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Chinese Optics Letters 2024年第7期22卷 126-131页

作者： Xiao Yu Jia Ye Lianshan Yan Tao zhou yue Zhu Peng Li Xihua Zou Wei Pan Center for Information Photonics and Communications School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China Key Laboratory of Electronic Information Control Southwest China Research Institute of Electronic EquipmentChengdu 610029China Microwave Photonics Research Laboratory School of Electrical Engineering and Computer ScienceUniversity of OttawaOttawaONK1N6N5Canada

We propose and experimentally demonstrate a photonic method for wideband multipath self-interference cancellation using a silicon photonic modulator *** chip generates phase-inverted reference signals by leveraging the opposite phase between optical *** managing amplitude and phase imbalances between self-interference and reference signals,the approach rectifies discrepancies through consistent chip manufacturing and packaging *** photonic multi-dimensional multiplexing,including wavelength and polarization,enables the acquisition of multiple reference *** results show multipath cancellation depths of 25.53 dB and 23.81 dB for bandwidths of 500 MHz and 1 GHz,achieved by superimposing 2-path reference signals.

关键词： microwave photonics multipath self-interference silicon photonics

Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor

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World Journal of Gastroenterology 2024年第8期30卷 863-880页

作者： gui-Ming Deng Hai-Bin Song Zhong-Ze Du Ying-Wei Xue Hong-Jiang Song Yuan-zhou Li Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND The development and progression of gastric cancer(GC)are closely linked to the nutritional status of *** immunotherapy has been demonstrated to be clinically effective,the relationships of sarcopenia and myosteatosis with the use of immune checkpoint inhibitors(ICIs)in patients with gastric cancer remain to be *** We performed a retrospective study of patients who were undergoing immuno-therapy for *** the evaluation of sarcopenia,the optimal cut-off value for the skeletal muscle index was established using receiver operating characteristic analysis of data obtained from pre-treatment computed tomography images at the L3 vertebral *** was defined using the mean skeletal muscle density(SMD),with a threshold value of<41 Hounsfield units(HU)for patients with a body mass index(BMI)<25 kg/m^(2)and<33 HU for those with a BMI≥25 kg/m^(2).The log-rank test was used to compare progression-free survival(PFS)and overall survival(OS),and a Cox proportional hazard model was used to identify prognostic *** were developed to predict the PFS and OS of patients on the basis of the results of multivariate *** We studied 115 patients who were undergoing ICI therapy for GC,of whom 27.4%had sarcopenia and 29.8%had *** with sarcopenia or myosteatosis had significantly shorter PFS and OS than those without these ***,both sarcopenia and myosteatosis were found to be independent predictors of PFS and OS in patients with GC administering an *** prediction models created for PFS and OS were associated with C-indexes of 0.758 and 0.781,*** The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.

关键词： Gastric cancer Sarcopenia Myosteatosis,Immune checkpoint inhibitor Prognostic factor Overall survival Progression-free survival

circRNA3669 promotes goat endometrial epithelial cells proliferation via miR-26a/RCN2 to activate PI3K/AKT-mTOR and MAPK pathways

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Journal of Integrative Agriculture 2024年第3期23卷 960-974页

作者： Xiaorui Liu Jiuzeng Cui Mengyao Wei Xiaofei Wang yuexia Liu Zhongshi Zhu Min zhou gui Ba Langda Suo Yuxuan Song Lei Zhang Division of Laboratory Safety and Services Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial epithelial cells(GEECs) proliferation

Wide temperature range,air stable,transparent,and self-powered photodetectors enabled by a hybrid film of graphene and singlewalled carbon nanotubes

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Nano Research 2024年第7期17卷 6582-6593页

作者： Ying yue Di Zhang Pengyu Wang Xin Wu yuejuan Zhang Yanchun Wang Xiao Zhang Xiaojun Wei Huaping Liu Weiya zhou Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences and College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Beijing Key Laboratory for Advanced Functional Materials and Structure Research Beijing 100190China

Transparent photovoltaic devices(TPVDs)have attracted increasing attention in emerging electronic *** the application scenarios extend,there raise higher requirements regarding the stability and operating temperature range of *** this work,a unique preparation strategy is proposed for air stable TPVD with a wide operating temperature range,i.e.,a nanoscale architecture termed as H-TPVD is constructed that integrates a free-standing and highly transparent conductive hybrid film of graphene and single-walled carbon nanotubes(G-SWNT TCF for short)with a metal oxide NiO/TiO_(2)*** preparation approach is suitable for scaling *** to the excellent transparent conductivity of the freestanding G-SWNT hybrid film and the ultrathin NiO/TiO_(2)heterojunction(100 nm),H-TPVD selectively absorbs the ultraviolet(UV)band of sunlight and has a transparency of up to 71%in the visible *** integrated nanoscale architecture manifests the significant holecollecting capability of the G-SWNT hybrid film and the efficient carrier generation and separation within the ultrathin NiO/TiO_(2)heterojunction,resulting in excellent performance of the H-TPVD with a specific detectivity of 2.7×10^(10) ***,the freestanding G-SWNT TCF is a super stable and non-porous two-dimensional film that can insulate gas molecules,thereby protecting the surface properties of NiO/TiO_(2)heterojunctions and enhancing the stability of *** subjected to 20,000 cycles and storage in air for three months,the performance parameters such as photo-response signal,output power,and specific detectivity show no noticeable *** particular,the as-fabricated self-powered H-TPVD can operate over a wide temperature range from −180 to 300℃,and can carry out solar-blind UV optical communication in this *** addition,the 4×4 array H-TPVD demonstrates clear optical *** results make it possible for H-TPVD to expand its potential application scenarios.

关键词： transparent photovoltaic devices hybrid films of graphene and single-walled carbon nanotubes metal oxides stability wide temperature range

Microfluidic synthesis of hollow CsPbBr_(3) perovskite nanocrystals through the nanoscale Kirkendall effect

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Nano Research 2024年第9期17卷 8487-8494页

作者： yue Chen Xiaoyu Zhang Jinzhou Jiang Gaoyu Chen Kunhong zhou Xinwen Zhang Fajing Li Caojin Yuan Jianchun Bao Xiangxing Xu Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BatteriesSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Key Laboratory for Organic Electronics and Information Displays Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Frontiers Science Center for Flexible Electronics Institute of Flexible Electronics(IFE)Northwestern Polytechnical UniversityXi’an 710072China Jiangsu Key Laboratory for Opto-Electronic Technology School of Physics and TechnologyNanjing Normal UniversityNanjing 210023China State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China

All inorganic metal halide perovskite nanocrystals(NCs)have attracted much attention for their outstanding optoelectronic properties,which can be tuned by the composition,surface,size and morphology in ***,we report the microfluidic synthesis of hollow CsPbBr_(3)perovskite NCs through the nanoscale Kirkendall *** formation mechanism of the hollow structure(Kirkendall void)controlled by the temperature,flow rate,ratios of precursors and ligands was *** with the solid CsPbBr_(3)NCs of the same size,the hollow CsPbBr_(3)NCs exhibit blue shifts in ultraviolet-visible(UV-vis)absorption and photoluminescence(PL)spectra,and remarkably longer PL average lifetime(~98.2 ns).Quantum confinement effect,inner surface induced additional trap states and lattice strain of the hollow CsPbBr_(3)NCs were discussed in understanding their unique optoelectronic *** hollow CsPbBr_(3)NC based photodetector exhibits an outstanding negative photoconductivity(NPC)detectivity of 8.9×10^(12)*** also show potentials in perovskite NC based photovoltaic and light emitting diodes(LEDs).

关键词： perovskite nanocrystals hollow nanocrystals nanoscale Kirkendall effect microfluidic synthesis

Torque effect on vibration behavior of high-speed train gearbox under internal and external excitations

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Railway Engineering Science 2024年第2期32卷 229-243页

作者： yue zhou Xi Wang Hongbo Que Rubing Guo Xinhai Lin Siqin Jin Chengpan Wu Yu Hou School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China CRRC Qishuyan Institute Co. Ltd.No.258Wuyi RoadQishuyanChangzhou 213011China Frontiers Science Center for Smart High-Speed Railway System Beijing Jiaotong UniversityBeijing 100044China

The high-speed train transmission system,experiencing both the internal excitation originating from gear meshing and the external excitation originating from the wheel-rail interaction,exhibits complex dynamic behavior in the actual service *** paper focuses on the gearbox in the high-speed train to carry out the bench test,in which various operat-ing conditions(torques and rotation speeds)were set up and the excitation condition covering both internal and external was *** responses on multiple positions of the gearbox were acquired in the test and the vibration behavior of the gearbox was ***,a stochastic excitation modal test was also carried out on the test bench under different torques,and the modal parameter of the gearbox was ***,the sweep frequency response of the gearbox under gear meshing excitation was analyzed through dynamic *** results showed that the torque has an attenuating effect on the amplitude of gear meshing frequency on the gearbox,and the effect of external excitation on the gearbox vibration cannot be ignored,especially under the rated operating *** was also found that the torque affects the modal param-eter of the gearbox *** torque has a great effect on both the gear meshing stiffness and the bearing stiffness in the transmission system,which is the inherent reason for the changed modal characteristics observed in the modal test and affects the vibration behavior of the gearbox consequently.

