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Stereoselectivities in α- and β-Amino Acids Catalyzed Mannich Reactions Involving Cyclohexanone

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Chemical Research in chinese Universities 2011年第4期27卷 673-677页

作者： WANG Ying FU Ai-ping LI Hong-liang TIAN feng-hui {1. Shu-ping SI Hong-zong DUAN Yun-bo WANG Zong-{2. institute for Computational Science and Engineering Laboratory of New Fiber Materials and Modern Textile Growing Base for State Key Laboratory College of Chemical and Environmental Engineering Qingdao University Qingdao 266071 P. R. China

The effects of two different amino acid catalysts on the stereoselectivities in the direct Mannich reactions of cyclohexanone,p-anisidine and p-nitrobenzaldehyde were studied with the aid of density functional *** states of the stereo-determining C ＂C bond-forming step with the addition of enamine intermediate to the imine for the L-proline（·-amino acid） and （R）-3-pyrrolidinecarboxylic acid（·-amino acid）-catalyzed processes were reported.B3LYP/6-31. calculations provide a good explanation for the opposite syn *** diastereoselectivities of these two different kinds of catalysts（syn-selectivity for the ·-amino acid catalysts,anti-selectivity for the ·-amino acid catalysts）.Calculated and observed diastereomeric ratio and enantiomeric excess values are in reasonable agreement.

关键词： Syn-and anti-Mannich reaction Stereoselectivity Amino acid Transition state

Efficacy of rhNGF-loaded amniotic membrane transplantation for rabbit corneal epithelial and nerve regeneration

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1653-1659页

作者： Lu-Qin Wan Yang-Yang Zhang Hui-feng Wang Chen Chen {1. Li {2. Zhang Jun-Fa Xue Qing-Jun Zhou Li-Xin Xie Medical College of qingdao University Qingdao 266000Shandong ProvinceChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina

AIM:To evaluate the efficacy of recombinant human nerve growth factor-loaded amniotic membrane(rh NGF-AM)on corneal epithelial and nerve regeneration in rabbit ***:Freshly prepared human amniotic membrane(AM)were immersed into PBS buffer containing 1.0 or 500μg/mL rh NGF for 1.,30,and 60 min at 4℃.The in vitro release kinetics of rh NGF was measured with *** in vivo evaluation,the AM were immersed with 500μg/mL rh NGF for 30 ***-seven rabbits were selected to establish corneal epithelial defect *** addition to the 1. rabbits in control group,38 rabbits received AM transplantation with or without rh NGF after the removal of central *** epithelial defect area,sub-epithelial nerve fiber density,corneal sensitivity,rh NGF contents in resident AM and corneas were measured after the ***:rh NGF was sustained release from the AM within 1. d in vitro,with the positive correlation with initial immersion *** immersion of AM in 500μg/mL rh NGF for 30 min achieved the most stable release within 1. *** transplantation in rabbit cornea,a high concentration of rh NGF in resident rh NGF-AM and cornea was maintained within 8 *** epithelial healing,nerve fiber regeneration and the recovery of corneal sensitivity were significantly accelerated after the rh NGF-AM transplantation when compared to simple AM transplantation(all P<0.05).CONCLUSION:Simple immersion of AM achieves the sustained release of rh NGF,and promotes corneal epithelial wound healing and nerve regeneration,as well as the recovery of corneal sensitivity in rabbit.

关键词： recombinant human nerve growth factor amniotic membrane drug-loaded corneal epithelium nerve regenerati on

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赤霉素和脱落酸对花生生长与后熟进程的影响

花生学报 2024年第2期53卷 10-19,30页

作者：宋兆锋张志民李美君丁红赵跃孙日丹陈小姝李春雨赫思聪高华援吉林省农业科学院吉林公主岭136100 山东省花生研究所山东青岛266100

脱落酸(ABA)和赤霉素(GA)是影响作物后熟作用和休眠的两大主要植物激素。以吉花2.为试验材料,采用随机区组试验,以空白处理为对照(CK),分别设置ABA、GA以及两者不同浓度比的混合溶液共5个处理:A(0.1.mmol/L ABA)、G(0.2.mmol/L GA)、AG... 详细信息

