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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan xu Kang He Chang-qing liu li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

A Type-2 Fuzzy Approach to Driver-Automation Shared Driving Lane Keeping Control of Semi-Autonomous Vehicles Under Imprecise Premise Variable

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Chinese Journal of Mechanical Engineering 2022年第2期35卷 210-227页

作者： yue liu qing xu Hongyan guo Hui Zhang School of Transportation Science and Engineering Beihang UniversityBeijing 100091China School of Vehicle and Mobility Tsinghua UniversityBeijing 100000China College of Automotive Engineering Jilin UniversityChangchun 130000China

The driver-automation shared driving is a transition to fully-autonomous driving,in which human driver and vehicular controller cooperatively share the control *** paper investigates the shared steering control of semi-autonomous vehicles with uncertainty from imprecise *** considering driver’s lane-keeping behavior on the vehicle system,a driver-automation shared driving model is introduced for control *** on the interval type-2(IT2)fuzzy theory,moreover,the driver-automation shared driving model with uncertainty from imprecise parameter is described using an IT2 fuzzy *** that,the corresponding IT2 fuzzy controller is designed and a direct Lyapunov method is applied to analyze the system *** this work,sufficient design conditions in terms of linear matrix inequalities are derived,to guarantee the closed-loop stability of the driver-automation shared control *** addition,an H∞performance is studied to ensure the robustness of control ***,simulation-based results are provided to demonstrate the performance of proposed control ***,an existing type-1 fuzzy controller is introduced as comparison to verify the superiority of the proposed IT2 fuzzy controller.

关键词： Driver-automation shared control Fuzzy control Interval type-2 fuzzy system Autonomous vehicles

Phase Separation and Transport Behavior in La_(0.67-x)Sm_xSr_(0.33)MnO_3 System

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Chemical Research in Chinese Universities 2005年第6期21卷 707-713页

作者： liu Ning YAN guo-qing xu Su-jun Department of Physics Suzhou College Suzhou 23400 P. R. China Structure Research Laboratory Science and Technology University of China Hefei 230026 P. R. China

The magnetic behavior and the transport behavior of La0.67-x Smx Sr0.33 MnO3 （x = 0. 00, 0. 10, 0. 20, 0. 30, 0. 40, 0. 50 and 0. 60 ） systems were studied through measuring the M-T curves, electron spin resonance （ ESR ） curves and ρ-T curves. The samples exhibit a long-range ferromagnetic order when x = 0. 00, 0. 10, a cluster-spin glass state when x = 0. 20 and 0. 30, and an anti-ferromagnetic state at low temperatures when x = 0. 40, 0. 50 and 0. 60. The samples of x = 0. 30 and 0.40 show phase separation at temperatures above Te. The transport behavior of the sample of x = 0. 60 becomes abnormal when the doping is high, and an insulator-metal transition occurs near To and then a metal-insulator transition occurs, which rarely appears in an ABO3 structure. It is concluded that the magnetic and electric behavior changes of the systems depend on the extra magnetism and lattice distortion effect induced by Sm doping.

关键词： Magnetic structure Phase separation Transport behavior Colossal magnetoresistance effect

A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity for enhanced diabetic wound repair

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Nano Research 2022年第6期15卷 5305-5315页

作者： Zejun xu Guiting liu qing li jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China The State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China School and Hospital of Stomatology Cheeloo College of MedicineShandong UniversityJinan 250012China

