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Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

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一种内线转移可见光CCD光电特性模拟分析

半导体光电 2014年第5期35卷 773-776,781页

作者：杨洪李立吕玉冰白雪平重庆光电技术研究所重庆400060

运用半导体二维数值模拟软件sentaurus TCAD,对内线转移可见光CCD积分过程、读出过程光敏区域电势变化规律进行了数值模拟研究,建立了sentaurus TCAD软件模拟内线转移CCD器件的仿真模型;对影响器件电荷容量、抗晕性能的纵向抗晕p阱浓度... 详细信息

运用半导体二维数值模拟软件sentaurus TCAD,对内线转移可见光CCD积分过程、读出过程光敏区域电势变化规律进行了数值模拟研究,建立了sentaurus TCAD软件模拟内线转移CCD器件的仿真模型;对影响器件电荷容量、抗晕性能的纵向抗晕p阱浓度、结深进行了模拟分析,得出p阱浓度应控制在（2.5～5.5）×1016 cm-3,结深应控制在5.5～6.5μm的结论。

关键词：内线转移CCD 光电特性纵向抗晕数值模拟

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823×592元内线转移CCD图像传感器

半导体光电 2015年第6期36卷 905-908页

作者：杨洪雷仁方郑渝吕玉冰翁雪涛重庆光电技术研究所重庆400060

采用三层多晶硅、埋沟、双层金属工艺研制了1/2英寸823×592、8.3μm×8.3μm内线转移CCD,该器件设计制作了纵向抗晕结构,实现了内线转移器件光晕抑制。该器件水平驱动频率可达30MHz,峰值响应波长位于550nm,动态范围62.6dB。

关键词：内线转移CCD 光电特性纵向抗晕

一种内线转移可见光CCD弥散特性的模拟分析

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半导体光电 2016年第6期37卷 788-791页

作者：杨洪翁雪涛李立白雪平吕玉冰重庆光电技术研究所重庆400060

运用半导体二维数值模拟软件sentaurus TCAD,对基于p型衬底制作的横向抗晕内线转移CCD的弥散特性进行了数值模拟研究,建立了sentaurus TCAD软件模拟横向抗晕内线转移CCD器件仿真模型,对影响器件弥散特性的光敏区n型区域、垂直CCD p阱进... 详细信息

运用半导体二维数值模拟软件sentaurus TCAD,对基于p型衬底制作的横向抗晕内线转移CCD的弥散特性进行了数值模拟研究,建立了sentaurus TCAD软件模拟横向抗晕内线转移CCD器件仿真模型,对影响器件弥散特性的光敏区n型区域、垂直CCD p阱进行了模拟分析。结果表明,光敏区n型区域注入能量控制在450~550keV,垂直CCD p阱注入能量控制在200~600keV,剂量控制在4.0×10^(12)~8.0×10^(12) cm^(-2),器件弥散特性最佳。

关键词：内线转移CCD 弥散特性横向抗晕数值模拟

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

总剂量辐照效应模型在TDI-CCD器件中的应用

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半导体光电 2014年第5期35卷 782-784页

作者：吕玉冰王颖汪朝敏李金刘昌林重庆光电技术研究所重庆400060

介绍了抗辐射加固设计使用的总剂量辐照效应模型,研究了它在时间延迟积分电荷耦合器件(TDI-CCD)电荷转移效率参数衰减中的应用,并通过不同剂量60Coγ辐照试验,验证了该模型在TDI-CCD器件抗辐射加固设计中的应用价值。

关键词： TDI-CCD器件总剂量辐照效应模型缺陷电荷转移效率

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei lv Wei Qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

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CMOS图像传感器抗电离辐射加固技术研究

半导体光电 2020年第3期41卷 331-335页

作者：吕玉冰吴琼瑶刘昌举李明周亚军刘戈扬重庆光电技术研究所重庆400060

太空环境中的电离辐射会导致CMOS图像传感器性能退化,甚至造成永久性损毁。文章对CMOS图像传感器抗电离辐射加固技术进行了研究,从版图设计、电路设计等方面提出相应的抗辐射策略,并进行了总剂量和单粒子试验。试验结果表明,采用抗辐射... 详细信息

太空环境中的电离辐射会导致CMOS图像传感器性能退化,甚至造成永久性损毁。文章对CMOS图像传感器抗电离辐射加固技术进行了研究,从版图设计、电路设计等方面提出相应的抗辐射策略,并进行了总剂量和单粒子试验。试验结果表明,采用抗辐射加固技术设计制作的CMOS图像传感器具备抗总剂量和单粒子辐射能力,当总剂量达到100krad(Si)、单粒子辐射总注量达到1×10^7 p/cm^2时,器件的关键指标变化符合预期要求。

关键词： CMOS图像传感器抗电离辐射加固总剂量效应单粒子