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Controllable shaping of high-index dielectric nanoparticles by exploiting the giant optical force of femtosecond laser pulses

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Photonics Research 2024年第2期12卷 282-291页

作者： yuheng mao SHUWEN BAI MINGCHENG PANMAI LIDAN ZHOU SHIMEI LIU SHULEI LI HAIYING LIU HAIHUA FAN JUN DAI SHENG LAN Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Shenzhen Institute of Terahertz Technology and Innovation Shenzhen 518102China State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510006China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China

Nanoparticles made of different materials usually support optical resonances in the visible to near infrared spectral range,such as the localized surface plasmons observed in metallic nanoparticles and the Mie resonances observed in dielectric *** optical resonances,which are important for practical applications,depend strongly on the morphologies of *** irradiation is a simple but effective way to modify such optical resonances through the change in the morphology of a *** laser-induced shaping of metallic nanoparticles has been successfully demonstrated,it remains a big challenge for dielectric nanoparticles due to their larger Young’s modulus and smaller thermal ***,we proposed and demonstrated a strategy for realizing controllable shaping of high-index dielectric nanoparticles by exploiting the giant optical force induced by femtosecond laser *** was found that both Si and Ge nanoparticles can be lit up by resonantly exciting the optical resonances with femtosecond laser pulses,leading to the luminescence burst when the laser power exceeds a *** addition,the morphologies of Si and Ge nanoparticles can be modified by utilizing the giant absorption force exerted on them and the reduced Young’s modulus at high *** shape transformation from sphere to ellipsoid can be realized by laser irradiation,leading to the blueshifts of the optical *** was found that Si and Ge nanoparticles were generally elongated along the direction parallel to the polarization of the laser *** shaping of Si and Ge can be achieved by deliberately adjusting the excitation wavelength and the laser *** findings are helpful for understanding the giant absorption force of femtosecond laser light and are useful for designing nanoscale photonic devices based on shaped highindex nanoparticles.

关键词： optical polarization dielectric

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Harnessing innate immune pathways for therapeutic advancement in cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao Lin yuheng Liao Hui Yang Ying mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

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彝药苦刺化学成分和生物活性的研究进展

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西北药学杂志 2024年第3期39卷 242-252页

作者：王瑞毛宇恒丁正伟高阳刘霞高昕张海龙张红西安交通大学药学院西安710061 陕西省中医药研究院西安710003

目的总结近年来彝族民族药苦刺的化学成分和生物活性的研究进展,为进一步开发利用该民族药提供参考。方法通过万方、维普、CNKI、SCI finder、PubMed等数据库查阅国内外有关苦刺的文献,对其化学成分和药理活性研究结果进行归纳和总结。... 详细信息

目的总结近年来彝族民族药苦刺的化学成分和生物活性的研究进展,为进一步开发利用该民族药提供参考。方法通过万方、维普、CNKI、SCI finder、PubMed等数据库查阅国内外有关苦刺的文献,对其化学成分和药理活性研究结果进行归纳和总结。结果苦刺的根、茎、叶、花和种子皆可入药;该植物所含成分结构类型多样,其中以生物碱和黄酮为主;苦刺具有抗炎、抗糖尿病、抗肿瘤、抗胃溃疡等多种药理作用。结论苦刺是一种富含生物碱和黄酮且生物活性多样的民族药,具有进一步研究开发的价值。

关键词：民族药苦刺化学成分生物碱生物活性

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All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1131-1144页

作者： Junning Pu Daiwen Chen Gang Tian Jun He Ping Zheng Zhiqing Huang Xiangbing mao Jie Yu yuheng Luo Junqiu Luo Hui Yan Aimin Wu Bing Yu Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130SichuanPeople’s Republic of China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan Province611130 ChengduSichuanPeople’s Republic of China

Background Transmissible gastroenteritis virus(TGEV)is one of the main pathogens causing severe diarrhea of *** pathogenesis of TGEV is closely related to intestinal ***-trans retinoic acid(ATRA)is the main active metabolite of vitamin A,which has immunomodulatory and anti-inflammatory ***,it is unclear whether ATRA can alleviate TGEV-induced intestinal inflammation and barrier dysfunction in *** study aimed to investigate the effects of ATRA on growth performance,diarrhea,intestinal inflammation and intesti-nal barrier integrity of TGEV-challenged *** In a 19-d study,32 weaned piglets were randomly divided into 4 treatments:Control group(basal diet),TGEV group(basal diet+TGEV challenge),TGEV+ATRA5 group(basal diet+5 mg/d ATRA+TGEV challenge)and TGEV+ATRA15 group(basal diet+15 mg/d ATRA+TGEV challenge).On d 14,piglets were orally administered TGEV or the sterile *** Feeding piglets with 5 and 15 mg/d ATRA alleviated the growth inhibition and diarrhea induced by TGEV(P<0.05).Feeding piglets with 5 and 15 mg/d ATRA also inhibited the increase of serum diamine oxidase(DAO)activ-ity and the decrease of occludin and claudin-1 protein levels in jejunal mucosa induced by TGEV,and maintained intestinal barrier integrity(P<0.05).Meanwhile,5 mg/d ATRA feeding increased the sucrase activity and the expres-sions of nutrient transporter related genes(GLUT2 and SLC7A1)in jejunal mucosa of TGEV-challenged piglets(P<0.05).Furthermore,5 mg/d ATRA feeding attenuated TGEV-induced intestinal inflammatory response by inhibit-ing the release of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α),and promoting the secretion of IL-10 and secretory immunoglobulin A(sIgA)(P<0.05).Feeding 5 mg/d ATRA also down-regulated the expressions of Toll-like receptors and RIG-I like receptors signaling pathway related genes(TLR3,TLR4,RIG-I,MyD88,TRIF and MAVS)and the phosphorylation level of nuclear factor-κB-p65(NF-κB p65),and

关键词： All-trans retinoic acid Inflammation Intestinal barrier Piglets Transmissible gastroenteritis virus

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抗类风湿性关节炎方剂通痹化瘀膏的药效物质基础研究

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西北药学杂志 2024年第4期39卷 5-10页

作者：杨敏飞刘娜娜黄小强职利琴鲍和刘杏王瑞毛宇恒荣真吉于春萍王儒月高阳张海龙西安市第五医院西安710082 西安交通大学药学院西安710061 西安交通大学第二附属医院药学部西安710004 高陵区妇幼保健院西安710200

目的初步阐明抗类风湿性关节炎方剂通痹化瘀膏的药效物质基础,为其临床应用提供科学依据。方法用硅胶柱色谱、反相硅胶柱色谱、高效液相色谱等现代分离技术对通痹化瘀膏的有效部位进行分离纯化,结合化合物的理化性质和各种波谱技术对分... 详细信息

目的初步阐明抗类风湿性关节炎方剂通痹化瘀膏的药效物质基础,为其临床应用提供科学依据。方法用硅胶柱色谱、反相硅胶柱色谱、高效液相色谱等现代分离技术对通痹化瘀膏的有效部位进行分离纯化,结合化合物的理化性质和各种波谱技术对分离得到的化合物进行结构鉴定。结果从通痹化瘀膏有效部位中分离鉴定出14个化合物,分别是花椒素(1)、2-methoxyfuranoguaia-9-ene-8-one(2)、棕榈酸(3)、2-methoxy-5-acetoxy fruranogermacr-1(10)-en-6-one(4)、sarcophytol M(5)、ntetradecanyl oleate(6)、alismol(7)、2-methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one(8)、bis(2-ethyloctyl)phthalate(9)、(24S)-24-ethylcholest-5-en-3β-ol(10)、myrrhterpenoid E(11)、okilactomycin D(12)、bis(2-ethylhexyl)benzene-1,2-dicarboxylate(13)和5-羟甲基糠醛(14)。结论这14个化合物包括7个萜类、3个芳香族化合物、2个脂肪酸或酯、1个甾体和1个糠醛。本研究是首次对院内制剂通痹化瘀膏的药效物质基础进行研究。

关键词：院内制剂通痹化瘀膏类风湿性关节炎活性部位化学成分

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不同相对分子质量果胶多糖益生特性的比较研究

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食品科技 2022年第4期47卷 216-223页

作者：李衍衡赵明珠徐艺璇宋丰林毛钰蘅杨燕中山大学公共卫生学院(深圳) 广东深圳518107 广东省营养与健康重点实验室广东广州510080 广东省营养转化工程技术研究中心广东广州510080 广东药科大学食品科学学院广东中山528458

为比较研究不同相对分子质量果胶多糖的益生特性,采用三氟乙酸降解橘皮果胶(Pectin),得到2种果胶多糖Pec1、Pec2,通过测定相对分子质量、黏度、酯化度、甲氧基含量和红外光谱,对不同果胶多糖进行理化性质的评价。以Pectin、Pec1和Pec2... 详细信息