Enhanced diabetic wound repair remained a global ***,we reported a novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity for enhanced diabetic wound *** this study,gallic acid(GA)with strong antioxidant activity was grafted onto chitosan(CS)chains by one-step synthesis,and then incorporated into poly(ethylene glycol)diacrylate(PEG-DA)hydrogel matrix to obtain a novel antioxidant hybrid hydrogel(PEG-DA/CS-GA).Meanwhile,polyethyleneimine(PEI)was modified with a unique glucose-sensitive phenylboronic acid(PBA)molecule to load insulin(PEIPBA/insulin nano-particles,PEI-PBA/insulin NPs),which could be immobilized in the PEG-DA/CS-GA hybrid hydrogel by the formation of dynamic borate bond between the phenylboronic acid groups on the PEI-PBA and the polyphenol groups on the *** results indicated that the PEG-DA/PEI-PBA/insulin/CS-GA(PPIC)hydrogel platform not only had remarkable biocompatibility,but also displayed extraordinary antioxidant properties(DPPH scavenging rate>95.0%),and effectively protected cells from oxidative damage(decreased MDA levels,increased Superoxide dismutase(SOD)levels and stable GSH/GSSG levels).Meanwhile,the PPIC hydrogel also exhibited unique glucose-responsive insulin release characteristics,and effectively regulated the blood glucose *** in vitro and in vivo results demonstrated that our PPIC hydrogel could promoted angiogenesis(increased VEGF and CD 31 expression),reshaped the inflammatory microenvironment(decreased IL-6 and increased IL-10 level),and achieved wound closure within 20 *** these results strongly indicated that the PPIC hydrogel represented a tough and efficient platform for diabetic wound treatment.

关键词： diabetic wound glucose responsive antioxidation hyperglycemia regulation insulin

Hot deformation behavior and microstructural evolution of powder metallurgical TiAl alloy

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Rare Metals 2017年第4期36卷 236-241页

作者： Na liu Zhou li Wen-Yong xu yue Wang guo-qing Zhang Hua Yuan Science and Technology on Advanced High TemperatureStructural Materials Laboratory Beijing Institute of Aeronautical Materials Beijing 100095 China

The hot deformation behavior of powder met- allurgical （PM） TiAI alloys was investigated on Gleeble- 3500 thermomechanical simulator, at a temperature range of 1050-1200 ℃ with an interval of 50℃ and a strain rate range of 0.001-1.000 s-1. The results show that the flow stress of PM TiAI alloy is sensitive to deformation tem- perature and strain rate, the peak stress decreases with the increase in deformation temperature and decrease in strain rate, and dynamic recrystallization occurs during the hot compression. The deformation active energy was calcu- lated and the flow stress model during high-temperature deformation was established based on the Arrhenius equations and Zener-Hollomon parameter. The deformed microstructure consists of refined homogeneous γ and α2/γ grains.

关键词： TiAI alloy Powder metallurgy Hotdeformation Flow stress

Biomarker Identification of Rat liver Regeneration via Adaptive Logistic Regression

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International Journal of Automation and computing 2016年第2期13卷 191-198页

作者： liu-Yuan Chen Jie Yang guo-guo xu Yun-qing liu jun-Tao li Cun-Shuan xu School of Information Engineering Wuhan University of Technology College of Mathematics and Information Sciences Henan Normal University State Key Laboratory Cultivation Base for Cell Differentiation Regulation Henan Normal University

This paper is devoted to identifying the biomarkers of rat liver regeneration via the adaptive logistic regression. By combining the adaptive elastic net penalty with the logistic regression loss, the adaptive logistic regression is proposed to adaptively identify the important genes in groups. Furthermore, by improving the pathwise coordinate descent algorithm, a fast solving algorithm is developed for computing the regularized paths of the adaptive logistic regression. The results from the experiments performed on the microarray data of rat liver regeneration are provided to illustrate the effectiveness of the proposed method and verify the biological rationality of the selected biomarkers.

