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谐波和间谐波三参数识别的SSI-LS方法

电力系统保护与控制 2011年第10期39卷 42-46页

作者：李天云袁明哲郑波许洁于奉振东北电力大学电气工程学院吉林吉林132012 澳大利亚皇家墨尔本理工大学电气和计算机工程学院

为精确检测谐波和间谐波的三参数,提出了基于随机子空间辨识(Stochastic Subspace Identification,SSI)与最小二乘(Least Square)法的谐波和间谐波三参数检测方法。运用奇异值差值法确定SSI-LS算法的阶数;利用SSI算法直接对原始含噪信... 详细信息

为精确检测谐波和间谐波的三参数,提出了基于随机子空间辨识(Stochastic Subspace Identification,SSI)与最小二乘(Least Square)法的谐波和间谐波三参数检测方法。运用奇异值差值法确定SSI-LS算法的阶数;利用SSI算法直接对原始含噪信号精确检测出各谐波和间谐波分量的频率;当信噪比大于20dB时,应用最小二乘法对各谐波和间谐波分量进行幅值和相位的估计,从而实现了谐波和间谐波的三参数识别。分别针对含有噪声和直流分量的谐波和间谐波数值仿真信号和频率相近且幅值相差百倍的谐波和间谐波信号作谐波和间谐波的三参数识别。仿真分析表明该方法抗噪声能力强、检测精度高、计算速度快,尤其是对信号中各谐波和间谐波分量的相位检测精度高、对频率相近且幅值相差百倍的谐波和间谐波信号具有较高的分辨率,为电力系统谐波和间谐波的精确检测提供了新的思路与方法。

关键词：谐波间谐波奇异值差值法随机子空间最小二乘法

Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway

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Genes & Diseases 2024年第1期11卷 430-448页

作者： Jun Fan zhe Zhang Hongqiang Chen Dongjiao Chen Wenbo yuan Jingzhi Li Yong Zeng Shimeng Zhou Shu Zhang Gang Zhang Jiashen Xiong Lu Zhou Jing Xu Wenbin Liu Yan Xu Department of Breast and Thyroid Surgery Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Institute of Toxicology College of Preventive MedicineArmy Medical University(Third Military Medical University)Chongqing 400038China Department of Environmental Health College of Preventive MedicineArmy Medical University(Third Military Medical University)Chongqing 400038China Anesthesia and Intensive Care Chinese University of Hong KongHong Kong SAR 999077China School of Public Health Xinxiang Medical UniversityXinxiangHenan 453003China School of Public Health China Medical UniversityShenyangLiaoning 110122China

Emerging evidence suggested that zinc finger protein 831(ZNF831)was associated with immune activity and stem cell regulation in breast ***,the roles and molec-ular mechanisms of ZNF831 in oncogenesis remain ***831 expression was significantly diminished in breast cancer which was associated with promoter CpG methylation but not *** over-expression of ZNF831 suppressed breast cancer cell proliferation and col-ony formation and promoted apoptosis in vitro,while knockdown of ZNF831 resulted in an opposite ***-proliferation effect of ZNF831 was verified in *** analysis of public databases and transcriptome sequencing both showed that ZNF831 could enhance apoptosis through transcriptional regulation of the JAK/STAT *** and luciferase report assays demonstrated that ZNF831 could directly bind to one specific region of STAT3 promoter and induce the transcriptional inhibition of *** a result,the attenuation of STAT3 led to a restraint of the transcription of Bcl2 and thus accelerated the apoptotic *** of STAT3 diminished the apoptosis-promoting effect of ZNF831 in breast cancer cell ***,ZNF831 could ameliorate the anti-proliferation effect of capecitabine and gemcitabine in breast cancer cell *** findings demonstrate for the first time that ZNF831 is a novel transcriptional suppressor through inhibiting the expression of STAT3/Bcl2 and promoting the apoptosis process in breast cancer,suggesting ZNF831 as a novel biomarker and potential therapeutic target for breast cancer patients.

关键词： Apoptosis Breast cancer Chemosensitivity STAT3 ZNF831

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基于支持向量回归的棉铃虫蛹发育历期估测

昆虫学报 2011年第1期54卷 83-88页

作者：谭显胜王志明李兰芝袁哲明湖南农业大学生物安全科学技术学院长沙410128 湖南省作物种质创新与资源利用重点实验室长沙410128 湖南人文科技学院生命科学系湖南娄底417000

温度与发育速率关系模拟是昆虫学研究的一个重要内容,传统基于经验风险最小的非线性参数模型(Logan模型、Lactin模型和王氏模型)存在诸多弊端。本文基于结构风险最小的改进支持向量回归(SVR)研究温度与棉铃虫Helicoverpa armigera蛹发... 详细信息

