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Spatiotemporal evolution and driving forces of changes in rural settlements in the poverty belt around Beijing and Tianjin： a case study of Zhangjiakou city, Hebei Province

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Journal of Mountain Science 2017年第5期14卷 980-997页

作者： SUN Pi-ling xu yue-qing liu qing-guo liu Chao WANG Hong-liang College of Resource and Environmental Sciences China Agricultural University Belling 100193 China Qianjiang Xinhua Middle School Chongqing 409000 China

The rural settlement is one of important aspects to understand regional human-environment relationships. Zhangjiakou city, located in the poverty belt around Beijing and Tianjin, was used as an example to analyze the evolution of rural settlements during 1985–2010 through the use of statistical and spatial analysis methods. The results demonstrate the following:(1) the area of rural settlements expanded from 665.76 to 928.14 km2 during 1985–2010. Rural settlements in prefecture city of Zhangjiakou were significantly agglomerated in terms of their spatial distribution, which presented an approximately normal distribution over the entire period. Rural settlements were usually distributed within regions where the terrain niche had an elevation of between 900 and 1500 m, and a slope from 5? to 20?;(2) there were significant regional differences in the density and size distribution of rural settlements in Zhangjiakou. The density of rural settlements in 2010 was higher than that in 1985, while there was a clustered distribution of rural settlements in 2010. There was a significant high value cluster in the size distribution, and a local negative correlation between the size and density distribution of rural settlements in Zhangjiakou;(3) rural economic development, investment in agricultural technology, and infrastructure improvement played important roles in the evolution of rural settlements. There were spatial differences in the relationship between the distribution of rural settlements and socio-economic factors in Zhangjiakou. This study provides practical guidance for the achievement of urban and rural integration development and the promotion of a new form of countryside construction.

关键词： Rural settlement Spatiotemporal evolution Driving factors Geographical weighted regression Zhangjiakou city

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小檗碱介导BMAL1:CLOCK复合体调控糖脂代谢改善脂肪胰岛素抵抗的效应机制

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中国中药杂志 2024年第17期49卷 4586-4596页

作者：王颖徐中华延李科崔灿刘伟华肖汉月涂珺江西中医药大学江西省中医病因学重点实验室&中医基础理论分化发展研究中心江西省中药药理重点实验室

探究小檗碱介导脑和肌肉芳香烃受体核转位样蛋白1（brain and muscle arnt-like 1,BMAL1）:昼夜自发输出周期蛋白kaput（circadian locomotor output cycles kaput, CLOCK）复合体，调控糖脂代谢改善脂肪胰岛素抵抗（insulin resistance, IR）的作用机制。地塞米松诱导96 h建立IR-3T3-L1脂肪细胞模型，0.5、1、5、10、20μmol·L-1小檗碱给药24 h。葡萄糖氧化酶法和细胞活性（cell counting kit-8,CCK-8）试剂盒分别检测胞外葡萄糖含量和细胞活力；酶比色法检测甘油三酯（triglyceride, TG）和甘油含量；油红O染色检测脂滴；荧光染色检测Ca2+、线粒体结构及活性氧（reactive oxygen species, ROS）;蛋白免疫印迹（Western blot, WB）检测脂联素（adiponectin, ADPN）、BMAL1、CLOCK、激素敏感性脂肪酶（hormone-sensitive triglyceride lipase, HSL）、碳水化合物反应元件结合蛋白（carbohydrate-responsive element-binding protein, ChREBP）、固醇调节元件结合蛋白1C（sterol regulatory element-binding protein 1C,SREBP-1C）、过氧化物酶体增殖物激活受体γ共激活剂1α（peroxisome proliferator activated receptor γ coactivator 1α,PGC1α）、肉碱棕榈酰基转移酶1α（choline phosphotransferase 1α,CPT1α）、过氧化物酶体增殖物激活受体α（peroxisome proliferators-activated receptors α,PPARα）,免疫荧光检测BMAL1核定位。此外，添加20μmol·L-1CLK8（CLOCK抑制剂）检测葡萄糖消耗量及BMAL1/ChREBP/PPARα蛋白。研究结果显示小檗碱增加IR-3T3-L1脂肪细胞葡萄糖消耗量，且不影响细胞活力；小檗碱降低IR-3T3-L1脂肪细胞胞内TG,5μmol·L-1小檗碱升高甘油含量，减少脂滴积累，提示其加强脂解，而10μmol·L-1小檗碱不影响甘油含量且脂滴更少，提示其可能同时加强脂解和甘油利用。此外，小檗碱降低IR-3T3-L1脂肪细胞胞内Ca2+和ROS改善线粒体功能，上调PGC1α有助于维护线粒体结构。结果还显示小檗碱上调ADPN,提示其增加IR-3T3-L1脂肪细胞胰岛素敏感性，上调外周节律调控蛋白BMAL1和CLOCK并增加BMAL1核定位，上调脂解关键蛋白HSL和脂氧化限速酶CPT1α,下调TG合成关键蛋白SREBP-1C,小檗碱同时上调IR-3T3-L1脂肪细胞ChREBP和PPARα,以上结果共同提示其促糖转脂增强降糖效应。鉴于CLK8特异性抑制CLOCK酰基化修饰BMAL1形成复合体，结果显示CLK8添加小檗碱可降低葡萄糖消耗量，提示小檗碱上调BMAL1:CLOCK复合体改善糖代谢。CLK8添加小檗碱组上调BMAL1但下调ChREBP和PPARα,因而推测小檗碱介导BMAL1:CLOCK复合体调控细胞糖脂代谢减轻脂肪细胞IR。