为比较研究不同相对分子质量果胶多糖的益生特性,采用三氟乙酸降解橘皮果胶(Pectin),得到2种果胶多糖Pec1、Pec2,通过测定相对分子质量、黏度、酯化度、甲氧基含量和红外光谱,对不同果胶多糖进行理化性质的评价。以Pectin、Pec1和Pec2作为双歧杆菌和乳酸菌发酵的主要碳源进行体外发酵培养,比较不同果胶多糖的益生特性。结果表明,随着酸降解时间延长,果胶多糖相对分子质量、黏度、酯化度和甲氧基含量逐渐下降,而红外光谱分析显示3种果胶多糖结构无明显差异。在体外发酵培养后,Pec1和Pec2均能促进细菌生长、增加细菌活力和产生短链脂肪酸的含量。益生指数(PI)显示降解后的2种果胶多糖具有较好的益生特性,相比阳性对照组菊粉(Inulin),Pec2对短双歧杆菌(***)有更好的益生效果。因此,具有一定相对分子质量的果胶多糖有着更好的益生特性,且可能与特定菌株组成为最佳合生元组合。

关键词：果胶多糖相对分子质量双歧杆菌乳酸菌益生特性

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主动脉瓣钙化的影像学评估方法

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华西医学 2024年第3期39卷 500-504页

作者：彭岗贾宇恒陈茂四川大学华西医院心脏内科成都610041

主动脉瓣钙化(aortic valve calcification, AVC)是主动脉瓣狭窄(aortic stenosis, AS)的主要原因之一,其发病机制与炎症浸润、脂质沉积、内皮细胞损伤、钙化成骨、血管生成等相关。既往研究表明AVC与AS程度、心血管事件发生率、死亡率... 详细信息

主动脉瓣钙化(aortic valve calcification, AVC)是主动脉瓣狭窄(aortic stenosis, AS)的主要原因之一,其发病机制与炎症浸润、脂质沉积、内皮细胞损伤、钙化成骨、血管生成等相关。既往研究表明AVC与AS程度、心血管事件发生率、死亡率以及手术结局等相关。利用影像学方法对AVC进行定量分析不仅对AS具有诊断价值,而且对于手术时机的选择、手术风险的评估及预后预测都有着指导意义。该文就超声心动图、CT和正电子发射体层成像评估AVC的方法及其价值进行全面阐述。

关键词：主动脉瓣钙化主动脉瓣狭窄经导管主动脉瓣置换术

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Extensional Setting of Hainan Island in Mesoproterozoic:Evidence from Granitic Intrusions in the Baoban Group

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Acta Geologica Sinica(English Edition) 2022年第4期96卷 1199-1212页

作者： LIU yuheng mao Jingwen QIU Kunfeng HU Jun WANG Lei XU Deming MNR Key Laboratory of Geochemical Exploration Institute of Geophysical and Geochemical ExplorationChinese Academy of Geological SciencesLangfangHebei 065000China UNESCO International Centre on Global-scale Geochemistry LangfangHebei 065000China MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China China University of Geosciences(Beijing) Beijing 100083China State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of Geosciences(Beijing)Beijing 100083China Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Lab of Submarine Geosciences and Prospecting TechniquesMOE and College of Marine GeosciencesOcean University of ChinaQingdaoShandong 266100China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China Wuhan Center of China Geological Survey(Central South China Innovation Center for Geosciences) Wuhan 430205China

The Mesoproterozoic Baoban Group is the oldest basement in Hainan Island and has played an important role in Columbia(Nuna)supercontinent *** Mesoproterozoic granitic intrusions in the Baoban Group are the most widely-exposed Precambrian magmatic rocks and are the key to understanding the tectonic settings of Hainan Island and its relationship with the South China Block and the Columbia *** LA-ICP-MS zircon U-Pb dating on three mylonitic granite samples from the Tuwaishan and Baoban areas yield ages ranging from 1447 Ma to 1437 Ma,representing the absolute timing of the emplacement of the granitic *** with previously published geochronological data for rocks from the Baoban Group and regional mafic intrusions,it is concluded that the Baoban Group formed at 1460-1430 Ma,coeval with the emplacement of the granitic and mafic *** in-situ zircon LuHf isotope analyses for the three mylonitic granite samples yielded positiveε(t)values,ranging from+0.49 to+8.27,with model ages(T~C)ranging from 2181 Ma to 1687 Ma,suggesting that the granitic intrusions originated from a mixed source of Paleoproterozoic crust with juvenile *** zircon trace element data show characteristics of high Th/U values of 0.24-1.50,steep slopes from LREE to HREE and negative Pr,Eu anomalies with positive Ce,Sm anomalies,representing typical magmatic zircons formed in continental *** with available magmatic and detrital zircon ages from Precambrian rocks in the Cathaysia Block,Yangtze Block and western Laurentia,it is inferred that Hainan Island was separated from both the Cathaysia Block and the Yangtze Block,instead being connected with western Laurentia in the Columbia *** the decreasing tendency of basin deposition time along the western margin of Laurentia,it is proposed that Hainan Island was located to the north or northwest of the Belt-Purcell Supergroup,along the western margin of Laurentia,during

