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Identification and biosynthesis of plant papanridins,a group of novel oligomeric flavonoids

Molecular Plant 2023年第11期16卷 1773-1793页

作者： yue Zhu Seyit Yuzuak xiaoyan Sun De-Yu Xie Department of Plant and Microbial Biology North Carolina State UniversityRaleighNCUSA Department of Chemistry North Carolina State UniversityRaleighNCUSA Department of Molecular Biology&Genetics Mehmet Akif Ersoy UniversityBurdurTurkey

The discovery of novel flavonoids and elucidation of their biosynthesis are fundamental to understanding their roles in plants and their benefits for human and animal health.Here,we report a new pathway for polymerization of a group of novel oligomeric flavonoids in plants.We engineered red cells for discovering genes of interest involved in the flavonoid pathway and identified a gene encoding a novel flavanol polymerase(FP)localized in the central vacuole.FP catalyzes the polymerization of flavanols,such as epicatechin and catechin,to produce yellowish dimers or oligomers.Structural elucidation shows that these compounds feature a novel oligomeric flaven–flavan(FF)skeleton linked by interflavan–flaven and interflaven bonds,distinguishing them from proanthocyanidins and dehydrodicatechins.Detailed chemical and physical characterizations further confirmed the novel FFs as flavonoids.Mechanistic investigations demonstrated that FP polymerizes flavan-3-ols and flav-2-en-3-ol carbocation,forming dimeric or oligomeric flaven-4→8-flavans,which we term“papanridins.”Data from transgenic experiments,mutant analysis,metabolic profiling,and phylogenetic analyses show that the biosynthesis of papanridins is prevalent in cacao,grape,blueberry,corn,rice,Arabidopsis,and other species in the plant kingdom.In summary,our study discoveries a group of novel oligomeric flavonoids,namely papanridins,and reveals that a novel FP-mediated polymerization mechanism for the biosynthesis of papanridins in plants.

关键词： flavanol polymerase papanridin flavan-3-ol flav-2-en-3-ol flavan- flaven

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Insights into the cross-amyloid aggregation of Aβ_(40) and its N-terminal truncated peptide Aβ_(11-40) affected by epigallocatechin gallate

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Chinese Journal of Chemical Engineering 2022年第5期35卷 284-293页

作者： yue Liang Wenjuan Wang Yan Sun xiaoyan Dong Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300354China

Inhibition of protein misfolding and aggregation is a great challenge in the field of biochemical and biopharmaceutical engineering.Alzheimer’s disease(AD)is a protein-misfolding disease,and the interactions between 40-amino-acid-residueβ-amyloid peptide(Aβ_(40)) and its N-terminal truncated peptide Aβ_(11-40) demonstrate that Aβ_(11-40) may play an important role in the pathological process of AD.However,the effect of inhibitors on Aβ_(11-40) aggregation and on the cross-amyloid aggregation(coassembly)between Aβ_(40) and Aβ_(11-40) has never been studied.Herein,coaggregation and seeding interactions between Aβ_(40) and Aβ_(11-40) as well as the effect of epigallocatechin gallate(EGCG),a small molecule inhibitor,on the cross-amyloid aggregation have been investigated by extensive analyses.It is found that Aβ_(11-40) participates in the aggregation of Aβ_(40) and leads to the formation of coaggregates that contain lessβ-sheet structures than pure Aβ_(40) aggregates.The aggregation kinetics along with morphologies and secondary structures of the coaggregates are also significantly affected by the Aβ_(40)/Aβ_(11-40) ratio.EGCG accelerates the nucleation of Aβ_(40) but retards that of Aβ_(11-40) by affecting their elongation and secondary nucleation processes in solution and on solid surfaces.Meanwhile,EGCG makes the conformations of the seeding-induced Aβaggregates more compact,especially for the homologous seedings.Isothermal titration calorimetry measurement indicates that hydrophobic interactions mainly contribute to the inhibition of the two Aβisoforms by EGCG.The findings of this research have provided new insights into Aβaggregation and the effect of an important inhibitor and the results would benefit in the development of potent inhibitors against co-assembly of different amyloid proteins.