关键词：胰岛素抵抗脂代谢糖代谢 BMAL1:CLOCK复合体小檗碱

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好氧颗粒污泥技术的工业废水处理工程实例

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中国给水排水 2024年第4期40卷 84-88页

作者：梅慧瑞王驰傅先松徐礼灿文志军张新国刘青北创环保<北京>有限公司北京100102 龙游华水水业发展有限公司浙江衢州324400

浙江某工业园区新建污水厂设计规模为2×104m3/d,基于用地紧张、水质排放标准提高的现状,确定以生物池(以SBR为基础的好氧颗粒污泥技术)+高效澄清池+反硝化深床滤池为主体工艺的设计方案。相较原污水厂的活性污泥法(一、二期分别采用CAS... 详细信息

浙江某工业园区新建污水厂设计规模为2×104m3/d,基于用地紧张、水质排放标准提高的现状,确定以生物池(以SBR为基础的好氧颗粒污泥技术)+高效澄清池+反硝化深床滤池为主体工艺的设计方案。相较原污水厂的活性污泥法(一、二期分别采用CASS、A2O工艺),本工艺节省占地约40%、降低运行费用30%以上。启动调试期间,在进水COD、氨氮、总氮、总磷分别为360~660、20~42、35~55、1.65~3.66 mg/L波动的情况下,出水COD、氨氮、总氮、总磷分别保持在38、1.9、10.5、0.3 mg/L以下,满足浙江省《城镇污水处理厂主要水污染物排放标准》(DB 33/2169—2018)要求。后期培养出的颗粒污泥粒径达到1.4 mm以上,污泥体积指数(SVI)保持在30 mL/g以下,混合液悬浮固体浓度(MLSS)由4.28 g/L增加至10.64 g/L。该项目为好氧颗粒污泥技术在国内首次大型工程化的成功案例,对该技术的应用具有指导意义。

关键词：好氧颗粒污泥技术工业废水同步脱氮除磷高效节能

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Stress-Structure Relationship of the Reversible Associating Polymer Network under Start-up Shear Flow

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Chinese Journal of Polymer Science 2021年第3期39卷 387-396,I0008页

作者： Ai-qing liu li-jun liu Wen-Sheng xu Xiao-Lei xu Ji-Zhong Chen li-Jia An College of Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei230026China

We adopt Langevin dynamics to explore the stress-structure relationship of telechelic reversible associating polymer gel during startup shear flow, with shear strengths varying from Wi=12.6 to Wi=12640. At weak shear flow Wi=12.6, the shear stress proportionally increases with shear strain at short times, followed by a strain hardening behavior and then passes through a maximum(σmax, γmax) and finally decreases until it reaches the steady state. During the evolution of stress, the gel network is only slightly broken and essentially maintains its framework, and the strain hardening behavior originates from the excessive stretching of chains. On the other hand, the stress-strain curve at intermediate shear flow Wi=505.6 shows two differences from that at Wi=12.6, namely, the absence of strain hardening and a dramatic increase of stress at large strains,which is caused by the rupture of gel network at small strains and the network recovery at large strains, respectively. Finally, at very strong shear flow Wi=6319.7, the gel network is immediately broken by shear flow and the stress-strain curve exhibits similar behaviors to those of classical polymeric liquids.

关键词： Associating polymer Start-up shear Stress-structure relationship

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石羊河流域生态系统碳储量时空变化及多情景模拟

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中国环境科学 2024年第6期44卷 3365-3375页

作者：许澳康胡梦珺石晶孟祥云白清竹郭婧玲刘烁雅张嗣阳西北师范大学地理与环境科学学院甘肃省绿洲资源环境与可持续发展重点实验室甘肃兰州730070

以石羊河流域为例,利用InVEST模型评估1990~2020年土地利用变化带来的碳储量效应,耦合PLUS模型模拟2035年在自然发展、生态保护、水资源约束和经济发展情景下土地利用变化及其对碳储量的影响.结果表明:石羊河流域土地利用主要以未利用地... 详细信息

以石羊河流域为例,利用InVEST模型评估1990~2020年土地利用变化带来的碳储量效应,耦合PLUS模型模拟2035年在自然发展、生态保护、水资源约束和经济发展情景下土地利用变化及其对碳储量的影响.结果表明:石羊河流域土地利用主要以未利用地,草地和耕地为主,占流域总面积的93%.1990~2020年石羊河流域耕地,水域和建设用地面积呈增长趋势,其余用地面积呈减少趋势.2020~2035年多情景模拟下,只有生态情境中林地和草地面积增加显著.1990~2020年流域碳储量整体呈增长趋势,其中以草地,未利用地和耕地碳储量贡献为主,占碳总量的86%.2020~2035年4种情景下的碳储量均有所增加,但生态保护情景中碳储量增加最为显著,共增加3.75×10^(6)t.自然发展情景和经济发展情景下,林地和草地转为耕地的面积远大于转入,碳储量损失较多.水资源约束情景下,耕地主要转出为草地和建设用地,其他各地类之间转换所承载的碳储量基本平衡.生态保护情景下,林地,草地等生态用地转入面积大于转出使区域碳储量增加.研究结果以期为石羊河流域提升陆地生态系统碳储量和规划未来国土空间提供科学依据.

关键词：碳储量 InVEST模型 PLUS模型土地利用石羊河流域

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Effects of a novel mesoionic insecticide,triflumezopyrim,on the feeding behavior of rice planthoppers,Nilaparvata lugens and Sogatella furcifera(Hemiptera:Delphacidae)

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Journal of Integrative Agriculture 2020年第10期19卷 2488-2499页

作者： ZHU jun SUN Wen-qing li Yao GE lin-quan YANG guo-qing xu Jian-xiang liu Fang College of Horiculture and Plant Protection Yangzhou UniversityYangzhou 225009P.R.China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou 225009P.R.China Joint International Research Laboratory of Agriculture&Agri-Product Safety Yangzhou UniversityYangzhou 225009P.R.China

The rice planthoppers,Nilaparvata lugens and Sogatella furcifera,are important sap-sucking pests of rice in *** mesoionic insecticide tifumezopyrim was previously shown to be highly effective in controlling both *** and *** this study,electropenetrography(EPG)was used to evaluate the effect of three triflumezopyrim concentrations(LC。LC。and LC)on the feeding behavior of *** and *** signals of planthoppes indicated that there were six different waveforms NP,N1,N2,N3,N4,and N5,which corresponded to non-penetration,stylet penetration into epidermis,salivation,extracellular movement of stylet,sap ingestion in phloem,and water ingestion in xylem during *** to untreated controls,triflumezopyrim at LC。and LC。prolonged the duration of the non-penetration period by 105.3 to 333.7%.The probing frequencies of *** exposed to tiflumezopyrim at LC1。and LCso were significantly increased;however,the probing frequencies of *** showed a significant decrease when exposed to triflumezopyrim at all *** exposure prolonged the duration of salivation and shortened the duration of extracellular *** duration of phloem sap ingestion decreased from 37.2 to 77.7%in the LCgo and LCgo treatments,*** in feeding behavior in response to triflumezopyrim and pymetrozine were *** summary,the results show that the LC。and LCgo concentrations of trflumezopyrim inhibit the feeding activities of *** and *** mainly by prolonging the duration of non penetration and by shortening the duration of phloem sap ingestion,which may foster more efficient use of triflumezopyrim in Asia.

关键词： Nilaparvata lugens Sogatella furcifera triflumezopyrim pymetrozine,feeding behavior EPG

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Stable operation of polymer electrolyte-solid-state batteries via lonepair electron fillers

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Nano Research 2023年第11期16卷 12727-12737页

作者： Hongbin liu qing Sun jun Cheng Hongqiang Zhang Xiao xu Yuanyuan li Zhen Zeng yue Zhao Deping li Jingyu Lu lijie Ci State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China School of Science Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Research Center for Carbon Nanomaterials Key Laboratory for Liquid–Solid Structural Evolution&Processing of Materials(Ministry of Education)School of Materials Science and EngineeringShandong UniversityJinan 250061China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018China

Due to the increasing demand and wide applications of lithium-ion batteries,higher requirements have been placed on the energy density and *** solid-state electrolytes have gained significant popularity due to their excellent interface compatibility and ***,their applications have been greatly restricted by the high crystallinity at room temperature,which hinders the transport of lithium ***,we utilize inorganic tubular fillers with abundant lone-pair atoms to reduce the crystallinity of the polyethylene oxide(PEO)solid-state electrolyte membrane and improve its ionic conductivity at room temperature,enabling stable operation of the *** tubular lone-pair-rich inorganic fillers play a key role in providing avenues for both internal and external charge *** surface lone-pair electrons facilitate the dissociation and transport of lithium ions,while the internally tubular electron-rich layer attracts ions into the cavities,further enhancing the ion *** 100 cycles at room temperature,the lithium battery loaded with this solid-state electrolyte membrane delivers a specific capacity of 141.6 mAh·g−1,which is 51.3%higher compared to the membrane without the fillers.

关键词： nanotube filler polymer electrolyte ion transport room temperature(RT)operation

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正高程差下边坡爆破对X70钢管振速的影响

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工程爆破 2024年第1期30卷 133-140页

作者：许柏园刘跃吴锦达厉擎阳曲艳东辽宁工业大学土木建筑工程学院辽宁锦州121001 大连民族大学土木工程学院辽宁大连116650

为了探究正高程差边坡爆炸施工对邻近埋地管道振速的影响,基于商用有限元软件ANSYS/LS-DYNA采用数值模拟方法研究了炸药量相同(30 kg),正高程差不同(2.1、2.6、3.1、3.6、4.1、4.6和5.1 m)时,边坡爆破振动对既有X70管道振速的影响,并与... 详细信息

为了探究正高程差边坡爆炸施工对邻近埋地管道振速的影响,基于商用有限元软件ANSYS/LS-DYNA采用数值模拟方法研究了炸药量相同(30 kg),正高程差不同(2.1、2.6、3.1、3.6、4.1、4.6和5.1 m)时,边坡爆破振动对既有X70管道振速的影响,并与平面地形结果作对比分析。研究表明:相较于平面地形,在水平距离不变的条件下,管道Y方向上会出现振速放大现象,且随着高程增大,振速加快衰减。管道振速放大系数随着高程差的增大呈现先增大后减小的趋势。当高程差为3.1 m时,管道迎爆面测点的振速放大系数最大,为1.998;当高程差为3.6 m时,管道背爆面测点的放大系数最大,为1.622。爆炸地震波在不同的介质界面发生折射和反射所形成的叠加效应以及在坡脚发生绕射,是产生高程放大效应的主要原因。

关键词：正高程差 X70钢管爆破振动放大效应边坡爆破

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基于酶促恒温扩增技术快速鉴别天麻真伪检测方法的建立与应用

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药物分析杂志 2024年第4期44卷 729-736页

作者：马秋贺马玉贺李涛刘悦柴金军徐子强刘昂高丽君夏薇李明成曲永梅北华大学医学技术学院吉林132013 吉林省中药DNA指纹检测技术科技创新中心吉林132013 吉林国安药业有限公司吉林132013

目的:基于酶促恒温扩增(enzymatic recombinase amplification, ERA)技术建立一种可快速定性鉴别道地药材天麻真伪的方法。方法:遵循ERA引物设计原则,应用Oligo 7.0软件根据天麻及其常见伪品的ITS2基因组序列,筛选优化天麻ERA特异性引物... 详细信息

目的:基于酶促恒温扩增(enzymatic recombinase amplification, ERA)技术建立一种可快速定性鉴别道地药材天麻真伪的方法。方法:遵循ERA引物设计原则,应用Oligo 7.0软件根据天麻及其常见伪品的ITS2基因组序列,筛选优化天麻ERA特异性引物,应用Primer Premier 5.0软件设计天麻特异性PCR鉴别引物,通过对ERA、PCR反应体系的优化,最终确定ERA最佳反应时间为17 min,最适反应温度为40℃;PCR最优退火温度为57℃,循环为32次,对所建立的方法进行灵敏度、特异性验证,并选取中药市场市售天麻样品进行检测。结果:所设计的天麻ERA鉴别引物与其常见伪品间无交叉反应,特异性良好;重复性结果显示,3次重复性检测结果一致,未出现假阳性与假阴性;该方法对天麻基因组DNA的灵敏度为1 pg·μL^(-1),比传统PCR灵敏性高;ERA技术能够用于天麻市售样品的快速鉴定,且检测结果与PCR方法相同。结论:所建立的检测方法操作简单、快速,具有较高的特异性和灵敏度,为道地药材天麻的真伪鉴别提供了一种新手段。

关键词：酶促恒温扩增聚合酶链式反应天麻定性真伪鉴定快速检测

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Ferrostatin-1 protects HT-22 cells from oxidative toxicity

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Neural Regeneration Research 2020年第3期15卷 528-536页

作者： jun Chu Chen-xu liu Rui Song qing-lin li Xin’an Key Laboratory of Medicine Ministry of Education Anhui University of Chinese Medicine

Ferroptosis is a type of programmed cell death dependent on *** is different from other forms of cell death such as apoptosis,classic necrosis and *** is involved in many neurodegenerative *** role of ferroptosis in glutamate-induced neuronal toxicity is not fully *** test its toxicity,glutamate(1.25–20 mM)was applied to HT-22 cells for 12 to 48 *** optimal experimental conditions occurred at 12 hours after incubation with 5 mM *** were cultured with 3–12μM ferrostatin-1,an inhibitor of ferroptosis,for 12 hours before exposure to *** cell viability was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** was determined by monodansylcadaverine staining and apoptosis by caspase 3 *** to cell structures was observed under light and by transmission electron *** release of lactate dehydrogenase was detected by the commercial *** oxygen species were measured by flow *** peroxidase activity,superoxide dismutase activity and malondialdehyde level were detected by the appropriate commercial *** peroxidase synthase 2 and glutathione peroxidase 4 gene expression was detected by real-time quantitative polymerase chain *** peroxidase 4 and nuclear factor erythroid-derived-like 2 protein expression was detected by western blot *** showed that ferrostatin-1 can significantly counter the effects of glutamate on HT-22 cells,improving the survival rate,reducing the release of lactate dehydrogenase and reducing the damage to mitochondrial ***,it did not affect the caspase-3 expression and monodansylcadaverine-positive staining in glutamate-injured HT-22 ***-1 reduced the levels of reactive oxygen species and malondialdehyde and enhanced superoxide dismutase *** decreased gene expression of prostaglandin peroxidase synthase 2 and increased gene expre

关键词： ferroptosis ferrostatin-1 glutamate glutathione peroxidase 4 HT-22 cell oxidative toxicity prostaglandin peroxidase synthase 2 reactive oxygen species

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