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Lung ultrasound score evaluation of the effect of pressure-controlled ventilation volume-guaranteed on patients undergoing laparoscopicassisted radical gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1717-1725页

作者： Jian Tan cheng-Ming Bao Xiao-yuan Chen Department of Critical Care Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina Department of Ultrasound Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina

BACKGROUND Laparoscopic-assisted radical gastrectomy(LARG)is the standard treatment for early-stage gastric carcinoma(GC).However,the negative impact of this proce-dure on respiratory function requires the optimized intraoperative management of patients in terms of *** To investigate the influence of pressure-controlled ventilation volume-guaranteed(PCV-VG)and volume-controlled ventilation(VCV)on blood gas analysis and pulmonary ventilation in patients undergoing LARG for GC based on the lung ultrasound score(LUS).METHODS The study included 103 patients with GC undergoing LARG from May 2020 to May 2023,with 52 cases undergoing PCV-VG(research group)and 51 cases undergoing VCV(control group).LUS were recorded at the time of entering the operating room(T0),20 minutes after anesthesia with endotracheal intubation(T1),30 minutes after artificial pneumoperitoneum(PP)establishment(T2),and 15 minutes after endotracheal tube removal(T5).For blood gas analysis,arterial partial pressure of oxygen(PaO_(2))and partial pressure of carbon dioxide(PaCO_(2))were *** airway pressure(P_(peak)),plateau pressure(Pplat),mean airway pressure(P_(mean)),and dynamic pulmonary compliance(C_(dyn))were recorded at T1 and T2,1 hour after PP establishment(T3),and at the end of the operation(T4).Postoperative pulmonary complications(PPCs)were ***-and postoperative serum interleukin(IL)-1β,IL-6,and tumor necrosis factor-α(TNF-α)were measured by enzyme-linked immunosorbent *** Compared with those at T0,the whole,anterior,lateral,posterior,upper,lower,left,and right lung LUS of the research group were significantly reduced at T1,T2,and T5;in the control group,the LUS of the whole and partial lung regions(posterior,lower,and right lung)decreased significantly at T2,while at T5,the LUS of the whole and some regions(lateral,lower,and left lung)increased *** comparison with the control group,the whole and regional LUS of the research group were reduc

关键词： Lung ultrasound score Pressure-controlled ventilation volume-guaranteed Laparoscopic-assisted radical gastrectomy Blood gas analysis indexes Pulmonary ventilation

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Gut-targeted therapies for type 2 diabetes mellitus: A review

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World Journal of Clinical Cases 2024年第1期12卷 1-8页

作者： Tian-cheng Xu yun Liu Zhi Yu Bin Xu Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by hyperglycemia and insulin *** global prevalence of T2DM has reached epidemic proportions,affecting approximately 463 million adults worldwide in *** treatments for T2DM include lifestyle modifications,oral antidiabetic agents,and insulin ***,these therapies may carry side effects and fail to achieve optimal glycemic control in some ***,there is a growing interest in the role of gut microbiota and more gut-targeted therapies in the management of *** gut microbiota,which refers to the community of microorganisms that inhabit the human gut,has been shown to play a crucial role in the regulation of glucose metabolism and insulin *** in gut microbiota composition and diversity have been observed in T2DM patients,with a reduction in beneficial bacteria and an increase in pathogenic *** dysbiosis may contribute to the pathogenesis of the disease by promoting inflammation and impairing gut barrier *** gut-targeted therapies have been developed to modulate the gut microbiota and improve glycemic control in *** potential approach is the use of probio-tics,which are live microorganisms that confer health benefits to the host when administered in adequate *** randomized controlled trials have demonstrated that certain probiotics,such as Lactobacillus and Bifidobacterium species,can improve glycemic control and insulin sensitivity in T2DM *** may include the production of short-chain fatty acids,the improvement of gut barrier function,and the reduction of *** gut-targeted therapy is fecal microbiota transplantation(FMT),which involves the transfer of fecal material from a healthy donor to a *** has been used successfully in the treatment of Clostridioides difficile infection and is now being investigated as a potential therapy for T2DM.A recent rand

关键词： Type 2 diabetes mellitus Gastroenterology Bacteria Implanted device

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Parameter selection for the hydroconversion of waste polyethylene plastic under mild conditions: A comprehensive evaluation

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Science China(Technological Sciences) 2024年第8期67卷 2413-2426页

作者： cheng LeiLei CHEN RuiZhe ZHU WeiQiang TIAN ShaoNan GU Jing yuan HaoRan CHEN Yong Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China School of Energy Science and Engineering University of Science and Technology of ChinaHefei 230026China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China