关键词： zircon U-Pb dating Lu-Hf isotopes granitic intrusions Baoban Group extensional setting Hainan Island

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互联网视域下的城市工业遗址更新项目研究——以南京为例

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艺术科技 2021年第22期34卷 21-24页

作者：毛宇恒胡凡曹加杰南京林业大学风景园林学院南京林业大学土木工程学院江苏南京210037

工业遗址更新作为一种新型的现代城市更新项目,可以激发地区板块的活力,促进地区经济发展。随着互联网时代的到来,新的价值链条以及商业形态不断涌现,深刻影响了工业遗址更新的思路、方式以及形态。文章在南京的工业遗址更新项目中选取... 详细信息

工业遗址更新作为一种新型的现代城市更新项目,可以激发地区板块的活力,促进地区经济发展。随着互联网时代的到来,新的价值链条以及商业形态不断涌现,深刻影响了工业遗址更新的思路、方式以及形态。文章在南京的工业遗址更新项目中选取研究点位,基于互联网平台讨论以及高德开放平台POI(Point Of Interest)数据,分析南京工业遗产更新项目的商业业态、入驻企业类型以及互联网平台用户评价。针对现代城市工业遗址的更新现状,对城市工业遗址未来发展方向提出建议。目前城市工业遗产更新出现了同质化问题,文章根据所处地域和自身的多层因素,得出垂直化更新趋势的结论。

关键词：工业遗址城市活力城市更新互联网

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Effect of fermented rapeseed meal on growth performance,nutrient digestibility,and intestinal health in growing pigs

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Animal Nutrition 2023年第4期15卷 420-429页

作者： Changyi Shuai Daiwen Chen Bing Yu yuheng Luo Ping Zheng Zhiqing Huang Jie Yu Xiangbing mao Hui Yan Jun He Institute of Animal Nutrition Sichuan Agricultural UniversitySichuan ProvinceChengdu611130China Key Laboratory of Animal Disease-resistant Nutrition Sichuan ProvinceChengdu611130China

To explore the effects of fermented rapeseed meal(FRSM)on growth performance and intestinal health,a total of 30 growing pigs were randomly allotted to three treatments consisting of corn-soybean meal diet(CSD),rapeseed meal diet(RSD),and fermented rapeseed meal diet(FRSD).Results showed that compared with RSD,FRSD feeding increased the average daily gain and final body weight in pigs(P<0.01).Compared with RSD feeding,FRSD feeding elevated the apparent digestibility of crude protein,acid detergent fiber,and ether extract in pigs(P<0.01).Moreover,the FRSD group exhibited greater apparent ileal digestibility of His,Thr,Lys,and Ser than the RSD group(P<0.01).The digestible energy,metabolic energy,and nitrogen utilization were higher in the FRSD and CSD groups than in the RSD group(P<0.01).As compared to the RSD,FRSD feeding decreased the serum concentration of leptin but significantly increased the concentrations of immunoglobulin(Ig)A,IgG,ghrelin,and enzyme activities of amylase,lipase,and trypsin in the pancreas(P<0.05).Interestingly,the villus height,the ratio of villus height to crypt depth,and the activities of brush border enzymes(e.g.,maltase and sucrase)in the small intestine were higher in the CSD and FRSD groups than in the RSD group(P<0.05).As compared to the RSD,the FRSD feeding not only increased the expression level of the occludin in the small intestinal epithelium(P<0.05)but also elevated the expression levels of claudin-1,MUC1,and PepT1 genes in the duodenum,and elevated the expression levels of SGLT1 and CAT1 genes in the jejunum(P<0.05).Importantly,FRSD feeding significantly decreased the abundance of Escherichia coli,but increased the abundance of Lactobacillus and the content of butyrate in the cecum and colon(P<0.05).These results indicated that compared with rapeseed meal,fermented rapeseed meal exhibited a positive effect on improving the growth performance and intestinal health in growing pigs,and the results may also help develop novel protein

关键词： Fermented rapeseed meal Growing pigs Growth performance Nutrient digestibility Intestinal health

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