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PathMarker:protecting web contents against inside crawlers

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Cybersecurity 2019年第1期2卷 100-116页

作者： Shengye Wan yue li Kun Sun Department of Computer Science College of William and Mary Williamsburg 23187-8795VAUSA Department of Information Sciences and Technology George Mason University Fairfax 22030VAUSA

Web crawlers have been misused for several malicious purposes such as downloading server data without permission from the website ***,armoured crawlers are evolving against new anti-crawler mechanisms in the arm races between crawler developers and crawler *** this paper,based on one observation that normal users and malicious crawlers have different short-term and long-term download behaviours,we develop a new anti-crawler mechanism called PathMarker to detect and constrain persistent distributed *** adding a marker to each Uniform Resource Locator(URL),we can trace the page that leads to the access of this URL and the user identity who accesses this *** this supporting information,we can not only perform more accurate heuristic detection using the path related features,but also develop a Support Vector Machine based machine learning detection model to distinguish malicious crawlers from normal users via inspecting their different patterns of URL visiting paths and URL visiting *** addition to effectively detecting crawlers at the earliest stage,PathMarker can dramatically suppress the scraping efficiency of crawlers before they are *** deploy our approach on an online forum website,and the evaluation results show that PathMarker can quickly capture all 6 open-source and in-house crawlers,plus two external crawlers(i.e.,Googlebots and Yahoo Slurp).

关键词： Anti-Crawler mechanism Stealthy distributed inside crawler Confidential Website content protection

Current noninvasive tests for colorectal cancer screening: An overview of colorectal cancer screening tests

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World Journal of Gastrointestinal Oncology 2016年第11期8卷 793-800页

作者： Le-Le Song yue-Min li Department of Radiotherapy the Chinese PLA 309 Hospital BioChain(Beijing) Science and Technology Inc.

Colorectal cancer(CRC) has become the third most common cancer in the world. Screening has been shown to be an effective way to identify early CRC and precancerous lesions, and to reduce its morbidity and mortality. Several types of noninvasive tests have been developed for CRC screening, including the fecal occult blood test(FOBT), the fecal immunochemical test(FIT), the fecal-based DNA test and the bloodbased DNA test(the SEPT9 assay). FIT has replaced FOBT and become the major screening test due to high sensitivity, specificity and low costs. The fecal DNA test exhibited higher sensitivity than FIT but its current cost is high for a screening assay. The SEPT9 assay showed good compliance while its performance in screening needs further improvements. These tests exhibited distinct sensitivity and specificity in screening for CRC and adenoma. This article will focus on the performance of the current noninvasive in vitro diagnostic tests that have been used for CRC screening. The merits and drawbacks for these screening methods will also be compared regarding the techniques, usage and costs. We hope this review can provide suggestions for both the public and clinicians in choosing the appropriate method for CRC screening.

关键词： Colorectal cancer Adenoma Fecal immunochemical test Fecal DNA SEPT9 Septin 9

Identification of pathogenic genes of pterygium based on the Gene Expression Omnibus database

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 529-535页

作者： Xiao-li yue Zi-Qing Gao Department of Ophthalmology the First Affiliated Hospital of Bengbu Medical College

AIM: To identify the pathogenic genes in ***: We obtained m RNA expression profiles from the Gene Expression Omnibus database(GEO) to identify differentially expressed genes(DEGs) between pterygium tissues and normal conjunctiva tissues. The Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway analysis, protein-protein interaction(PPI) network and transcription factors(TFs)-target gene regulatory network was performed to understand the function of DEGs. The expression of selected DEGs were validated by the quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS: A total of 557 DEGs were identified between pterygium and normal individual. In PPI network, several genes were with high degrees such as FN1, KPNB1, DDB1, NF2 and BUB3. SSH1, PRSS23, LRP5L, MEOX1, RBM14, ABCA1, JOSD1, KRT6 A and UPK1B were the most downstream genes regulated by TFs. q RT-PCR results showed that FN1, PRSS23, ABCA1, KRT6A, ECT2 and SPARC were significantly up-regulated in pterygium and MEOX1 and MMP3 were also up-regulated with no significance, which was consistent with the our integrated analysis. CONCLUSION: The deregulated genes might be involved in the pathology of pterygium and could be used as treatment targets for pterygium.

