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Natural products are the treasure pool for antimalarial agents

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National Science Review 2022年第11期9卷 11-13页

作者： Bin Zhou Jian-min yue State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences

The history of mankind is a constant struggle against diseases, and humans have learned to use natural sources as the remedies to alleviate and/or treat diseases since prehistoric times.e structural diversity and complexity of molecules originated from natural sources are far beyond the scope of human creativity and imagination.

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Attractive natural products with strained cyclopropane and/or cyclobutane ring systems

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Science China Chemistry 2016年第9期59卷 1126-1141页

作者： Yao-yue Fan Xin-Hua Gao Jian-min yue Shanghai Institute of Materia Medica Chinese Academy of Sciences

The strained cyclopropane and/or cyclobutane subunits occurred in many complex natural products including terpenoids, steroids and alkaloids. Natural products with cyclopropane and/or cyclobutane motifs not only furnished fascinating structures, but also exhibited versatile biological activities, such as cytotoxic, anti-HIM antimicrobial, antiviral, and immunosuppressive effects. This review covered a large array of structurally unique natural products with strained cyclopropane and/or cyclobutane motifs and summarized their structural features, distributions, biological activities, as well as biogenetic considerations.

关键词： natural products cyclopropane-containing cyclobutane-containing biological activity biosynthetic pathway

Quantitative estimation of photosynthetic pigments using new spectral indices

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Journal of Forestry Research 2013年第3期24卷 477-483页

作者： XIONG Ying LI Ru yue yue-min Department of Resources and Environmental Sciences Changsha University of Science and Technology Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Institute of Subtropical Agriculture Chinese Academy of Sciences

Foliar chlorophylls are the most important pigments related to the physiological function of plants. Quantitative estimation of photosynthetic pigments can provide important information about relationships between plants and their environmental conditions. In this study, new spectral indices were designed to enhance spectral resistance to noise, using the area of the spectral curve and axis. The specific area was around the red edge （Rdaa）, instead of the sum of the first derivative of the spectrum, specifically the area of red edge （Rda）. Meanwhile, three reference indices were also introduced as non-sensitive bands of chlorophylls. The results show that by dividing spectral references, a kind of re-projection, the spectral indices can be calibrated to allow direct and reasonable comparisons of the results. The sensitivity of these reference indices to chlorophylls was also evaluated in this study. The regression results show that Rdaa and its derivates are highly related to chlorophylls and resistant to noise.

关键词： chlorophyll spectral indices red edge indicator paddy rice

Heteroscedastic regression analysis method for mixed data

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航空动力学报 2011年第4期26卷 721-726页

作者： FU Hui-min yue Xiao-rui Research Center of Small Sample Technology Beijing University of Aeronautics and Astronautics Beijing 100191 China

The heteroscedastic regression model was established and the heteroscedastic regression analysis method was presented for mixed data composed of complete data,type-Ⅰ censored data and type-Ⅱ censored data from the location-scale *** best unbiased estimations of regression coefficients,as well as the confidence limits of the location parameter and scale parameter were ***,the point estimations and confidence limits of percentiles were ***,the traditional multiple regression analysis method which is only suitable to the complete data from normal distribution can be extended to the cases of heteroscedastic mixed data and the location-scale *** the presented method has a broad range of promising applications.

关键词： heteroscedastic regression analysis censored data performance test life prediction reliability analysis

Numerical Investigation on the Harbour Resonance Inside A Harbour with Lateral Cavities

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China Ocean Engineering 2024年第5期38卷 838-844页

作者： YU yue-min HUANG Xiao-hua School of Marine Science and Engineering Hainan UniversityHaikou 570228China Key Laboratory for Sustainable Utilization of Open-Sea Fishery Ministry of Agriculture and Rural AffairsGuangzhou 510300China South China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesGuangzhou 510300China

Wave-induced harbour resonance is numerically investigated inside a harbour with lateral *** theoretical solutions for the amplification parameter are compared with the simulated results under varying dimensionless wave numbers in order to verify the simulation model in a rectangular harbour at a constant *** results indicate that the numerical model can correctly calculate the natural frequency and the natural wave height.A range of calculations are performed for harbour resonance with one pair of lateral cavities,two pairs of lateral cavities and three pairs of lateral cavities,*** simulated results indicate that the amplitude of the amplification parameter decreases both at the primary natural oscillation and the secondary natural oscillation,as the number of lateral cavities *** dimensionless wave number reduces as the number of lateral cavities increases both at the primary natural oscillation and the secondary natural oscillation as well.

关键词： harbour resonance lateral cavity numerical simulation amplification parameter

Frontier studies on natural products:moving toward paradigm shifts

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Science China Chemistry 2023年第4期66卷 928-942页

作者： Jin-Xin Zhao Jian-min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

1 Introduction Natural products(NPs)historically serve as a valuable and productive source of bioactive compounds for drug *** discovery of a range of alkaloids in the early1800s,including strychnine,morphine,etc.,her... 详细信息

关键词： alkaloids moving compounds

Automatic segmentation of bladder in CT images

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 239-246页

作者： Feng SHI Jie YANG yue-min ZHU Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai 200240 China CREATIS. LNSA of Lyon University of Lyon 1 Villeurbanne France

Segmentation of the bladder in computerized tomography(CT) images is an important step in radiation therapy planning of prostate cancer. We present a new segmentation scheme to automatically delineate the bladder contour in CT images with three major steps. First,we use the mean shift algorithm to obtain a clustered image containing the rough contour of the bladder,which is then extracted in the second step by applying a region-growing algorithm with the initial seed point selected from a line-by-line scanning process. The third step is to refine the bladder contour more accurately using the rolling-ball algorithm. These steps are then extended to segment the bladder volume in a slice-by-slice manner. The obtained results were compared to manual segmentation by radiation oncologists. The average values of sensitivity,specificity,positive predictive value,negative predictive value,and Hausdorff distance are 86.5%,96.3%,90.5%,96.5%,and 2.8 pixels,respectively. The results show that the bladder can be accurately segmented.

关键词： Image segmentation Computerized tomography (CT) Mean shift Bladder Rolling ball

Properties and effect of forming sewage sludge into lightweight ceramics

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Frontiers of Environmental Science & Engineering 2012年第1期6卷 117-124页

作者： min yue Qinyan yue Yuanfeng QI Baoyu GAO Hui YU Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityJinan 250100China

In this work we investigated the chemical, thermal and toxic properties of dried sewage sludge （DSS）, the preparation and properties of lightweight sludge ceramic （LSC） and the mechanisms of action of the organic and inorganic foaming agents （OFAs and IFAs）. The chemical components and thermal properties of the raw materials were studied by Energy Dispersive X-ray Detection （EDX） and Thermogravimetric Analysis and Differential Scanning Calorimetry （DSC/TGA）. The mineral phases of the raw materials and the formed ceramics were determined by X-ray Diffraction （XRD）. The leaching characteristics of heavy metals were investigated with inductively Coupled Plasma Atomic Emission Spectrometry （ICP-AES）. Different ratios of DSS and clay were mixed and pressed into raw pellets. After drying and preheating treatment, the raw pellets were sintered at 1150℃ for 10 rain. The physical properties of LSC （50 wt% DSS added） were tested. The results showed that when the addition of DSS was above 50 wt%, LSC began to shrink, and a maximum density occurred. The environmental safety of LSC was satisfactory. XRD showed that some new mineral phases formed in the LSC. Observation of the microstructure by Scanning Electron Microscope （SEM） indicated that the body of LSC was porous.

关键词： sludge foaming agents ceramics preheating process

Current noninvasive tests for colorectal cancer screening: An overview of colorectal cancer screening tests

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World Journal of Gastrointestinal Oncology 2016年第11期8卷 793-800页

作者： Le-Le Song yue-min Li Department of Radiotherapy the Chinese PLA 309 Hospital BioChain(Beijing) Science and Technology Inc.

Colorectal cancer(CRC) has become the third most common cancer in the world. Screening has been shown to be an effective way to identify early CRC and precancerous lesions, and to reduce its morbidity and mortality. Several types of noninvasive tests have been developed for CRC screening, including the fecal occult blood test(FOBT), the fecal immunochemical test(FIT), the fecal-based DNA test and the bloodbased DNA test(the SEPT9 assay). FIT has replaced FOBT and become the major screening test due to high sensitivity, specificity and low costs. The fecal DNA test exhibited higher sensitivity than FIT but its current cost is high for a screening assay. The SEPT9 assay showed good compliance while its performance in screening needs further improvements. These tests exhibited distinct sensitivity and specificity in screening for CRC and adenoma. This article will focus on the performance of the current noninvasive in vitro diagnostic tests that have been used for CRC screening. The merits and drawbacks for these screening methods will also be compared regarding the techniques, usage and costs. We hope this review can provide suggestions for both the public and clinicians in choosing the appropriate method for CRC screening.

关键词： Colorectal cancer Adenoma Fecal immunochemical test Fecal DNA SEPT9 Septin 9