The hydrogenolysis/hydrocracking of waste polyethylene(PE) has recently been intensively studied, with the general pursuit of low-temperature reaction conditions, increased oil-phase yield, and narrower carbon chain distribution. Before this, we utilized a ball-milled ZSM-22 catalyst loaded with Ru nanoparticles(NPs), which exhibited excellent hydroconversion performance. It deconstructed PE into >80 wt.% oil products under low temperatures and short reaction times. Herein, we investigated the influence of varying temperature/pressure parameters on the degree of specific hydrocracking/internal hydrogenolysis/terminal hydrogenolysis reactions. From the comprehensive energy efficiency perspective, including stirring, reaction, and product separation, as well as taking into account the degree of product isomerization and catalyst lifespan, we analyzed the optimization of parameters. This research abandons the notion that lower temperatures are better and proposes a more comprehensive evaluation framework for low-consumption hydroconversion of PE to produce high-value products.

关键词： plastic upcycling polyethylene hydrocracking hydrogenolysis comprehensive energy efficiency

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A Deep Learning Approach to Shape Optimization Problems for Flexoelectric Materials Using the Isogeometric Finite Element Method

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1935-1960页

作者： Yu cheng Yajun Huang Shuai Li Zhongbin Zhou Xiaohui yuan Yanming Xu College of Architecture and Civil Engineering Xinyang Normal UniversityXinyang464000China Henan Unsaturated Soil and Special Soil Engineering Technology Research Center Xinyang Normal UniversityXinyang464000China College of Intelligent Construction Wuchang University of TechnologyWuhan430223China College of Civil Engineering and Architecture Dalian UniversityDalian116622China Henan International Joint Laboratory of Structural Mechanics and Computational Simulation School of Architecture and Civil EngineeringHuanghuai UniversityZhumadian463000China

A new approach for flexoelectricmaterial shape optimization is proposed in this *** this work,a proxymodel based on artificial neural network(ANN)is used to solve the parameter optimization and shape optimization *** improve the fitting ability of the neural network,we use the idea of pre-training to determine the structure of the neural network and combine different optimizers for *** isogeometric analysis-finite element method(IGA-FEM)is used to discretize the flexural theoretical formulas and obtain samples,which helps ANN to build a proxy model from the model shape to the target *** effectiveness of the proposed method is verified through two numerical examples of parameter optimization and one numerical example of shape optimization.

关键词： Shape optimization deep learning flexoelectric structure finite element method isogeometric

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Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1)O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： Jia-Qi Peng yuan-yuan Wei Dong-Ming Liu yun Li Bin Hu Bin Huang Jian-Wen Yang Shun-Hua Xiao Ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

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A systematic understanding of microbial reductive dechlorination towards an improved “one health” soil bioremediation: A review and perspective

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Science China Technological Sciences 2024年第10期67卷 3009-3031页

作者： HE Yan LI ShuYao yuan Jing cheng Jie DOU JiBo YANG XueLing XU JianMing Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang University Key Laboratory of Environment Remediation and Ecological Health Ministry of Education Microbiome Network and Department of Agricultural Biology Colorado State University Departments of Chemistry and Chemical & Biomolecular Engineering Institute for Functional Intelligent Materials (I-FIM)National University of Singapore

Chlorinated organic pollutants(COPs), both emerging and traditional, are typical persistent pollutants that harm soil health worldwide. Dechlorinators mediated reductive dechlorination is the optimal way to completely remove COPs from anaerobic soil through a redox reaction driven by electron transfer during microbial anaerobic respiration. Generally, the dechlorinated depletion of COPs in situ often interacts with multiple element biogeochemical activities, e.g., methanogenesis, sulfate reduction, iron reduction, and denitrification. Elucidating the relevance of biogeochemical cycles between COPs and multiple elements and the coupled mechanisms involved, thus, helps to develop effective pollution control strategies with the balance between pollution degradation and element cycles in heterogeneous soil, ultimately contributing to “one health” goal. In this review, we summarized the microbial-chemical coupling redox processes and the driving factors, elucidated the interspecies metabolites exchange and electron transfer mechanisms within COP-dechlorinating communities, and further proposed a detailed design, construction, and analysis framework of engineering COP-dechlorinating microbiomes via “top-down” selfassembly and “bottom-up” synthesis to pave the way from laboratory to practical field application. Especially, we delve into the major challenges and perspectives surrounding the design of state-of-the-art synthetic microbial communities. Our goal is to improve the understanding of the microbial-mediated coupling between reductive dechlorination and element biogeochemical cycling, with a particular focus on the implications for health-integrated soil bioremediation under the “one health” concept.