脱落酸(ABA)和赤霉素(GA)是影响作物后熟作用和休眠的两大主要植物激素。以吉花2.为试验材料,采用随机区组试验,以空白处理为对照(CK),分别设置ABA、GA以及两者不同浓度比的混合溶液共5个处理:A(0.1.mmol/L ABA)、G(0.2.mmol/L GA)、AGⅠ(ABA:GA=1.1.、AGⅡ(ABA:GA=2.1.、AGⅢ(ABA:GA=1.2.,研究不同处理对植株性状、干物质积累、光合作用、生理生化指标、不同收获时期产量和品质的影响,同时比较不同收获时间花生种子的萌发特性,筛选促进花生生长及花生种子后熟的最适方案。结果表明,与CK相比,GA单施处理均能增加花生结荚期前的主茎高、侧枝长、叶面积、干物质积累量及光合速率,除ABA单施处理对叶面积具有增加作用外,ABA单施及二者不同比例混施处理均对其他农艺性状及光合速率无显著影响。各处理下花生叶片抗氧化酶活性表现趋势不同,但GA单施处理能够增加叶片抗氧化酶活性,降低MDA含量。与CK相比,无论是否提前收获,GA单施处理均能增加三个不同收获时间的花生产量,提高籽仁品质,产量增加幅度分别为9.2.%、5.1.%和1..83%。GA单施处理下三个不同收获时间的种子发芽率、发芽指数和活力指数均高于对照。由此表明,0.2.mmol/L GA单施处理是最佳激素施用方案,能促进花生前期生长发育,影响花生体内各时期抗氧化酶活性,促使其成熟,提高花生产量及品质。单施GA能在早收的情况下保证种子发芽率和活力,加快花生种子的后熟进程。

关键词：赤霉素脱落酸花生生理生化产量后熟作用

Liquefaction structures induced by the M5.7 earthquake on May 2., 2.1. in Songyuan, Jilin Province, NE{1. and research implication

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Journal of Palaeogeography 2020年第1期9卷 109-127页

作者： Zhu-Fu Shao Jian-hua Zhong John Howell Bing Hao Xi-Wu Luan Ze-Xuan Liu Wei-Min Ran Yun-{1. Zhang Hong-Qi {2. Jing-Jing Liu Liang-Tian Ni Guan-Xian Song Jin-Lin Liu Wen-Xin Zhang Bing Zhao School of Geosciences Northeast Petroleum UniversityDaqing 163318Heilongjiang ProvinceChina Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Mineral Shandong University of Science and TechnologyQingdao 266590Shandong ProvinceChina Department of Geology and Petroleum Geolog University of AberdeenAberdeen AB243UEUK School of Geosciences China University of PetroleumQingdao 266580Shandong ProvinceChina qingdao {1. of Marine Geology China Geological SurveyQingdao 266071Shandong ProvinceChina.

An earthquake of magnitude M5.7 occurred in Yamutu village,Songyuan City,Jilin Province,NE{1.(45°1.′1.″N/1.4°42.35″E)on May 2.,2.1.,with a focal depth of 1. *** epicenter is located at the intersection of the Fuyu/Songyuan-Zhaodong Fault,Second Songhua River Fault and Fuyu North Fault which lies northwest of TanchengLujiang Fault(Tan-Lu Fault).The earthquake-induced widespread liquefaction structures and ground surface fissures within 3 km from the epicenter,caused serious disasters to the local *** visible liquefied structures include sand volcanoes,liquefied sand mounds,sand dikes and sand *** volcanoes can be divided into sand volcano with a crater,sand volcano without a crater and water volcano(no sand).Other soft-sediment deformation structures(SSDS)induced by the earthquake include deformation lamination,load and flame structures,deformation folds,dish structures,convolute bedding and water-escape *** formation process of the sand volcanoes comprises three stages:(1.building up excess pore-fluid pressure in the liquefied layer,(2.cracking of the low-permeable overlying layer,and(3)mixture of sand-water venting out of the ground *** the upward movement,the liquefied sand is injected into the low-permeable layer to form sand veins,sand sills and various types of deformation *** distribution of seismic liquefaction structure can be divided into four zones:the thoroughly liquefied zone,the lower liquefied zone with SSDS,the upper liquefied zone with SSDS,and the ground surface liquefied *** liquefaction occurred at a burial depth of 2.5 m,and the thickness of liquefied sand is 2.***-SW(35°–2.1}°)trending compressive stress is possibly the seismogenic trigger of the Songyuan M5.7 earthquake that caused the fault(Fuyu/Songyuan-Zhaodong Fault)to *** study of the Songyuan seismic liquefaction structures gives insight into the prediction of modern earthquakes and disasterprone ***

关键词： Earthquake Soft-sediment deformation structures Liquefaction structure Sand volcano Songyuan

