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Specific photoacoustic cavitation through nucleus targeted nanoparticles for high-efficiency tumor therapy

Nano Research 2020年第3期13卷 719-728页

作者： yuan wang Guangle Niu Shaodong Zhai Wenjia Zhang Da Xing MOE Key Laboratory cf Laser Life Science&Institute of Laser Life Science South China Normal UniversityGuangzhou 510631China College of Biophotonics South China Normal UniversityGuangzhou 510631China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute cf Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Pharmacology&Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong Kongt PokfulamHong KongChina

As a new type of cancer treatment,photoacoustic(PA)therapy is based on PA shockwave for rapid,selective and effective killing of cancer *** nucleus has been widely used as a target for tumor therapy,which has obtained a very considerable therapeutic *** situ destruction of tumor cell nucleus by photoacoustic therapy has not been *** this paper,a highly efficient nucleus-targeted photoacoustic theranostic polymer was developed for fluorescence and photoacoustic dual-mode imaging-guided PA *** prepared polymer consists of nucleus targeting TAT peptide(TAT:YGRKKRRQRRR),hydrophilic chain poly(N,N-dimethylacrylamide)(PDMA),and near-infrared(NIR)light absorbing agent(hCyR),which can self-assemble to form nanoparticles of approximately 28 nm(denoted as TAT-PDMA-hCyR NPs).The designed nanoparticles show excellent nucleus targeting and tumor cell death(up to 80%)caused by DNA damage under pulsed laser irradiation compared to non-nucleus target counterpart PDMA-hCyR NPs without TAT peptide in *** expected,the fluorescence and PA dual-mode imaging observed that TAT-PDMA-hCyR NPs were able to passively target and enrich in tumors,providing an experimental basis for in vivo treatment and thus ensuring a significant tumor inhibition rate(about 92%).In conclusion,this study provides a new and practicable method for the development of nucleus-targeting nanoparticles as potential theranostic agent for in vivo cancer imaging and therapy.

关键词： photoacoustic therapy nucleus near-infrared light targeted therapy

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Coronary CT Angiography Using Low Iodine Delivery Rate and Tube Voltage Determined by Body Mass Index:Superiority in Clinical Practice

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Current Medical Science 2019年第5期39卷 825-830页

作者： wang yuan Ting-ting QU Hui-juan wang Mei-yu wang yuan QU Gang NIU Jian YANG Department of Diagnostic Radiology the First Hospital of Medical Science CentreXi'an Jiaotong UniversityXi'an 710061China Department of Dermatology the Ninth Hospital of Xi'anXi'an 710054China

To explore the feasibility and superiority of iodine delivery rate(IDR)and tube voltage determined by patients'body mass index(BMI)in coronary CT angiography(CCTA),a total of 1567 patients undertaking CCTA during *** Dec.2016 were enrolled and divided into two *** the control group,the IDR and tube voltage were fixed,while in the experimental group,the IDR and tube voltage were determined by patients,*** volume of iodinated contrast media(ICM),extravasation rate,extravasation volume,extravasation recovery interval,incidence rate of adverse reactions,effective dose(ED)and image quality of the two groups were *** experiments demonstrated that the ICM volume,extravasation rate,extravasation volume,extravasation recovery interval,incidence of adverse reactions and ED were lower or shorter in the experimental group than in the control group,and the differences were statistically significant(all P<0.05).However,there were no significant differences in the mean CT value,image noise,signal to noise ratio and contrast to noise ratio between the two groups(all P<0.05),which were consistent with the diagnosticians*subjective evaluation *** findings suggested that in CCTA,it is feasible to determine the IDR and tube voltage based on patients'BMI;low tube voltage and IDR are superior to the fixed tube voltage and IDR and are worthy of clinical promotion.

关键词： iodinated contrast media iodine delivery rate tube voltage ICM extravasation adverse reactions

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A novel excitation controller using support vector machines and approximate models

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控制理论与应用（英文版） 2008年第3期6卷 239-245页

作者： Xiaofang yuan Yaonan wang Shutao LI College of Electrical and Information Engineering Hunan University Changsha Hunan 410082 China

This paper proposes a novel excitation controller using support vector machines （SVM） and approximate models. The nonlinear control law is derived directly based on an input-output approximation method via Taylor expansion, which not only avoids complex control development and intensive computation, but also avoids online learning or adjustment. Only a general SVM modelling technique is involved in both model identification and controller implementation. The robustness of the stability is rigorously established using the Lyapunov method. Several simulations demonstrate the effectiveness of the proposed excitation controller.

