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Design,synthesis,and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors

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Journal of Pharmaceutical Analysis 2022年第4期12卷 653-663页

作者： yuan-yuan Hei Si Wang Xiao-Xiao Xi Hai-Peng Wang yuanxu Guo Minhang Xin Congshan Jiang Shemin Lu San-Qi Zhang Department of Medicinal Chemistry School of PharmacyXi'an Jiaotong University Health Science CenterXi'an710061China Institute of Molecular and Translational Medicine(IMTM) and Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesXi'an Jiaotong University Health Science CenterXi'an710061China Key Laboratory of Environment and Genes Related to Diseases(Xi'an Jiaotong University) Ministry of EducationXi'an710061China Department of Medical Oncology Shaanxi Provincial People's HospitalXi'an710068China

MicroRNA-21(miRNA-21)is highly expressed in various ***-molecule inhibition of miRNA-21 is considered to be an attractive novel cancer therapeutic *** this study,fluoroquinolone derivatives A1eA43 were synthesized and used as miRNA-21 *** A36 showed the most potent inhibitory activity and specificity for miRNA-21 in a dual-luciferase reporter assay in HeLa *** A36 significantly reduced the expression of mature miRNA-21 and increased the protein expression of miRNA-21 target genes,including programmed cell death protein 4(PDCD4)and phosphatase and tensin homology deleted on chromosome ten(PTEN),at 10 μM in HeLa *** Cell Counting Kit-8 assay(CCK-8)was used to evaluate the antiproliferative activity of A36;the results showed that the IC_(50) value range of A36 against six tumor cell lines was between 1.76 and 13.0 μ***,A36 did not display cytotoxicity in BEAS-2B cells(lung epithelial cells from a healthy human donor).Furthermore,A36 significantly induced apoptosis,arrested cells at the G_(0)/G_(1) phase,and inhibited cell-colony formation in HeLa *** addition,mRNA deep sequencing showed that treatment with A36 could generate 171 dysregulated mRNAs in HeLa cells,while the expression of miRNA-21 target gene dual-specificity phosphatase 5(DUSP5)was significantly upregulated at both the mRNA and protein ***,these findings demonstrated that A36 is a novel miRNA-21 inhibitor.

关键词： Quinolone derivatives Small-molecule miRNA-21 inhibitor Antitumor agent Drug design

Extraordinary hot extreme in summer 2022 over the Yangtze River basin modulated by the La Nina condition under global warming

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Advances in Climate Change Research 2024年第1期15卷 21-30页

作者： Zhen LIAO Yu-Feng yuan Yang CHEN Pan-Mao ZHAI State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China

A widespread and prolonged hot extreme hit the Yangtze River basin in summer 2022,with 300 sites established new temperature records and nearly 96%stations endured more than 40 hot *** the perspective of the combination effect of the global warming and La Nina condition,potential mechanisms of the hot extreme were *** a record-breaking hot extreme was caused by an extremely strong and westward-shifted western Pacific subtropical high(WPSH).The global warming effect contributed primarily to the abnormal hot days in the Yangtze River basin,coupled with the modulation of the La Nina *** sea surface temperature anomaly pattern under La Nina condition favored more convection activities over the western Pacific,encouraging an enhanced and westward-extended *** addition,an observation-based attribution analysis indicates that anthropogenic warming may increase the probability of such extensively persistent hot extremeby1.8 times.

关键词： Hot extreme The Yangtze River basin Global warming Tropical Pacific forcing

On the k-error linear complexity of 2p~2-periodic binary sequences

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Science China(Information Sciences) 2020年第9期63卷 263-276页

作者： Zhihua NIU Can yuan Zhixiong CHEN Xiaoni DU Tao ZHANG School of Computer Engineering and Science Shanghai University College of Mathematics and Statistics Northwest Normal University Provincial Key Laboratory of Applied Mathematics Putian University

Dear editor,Pseudorandom sequences play an important role in cryptography. In particular in symmetric cryptography they serve as the secret key. So the designs of pseudorandom sequences and cryptographic indicators ar...