关键词： Protein Aggregation Kinetics Nucleation Elongation Molecular interactions

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Hypo-toxicity and prominent passivation characteristics of 316 L stainless steel fabricated by direct metal laser sintering in a simulated inflammation environment

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Journal of Materials Science & Technology 2021年第34期93卷 205-220页

作者： Xiaoqi yue Lei Zhang xiaoyan He Decheng Kong Yong Hua Corrosion and Protection Centre University of Science and Technology BeijingBeijing 100083China Shunde Graduate School University of Science and Technology BeijingFoshan 528399China Reliability Engineering Institute National Engineering Research Center for Water Transport SafetyWuhan University of Technology.Wuhan 430063China Institute of Functional Surfaces School of Mechanical Engineering.University of LeedsLeeds LS29JTUnited Kingdom

3D-printing is an emerging technology that challenged wrought counterparts by one-step manufacturing for complicated biological devices.However,the material properties and surface features due to manufacturing parameters play an important role on the corrosion behaviour and influence the toxicity of the material as an implant.In this paper,the improvement of pitting potential was observed by electrochemical experiments as the result of grain refinement of DMLS 316 L at 200 W laser power.The ICP results verified the supressed release of toxic cations after the formation of the passive film with enhanced characteristics.However,the pores from DMLS 316 L have the potential to develop into pits when polarised above pitting potential,promoting the risk of using 3D-printed 316 L as implant materials.

关键词： Inflammation 3D-printing implant Passive film Hypo-toxicity porosity

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Room temperature pretreatment of pubescens by AlCl_3 aqueous solution

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Journal of Energy Chemistry 2019年第4期28卷 138-147页

作者： yue Wang xiaoyan Lv Jindong Li Qiuxing Li Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University College of Chemical Engineering Sichuan University

Room temperature(about 16°C)pretreatment of pubescens by Al Cl_3aqueous solution with different concentrations was studied.In the presence of 20 wt%Al Cl_3for pretreatment within 24 h,the degradation of hemicellulose reached 19.5 wt%without obvious degradation of cellulose and lignin(2.7 wt%and2.4 wt%,respectively).The extracted hemicellulose from pubescens could be divided into two parts,i.e.,small molecular weight products(saccharides and carboxylic acid,which occupy approximately 28.2%)and oligomers(approximately 71.8%).Low concentration of AlCl_3(<10 wt%)slightly promoted the formation of oligomers with molecular weight in the range of 200–1000 Da,while high concentration of Al Cl_3(10–20 wt%)promoted the formation of oligomers in the molecular weight range above 20,000 Da.The conversion of hemicellulose with acceptable selectivity resulted in the cleavage of bond between hemicellulose and lignin yielding three classical Lignin-Carbohydrate complexes.

关键词： AlCl3 Pretreatment Pubescens Hemicellulose Lignin-Carbohydrate complex(LCC)

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Urban traffic congestion in China:causes and countermeasures

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China Finance and Economic Review 2015年第2期4卷 47-59页

作者： Liu Zhiyan YUE Xiaoyan Zhao Rui Zhang Ying Institute for Urban and Environmental Studies Chinese Academy of Social SciencesBeijingChina

Based on the analysis of the current situation and causes of urban traffic congestion in China,this paper points out that the rapidly rising gap between demand and supply in transportation,inappropriate urban space arrangement,and inefficient traffic management are the underlying causes of traffic congestion.Drawing on the advanced experience of foreign countries,this paper also offers suggestions for countermeasures against urban traffic congestion in China.

关键词： urban traffic traffic congestion countermeasures

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The circular RNA circCPE regulates myoblast development by sponging miR-138

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Journal of Animal Science and Biotechnology 2022年第1期13卷 66-81页

作者： Wenxiu Ru Ao Qi Xuemei Shen Binglin yue xiaoyan Zhang Jian Wang Hui Cao Hong Chen Key laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100ShaanxiChina Shaanxi Kingbull Livestock co. LTDYangling 712100ShaanxiChina