温度与发育速率关系模拟是昆虫学研究的一个重要内容,传统基于经验风险最小的非线性参数模型(Logan模型、Lactin模型和王氏模型)存在诸多弊端。本文基于结构风险最小的改进支持向量回归(SVR)研究温度与棉铃虫Helicoverpa armigera蛹发育历期关系。结果表明:与传统非线性模型相比,SVR模型性能优异;基于全部92个样本,SVR模型拟合和留一法预测的决定系数R^2分别为0.998和0.996,估测的蛹期三基点温度更可信。从全部样本中依温度均匀选取部分样本实施独立预测,当训练集为20个样本时,SVR模型独立预测的R^2为0.981,优于传统非线性模型中独立预测最佳的Lactin模型(R^2=0.958);当训练集进一步减少到12个样本时,SVR模型的R^2仅降低到0.964,而传统非线性模型均已不适用。结果提示SVR模型在小样本情况下较传统非线性模型优势明显,在昆虫发育历期估测建模中有应用前景。

关键词：棉铃虫支持向量回归蛹期温度发育历期非线性模型

基于EMD和选择性集成学习算法的磨机负荷参数软测量

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自动化学报 2014年第9期40卷 1853-1866页

作者：汤健柴天佑丛秋梅苑明哲赵立杰刘卓余文中国人民解放军92941部队葫芦岛125001 东北大学自动化研究中心中国沈阳110004 中国科学院沈阳自动化研究所信息服务与智能控制技术研究室中国沈阳110016 沈阳化工大学信息工程学院中国沈阳110142 墨西哥国立理工大学高级研究中心墨西哥墨西哥07360

针对磨机筒体振动和振声信号组成复杂难以解释、蕴含信息存在冗余性和互补性、与磨机负荷参数映射关系难以描述等问题,提出了基于经验模态分解(Empirical mode decomposition,EMD)技术和选择性集成学习算法分析筒体振动与振声信号组成,... 详细信息

针对磨机筒体振动和振声信号组成复杂难以解释、蕴含信息存在冗余性和互补性、与磨机负荷参数映射关系难以描述等问题,提出了基于经验模态分解(Empirical mode decomposition,EMD)技术和选择性集成学习算法分析筒体振动与振声信号组成,建立磨机负荷参数软测量模型的新方法.首先从机理上定性分析了筒体振动及振声信号组成的复杂性;然后采用EMD技术将原始信号自适应分解为具有不同时间尺度的系列组成成分,即本征模态函数(Intrinsic mode function,IMF);接着在频域内基于互信息(Mutual information,MI)方法分析并选择IMF频谱特征;最后采用基于核偏最小二乘(Kernel partial least square,KPLS)建模方法、分支定界优化算法的选择性集成学习方法建立磨机负荷参数软测量模型,实现了多源多尺度频谱特征的选择性信息融合.基于实验球磨机的实际运行数据仿真验证了该方法的有效性.

关键词：经验模态分解选择性集成建模磨机负荷参数选择性信息融合频谱特征

基于均匀设计与支持向量回归的棉铃虫幼虫全纯人工饲料配方优化

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昆虫学报 2012年第1期55卷 124-132页

作者：周世豪李俊姚润贤张星袁哲明湖南省作物种质创新与资源利用重点实验室长沙410128 湖南农业大学生物安全科学技术学院长沙410128

昆虫全纯人工饲料配方是精细研究昆虫营养生理的前提。本研究以棉铃虫Helicoverpa armigera幼虫为供试对象,以本研究室前期发展的多因素多水平配方优化实验设计与分析方法UD-SVR为指导,以略加修改的苹浅褐卷蛾Epiphyas postvittana幼虫... 详细信息

昆虫全纯人工饲料配方是精细研究昆虫营养生理的前提。本研究以棉铃虫Helicoverpa armigera幼虫为供试对象,以本研究室前期发展的多因素多水平配方优化实验设计与分析方法UD-SVR为指导,以略加修改的苹浅褐卷蛾Epiphyas postvittana幼虫全纯人工饲料为初始配方,先优化20种天然氨基酸,再优化蔗糖等其他8种非氨基酸营养组分,经4轮97个处理组合,获得一个棉铃虫幼虫全纯人工饲料满意配方,平均蛹重、化蛹率分别由初始配方的0.160g和10.4%高效增至满意配方的0.255g和97.9%。该全纯人工饲料满意配方的获得,不但再次证实了UD-SVR方法的有效性,同时为进一步深入研究棉铃虫营养需求与营养代谢奠定了基础。

关键词：棉铃虫全纯人工饲料均匀设计支持向量回归配方优化

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富氧底吹铜熔炼过程熔体温度软测量研究

计算机仿真 2018年第7期35卷 165-169页

作者：王斌苑明哲王卓于海斌中国科学院沈阳自动化研究所辽宁沈阳110016 中国科学院大学北京100049 中国科学院网络化控制系统重点实验室辽宁沈阳110016

富氧底吹铜熔炼过程工况复杂多变,针对其重要参数熔体温度难以在线检测和单一软测量模型精度不足的问题,提出了一种新的基于PAPE(PLS-Adaboost-PLS-Ensemble)的熔体温度集成软测量建模方法对熔体温度进行在线预测,并应用某企业的实际数... 详细信息

