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Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-xiu yuan Qi-Gui Cai Zhen-Yang Zhang Jian-Zhong Zhou Cai-Yun Lan Jiang-Bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of debate.AIM To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database Article.Studies up to December 2022 comparing nCRT and nCT in patients with EC were selected.RESULTS The analysis revealed significant differences between nCRT and nCT in terms of disease-free survival.The results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than nCRT.Moreover,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for LAEC.However,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis

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Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

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BIOCELL 2024年第3期48卷 415-429页

作者： SHAN OU YUN XU QINGLAN LIU TIANWEN YANG WEI CHEN xiu yuan XIN ZUO PENG SHI JIE YAO Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical and Pharmaceutical CollegeChongqingChina

Background:The interrelation between intestinal polyps,metabolic syndrome(MetS),and colorectal cancer(CRC)is a critical area of study.This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation,metabolic irregularities,and CRC progression.Methods:We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps.Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes.These targets were then validated through immunohistochemistry(IHC).Following the RNA interference of key target expression,a series of experiments,including the cell counting kit-8 assay,colony formation,wound healing,and Transwell assays,were conducted.Results:Comparative analysis revealed 75 up-regulated and 61 down-regulated differentially expressed genes(DEGs)in the MetS polyp group vs.the control.Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment suggested these DEGs were primarily associated with cell cycle and mitosis.Integration with comparative toxicogenomics database(CTD)and the cancer genome atlas(TCGA)databases highlighted 44 key CRC-related genes.Protein interaction networks indicated connections of purkinje cell protein 4(PCP4),olfactomedin 1(OLFM1),fibronectin 1(FN1),and transforming growth factor beta 3(TGF-β3)with the mitogen-activated protein kinase(MAPK)pathway.Tumor correlation studies suggested higher risk associations with FN1,PCP4,and TGF-β3,while OLFM1 was identified as a lower risk gene.Immunohistochemical analysis revealed a decrease in OLFM1 in MetS-associated intestinal polyps.Upon interference with OLFM1 in polyp epithelial cells,there was a significant enhancement in cell proliferation,colony formation,and cell migration and invasion capabilities.Conclusion:Our study highlights a significant decrease in OLFM1 expression in MetS-associated intestinal polyps.And,this reduction in OLFM1 is associate

关键词： Colorectal cancer Metabolic syndrome Intestinal polyp OLFM1 Exosome

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Electronic property and topological phase transition in a graphene/CoBr_(2) heterostructure

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Chinese Physics B 2024年第2期33卷 498-505页

作者：秦元秀李胜世纪维霄张昌文 School of Physics and Technology Institute of SpintronicsUniversity of JinanJinan 250022China

Recently,significant experimental advancements in achieving topological phases have been reported in van der Waals(vdW)heterostructures involving graphene.Here,using first-principles calculations,we investigate graphene/CoBr_(2)(Gr/CoBr_(2))heterostructures and find that an enhancement of in-plane magnetic anisotropy(IMA)energy in monolayer CoBr_(2) can be accomplished by reducing the interlayer distance of the vdW heterostructures.In addition,we clarify that the enhancement of IMA energy primarily results from two factors:one is the weakness of the Co-d_(xy) and Co-d_(x^(2)-y^(2)) orbital hybridization and the other is the augmentation of the Co-d_(yz) and Co-d_(z)2 orbital hybridization.Meanwhile,calculation results suggest that the Kosterlitz–Thouless phase transition temperature(TKT)of a 2D XY magnet Gr/CoBr_(2)(23.8 K)is higher than that of a 2D XY monolayer CoBr_(2)(1.35 K).By decreasing the interlayer distances,the proximity effect is more pronounced and band splitting appears.Moreover,by taking into account spin–orbit coupling,a band gap of approximately 14.3 meV and the quantum anomalous Hall effect(QAHE)are attained by decreasing the interlayer distance by 1.0 A.Inspired by the above conclusions,we design a topological field transistor device model.Our results support that the vdW interlayer distance can be used to modulate the IMA energy and QAHE of materials,providing a pathway for the development of new low-power spintronic devices.