Background:Skeletal muscle development,a long-term and complex process,is controlled by a set of the myogenic genes.Circular RNAs(circRNAs),a class of noncoding RNA,have been shown to regulate various biological processes.Recent studies indicate circRNAs may be involved in myogenesis,but the role and regulatory mechanism of circRNAs in myogenesis is largely unknown.In the present study,circCPE was firstly found to promote the bovine myoblast proliferation and inhibit cell apoptosis and differentiation by influencing the expression of FOXC1 in a miR138-mediated manner.And in vivo experiments revealed that overexpression of circCPE attenuates skeletal muscle regeneration.Results:We identified a novel circular RNA circCPE by analyzing circRNAs sequencing data of bovine muscle tissue.Sequencing verification,RNase R treatment and Actinomycin D treatment confirmed the circular nature of circCPE in bovine muscle.Functional assays showed that overexpression of circCPE could inhibit bovine myoblast apoptosis and differentiation,as well as facilitate cell proliferation.Moreover,in vivo experiments revealed that overexpression of circCPE attenuates skeletal muscle regeneration.In consideration of circRNA action as miRNAs sponge,we found that circCPE harbors miR-138 binding sites and absorbed miR-138.Mechanistically,the rescue experiments showed that the overexpression of circCPE can counteract the inhibitory effect of miR-138 on the cell proliferation and the accelerated effects on the differentiation and apoptosis.Subsequently,we found that circCPE sequester the inhibitory effect of miR-138 on FOXC1 so as to involve in myogenesis.Conclusions:Collectively,we constructed a novel circCPE/miR-138/FOXC1 regulatory network in bovine myogenesis,which further provide stronger evidence that circRNA involved in muscle development acting as miRNA sponge.

关键词： Apoptosis Bovine CircRNA Differentiation MiR-138 Proliferation

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High levels of serum IL-10 indicate disease progression,extramedullary involvement,and poor prognosis in multiple myeloma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第11期23卷 968-974页

作者： xiaoyan yue Linlin HUANG Yang YANG Yi ZHAO Donghua HE xiaoyan HAN Gaofeng ZHENG Yi LI Enfan ZHANG Zhen CAI Xin HUANG Jingsong HE Bone Marrow Transplantation Center Department of Hematologythe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Institute of Hematology Zhejiang UniversityHangzhou 310058China Zhejiang Laboratory for Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 311121China Institute of Hematology Department of Hematologythe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Multiple myeloma(MM)is a common malignant hematological tumor in adults,which is characterized by clonal malignant proliferation of plasma cells in the bone marrow and secretion of a large number of abnormal monoclonal immunoglobulins(M protein),leading to bone destruction,hypercalcemia,anemia,and renal insufficiency(Alexandrakis et al.,2015;Yang et al.,2018).Since a large number of new drugs,represented by proteasome inhibitors and immunomodulators,have been successfullyused to treat MM.

关键词： al. involvement myeloma

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Rare earth monosilicates as oxidation resistant interphase for SiCf/SiC CMC:Investigation of SiC_(f)/Yb_(2)SiO_(5)model composites

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Journal of Advanced Ceramics 2022年第5期11卷 702-711页

作者： Xirui LV Mengkun yue Xue FENG xiaoyan LI Yumin WANG Jiemin WANG Jie ZHANG Jingyang WANG Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China AML Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Center for Mechanics and Materials Tsinghua UniversityBeijing 100084China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Model composites consisting of SiC fiber and Yb_(2)SiO_(5)were processed by the spark plasma sintering(SPS)method.The mechanical compatibility and chemical stability between Yb_(2)SiO_(5)and SiC fiber were studied to evaluate the potential application of Yb monosilicate as the interphase of silicon carbide fiber reinforced silicon carbide ceramic matrix composite(SiC_(f)/SiC CMC).Two kinds of interfaces,namely mechanical and chemical bonding interfaces,were achieved by adjusting sintering temperature.SiC_(f)/Yb_(2)SiO_(5)interfaces prepared at 1450 and 1500℃exhibit high interface strength and debond energy,which do not satisfy the crack deflection criteria based on He-Hutchison diagram.Raman spectrum analyzation indicates that the thermal expansion mismatch between Yb_(2)SiO_(5)and SiC contributes to high compressive thermal stress at interface,and leads to high interfacial parameters.Amorphous layer at interface in model composite sintered at 1550℃is related to the diffusion promoted by high temperature and DC electric filed during SPS.It is inspired that the interfacial parameters could be adjusted by introducing Yb_(2)Si_(2)O_(7)-Yb_(2)SiO_(5)interphase with controlled composition to optimize the mechanical fuse mechanism in SiC_(f)/SiC CMC.