关键词： High-speed train Gearbox Bench test Vibration behavior Modal identification

Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 110-117页

作者： Chuan-Yu Wang Xiao-Jing Fan Fei-Liang Wang yue-yue Ge Zhao Cai Wei Wang Xin-Ping zhou Jun Du De-Wei Dai Department of Ultrasound Medicine Beijing HospitalBeijing 100005China Department of Gastroscopy Beijing HospitalBeijing 100005China Department of General Surgery Beijing HospitalBeijing 100005China Department of Pathology Beijing HospitalBeijing 100005China

BACKGROUND The incidence of gastric cancer remains high,and it is the sixth most common cancer and the fourth leading cause of cancer deaths *** contrastenhanced ultrasonography is a simple,non-invasive,and painless method for the diagnosis of gastric *** To explore the diagnostic value of oral contrast-enhanced ultrasonography for the detection of gastric *** The screening results based on oral contrast-enhanced ultrasonography and electronic gastroscopy were compared with those of the postoperative pathological *** Among 42 patients with gastric tumors enrolled in the study,the diagnostic accordance rate was 95.2%for oral contrast-enhanced ultrasonography(n=40)and 90.5%for electronic gastroscopy(n=38)compared with postoperative pathological *** Kappa value of consistency test with pathological findings was 0.812 for oral contrast-enhanced ultrasonography and 0.718 for electronic gastroscopy,and there was no significant difference between them(P=0.397).For the TNM staging of gastric tumors,the accuracy rate of oral contrast enhanced ultrasonography was 81.9%for the overall T staging and 50%,77.8%,100%,and 100%for T1,T2,T3,and T4 staging,*** sensitivity and specificity were both 100%for stages T3 and *** diagnostic accuracy rate of oral contrast-enhanced ultrasonography was 93.8%,80%,100%,and 100%for stages N0,N1-N3,M0,and M1,*** The accordance rate of qualitative diagnosis by oral contrast-enhanced ultrasonography is comparable to that of gastroscopy,and it could be used as the preferred method for the early screening of gastric tumors.

关键词： Oral contrast-enhanced ultrasonography Gastric tumor Electronic gastroscopy Controlled study Pathological examination Diagnosis

High-pressure capacity expansion and water injection mechanism and indicator curve model for fractured-vuggy carbonate reservoirs

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Petroleum 2024年第3期10卷 511-519页

作者： Lixin Chen Chengzao Jia Rujie Zhang Ping yue Xujian Jiang Junfang Wang zhou Su Yun Xiao Yuan Lv Institute of Unconventional Oil and Gas Science and Technology China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Reservoir Geology and Development Southwest Petroleum UniversityChengdu610500China Tarim Oilfield Company PetroChinaKorla841000China

Water injection for oil displacement is one of the most effective ways to develop fractured-vuggy carbonate *** the increase in the number of rounds of water injection,the development effect gradually *** emergence of high-pressure capacity expansion and water injection technology allows increased production from old *** high-pressure capacity expansion and water injection technology has been implemented in practice for nearly 10 years in fractured-vuggy reservoirs,its mechanism remains unclear,and the water injection curve is not *** the past,evaluating its effect could only be done by measuring the injection-production *** this study,we analyze the mechanism of high-pressure capacity expansion and water *** propose a fluid exchange index for high-pressure capacity expansion and water injection and establish a discrete model suitable for high-pressure capacity expansion and water injection curves in fractured-vuggy *** propose the following mechanisms:replenishing energy,increasing energy,replacing energy,and releasing *** above mechanisms can be identified by the high-pressure capacity expansion and water injection curve of the well HA6X in the Halahatang Oilfield in the Tarim *** solving the basic model,the relative errors of Reservoirs I and II are found to be 1.9%and 1.5%,respectively,and the application of field examples demonstrates that our proposed high-pressure capacity expansion and water injection indicator curve is reasonable and *** research can provide theoretical support for high-pressure capacity expansion and water injection technology in fracture-vuggy carbonate reservoirs.