关键词： van der Waals heterostructure in-plane magnetic anisotropy energy quantum anomalous Hall effect

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CREM基因在miR-199b-5p敲除小鼠精液和睾丸中的表达研究

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中华男科学杂志 2024年第2期30卷 111-117页

作者：袁秀秀王煜内蒙古医科大学附属医院生殖医学中心内蒙古呼市浩特010000 大同市第三人民医院生殖医学科山西大同037000

目的:探讨miR-199b-5p基因敲除对雄性小鼠精液和睾丸中CREM表达水平的影响。方法:选miR-199b-5p基因敲除(KO)雄性小鼠和野生型(WT)雄性C57BL/6小鼠。观察2组小鼠体重和睾丸指数。HE染色观察睾丸结构变化。显微镜下观察精子形态及计数精... 详细信息

目的:探讨miR-199b-5p基因敲除对雄性小鼠精液和睾丸中CREM表达水平的影响。方法:选miR-199b-5p基因敲除(KO)雄性小鼠和野生型(WT)雄性C57BL/6小鼠。观察2组小鼠体重和睾丸指数。HE染色观察睾丸结构变化。显微镜下观察精子形态及计数精子浓度。数据库预测CREM与miR-199b-5p的靶向关系。RT-qPCR和Western印迹法分别检测2组小鼠睾丸中CREM mRNA和蛋白表达水平变化。结果:两组之间小鼠体重和睾丸指数无明显变化;与WT组比较,KO组小鼠精液精子计数稍下降,但无统计学差异(P>0.05);精液涂片示KO组精子浓度较WT组稀疏,但无统计学差异(P>0.05);睾丸病理示:与WT组比较,KO组睾丸体积较小,睾丸组织正常,生精小管可见各级生精细胞和支持细胞,生精小管界膜、管径无明显异常;数据库预测CREM基因是miR-199b-5p的靶基因;RT-qPCR结果示:与WT组比较,KO组雄鼠精液和睾丸组织中CREM mRNA表达水平均明显下降(P<0.05),差异有统计学意义。Western印迹结果显示:与WT组比较,KO组雄鼠睾丸组织中CREM蛋白表达水平明显下降(P<0.05),差异有统计学意义。随访半年,统计两组雄性小鼠出生数,发现KO组雄鼠的出生数较WT组明显下降(P<0.05)。结论:miR-199b-5p敲除小鼠精液和睾丸中CREM基因表达下调,推测miR-199b-5p可能靶向作用于CREM基因进而影响雄性小鼠的生育功能。

关键词： miR-199b-5p CREM基因精液睾丸

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Soil microbial properties under different vegetation types on Mountain Han

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Science China(Life Sciences) 2013年第6期56卷 561-570页

作者： WANG Miao QU LaiYe MA KeMing yuan xiu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-environmental ScienceChinese Academy of Sciences University of Chinese Academy of Sciences

This study investigated the influence of broadleaf and conifer vegetation on soil microbial communities in a distinct vertical distribution belt in Northeast China.Soil samples were taken at 0-5,5-10 and 10-20 cm depths from four vegetation types at different altitudes,which were characterized by poplar(Populus davidiana)(1250-1300 m),poplar(P.davidiana) mixed with birch(Betula platyphylla)(1370-1550 m),birch(B.platyphylla)(1550-1720 m),and larch(Larix principis-rupprechtii)(1840-1890 m).Microbial biomass and community structure were determined using the fumigation-extraction method and phospholipid fatty acid(PLFA) analysis,and soil fungal community level physiological profiles(CLPP) were characterized using Biolog FF Microplates.It was found that soil properties,especially soil organic carbon and water content,contributed significantly to the variations in soil microbes.With increasing soil depth,the soil microbial biomass,fungal biomass,and fungal catabolic ability diminished;however,the ratio of fungi to bacteria increased.The fungal ratio was higher under larch forests compared to that under poplar,birch,and their mixed forests,although the soil microbial biomass was lower.The direct contribution of vegetation types to the soil microbial community variation was 12%.If the indirect contribution through soil organic carbon was included,variations in the vegetation type had substantial influences on soil microbial composition and diversity.