关键词： silicon carbide fiber reinforced silicon carbide ceramic matrix composite(SiCf/SiC CMC) interphase rare earth(RE)silicates interfacial parameters

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Realizing enhanced energy storage and hardness performances in 0.90NaNbO_(3)-0.10Bi(Zn_(0.5)Sn_(0.5))O_(3)ceramics

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Journal of Advanced Ceramics 2022年第5期11卷 729-741页

作者： xiaoyan DONG Xu LI Hongyun CHEN Qinpeng DONG Jiaming WANG Xiang WANG yue PAN Xiuli CHEN Huanfu ZHOU Collaborative Innovation Center for Exploration of Hidden Nonferrous Metal Deposits and Development of New Materials in Guangxi Key Laboratory of Nonferrous Materials and New Processing TechnologyMinistry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China

Ceramic dielectric capacitors have a broad scope of application in pulsed power supply devices.Relaxor behavior has manifested decent energy storage capabilities in dielectric materials due to its fast polarization response.In addition,an ultrahigh energy storage density can also be achieved in NaNbO_(3)(NN)-based ceramics by combining antiferroelectric and relaxor characteristics.Most of the existing reports about lead-free dielectric ceramics,nevertheless,still lack the relevant research about domain evolution and relaxor behavior.Therefore,a novel lead-free solid solution,(1-x)NaNbO_(3)-xBi(Zn_(0.5)Sn_(0.5))O_(3)(abbreviated as xBZS,x=0.05,0.10,0.15,and 0.20)was designed to analyze the domain evolution and relaxor behavior.Domain evolutions in xBZS ceramics confirmed the contribution of the relaxor behavior to their decent energy storage characteristics caused by the fast polarization rotation according to the low energy barrier of polar nanoregions(PNRs).Consequently,a high energy storage density of 3.14 J/cm^(3)and energy efficiency of 83.30%are simultaneously available with 0.10 BZS ceramics,together with stable energy storage properties over a large temperature range(20-100℃)and a wide frequency range(1-200 Hz).Additionally,for practical applications,the 0.10 BZS ceramics display a high discharge energy storage density(W_(dis)≈1.05 J/cm^(3)),fast discharge rate(t_(0.9)≈60.60 ns),and high hardness(H≈5.49 GPa).This study offers significant insights on the mechanisms of high performance lead-free ceramic energy storage materials.

关键词： energy storage NaNbO3(NN)-based domain evolutions hardness

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Microwave-assisted synthesis of oxygen vacancy associated TiO_(2)for efficient photocatalytic nitrate reduction

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Chinese Chemical Letters 2022年第8期33卷 3835-3841页

作者： Qian Li Yunni Liu Zhe Wan Haiyan Cao Shao Zhang yue Zhou Xingyu Ye xiaoyan Liu Dieqing Zhang The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource ChemistryMinistry of Educationand Shanghai Key Laboratory of Rare Earth Functional MaterialsCollege of Chemistry and Materials ScienceShanghai Normal UniversityShanghai 200234China School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200234China

The solar-driven photocatalytic technology has shown great potential in nitrate(NO_(3)^(-))pollutants reduction,however,it has been greatly hindered by the complex preparation and high cost of photocatalysts.Herein,a relatively low-cost photocatalyst,rutile and anatase mixed phase TiO_(2) was synthesized by a facile microwave-hydrothermal method.Meanwhile,oxygen vacancy is successfully generated,leading to an acidic surface for strong adsorption towards NO_(3)^(-),which further improved the reduction activity.Compared with the commercial P25,a higher NO_(3)^(-) conversion of ca.100%and nitrogen(N_(2)) selectivity of 87%were achieved under UV(365 nm)irradiation within 2 h.This research provides a promising strategy for designing efficient noble metal free photocatalyst in the NO_(3)^(-) reduction.

关键词： Photocatalysis TiO_(2) Oxygen vacancy Nitrate reduction

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