富氧底吹铜熔炼过程工况复杂多变,针对其重要参数熔体温度难以在线检测和单一软测量模型精度不足的问题,提出了一种新的基于PAPE(PLS-Adaboost-PLS-Ensemble)的熔体温度集成软测量建模方法对熔体温度进行在线预测,并应用某企业的实际数据进行训练和验证。结果表明,与传统方法相比,PAPE熔体温度集成软测量模型能够实现对熔体温度的在线检测,并提高了预测精度和泛化能力。因此熔体温度集成软测量模型更适用于底吹炉的实际生产当中。

关键词：富氧底吹铜熔炼过程熔体温度软测量

上海某河口型景观湖冬季附着藻类的建群过程初探

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生态与农村环境学报 2019年第3期35卷 345-351页

作者：陈姗柳昭莹张玮袁明哲王丽卿上海海洋大学农业部鱼类营养与环境生态研究中心上海201306 上海海洋大学水产种质资源发掘与利用教育部重点实验室上海201306 上海海洋大学水产科学国家级实验教学示范中心上海201306

为了解河口型水体附着藻类的建群过程,并获得群落成熟时间,于2015年冬季采用载玻片法对上海临港地区某景观湖进行研究。结果表明,附着藻类共检测出4门37属65种,其中硅藻门数量最多,占附着藻类数量的69.57%,其次为绿藻门,占25.95%。附着... 详细信息

为了解河口型水体附着藻类的建群过程,并获得群落成熟时间,于2015年冬季采用载玻片法对上海临港地区某景观湖进行研究。结果表明,附着藻类共检测出4门37属65种,其中硅藻门数量最多,占附着藻类数量的69.57%,其次为绿藻门,占25.95%。附着藻类总丰度在27 d时达到峰值,丰度为1.13×10~4～500×10~4 cm^(-2);硅藻丰度在25 d时出现峰值,丰度为1.13×10~4～299.05×10~4 cm^(-2)。聚类分析(CA)、非度量多维尺度分析(N-MDS)和相似性分析(ANOSIM)将附着藻类建群过程分为5个阶段,各阶段主要优势属分别为菱形藻属、针杆藻属和脆杆藻属,菱形藻属和针杆藻属,菱形藻属,菱形藻属和毛枝藻属,以及异极藻属和毛枝藻属。另外,通过分析藻类群落光合荧光参数动态变化发现,PSⅡ最大光能转换效率(F_v/F_m)变化与附着藻类总丰度变化趋势较一致,可作为指示附着藻类建群过程的潜在指标。挂片后3.5～4周,附着藻类群落发育逐渐成熟,此时段采样效果较佳。

关键词：建群过程河口型附着藻类成熟时间人工基质

Research on Improving the Thermal Conductivity of Epoxy Resin with Flexible Assisted Rigid Groups

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Chinese Journal of Polymer Science 2024年第11期 1845-1854页

作者： Hong-Yu Zhu Yan-Ji Zhu Di Bao Lu-Chao Pei Fei Xu zhe Wang Huai-yuan Wang School of Materials Science and Engineering Tianjin University Collaborative Innovation Centre of Chemical Science and Engineering (Tianjin) Tianjin University Tianjin Key Laboratory of Chemical Process Safety and Equipment Technology Tianjin University School of Chemical Engineering and Technology and State Key Laboratory for Chemical Engineering Tianjin University

Epoxy resins are cross-linked polymeric materials with typically low thermal ***,the introduction of rigid groups into epoxy resins is the main method to improve their intrinsic thermal *** researchers explored the relationship between the flexible chains of epoxy monomers and the thermal conductivity of the modified epoxy resins （MEP）.The effect of flexible chain length on the introduction of rigid groups into the cross-linked structure of epoxy is worth investigating,which is of great significance for the improvement of thermal conductivity of polymers and related *** prepared a small molecule liquid crystal （SMLC） containing a long flexible chain via a simple synthesis reaction,and introduced rigid mesocrystalline units into the epoxy resin via a curing *** high-temperature curing,the introduced mesocrystalline units underwent orientational stacking and were immobilized within the *** and TGA tests showed that the ordering within the modified epoxy resin was increased,which improved the thermal conductivity of the epoxy ***,during the above process,the flexible chains of SMLC provide space for the biphenyl groups to align and therefore affect the thermal conductivity of the ***,the MEP-Ⅵ cured with SMLC-Ⅵ containing six carbon atoms in the flexible chain has the highest thermal conductivity of 0.40W·m-1·K-1,which is 125%of the thermal conductivity of SMLC-IV of 0.32 W·m-1·K-1,111%of the thermal conductivity of SMLC-Ⅷ of 0.36W·m-1·K-1,and 182%of the thermal conductivity of pure epoxy of 0.22 W·m-1·*** introduction of appropriate length flexible chains for SMLC promotes the stacking of rigid groups within the resin while reducing the occurrence of chain *** study will provide new ideas for the enhancement of thermal conductivity of cross-linked polymeric materials.

关键词：

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-yuan Zou Tian-Yi Ren Jia-Qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-zhe Lin yuan-Yang Wang Xiao-zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets