检索结果-南通市图书馆

GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang Zhao Shuang Zhao Xueting Yu Runyang {1. You-en Zhang Haomin Li Lei huang Zhenyang Guo Zhentao Zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong huang Hao Lu Xin Zhao Zhaoyang Chen Wenbin Zhang Junjie Guo Hongchao Zheng Yue He Shengying Qin Haojie Lu Yun Zhao Xiangdong Wang Junbo Ge hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and institutes of Biomedical {1. Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(EndMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological ***,we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this *** addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial ***,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1.30,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial *** vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after ischemic ***,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

迪庆州云杉老龄林生态系统碳转移

引用

云南大学学报（自然科学版） 2018年第2期40卷 372-381页

作者：冯源朱建华肖文发毕艳玲皇宝林温庆忠邓喜庆中国林业科学研究院森林生态环境与保护研究所国家林业局森林生态环境重点实验室北京100091 南京林业大学南方现代林业协同创新中心江苏南京210037 云南省林业调查规划院云南昆明650051

研究老龄林生态系统内部及向外界的碳转移对评价区域尺度森林生态系统碳收支具有重要意义.基于森林资源规划设计调查、干扰统计数据和CBM-CFS3模型,估算云南省迪庆州云杉老龄林生态系统年均内部碳转移为1.8.66 Gg·a^(-1.,其中地上生物... 详细信息

研究老龄林生态系统内部及向外界的碳转移对评价区域尺度森林生态系统碳收支具有重要意义.基于森林资源规划设计调查、干扰统计数据和CBM-CFS3模型,估算云南省迪庆州云杉老龄林生态系统年均内部碳转移为1.8.66 Gg·a^(-1.,其中地上生物量和地下生物量碳库分别向死亡有机质碳库(DOM)转移87.48Gg·a^(-1.和71.1. Gg·a^(-1.;生态系统向外界年均碳转移1.6.22 Gg·a^(-1.,包含采伐木材产品移出33.09 Gg·a^(-1.、燃烧释放2.62 Gg·a^(-1.和分解释放1.0.51.Gg·a^(-1.;净初级生产力(NPP)、净生态系统生产力(NEP)与净生物群系生产力(NBP)分别为1.5.45、4.95 Gg·a^(-1.和-30.77 Gg·a^(-1..云杉老龄林为碳汇但在个别年份为弱碳源.采伐是生态系统碳转移的重要驱动力,连续采伐会加剧生态系统内部周转、移出木材产品、增加异养呼吸及燃烧释放从而增大云杉老龄林转变为碳源的风险.

关键词：迪庆云杉老龄林碳转移采伐

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

花椒叶在椒盐曲奇饼干制作工艺中的应用研究

引用

食品研究与开发 2018年第14期39卷 103-109页

作者：张欢梁晶晶刘阳乔明锋胡军姜元华四川旅游学院四川成都610100 中国科学院山地生态恢复与生物资源利用重点实验室生态恢复与生物多样性保育四川省重点实验室中国科学院成都生物研究所四川成都610041

以汉源花椒的副产品花椒叶作为原料,感官评分作为依据,先后在原料配方,工艺方案上采用单因素和正交试验,探讨影响花椒叶椒盐曲奇饼干感官评分值的因素,最后采用质构分析,用科学理论的方法确定感官评分值。最终确定花椒叶椒盐曲奇饼干配... 详细信息

以汉源花椒的副产品花椒叶作为原料,感官评分作为依据,先后在原料配方,工艺方案上采用单因素和正交试验,探讨影响花椒叶椒盐曲奇饼干感官评分值的因素,最后采用质构分析,用科学理论的方法确定感官评分值。最终确定花椒叶椒盐曲奇饼干配方为:低筋面粉1.0%,黄油70%,食盐2.7%,花椒叶粉1.5%,糖粉20%,水1.%。工艺优化最佳结果为搅拌时间8 min,烘烤时间1. mim,上火温度1.0℃,下火温度1.0℃。

关键词：花椒叶曲奇饼干单因素正交质构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

山东烤烟水溶性糖和Amadori化合物组成特征及其对感官质量的影响

引用

南方农业学报 2024年第4期55卷 1139-1148页

作者：任明波李静马志远戴华伟高峰邱军庞雪莉山东淄博烟草有限公司山东淄博255035 中国农业科学院烟草研究所山东青岛266101

【目的】明晰山东烤烟上、中2个部位B2F、C3F烟叶中水溶性糖和Amadori化合物组分构成及含量分布特征,分析化合物对烤烟感官质量的影响,为改进和精准调控山东烤烟感官品质提供数据支持。【方法】选取山东主产区生产的烤烟B2F和C3F叶片为... 详细信息

【目的】明晰山东烤烟上、中2个部位B2F、C3F烟叶中水溶性糖和Amadori化合物组分构成及含量分布特征,分析化合物对烤烟感官质量的影响,为改进和精准调控山东烤烟感官品质提供数据支持。【方法】选取山东主产区生产的烤烟B2F和C3F叶片为试验材料,利用气相色谱—质谱联用技术(GC-MS)和高效液相色谱—三重四极杆串联质谱技术(HPLC-MS/MS)对烤烟中水溶性糖和Amadori化合物进行分析,通过正交偏最小二乘判别分析(OPLS-DA)方法对B2F和C3F烟叶样品进行判别分析,并对卷烟样品进行评吸,通过相关分析揭示与山东烤烟各感官质量指标呈正/负相关的关键化学成分。【结果】定性定量分析山东烤烟中1.种水溶性糖和8种Amadori化合物,其中葡萄糖和果糖含量较高,蔗糖次之,其余水溶性糖含量较低;B2F和C3F烟叶间阿拉伯糖醇、阿洛酮糖和甘露醇含量差异显著(P3F烟叶的阿拉伯糖醇含量是B2F烟叶的1.50倍,B2F烟叶的阿洛酮糖和甘露醇含量分别是C3F烟叶的1.26和48.85倍;B2F和C3F烟叶中主要Amadori化合物均为1.脱氧-1.L-脯氨酸-D-果糖(Fru-Pro)(1.~45 mg/g),其次为1.脱氧-1.L-丙氨酸-D-果糖(Fru-Ala)、1.脱氧-1.L-谷氨酸-D-果糖(Fru-Glu)、1.脱氧-1.L-苯丙氨酸-D-果糖(Fru-Phe)、葡糖胺(GLU)和1.脱氧-1.L-色氨酸-D-果糖(Fru-Trp)(1.20 mg/g)。挖掘出对B2F和C3F烟叶区分贡献较大的化合物,按贡献大小排序为甘露醇>阿洛酮糖>核糖醇>来苏糖>核糖>1.脱氧-1.L-缬氨酸-D-果糖(Fru-Val)>GLU>果糖>Fru-Ala。C3F烟叶各感官质量指标得分均明显高于B2F烟叶。在B2F烟叶中,阿拉伯糖醇、Fru-Pro、阿拉伯糖、木糖醇、阿洛酮糖和Fru-Ala与部分感官评吸指标呈显著或极显著(P1.下同)正相关,Fru-Glu和GLU与部分感官评吸指标呈显著或极显著负相关。在C3F烟叶中,核糖、阿洛酮糖、果糖、葡萄糖和麦芽糖与部分感官评吸指标呈显著或极显著正相关,来苏糖、核糖醇、Fru-Glu和Fru-Phe与部分感官评吸指标呈显著或极显著负相关。【结论】山东烤烟水溶性糖和Amadori化合物的含量在部位间差异明显,进而对烟叶感官质量产生不同的影响。

关键词：山东烤烟水溶性糖 Amadori化合物感官质量

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hypothermia selectively protects the anterior forebrain mesocircuit during global cerebral ischemia

引用

Neural Regeneration Research 2022年第7期17卷 1512-1517页

作者： Xiao-hua Wang Wei Jiang Si-{1. Zhang Bin-Bin Nie Yi Zheng feng Yan Jian-feng Lei Tian-Long Wang Department of Anesthesiology Xuanwu HospitalCapital Medical UniversityBeijingChina National Clinical Research Center for Geriatric Disorders BeijingChina Department of Anesthesiology Third Medical Center of People’s Liberation Army General HospitalBeijingChina Daxing Hospital Affiliated to Capital Medical University BeijingChina Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijingChina Neuroprotection Research Laboratory Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Cerebrovascular Research Center Xuanwu HospitalCapital Medical UniversityBeijingChina

Hypothermia is an important protective strategy against global cerebral ischemia following cardiac ***,the mechanisms of hypothermia underlying the changes in different regions and connections of the brain have not been fully *** study aims to identify the metabolic nodes and connection integrity of specific brain regions in rats with global cerebral ischemia that are most affected by hypothermia treatment.1.F-fluorodeoxyglucose positron emission tomography was used to quantitatively determine glucose metabolism in different brain regions in a rat model of global cerebral ischemia established at 31.33℃.Diffusion tensor imaging was also used to reconstruct and explore the brain connections *** results showed that,compared with the model rats established at 37–37.5℃,the rat models of global cerebral ischemia established at 31.33℃had smaller hypometabolic regions in the thalamus and primary sensory areas and sustained no obvious thalamic *** selectively preserved the integrity of the anterior forebrain mesocircuit,exhibiting protective effects on the brain during the global cerebral *** study was approved by the Institutional Animal Care and Use Committee at Capital Medical University(approval ***-AD31.-97-01.)on December 1.,201..

关键词： anterior forebrain mesocircuit cardiac arrest corpus callosum global cerebral ischemia hypometabolic areas hypothermia magnetic resonance imaging positron emission tomography prefrontal cortex rats thalamus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新元古代陡山沱组具细胞裂殖结构的丝状蓝藻

引用

微体古生物学报 2002年第2期19卷 157-162页

作者：高峰陈均远李家维中国科学院南京地质古生物研究所南京210008 台湾新竹清华大学生命科学系

新元古代陡山沱组丝状蓝藻化石 Oscillatoriopsis sp.,具丝状蓝藻化石记录中罕见的细胞分裂结构 ;其胞壁内陷的二等分裂方式 ,可能的丝体断裂结构 ,是现生丝状蓝藻生长和繁殖的典型特征 ;不具异形胞结构的形态特征 ,可能与其当时生存的... 详细信息

新元古代陡山沱组丝状蓝藻化石 Oscillatoriopsis sp.,具丝状蓝藻化石记录中罕见的细胞分裂结构 ;其胞壁内陷的二等分裂方式 ,可能的丝体断裂结构 ,是现生丝状蓝藻生长和繁殖的典型特征 ;不具异形胞结构的形态特征 ,可能与其当时生存的海底表面的缺氧环境有关 ;这种基底环境 ,可能有利于 Oscillatoriopsis sp.

关键词：新元古代陡山沱组细胞裂殖结构丝状蓝藻细胞分裂

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of Antifungal Substance (Iturin A_2) Produced by Bacillus subtilis B47 and Its Effect on Southern Corn Leaf Blight

引用

Journal of Integrative Agriculture 2012年第1期11卷 90-99页

作者： YE Yun-feng LI Qi-qin FU Gang {1. Gao-qing MIAO Jian-hua LIN Wei College of Agriculture Guangxi University Nanning 530004 P.R.China Guangxi Botanical Garden of Medicinal Plant Nanning 530023 P.R. China Microbiology Research institute Guangxi Academy of Agricultural Sciences Nanning 530007 P.R. China

Bacillus subtilis B47 is an endophytic bacterium of tomato, and produces substance that strongly inhibits the growth of Bipolaris maydis, the pathogen of southern corn leaf blight （SCLB）, as well as several other phytopathogenic fungi. The antifungal substance was purified from the broth culture of the bacterium using acid precipitation, methanol extraction, and three-step chromatography. Based on FT-IR spectrometry, amino acid composition, and MALDI-TOF-MS/MS CID analyses, the antifungal substance was identified as iturin A2, a cyclic lipopeptide antibiotic. To evaluate the efficacy of iturin A2 for control of SCLB, partially purified iturin A2 （75%, w/v） was applied under different conditions. At the concentration of 300 mg kg-1. iturin A2 showed efficacy ranging from 1.0 to 53.1. under in vitro, in plot and in field conditions. This efficacy was higher than or similar to that of the fungicide chlorothalonil. When the concentration of iturin A2 was increased to 500 mg kg-1. the control efficacy was enhanced to 64.2% in field, which was significantly higher than that of chlorothalonil. These results indicate that iturin A2 has potential for SCLB control and could be a substitute to synthetic fungicides. To our knowledge, this is the first report on using partially purified iturin A for control of SCLB under field conditions.

关键词： identification Bipolaris maydis biocontrol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

测土配方施肥对玉溪油菜生长与效益的影响

引用

贵州农业科学 2012年第3期40卷 65-68页

作者：李明福李玉萍陈克龙杨云冯宝瑞华国璧玉溪农业职业技术学院云南玉溪653100 玉溪农业科学研究所云南玉溪653100

为了指导当前生产条件下玉溪市红塔区研和镇油菜测土配方施肥技术的推广,于201.-201.年进行了常规施肥和配方施肥的对比试验,以研究氮、磷、钾和硼肥施用对油菜产量及其相关性状的影响。结果表明:油菜栽培以配方施肥效益最好,对油菜增... 详细信息

为了指导当前生产条件下玉溪市红塔区研和镇油菜测土配方施肥技术的推广,于201.-201.年进行了常规施肥和配方施肥的对比试验,以研究氮、磷、钾和硼肥施用对油菜产量及其相关性状的影响。结果表明:油菜栽培以配方施肥效益最好,对油菜增产、增收效果显著,是保证高效生产的技术关键;配方施肥中,施尿素522.0kg/hm2,普钙450.0kg/hm2,硫酸钾1.0.0kg/hm2,硼砂1..0kg/hm2,可获得3 433.5kg/hm2的产量和20 601.00元/hm2的产值。

关键词：油菜氮磷钾硼产量效益

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

不同施氮水平对黑钙土花生碳氮代谢相关酶活性、产量和品质的影响

引用

中国油料作物学报 2024年第1期46卷 122-128页

作者：赵跃吕永超陈小姝李美君郭峰高华援张志民李春雨吉林省农业科学院花生研究所吉林公主岭136100 山东省农业科学院农作物种质资源研究所山东济南250100

为探讨黑钙土花生适宜施氮量,本研究以吉花25为试验材料,共设置6个氮肥水平,分别为施用纯氮0、1.2.5(传统施肥,N1.、90(减氮20%)、79.5(减氮30%)、1.9(增氮40%)、225 kg/hm^(2)(增氮1.0%),研究了氮肥对花生碳氮代谢相关酶的活性、产量... 详细信息

为探讨黑钙土花生适宜施氮量,本研究以吉花25为试验材料,共设置6个氮肥水平,分别为施用纯氮0、1.2.5(传统施肥,N1.、90(减氮20%)、79.5(减氮30%)、1.9(增氮40%)、225 kg/hm^(2)(增氮1.0%),研究了氮肥对花生碳氮代谢相关酶的活性、产量和品质的影响。结果表明,施用氮肥会提高硝酸还原酶(NR)活性、谷氨酰胺合成酶(GS)活性和谷氨酸脱氢酶(GDH)活性、蔗糖合成酶(SS)和蔗糖磷酸合成酶(SPS)活性,但过量施用氮肥会抑制NR、GS、GDH、SS和SPS活性。各施氮处理产量均高于对照,在传统施肥的基础上减氮施肥20%(施氮量90 kg/hm^(2))时,花生产量最高,与对照相比增产9.21.,相较于传统施肥增产1.57%,说明减氮20%即可既满足花生生长发育的氮肥需求,同时又能保证叶片中碳氮代谢相关酶的活性,增强了花生对氮素的吸收与利用的能力,并通过降低单株秕果数和单株单果数,提高单株双果数、百果重和百仁重,最终提高花生产量。

关键词：花生氮肥水平产量品质碳氮代谢酶

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Jiao Tong University Spectroscopic Telescope Project

引用

Astronomical Techniques and Instruments 2024年第1期1卷 16-30页

作者： JUST Team Chengze Liu Ying Zu Fabo feng Zhaoyu Li Yu Yu {1. Bai Xiangqun Cui Bozhong Gu Yizhou Gu Jiaxin Han Yonghui Hou Zhongwen Hu Hangxin Ji Yipeng Jing Wei Li Zhaoxiang Qi Xianyu Tan Cairang Tian De{1. Yang Xiangyan yuan Chao Zhai Congcong Zhang Jun Zhang Haotong Zhang Pengjie Zhang Yong Zhang Yi Zhao Xianzhong Zheng Qingfeng Zhu Xiaohu Yang Tsung-Dao Lee institute Shanghai Jiao Tong UniversityShanghai 200240China Department of Astronomy School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Nanjing institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China University of chinese {1. of sciences NanjingNanjing 211135China University of chinese {1. of sciences Beijing 101408China Lenghu Technology Innovation Industrial Park Management Committee Lenghu 817400China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Department of Astronomy University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China

The Jiao Tong University Spectroscopic Telescope(JUST)is a 4.4-meter f/6.0 segmented-mirror telescope dedicated to spectroscopic *** JUST primary mirror is composed of 1. hexagonal segments,each with a diameter of 1.1.*** provides two Nasmyth platforms for placing science *** Nasmyth focus fits a field of view of 1.′and the other has an extended field of view of 1.2°with correction optics.A tertiary mirror is used to switch between the two Nasmyth *** will be installed at a site at Lenghu in Qinghai Province,china,and will conduct spectroscopic observations with three types of instruments to explore the dark universe,trace the dynamic universe,and search for exoplanets:(1.a multi-fiber(2000 fibers)medium-resolution spectrometer(R=4000-5000)to spectroscopically map galaxies and large-scale structure;(2)an integral field unit(IFU)array of 500 optical fibers and/or a long-slit spectrograph dedicated to fast follow-ups of transient sources for multi-messenger astronomy;(3)a high-resolution spectrometer(R~1.0000)designed to identify Jupiter analogs and Earth-like planets,with the capability to characterize the atmospheres of hot exoplanets.

关键词： Astronomical instrumentation Optical telescopes Large-scale structure of the universe Redshift surveys Time domain astronomy Exoplanet astronomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：