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Semi-Empirical Algorithm for Wind Speed Retrieval from Gaofen-3 Quad-Polarization Strip Mode SAR Data

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Journal of Ocean University of China 2020年第1期19卷 23-35页

作者： ZHU Shuai SHAO Weizeng MARINO Armando SUN Jian yuan Xinzhe Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316000China Natural Sciences University of StirlingStirling FK94LAUK Physical Oceanography Laboratory Ocean University of ChinaQingdao 266100China Key Laboratory of Space Ocean Remote Sensing and Application National Satellite Ocean Application ServiceBeijing 100081China

Synthetic aperture radar(SAR)is a suitable tool to obtain reliable wind retrievals with high spatial *** geophysical model function(GMF),which is widely employed for wind speed retrieval from SAR data,describes the relationship between the SAR normalized radar cross-section(NRCS)at the copolarization channel(vertical-vertical and horizontal-horizontal)and a wind ***-measured NRCS at cross-polarization channels(horizontal-vertical and vertical-horizontal)correlates with wind *** this study,a semi-empirical algorithm is presented to retrieve wind speed from the noisy Chinese Gaofen-3(GF-3)SAR data with noise-equivalent sigma zero correction using an empirical ***-3 SAR can acquire data in a quad-polarization strip mode,which includes cross-polarization *** semi-empirical algorithm is tuned using acquisitions collocated with winds from the European Center for Medium-Range Weather *** particular,the proposed algorithm includes the dependences of wind speed and incidence angle on cross-polarized *** accuracy of SAR-derived wind speed is around 2.10ms−1 root mean square error,which is validated against measurements from the Advanced Scatterometer onboard the Metop-A/B and the buoys from the National Data Buoy Center of the National Oceanic and Atmospheric *** results obtained by the proposed algorithm considering the incidence angle in a GMF are relatively more accurate than those achieved by other *** work provides an alternative method to generate operational wind products for GF-3 SAR without relying on ancillary data for wind direction.

关键词： wind Gaofen-3 synthetic aperture radar cross-polarization

Flower-like tin oxide membranes with robust three-dimensional channels for efficient removal of iron ions from hydrogen peroxide

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Chinese Journal of Chemical Engineering 2024年第1期65卷 1-7页

作者： Risheng Shen Shilong Li Yuqing Sun yuan Bai Jian Lu Wenheng Jing State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 210009China National Energy Group Science and Technology Research Institute Co. Ltd.Nanjing 210023China

Membrane technology has become the mainstream process for the production of electronic grade hydrogen peroxide(H_(2)O_(2)).But due to the oxidation degradation of the organic membranes(***)by the strong oxidative radicals(e.g.OH)generated via the activation of H_(2)O_(2)by iron ions(Fe^(3+)),the short effective lifetime of membranes remains a *** nano tin oxide(SnO_(2))has great potential for the removal of Fe^(3+)in strongly oxidative H_(2)O_(2)because of its ability to stabilize H2O_(2)and preferentially adsorb Fe^(3+).Herein,we have designed for the first time a flower-like robust SnO_(2)membrane on the ceramic support by in situ template-free one-step hydrothermal *** three-dimensional loose pore structure in the membrane built by interlacing SnO_(2)nanosheets endows the SnO_(2)membrane with a high specific surface area and abundant adsorption sites(AOH).Based on the coordination complexation and electrostatic attraction between the SnO_(2)surface and Fe^(3+),the membrane shows a high Fe3+removal efficiency(83%)and permeability(24 L·m^(-2)·h^(-1)·MPa^(-1))in H_(2)O_(2).This study provides an innovative and simple approach to designing robust SnO_(2)membranes for highly efficient removal of Fe^(3+)in harsh environments,such as strong oxidation conditions.

关键词： Hydrogen peroxide SnO_(2)membrane Adsorption Hydrothermal

Globalization and Voluntary Environmental Management in Developing Countries

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2014年第1期9卷 138-163页

作者： Madhu Khanna yuan Liao Department of Agricultural and Consumer Economics University of Illinois at Urbana-Champaign. Urbana IL 61801 USA

Weak capacity to enforce regulations and sanction violators, and an emphasis on economic growth in developing countries has led to concerns about worsening environmental conditions and the potential for these countries becoming pollution havens for multinational corporations. International environmental standards, voluntary programs, and public disclosure programs have gained popularity because they engage market participants in providing incentives for self-regulation and have the potential to substitute for the lack of domestic regulatory capacity. This paper analyzes the motivations for firms to undertake voluntary environmental management and reviews the empirical evidence on the type of firms participating in such initiatives and their effectiveness in improving environmental performance. We also consider the special case of China that has witnessed dramatic globalization following its acceptance into the World Trade Organization and participation by its firms in global supply chains. We conclude with a discussion of the effectiveness of these efforts as a substitute for weak regulatory and civic society pressures in these countries.

关键词： voluntary programs ISO 14001 public disclosure programs,foreign direct investment export-oriented firms

From Polymerization Inhibition to Controlled Ring-Opening Metathesis Polymerization of Macromonomers with Tertiary Amine Groups:The Effect of Spacer Chain

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Chinese Journal of Chemistry 2021年第7期39卷 1927-1935页

作者： Tengda Zhao Kongying Zhu Xiaoliang Yu Xiaoyan yuan Lixia Ren School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350 China Analysis and Measurement Center Tianjin UniversityTianjin300072 China

Main observation and conclusion Ring-opening metathesis polymerization(ROMP)is a powerful toolbox in preparation of bottlebrush polymers for its high ***,the ROMP of macromonomers with repeating tertiary amine groups,... 详细信息

关键词： Bottlebrush polymers Metathesis Polymerization inhibition Ring-opening polymerization Amines

Climatic effects on soil organic nitrogen fractions and amino acid chirality in paddy soils

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Pedosphere 2023年第4期33卷 579-588页

作者： Qiang LI Jin WANG Hezhong yuan Baoshan CHEN Shunyao ZHUANG State Key Lab of Soil and Agricultural Sustainability Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) School of Environmental Science and Engineering Nanjing University of Information Science&TechnologyNanjing 210044(China) School of Marine and Atmospheric Sciences Stony Brook UniversityStony Brook NY 11794(USA)

Soil organic nitrogen(ON)accounts for more than 90%of the total nitrogen(TN)in paddy *** understanding of the different ON fractions in paddy soils and their corresponding bioavailability under different climatic conditions has constrained the development of appropriate nutrient management strategies for rice *** this study,we applied a modified Bremner method coupled with high-performance liquid chromatography to characterize how soil ON fractions and amino acid chirality varied under different climatic conditions at five typical rice production sites along a latitudinal *** to the results,climate had no obvious influence on TN,nitrogen(N)form,and individual amino acid ***,the proportions of various N forms in TN had linear relationships with annual mean temperature(AMT),with high correlation coefficient(r)*** acid components also exhibited similar trends,with r as high as *** notably,consistent linear relationships were observed between the D/L ratios of several amino acids and AMT in paddy soils(r=0.18–0.92).Findings of this study provide insights into ON and amino acid dynamics in paddy soil systems under intensive production along climate gradients.

关键词： amino acid-N amino sugar-N annual mean temperature D/L ratio hydrolysable ammonium-N rice total hydrolysable N unhydrolysable N

Risk-preparedness mechanism and audit quality:Evidence from mandatory increase of professional indemnity insurance and professional risk fund

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China Journal of Accounting Research 2023年第1期16卷 103-125页

作者： Yue Qi Qingbo yuan School of Business Sun Yat-sen UniversityGuangzhouChina Department of Accounting The University of MelbourneAustralia

We examine the risk-preparing benefits of Chinese audit firms’professional indemnity insurance(PII)and professional risk fund(PRF)by using the Notice on Adjusting the Application Requirement of Audit Firms for Securities Qualifications as an exogenous *** policy requires audit firms to raise the sum of the cumulative compensation limit of their PII and PRF from 6 million to 80million *** is found,first,that the capital market regards this policy revision as a signal to strengthen investor protection and responds positively;client firms with high audit risks have a stronger ***,auditors’governance of financial information has strengthened,resulting in the significant improvement of their clients’financial reporting quality,with a stronger effect on firms with higher earnings management *** is no evidence that audit firms pass the costs on to their ***,the mismatch between auditors and new client firms is *** show that in an emerging market with weak investor protection,establishing a sound risk-preparedness mechanism for audit firms and strengthening the capacity for civil compensation ex post greatly improve the adaptive degree between international auditing standards and the legal environment of China,thereby enhancing the overall service quality of the audit market.

关键词： Professional indemnity insurance Professional risk fund Audit quality Audit fees Auditor allocation