infertility treatment. Ovarian function and oocyte quality decrease with age, whereas the frequency of chromosomal abnormalities increases. In this study, improvement of oocyte quality and ovarian function were attempted using a herbal medicine comprising 7 crude drugs:Angelicae radix,Rehmanniae radix,Plantaginis semen,Lonicerae flos,Carthami flos,Ginseng radix, andCucurbita moschata Duch. Thirty-one women who repeatedly failed to conceive by intracytoplasmic sperm injection took the herbal medicine before breakfast and dinner from the start of menstrual cycle in the ovum pickup cycle. Average patient age was 38.5 ± 0.7 years, and the average ovum pickup frequency on the first dosage day was 7.9 ± 1.5. To analyze the effects of herbal medicine intake, the number of recovered and mature oocytes, their morphology and physical qualities, as well as the rates of fertilization, oocyte development, and pregnancy was compared before and after intake. The recovered and mature oocyte numbers, oocyte morphology and physical qualities, and fertilization rate were not significantly different before and after drug intake. However, the oocyte development rate was significantly higher(58.0%) after herbal medicine intake than before (32.5%;p = 0.0003). Moreover, the successful pregnancy rate was significantly higher after intake than before (6.9% versus 0%;p = 0.0111). Herbal medicine may constitute a useful adjunct to assisted reproductive technology in women.

关键词： Herbal Medicine Improvement of the Oocyte Development Rate Intracytoplasmic Sperm Injection Oocyte Quality Repeated Infertility Treatment Failure

Actual Status of Healthy Lifestyle Habits of Public Health Nurses in Japan

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Health 2018年第2期10卷 189-203页

作者： Yoko Nishida Keiko Koide Reiko Okamoto Saori Iwamoto Kayoko Goda Hiroko Seki yukiko Sugimoto Department of Nursing Faculty of Health and Welfare Kawasaki University of Medical Welfare Okayama Japan Faculty of Education Shitennoji University Osaka Japan Division of Health Sciences Graduate School of Medicine Osaka University Osaka Japan Graduate School of Biomedical Sciences Tokushima University Tokushima Japan Faculty of Nursing and Rehabilitation Konan Women’s University Hyogo Japan Former Graduate School of Health Sciences Okayama University Okayama Japan

Background: The public health nurse should make efforts to keep his/her own mental and physical health good, which is the professional responsibility. However, a variety of challenging issues have been pointed out with regard to well-being of healthcare professionals. Public health nurses are likely to face some difficulties in their habits of leading healthy lifestyles. The purpose of this study was to identify how Japanese public health nurses actually live their healthy lives. Methods: This study covered 1725 public health nurses in the Chugoku/Shikoku Region. We conducted an anonymous self-completed questionnaire survey. As basic attributes, the following 6 categories were set. The health practice indices used in this research consisted of the 7 practices of Breslow’s Health Practice Index (B-HPI), the Morimoto’s 8 practices, and 6 practices related to lifestyle habits that have been developed independently by the authors of this research (Health Lifestyle Index (HLI)), that is, 16 practices in total. The study plan was approved by the Ethics Committee of Okayama University. Results: We analyzed the 960 (55.7%) valid responses. This survey has demonstrated that the healthy life-style practices of public health nurses are generally good. However, there were some practices such as eating between meals, having little physical activity, and not having a good rest/sleep, that need to be improved. None of the assessment tools correlated with the length of experience. Conclusions: This survey has clarified that the healthy lifestyle practices of public health nurses did not correlated with their length of experience, indicating that the healthy lifestyle practices are not intensified by the accumulated career experience as public health nurses.

关键词： Public Health Nursing Related Factors Health Practice Breslow’s Health Practice

ON THE IMPORTANT MODULATION-FREQUENCY BANDS OF SPEECH FOR HUMAN SPEAKER RECOGNITION

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ON THE IMPORTANT MODULATION-FREQUENCY BANDS OF SPEECH FOR HU...