关键词： Fractured-vuggy carbonate reservoirs High-pressure capacity expansion and water injection Mechanism Water injection indicator curve

Enhanced electrical and mechanical properties of Bi_(2)Te_(3)-based thermoelectric thick films enabled by a practical dynamic regulation strategy

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Journal of Materiomics 2024年第2期10卷 480-489页

作者： Jie zhou Wei Zhu Qingqing Zhang Guangyu Han YuTong Liu Zhanpeng Guo Siming Guo yue Huang Yuan Deng School of Materials Science and Engineering Beihang UniversityBeijing 100191China Research Institute for Frontier Science Beihang UniversityBeijing 100191China Key Laboratory of Intelligent Sensing Materials and Chip Integration Technology of Zhejiang Province Hangzhou Innovation Institute of Beihang UniversityHangzhou310051China

The application of high-density and high-performance micro thermoelectric devices is still in its infancy,mainly restricted by the low performance of Bi_(2)Te_(3)-based thick film as well as the limited device *** this study,we proposed a dynamic regulation strategy to simultaneously strengthen the thermoelectric and mechanical properties for n-type Bi_(2)Te_(3)-based thick *** effects of growth temperature and time on thermoelectric properties have been firstly *** the thermoelectric properties exhibit consistent degradation with increasing thickness at static growth temperature,an effective rising temperature method is introduced to dynamically regulate the nucleation rate and growing diffusion ***,the grain refinement with compact texture structure leads to a relatively large carrier mobility(77.1 cm^(2)·V^(-1)·s^(-1))and appropriate concentration(5.25×10^(19)cm^(-3))as well as further 12%improvement of power factor with an average value up to 12.0 mW·cm^(-1)·K^(-2)over a wide temperature ranging from 313 K to 453 ***,significant enhancement of mechanical property is also achieved with high elastic modules(56.03 GPa),hardness(0.63 GPa)and large energy dissipation capacity to prevent *** study provides a practical solution with dynamic temperature control to fabricate high-performance Bi_(2)Te_(3) thick films with enhanced mechanical property and pro-cessing feasibility for micro thermoelectric devices.

关键词： Bi_(2)Te_(3)material Thick film Magnetron sputter Dynamic temperature Thermoelectric property Mechanical property

Heteroatom Structural Engineering Enables Ethenylene-Bridged Bisisoindigo-Based Copolymers to Exhibit Unique n-Type Transistor Performance

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CCS Chemistry 2024年第2期6卷 473-486页

作者： Yuchai Pan Weifeng Zhang Yankai zhou Xuyang Wei Hao Luo Jinbei Wei Liping Wang gui Yu Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049 School of Material Science and Engineering University of Science and Technology BeijingBeijing 100083

Herein,we report three novel electron-deficient aromatics,ethenylene-bridged bisisoindigos 3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoind-oline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one)(NCCN),3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one)(NFFN),and(3E,3″E)-6,6″-((E)-ethene-1,2-diyl)bis(1,1′-bis(4-decyltetradecyl)-[3,3′-bipyrrolo[2,3-b]pyridinylidene]-2,2′(1H,1′H)-dione)(NNNN),and their derived donor–acceptor(D–A)copolymers,namely poly[3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNCCN-FBT),poly[3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNFFNFBT),and poly[(3E,3″E)-6′,6‴-((E)-ethene-1,2-diyl)bis(1,1′-bis(4-decyltetradecyl)-[3,3′-bipyrrolo[2,3-b]pyridinylidene]-2,2′(1H,1′H)-dione-6-yl)]-alt-[5,6-difluoro-4,7-di[(thiophen-2-yl)-5-yl)]benzo[c][1,2,5]thiadiazole](PNNNN-FBT),in which 5,6-difluoro-4,7-di(thiophen-2-yl)benzo[c][1,2,5]thiadiazole(FBT)acts as the electron-donating *** ethenylene-bridging unit reduces the steric hindrance of the three *** of heteroatoms,such as fluorine and sp2-nitrogen atoms,endows them with multiple CH···F,CH···N,and N···S intramolecular hydrogen bonds/nonbinding interactions,resulting in increasing backbone planarity from NCCN,NFFN,to NNNN,and thus from PNCCN-FBT,PNFFN-FBT,to *** found that all copolymers formed an improved molecular packing in the 1-chloronaphthalene(CN)-processed thin film compared with the 1,2-d

关键词： D-A copolymers bisisoindigos heteroatom structural engineering n-type field-effect transistors electron mobilities