关键词： Adaptive logistic regression gene selection microarray classification grouping effect rat liver regeneration

Spatiotemporal evolution and driving forces of changes in rural settlements in the poverty belt around Beijing and Tianjin： a case study of Zhangjiakou city, Hebei Province

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Journal of Mountain Science 2017年第5期14卷 980-997页

作者： SUN Pi-ling xu yue-qing liu qing-guo liu Chao WANG Hong-liang College of Resource and Environmental Sciences China Agricultural University Belling 100193 China Qianjiang Xinhua Middle School Chongqing 409000 China

The rural settlement is one of important aspects to understand regional human-environment relationships. Zhangjiakou city, located in the poverty belt around Beijing and Tianjin, was used as an example to analyze the evolution of rural settlements during 1985–2010 through the use of statistical and spatial analysis methods. The results demonstrate the following:(1) the area of rural settlements expanded from 665.76 to 928.14 km2 during 1985–2010. Rural settlements in prefecture city of Zhangjiakou were significantly agglomerated in terms of their spatial distribution, which presented an approximately normal distribution over the entire period. Rural settlements were usually distributed within regions where the terrain niche had an elevation of between 900 and 1500 m, and a slope from 5? to 20?;(2) there were significant regional differences in the density and size distribution of rural settlements in Zhangjiakou. The density of rural settlements in 2010 was higher than that in 1985, while there was a clustered distribution of rural settlements in 2010. There was a significant high value cluster in the size distribution, and a local negative correlation between the size and density distribution of rural settlements in Zhangjiakou;(3) rural economic development, investment in agricultural technology, and infrastructure improvement played important roles in the evolution of rural settlements. There were spatial differences in the relationship between the distribution of rural settlements and socio-economic factors in Zhangjiakou. This study provides practical guidance for the achievement of urban and rural integration development and the promotion of a new form of countryside construction.

关键词： Rural settlement Spatiotemporal evolution Driving factors Geographical weighted regression Zhangjiakou city

Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry

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Chinese Chemical Letters 2006年第1期17卷 65-68页

作者： qing xuan xu li li Hao yue Zhi Qiang liu Ming Quart guo Shu Ying liu Laboratory of New Drug Research and Mass Spectrometry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022

The non-covalent complexes between lappaconitine （LA） and β-cyclodextrin （β-CD） have been detected and characterized by electrospray ionization combined with ion trap tandem mass spectrometry （ESI-MSn）. The experimental results showed that only 1：1 non-covalent complex can be formed in different starting molar ratios of LA to β-CD. Furthermore, the diagnostic fragmentation of the β-CD-LA complex, with a significant contribution of covalent fragmentation of LA leaving the N-acetyl anthranoyl （AN） moiety inserted to β-CD, provided the convincing evidence for the formation of non-covalent complex between LA and β-CD and the cite of LA molecule included to cavity of β-CD assigned to AN residue.

关键词： Lappaconitine β-cyclodextrin non-covalent complex ESI-MS CID.

Seasonal response of nitrogen exchange fluxes to crab disturbance at sediment-water interface in coastal tidal wetlands

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Water Science and Engineering 2024年第2期17卷 129-138页

作者： guo-fen Hua Shang-qing liu Xiang-dong liu Jin-li li yue Fang Wen-ting Xie Xiang xu College of Water Conservancy and Hydroelectric Power Hohai UniversityNanjing 210098China College of Renewable Energy Hohai UniversityNanjing 210098China

Coastal wetlands are hotspots for nitrogen(N)cycling,and crab burrowing is known to transform N in intertidal marsh ***,the underlying mechanisms remain *** study conducted field experiments and used indoor control test devices to investigate the seasonal response of nitrogen to crab disturbance at the sediment-water interface in coastal tidal flat *** results showed that crab disturbance exhibited significant seasonality with large seasonal differences in cave density and *** to crab disturbance,nitrogen fuxes at the sediment-water interface were much greater in the box with crabs than in the box without *** summer,NH-N showed a positive flux from the sediment to the overlying water,but NO2-N and NOg-N showed positive fluxes from the sediment to the overlying water only in early *** winter,NH-N showed a positive flux from the sediment to the overlying water,but NO-N and NO,-N both exhibited positive and negative *** results indicated that the presence of crab burrows can cause the aerobic layer to move downward by approximately 8-15 cm in summer and directly promote nitrification at the sediment surface.

关键词： Coastal tidal flat wetland Crab disturbance Nitrogen flux Nitrification Denitrification Sediment-water interface