关键词：微生物特性土壤样品植被类型土壤微生物生物量土壤有机碳真菌群落 BIOLOG 微生物群落

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Partitioning the effects of environmental and spatial heterogeneity on distribution of plant diversity in the Yellow River Estuary

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Science China(Life Sciences) 2012年第6期55卷 542-550页

作者： yuan xiu MA KeMing WANG De State Key Laboratory of Urban&Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Graduate University of Chinese Academy of Sciences Beijing 100049China yantai Institute of Coastal Zone Chinese Academy of SciencesYantai 264003China

For successful conservation and restoration of biodiversity,it is important to understand how diversity is regulated.In the ecological research community,a current topic of interest is how much of the variation in plant species richness and composition is explained by environmental variation(niche-based model),relative to spatial processes(neutral theory).The Yellow River Estuary(YRE) is a newly formed and fragile wetland ecosystem influenced by both the Yellow River and Bohai Bay.Here,we applied variance partitioning techniques to assess the relative effects of spatial and environmental variables on species richness and composition in the YRE.We also conducted a species indicator analysis to identify characteristic species for three subestuaries within the YRE.Partial redundancy analysis showed that the variations in species richness and composition were explained by both environmental and spatial factors.The majority of explained variation in species richness and composition was attributable to local environmental factors.Among the environmental variables,soil salinity made the greatest contribution to species abundance and composition.Soil salinity was the most important factor in the Diaokou subestuary,while soil moisture was the most important factor influencing species richness in the Qingshui and Chahe subestuaries.The combined effects of soil salinity and moisture determined species richness and composition in the wetlands.These results increase our understanding of the organization and assembly of estuarine plant communities.

关键词：空间异质性植物多样性河口环境黄河口湿地生态系统物种丰富度生物多样性保护分区

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高位堆积体远程滑坡动力侵蚀过程量化预测模型

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岩土力学 2024年第4期45卷 1190-1200页

作者：韩旭东杨秀元孙秀娟宋伟包一丁王春辉中国地质调查局水文地质环境地质调查中心自然资源部三峡库区地质灾害监测预警野外科学观测研究站重庆404700 中国地质调查局水文地质环境地质调查中心自然资源部地质环境监测工程技术创新中心河北保定071051 中国科学院山地灾害与环境研究所山地灾害与地表过程重点实验室四川成都610041

高位远程滑坡快速解体后,往往形成碎屑流,会沿程动力侵蚀坡体表层第四纪松散物质,改变滑坡滑移动力学特征,导致滑坡体积显著放大,灾害效应强烈,已成为近年来防灾减灾研究的重点。首先,针对高位堆积体远程滑坡动力侵蚀过程量化预测问题,... 详细信息

高位远程滑坡快速解体后,往往形成碎屑流,会沿程动力侵蚀坡体表层第四纪松散物质,改变滑坡滑移动力学特征,导致滑坡体积显著放大,灾害效应强烈,已成为近年来防灾减灾研究的重点。首先,针对高位堆积体远程滑坡动力侵蚀过程量化预测问题,基于深度积分水动力计算理论与固液两相界面剪应力侵蚀模型架构,构建了高位堆积体远程滑坡动力侵蚀过程量化预测的连续介质数值模型,自主进行了数值实现,编制了具有二阶计算精度的软件程序DisasterFlowV1.0。然后,通过经典的溃坝水流算例验证,结果表明所构建的数值模型的数值求解格式正确并具有较好的总变差不增特性(total variation diminishing,TVD)。再后,通过对柏杨林高位堆积体远程滑坡案例动力侵蚀过程预测可知,所构建的数值模型与传统雪橇模型对该滑坡滑移速度预测结果基本一致,但相较于传统雪橇模型,所构建的数值模型对滑动路径地形的适应能力强,滑移速度预测值振荡性较小。最后,利用所构建的数值模型在时间和空间维度上对柏杨林高位堆积体远程滑坡的动力侵蚀过程进行量化表达,结果表明所构建的数值模型能够对该滑坡动力侵蚀过程中各历时的滑移深度、速度及侵蚀堆积深度进行量化,这是传统雪橇模型所不具备的。所做研究可充实高位远程滑坡动力侵蚀过程量化预测理论与技术体系。

关键词：高位远程滑坡动力侵蚀数值模型 DisasterFlowV1.0 量化预测

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信息技术2.0背景下内蒙古中小学教师TPACK知识发展研究

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阴山学刊 2024年第4期37卷 99-105,112页

作者：袁秀利包头师范学院学报编辑部内蒙古包头014030

通过向内蒙古东部、中部和西部1492名中小学一线教师发放调查问卷量表,获取了中小学教师TPACK的整体情况、中小学教师TPACK各维度情况、教师TPACK不同变量的差异性数据。结合访谈,发现教师TK水平、教师教学经验、教师课堂教学设计、教... 详细信息

通过向内蒙古东部、中部和西部1492名中小学一线教师发放调查问卷量表,获取了中小学教师TPACK的整体情况、中小学教师TPACK各维度情况、教师TPACK不同变量的差异性数据。结合访谈,发现教师TK水平、教师教学经验、教师课堂教学设计、教师教学学术、职后培训是影响中小学教师TPACK发展的五大核心因素。基于《教育部关于实施全国中小学教师信息技术应用能力提升工程2.0的意见》的指导思想,重视发挥校长的信息化领导力、挖掘教师TPACK的个体生成力、发挥教师TPACK协同互助促进力、提升校本培训团队信息化指导力,是针对内蒙古中小学教师TPACK知识发展问题而提出的策略。

关键词：信息技术内蒙古中小学教师 TPACK

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划分聚类法在短历时雨型设计中的应用

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中国给水排水 2024年第3期40卷 113-119页

作者：金灿袁文秀周宏刘俊河海大学水文水资源学院江苏南京210098 江苏省水利工程规划办公室江苏南京210029

为更好地反映短历时暴雨特征,对雨型进行分类,基于四川省乐山国家基准气候站1981年—2021年逐分钟降雨数据资料,使用多种方法对90场历时60 min、78场历时120 min和86场历时180 min降雨选取最佳聚类数,采用K-means聚类和PAM聚类两种方法... 详细信息

为更好地反映短历时暴雨特征,对雨型进行分类,基于四川省乐山国家基准气候站1981年—2021年逐分钟降雨数据资料,使用多种方法对90场历时60 min、78场历时120 min和86场历时180 min降雨选取最佳聚类数,采用K-means聚类和PAM聚类两种方法对雨型进行分析。结果表明,K-means聚类法对城市短历时暴雨雨型分类的结果比PAM聚类法更直观有效;乐山气候站历时60 min的雨型分为3类、历时120 min的雨型分为2类、历时180 min的雨型分为3类,单峰靠前的雨型最为常见。研究结果可为乐山市海绵城市建设、排水防涝规划等提供参考,同时可为机器学习在设计暴雨雨型研究中的应用提供新思路。

关键词：设计暴雨雨型划分聚类 K-means聚类 PAM聚类乐山市

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装备试验鉴定数字化转型需求思考

实验室检测

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实验室检测 2024年第2期2卷 74-77页

作者：唐秀媛 32200部队锦州121000

在军队现代化进程加快的背景下,装备环境适应能力试验与评估显得尤为重要。然而,目前装备试验鉴定工作还不能适应新制度下的装备检测与评估的需求,亟须对其进行系统梳理与分析。我国已建立起较为完备的试验系统,无论是在硬件装备的建设... 详细信息

在军队现代化进程加快的背景下,装备环境适应能力试验与评估显得尤为重要。然而,目前装备试验鉴定工作还不能适应新制度下的装备检测与评估的需求,亟须对其进行系统梳理与分析。我国已建立起较为完备的试验系统,无论是在硬件装备的建设还是在试验人员的培训方面都有了长足的发展。在单体系武器装备评估试验中,其管理和技术也比较成熟、完备。为此,本文提出装备试验鉴定数字化转型的新型体系下装备环境适应能力试验验证的整体思路,把握试验识别全过程的关键环节,对装备进行全面评价。

关键词：装备试验鉴定数字化转型需求

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