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一种天波返回散射噪声数据的识别方法

地球物理学进展 2018年第3期33卷 928-933页

作者：华彩成冯静李雪田德元中国电波传播研究所山东青岛266107

本文提出了一种天波返回散射全噪声数据的识别方法,首先,通过对全噪声数据特征参数的分析,总结了全噪声数据的特点,然后对全噪声数据进行区域划分处理,计算了各区域的均方差参数值,分析对比了弱能量数据与全噪声数据的特征参数差别,最... 详细信息

本文提出了一种天波返回散射全噪声数据的识别方法,首先,通过对全噪声数据特征参数的分析,总结了全噪声数据的特点,然后对全噪声数据进行区域划分处理,计算了各区域的均方差参数值,分析对比了弱能量数据与全噪声数据的特征参数差别,最后利用阈值法对数据类型进行判断.本算法具有简单、快速、准确率高的特点,为实时性的短波通信设备性能提升提供了支撑.

关键词：返回散射全噪声数据阈值法

渤海湾盆地渤南洼陷沙河街组三段剩余压力梯度与油气分布关系

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石油与天然气地质 2020年第5期41卷 1083-1091页

作者：刘华李君冯月琳郝雪峰林红梅袁飞飞中国石油大学(华东)深层油气重点实验室山东青岛266580 海洋矿产资源评价与探测技术国家功能实验室山东青岛266071 中国石化胜利油田有限公司勘探开发研究院山东东营257001

为了量化表征超压对油气运聚和分布的关系,综合利用录井、测井和分析测试等资料,在渤海湾盆地渤南洼陷地层流体压力预测的基础上,计算了沙河街组三段(沙三段)剩余压力梯度,并分析了剩余压力梯度变化规律及其对油气分布的影响。研究发现... 详细信息

为了量化表征超压对油气运聚和分布的关系,综合利用录井、测井和分析测试等资料,在渤海湾盆地渤南洼陷地层流体压力预测的基础上,计算了沙河街组三段(沙三段)剩余压力梯度,并分析了剩余压力梯度变化规律及其对油气分布的影响。研究发现,渤南洼陷沙三段富含油气且超压普遍发育,深洼带剩余压力较大,剩余压力梯度最高,其次为陡坡带和断阶带,缓坡带剩余压力较小,梯度最低。受超压中心分布的影响,各地区油气运移动力条件及其油气富集空间存在较大差异:超压中心区油气运移动力较强,高剩余压力梯度主要分布于断层附近,油气多富集在渤深4断层附近;近超压中心区砂体侧向输导阻力不同,高剩余压力梯度主要出现在非均质性较强的地层中,剩余压力梯度较低的地区是油气运聚的指向区;而远离超压中心的地区剩余压力较小,油气运移浮力作用明显占主导,剩余压力梯度与油气分布关系不明显。

关键词：超压剩余压力梯度剩余压力油气分布沙河街组三段渤南洼陷渤海湾盆地

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平面压降梯度计算原则及其应用

石油实验地质 2019年第4期41卷 598-605页

作者：冯月琳刘华宋国奇袁飞飞中国石油大学(华东)地球科学与技术学院山东青岛266580 海洋矿产资源评价与探测技术国家功能实验室山东青岛266071 中国石化胜利油田分公司勘探开发研究院山东东营257001

超压作为油气运移的动力条件,其变化速率与油气运移方式存在一定的关系。为定量判识超压盆地中油气运移方式,建立了应用地层压降梯度分析的计算思路与方法,并以渤海湾盆地沾化凹陷渤南洼陷为例进行了应用和探讨。以实测压力与单井预测... 详细信息

超压作为油气运移的动力条件,其变化速率与油气运移方式存在一定的关系。为定量判识超压盆地中油气运移方式,建立了应用地层压降梯度分析的计算思路与方法,并以渤海湾盆地沾化凹陷渤南洼陷为例进行了应用和探讨。以实测压力与单井预测压力为基础,对油气主要运移层系进行了压力分布特征分析,结合超压成因机制分区、沉积相变以及断层发育特征,分别对压力均匀降低区、沉积相变非均匀降低区和断层分割非均匀降低区采用不同的压降梯度计算思路进行计算。渤南洼陷深洼带的压降梯度最高,其次为断阶带、陡坡带以及缓坡带,且垂向连通的断层附近压降梯度较高,定量地解释了在超压控制下油气运移方式的变化特征,从而有效判识油气优势富集的位置。

关键词：压降梯度运移动力油气运移方式渤南洼陷渤海湾盆地

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia {1. Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai {1.cheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen {1.-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng {1.jie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Han{1. Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core S{1.ngxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research institute Co. LtdBeijing Beijing institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china {1. of engineering physics MianyangSichuan china building materials {1. Beijing china Center of Advanced Science and Technology Beijing china {1. of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×1.^(34)cm^(-2.s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1. ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.1.)and the Conceptual Design Report(CDR,2.1.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-{1.0s.

关键词： initiated exceeding precise

Prospective, naturalistic study of open-label OROS methylphenidate treatment in chinese school-aged children with attention-deficit/hyperactivity disorder

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chinese Medical Journal 2011年第20期124卷 3269-3274页

作者： ZHENG Yi WANG Yu-feng QIN Jiong WANG Li-wen ZOU Li-ping J IN Xing-ming XU Tong WANG Yi OI {1.-li GONG Mei-en YIN Qing-yun MAI Jian-ning JING Jin LUO Xiang-yang MA Hong-wei LI Hai-bo XIE Ling LIYan Kuang Gui-fang YI Ming-ji WANG feng ZHU Xiao-hua YAO Yan-bin Department of Pediatrics Beijing Anding Hospital Capital Medical University Beijing 100088 China Department of Pediatrics Institute of Mental Health Peking University Beijing 100191 China Department of Pediatric Neurology Women＇s and Children＇s Department Peking University First Hospital Beijing 100034 China Department of Pediatric Neurology Capital Institute of Pediatrics Beijing 100020 China Department of Pediatric Medicine Beijing Children＇s Hospital of Capital Medical University Beijing 100045 China Department of Pediatrics Shanghai Children＇s Medical Center of Shanghai Jiaotong University Shanghai 200127 China Department of Pediatrics Shanghai Changzheng Hospital of Second Military Medical University Shanghai 200003 China Department of Pediatrics Pediatric Hospital of Fudan University Shanghai 200032 China Department of Psychiatry Institute of Mental Health Guangzhou Guangdong 510080 China Department of Psychology Second Affiliated Hospital of Guangzhou Medical College Guangzhou Guangdong 510150 China Department of Psychiatry Guangzhou Brain Hospital of Guangzhou Medical College Guangzhou Guangdong 510510 China Department of Neural Rehabilitation Guangzhou Children＇s Hospital Guangzhou Guangdong 510120 China Department of Pediatrics Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Pediatric Medicine Second Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510130 China Department of Child Health Second Hospital of China Medical University Shenyang Liaoning 110022 China Department of Pediatrics First Hospital of Jilin University Changchun Jilin 130021 China Department of Child Health Nanjing Children＇s Hospital of Nanjing Medical University Nanjing Jiangsu 210008 China Department of Neurology Children＇s Hospital of Soochow University Suzhou Jiangsu 215003 China Department of Pediatric Mental Health Qingdao Women and Children Health Care Centers Qingdao Shandong 266011 China D

Background Attention deficit hyperactivity disorder （ADHD） is one of the most common mental disorders during childhood, characterized by the core symptoms of hyperactivity, impulsivity and inattention and puts great burden on children themselves, their families and the society. Osmotic release oral system methylphenidate （OROS-MPH） is a once-daily controlled-release formulation developed to overcome some of the limitations associated with immediate-release methylphenidate （IR-MPH）. It has been marketed in china since 2.05 but still lacks data from large-sample clinical trials on efficacy and safety profiles. The aim of this study was to evaluate the effectiveness and safety of OROS-MPH in children aged 6 to 1. years with ADHD under naturalistic clinical setting. Methods This 6-week, multi-center, prospective, open-label study enrolled 1.47 ADHD children to once-daily OROS-MPH （1. mg, 36 mg or 54 mg） treatment. The effectiveness measures were parent-rated Inattention and Overactivity With Aggression （IOWA） Conners I/O and O/D subscales, physician-rated CGI-I and parent-rated global efficacy assessment scale. Blood pressure, pulse rate measurement, adverse events （AEs） and concomitant medications and treatment review were conducted by the investigator and were served as safety measures. Results A total of 1.47 children with ADHD （mean age （9.52._{1.6） years） were enrolled in this trial. Totally 96.8% children received an OROS-MPH modal dose of 1. mg, 3.1. with 36 mg and 0.1. with 54 mg at the endpoint of study. The parent IOWA Conners I/O score at the end of week 2.showed statistically significant （P 〈0.001. improvement with OROS-MPH （mean： 6.95±2..71. versus the score at baseline （1..45±2.72.. The change in the parent IOWA Conners O/D subscale, CGI-I and parent-rated global efficacy assessment scale also supported the superior efficacy for OROS-MPH treatment. Fewer than half of 1.47 patients （51. （35.3%）） reported AEs, and the majority of the events reported were mil

关键词： attention deficit hyperactivity disorder methylphenidate pharmacotherapy