关键词： reductive dechlorination biogeochemical redox processes interspecies interaction synthetic microbiomes, anaerobic soils

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The Contributions of Thrombospondin-1 to Epilepsy Formation

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Neuroscience Bulletin 2024年第5期40卷 658-672页

作者： Yao cheng Yujie Zhai Yi yuan Qiaoyun Wang Shucui Li Hongliu Sun School of Pharmaceutical Sciences Binzhou Medical UniversityYantai264003China

Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory *** synaptogenesis plays a vital role in the formation of overexcited *** evidence has confirmed that thrombospondin-1(TSP-1),mainly secreted by astrocytes,is a critical cytokine that regulates synaptogenesis during ***,numerous studies have reported that TSP-1 is also involved in other processes,such as angiogenesis,neuroinflammation,and regulation of Ca^(2+)homeostasis,which are closely associated with the occurrence and development of *** this review,we summarize the potential contributions of TSP-1 to epilepsy development.

关键词： Thrombospondin-1 Epileptogenesis Synaptogenesis Hyperexcitability

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A Multi-Constraint Path Optimization Scheme Based on Information Fusion in Software Defined Network

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Computers, Materials & Continua 2024年第4期79卷 1399-1418页

作者： Jinlin Xu Wansu Pan Longle cheng Haibo Tan Munan yuan Xiaofeng Li Hefei Institutes of Physical Science Chinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China

The existingmultipath routing in Software Defined Network (SDN) is relatively blind and inefficient, and there is alack of cooperation between the terminal and network sides, making it difficult to achieve dynamic adaptationof service requirements and network resources. To address these issues, we propose a multi-constraint pathoptimization scheme based on information fusion in SDN. The proposed scheme collects network topology andnetwork state information on the network side and computes disjoint paths between end hosts. It uses the FuzzyAnalytic Hierarchy Process (FAHP) to calculate the weight coefficients of multiple constrained parameters andconstructs a composite quality evaluation function for the paths to determine the priority of the disjoint paths. TheSDN controller extracts the service attributes by analyzing the packet header and selects the optimal path for flowrule forwarding. Furthermore, the service attributes are fed back to the path composite quality evaluation function,and the path priority is dynamically adjusted to achieve dynamic adaptation between service requirements andnetwork status. By continuously monitoring and analyzing the service attributes, the scheme can ensure optimalrouting decisions in response to varying network conditions and evolving service demands. The experimentalresults demonstrated that the proposed scheme can effectively improve average throughput and link utilizationwhile meeting the Quality of Service (QoS) requirements of various applications.

关键词： SDN multi-constraint path information fusion FAHP

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A Novel Divide and Conquer Solution for Long-term Video Salient Object Detection

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Machine Intelligence Research 2024年第4期21卷 684-703页

作者： yun-Xiao Li cheng-Li-Zhao Chen Shuai Li Ai-Min Hao Hong Qin State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China College of Computer Science and Technology China University of Petroleum(East China)Qingdao 266580China Department of Computer Science Stony Brook UniversityNew York 11794USA

Recently,a new research trend in our video salient object detection(VSOD)research community has focused on enhancing the detection results via model self-fine-tuning using sparsely mined high-quality keyframes from the given *** such a learning scheme is generally effective,it has a critical limitation,i.e.,the model learned on sparse frames only possesses weak generalization *** situation could become worse on“long”videos since they tend to have intensive scene ***,in such videos,the keyframe information from a longer time span is less relevant to the previous,which could also cause learning conflict and deteriorate the model ***,the learning scheme is usually incapable of handling complex pattern *** solve this problem,we propose a divide-and-conquer framework,which can convert a complex problem domain into multiple simple ***,we devise a novel background consistency analysis(BCA)which effectively divides the mined frames into disjoint *** for each group,we assign an individual deep model on it to capture its key attribute during the fine-tuning *** the testing phase,we design a model-matching strategy,which could dynamically select the best-matched model from those fine-tuned ones to handle the given testing *** experiments show that our method can adapt severe background appearance variation coupling with object movement and obtain robust saliency detection compared with the previous scheme and the state-of-the-art methods.

关键词： Video salient object detection background consistency analysis weakly supervised learning long-term information background shift.

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A robust genomic-based prognostic model for the assessment ofcancer stemness and survival for patients with hepatocellularcarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 97-102页

作者： cheng-Li Du Shen-Yu Wei yun-Hao Chen Kang-Jie Chen Division of Thoracic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang University School of Medicine Hangzhou 310003China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Hepatocellular carcinoma(HCC)is an aggressive malignancy with poor long-term prognosis[1].Liver cancer stem cell(CSC)can drive the metastasis,drug resistance,and recurrence of HCC[2].The regulatory mechanisms about liver cancer stemness have been investigated,which encouraged the identification and characterization of novel prognostic and therapeutic strategies for HCC[3].

关键词： cancer prognosis Liver

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