关键词： pterygium gene expression protein-protein interaction network pathogenesis

Paclitaxel-etoposide-carboplatin/cisplatin versus etoposidecarboplatin/cisplatin as first-line treatment for combined small-cell lung cancer: a retrospective analysis of 62 cases

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Cancer Biology & Medicine 2015年第2期12卷 117-125页

作者： yue-Ya li Chan Zhou Deng-Xia Yang Jing Wang Zhu-Jun liu Xin-yue Wang Kai li Department of Thoracic Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Lung Cancer Diagnosis and Treatment Center

Objective: To compare the efficacy and adverse effects of paclitaxel-etoposide-carboplatin/cisplatin(TEP/TCE) regimen with those of etoposide-carboplatin/cisplatin(EP/CE) regimen as first-line treatment for combined small-cell lung cancer(CSCLC).Methods: A retrospective study was conducted on 62 CSCLC patients who were treated at Tianjin Medical University Cancer Institute and Hospital from July 2000 to April 2013 and administered with TEP/TCE regimen(n=19) or EP/CE regimen(n=43) as first-line CSCLC treatment. All patients received more than two cycles of chemotherapy, and the response was evaluated every two cycles. The primary endpoint was overall survival(OS), and the secondary endpoints were progression-free survival(PFS), objective response rate(ORR), disease control rate(DCR), and adverse effects. Results: ORR between the TEP/TCE and EP/CE groups showed a statistical difference(90% vs. 53%, P=0.033). Both groups failed to reach a statistical difference in DCR(100% vs. 86%, P=0.212). The median PFS and OS of the TEP/TCE group were slightly longer than those of the EP/CE group, although both groups failed to reach a statistical difference(10.5 vs. 8.9 months, P=0.484; 24.0 vs. 17.5 months, P=0.457). However, stratified analysis indicated that the PFS of patients with stages III and IV CSCLC showed marginally significant difference between the TEP/TCE and EP/CE groups(19.5 vs. 7.6 months; P=0.071). Both rates of grade IV bone marrow depression and termination of chemotherapy in the TEP/TCE group were significantly higher than those in the EP/CE group(26.3% vs. 7.0%, P=0.036; 31.6% vs. 14.7%, P=0.004). Conclusion: The TEP/TCE regimen may not be preferred for CSCLC, and this three-drug regimen requires further exploration and research. To date, the EP/CE regimen remains the standard treatment for CSCLC patients.

关键词： Small cell lung carcinoma (SCLC) chemotherapy CE regimen adverse effects survival analysis prognosis

Study of simulation experiments on the TSR system and its effect on the natural gas destruction

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Science China Earth Sciences 2005年第8期48卷 1197-1202页

作者： yue Changtao li Shuyuan DING Kangle ZHONG Ningning State Key Lab of Heavy Oil Processing University of Petroleum Beijing 102249 China State Key Lab of Heavy Oil Processing University of Petroleum Beijing 102249 China State Key Lab of Heavy Oil Processing University of Petroleum Beijing 102249 China State Key Lab of Heavy Oil Processing University of Petroleum Beijing 102249 China

The TSR process may be one of the reasons to result in the natural gas destruction in deep carbonate reservoirs. The work on this field has been the subject of much research in recent years. In this paper, thermal simulation experiments on the reaction of CH4-CaSO4 were carried out using autoclave at high temperature and high pressure. The products were charac-terized by some advanced analytical methods. The thermodynamics and kinetics were discussed and the reaction mechanism was investigated tentatively. It is found that the reaction can pro-ceed spontaneously to produce H2S, H2O and CaCO3 as the main products at the temperature range of 550―700℃ . The activation energy and geological reaction rate calculated from the ki-netic model can be compared with those from previous work. The results obtained in this paper can provide important information on the explanation of geochemical depth limit for natural gas and on the exploration of gas reservoirs.

关键词： natural gas destruction, TSR, simulation experiments, kinetics.

Phosphine/Benzocyclone-based Neutral Nickel Catalysts for Ethylene Polymerization and Copolymerization with Polar Monomers

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Chinese Journal of Polymer Science 2024年第2期42卷 202-212,I0007页

作者： Fei Wang li Pan Vladislav A.Tuskaev Svetlana Ch.Gagieva yue-Sheng li Tianjin Key Lab of Composite&Functional Materials School of Material Science and EngineeringTianjin UniversityTianjin300072China Department of Chemistry Lomonosov Moscow State UniversityRussian Federation InstitutionLeninskie Gory 1Moscow119991Russian Federation A N Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesVavilova st.28Moscow119991Russian Federation

The efficient copolymerization of olefin with polar monomers using nickel-based catalysts presents a longstanding challenge. In this contribution, three phosphine-benzocyclone ligands and corresponding neutral nickel catalysts(Ni1: Ar = Ph;Ni2: Ar = 2-(C_(6)H_(5))C_(6)H_(4);Ni3: Ar = 2-[2',6'-(Me O)_(2)-C_(6)H3]C_(6)H_(4)) were prepared and applied for the ethylene polymerization and copolymerization with polar monomers without any cocatalyst. The bulky substituent groups in complexes Ni2 and Ni3 contributed to high catalytic activities(up to 7.24×10^(6) and 9.04×10^(6)g·mol Ni^(-1)·h^(-1), respectively), and produced high-molecular-weight polyethylene(Mw up to 545.7 k Da). Complex Ni3 exhibited high activities for ethylene polymerization at the level of 10^(6) g·mol Ni^(-1)·h^(-1) across a wide range from 30 ℃ to 120 ℃, exhibiting excellent high temperature tolerance. These nickel complexes were also effectively employed in the copolymerization of ethylene with methyl acrylate, ethyl acrylate, butyl acrylate and lauryl acrylate, producing copolymers with high molecular weights(Mw up to 80.5 k Da) and high polar monomer incorporation(up to 8.2 mol%). Microstructure analyses revealed that the introduction of large sterically hindered substituents facilitated the incorporation of polar functional units into the polymer backbone. This study demonstrates the potential of these nickel-based catalysts for efficient copolymerization of olefin with polar monomers.

关键词： Neutral nickel catalyst Ethylene polymerization Copolymerization Polar acrylate monomers

Dryland Expansion in Northern China from 1948 to 2008

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Advances in Atmospheric Sciences 2015年第6期32卷 870-876页

作者： li yue HUANG Jianping JI Mingxia RAN Jinjiang Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric Sciences Lanzhou University

This study examines the expansion of drylands and regional climate change in northern China by analyzing the variations in aridity index （AI）, surface air temperature （SAT）, precipitation and potential evapotranspiration （PET） from 1948 to 2008. It is found that the drylands of northern China have expanded remarkably in the last 61 years. The area of drylands of the last 15 years （1994--2008） is 0.65 × 106 km2 （12%） larger than that in the period 1948-62. The boundary of drylands has extended eastward over Northeast China by about 2 °of longitude and by about 1° of latitude to the south along the middle- to-lower reaches of the Yellow River. A zonal band of expansion of semi-arid regions has occurred, stretching from western Heilongjiang Province to southern Gansu Province, while shifts to the east of semi-arid regions in dry subhumid regions have also occurred. Results show that the aridity trend of drylands in northern China is highly correlated with the long-term trend of precipitation and PET, and the expansion of semi-arid regions plays a dominant role in the areal extent of drylands, which is nearly 10 times larger than that in arid and subhumid regions.

关键词： aridity index dryland expansion climate variation northern China

Glycemic and blood pressure control in older patients with hypertension and diabetes： association with carotid atherosclerosis

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Journal of Geriatric Cardiology 2011年第1期8卷 24-30页

作者： Hong-Wei Du Jia-yue li Yao He The Military General Hospital of Beijing Beijing 100041 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatrics Chinese PLA General Hospital Beijing 100853 China

Backgroud Numerous studies have confirmed the effectiveness of slowing the progression of atherosclerosis by blood pressure （Bp） control in patients with hypertension and several studies also showed the efficacy of intensive glycemic control in decreasing progression of carotid intima-media thickness （CIMT） in patients with type 1 and type 2 diabetes. However, few studies have compared the relative importance of glycemic w＇. Bp control in patients with diabetes and hypertension. We aimed to investigate the association between Bp and glycemic control and subclinical carotid atherosclerosis in older patients with hypertension and type 2 diabetes. Methods In a cross-sectional study, B-mode high-resolution ultrasonography of the carotid artery was performed in 670 subjects （508 males and 162 females） aged 60 years or over who had self-reported hypertension and diabetes but no history of coronary heart disease or stroke. Subjects were categorized by their systolic blood pressure： tight control, 〈 130 mmHg; usual control, 130-139 mmHg; or uncontrolled, 〉 140 mmHg, and by their hemoglobin Alc （HbAlc） level： tight control, 〈 6.5%; usual control, 6.5%-7.5%; or uncontrolled, 〉 7.5%, respectively. Results The mean CIMT was 8.20 ±0.11 mm, and carotid plaque was found in 52.5% （352/670） subjects. Overall, 62.1% of the subjects had subclinical carotid atherosclerosis, defined as having either carotid plaque or elevated CIMT （≥ 1.1 ram）. The mean CIMT was significantly different between Bp control categories （7.60 ± 0.09 mm, 7.90 ±0.08 mm, and 8.60 ± 0.12 mm, respectively, P = 0.03） but not between glycemic control categories （8.20± 0.10 mm, 8.1 ±0.08 mm, and 8.40 ± 0.14 ram, respectively, P = 0.13） using ANCOVA analysis. Multivariable logistic regression adjusting for potential confounding factors showed that usual or uncontrolled Bp control were associated with having carotid plaque （OR = 1.08 and OR=1.42, respectively）, or elevated CIMT [Odd ratio （OR） = 1.17, 95% confidence in

关键词： hypertension diabetes carotid intima-media thickness carotid plaque atherosclerosis

Leaching behavior and microstructure of phosphorus in converter slag

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Journal of Iron and Steel Research International 2024年第7期31卷 1646-1660页

作者： Chao-gang Zhou Jin-yue li Qing-gong Chen Yin-ye Yang Wei Gong li-qun Ai Shu-huan Wang Bei-yue Ma College of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina College of Materials Science and Engineering Guizhou Minzu UniversityGuiyang 550025GuizhouChina School of Materials and Architectural Engineering Guizhou Normal UniversityGuiyang 550025GuizhouChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

Converter slag is a by-product of the steelmaking process and contains a large amount of Ca,Fe,P and other *** the phosphorus in the converter slag can be effectively extracted,the resulting phosphorus can be used as a phosphate *** in converter slag is mainly enriched in 2CaO·SiO_(2)-3CaO·P_(2)O_(5)(C_(2)S-C_(3)P)solid solution and is easily dissolved in ***,acid leaching method was used to dissolve the solid solution to extract phosphorus in converter slag,so as to realize the recycling of phosphorus resources in converter *** leaching behavior of three actual converter slags from different steel mills in acid leaching solutions composed of citric acid,sodium hydroxide,hydrochloric acid and deionized water was studied by X-ray diffraction,scanning electron microscopy combined with energy dispersive spectrometry,Fourier transform infrared spectroscopy and Raman spectroscopy to reveal the change in object image structure as well as SiO_(4) and PO_(4) tetrahedron before and after acid *** results show that only a small amount of phosphorus in converter slag with too low basicity is enriched in C_(2)S-C_(3)P solid solution,resulting in poor leaching *** the converter slag has a high basicity,the removal effect of phosphorus is 70.64%-81.88%.In addition,when the basicity of converter slag is roughly the same,the dephosphorization effect of slag with high FeO content is relatively *** acid leaching will cause depolymerization behavior of SiO_(4) and PO_(4) tetrahedron,so that the mole fraction of Q0(Si)(asymmetric stretching vibration of Si-O bond in SiO_(4) tetrahedron with bridge oxygen number of 0)and NBO/Si(non-bridging oxygen in silicate tetrahedra)will ***-containing solids can be obtained from the solution after acid leaching through static precipitation,and the solids have the potential to make phosphate fertilizers.

关键词： Dephosphorization converter slag Acid leaching Phosphorus Solid solution Slag structure