关键词： Support vector machines Nonlinear control Approximate model Neural networks Identification

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Force Compensation Control for Electro-Hydraulic Servo System with Pump-Valve Compound Drive via QFT-DTOC

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 228-246页

作者： Kaixian Ba yuan wang Xiaolong He Chunyu wang Bin Yu Yaliang Liu Xiangdong Kong Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Qinhuangdao 066004China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China National Engineering Research Center for Local Joint of Advanced Manufacturing Technology and Equipment Yanshan UniversityQinhuangdao 066004China

Each joint of a hydraulic-driven legged robot adopts a highly integrated hydraulic drive unit(HDU),which features a high power-weight ***,most HDUs are throttling-valve-controlled cylinder systems,which exhibit high energy *** contrast,pump control systems offer a high ***,their response ability is *** fully utilize the advantages of pump and valve control systems,in this study,a new type of pump-valve compound drive system(PCDS)is designed,which can not only effectively reduce the energy loss,but can also ensure the response speed and response accuracy of the HDUs in robot joints to satisfy the performance requirements of ***,considering the force control requirements of energy conservation,high precision,and fast response of the robot joint HDU,a nonlinear mathematical model of the PCDS force control system is first *** addition,pressure-flow nonlinearity,friction nonlinearity,load complexity and variability,and other factors affecting the system are considered,and a novel force control method based on quantitative feedback theory(QFT)and a disturbance torque observer(DTO)is designed,which is denoted as QFT-DTOC *** method improves the control accuracy and robustness of the force control system,reduces the effect of the disturbance torque on the control performance of the servo motor,and improves the overall force control performance of the ***,experimental verification is performed using the PCDS performance test *** experimental results and quantitative data show that the QFT-DTOC proposed herein can significantly improve the force control performance of the *** relevant force control method can be used as a bottom-control method for the hydraulic servo system to provide a foundation for implementing the top-level trajectory planning of the robot.

关键词： Legged robot Pump-valve compound drive system(PCDS) Force compensation control Quantitative feedback theory(QFT) Disturbance torque observer(DTO)

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Enhanced-hydrogen gas production through underground gasification of lignite

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Mining Science and Technology 2009年第3期19卷 389-394页

作者： LIU Shu-qin wang yuan-yuan ZHAO Ke YANG Ning School of Chemistry and Environmental Engineering China University of Mining ＆ Technology Beijing 100083 China

Underground coal gasification is one of the clean technologies of in-situ coal *** production from underground gasification of lignite was investigated in this study based on simulation *** of lignite, gasification activity, oxygen-steam gasification and the effect of groundwater influx were *** well, the advantages of lignite for stable underground gasification were *** results indicate that lignite has a high activity for *** pyrolysis is an important source of hydrogen *** special heating conditions, hydrogen is released from coal seams at temperatures above 350 °C and reaches its maximum value between 725 and 825 °*** with a hydrogen concentration of 40% to 50% can be continuously obtained by oxygen-steam injection at an optimum ratio of steam to oxygen, while lignite properties will ensure stable *** influx can be utilized for hydrogen preparation under certain geological conditions through pressure ***, enhanced-hydrogen gas production through underground gasification of lignite has experimentally been proved.

关键词： underground coal gasification hydrogen lignite

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Discovery of Balmer broad absorption lines in the quasar LBQS 1206+1052

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Research in Astronomy and Astrophysics 2012年第4期12卷 369-382页

作者： Tuo Ji Ting-Gui wang Hong-Yan Zhou Hui-yuan wang Key Laboratory for Research in Galaxies and Cosmology University of Science and Technology of China （USTC） Hefei 230026 China Center for Astrophysics USTC Hefei 230026 China Polar Research Institute of China Shanghai 200136 China

We report the discovery of Balmer broad absorption lines （BALs） in the quasar LBQS 1206＋1052 and present a detailed analysis of the peculiar absorption line spectrum. Besides the Mg II λλ2796, 2803 doublet, BALs are also detected in the He I＊ multiplet at λλ2946, 3189, 3889 A arising from the metastable helium 2 3 S level, and in Hα and Hβ from the excited hydrogen H I＊ n = 2 level, which are rarely seen in quasar spectra. We identify two components in the BAL troughs of v ～ 2000 km s 1 width： One component shows an identical profile in H I＊, He I＊ and Mg II with its centroid blueshifted by v c ≈ 726 km s-1 . The other component is detected in He I＊ and Mg II with v c ≈ 1412 km s-1 . We estimate the column densities of H I＊, He I＊, and Mg II, and compare them with possible level population mechanisms. Our results favor the scenario that the Balmer BALs originate in a partially ionized region with a column density of N H ～ 10 21 10 22 cm-2 for an electron density of n e ～ 10 6 10 8 cm-3 via Lyα resonant scattering pumping. The harsh conditions needed may help to explain the rarity of Balmer absorption line systems in quasar spectra. With an i-band PSF magnitude of 16.50, LBQS 1206＋1052 is the brightest Balmer-BAL quasar ever reported. Its high brightness and unique spectral properties make LBQS 1206＋1052 a promising candidate for followup high-resolution spectroscopy, multi-band observations, and long-term monitoring.

关键词： galaxies active -- quasar absorption lines -- quasar individual (LBQS1206+1052)

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Signal modeling and impulse response shaping for semiconductor detectors

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Nuclear Science and Techniques 2022年第4期33卷 72-82页

作者： Xue-yuan wang Jian-Bin Zhou Ming wang Huai-Ping wang Xu Hong Yi Liu Ping Huang College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyErxian BridgeNo.1 East 3 RoadChenghua DistrictChengdu 610059China Jiangxi Engineering Technology Research Center of Nuclear Geoscience Data Science and System East China University of TechnologyNanchang 330013China China Testing Technology Co. LtdChengdu 610021China

The output-signal models and impulse response shaping(IRS)functions of semiconductor detectors are important for establishing high-precision measurement *** this paper,an output-signal model for semiconductor detector systems is *** to the proposed model,a multistage cascade deconvolution IRS algorithm was developed using the C-R inverse system,R-C inverse system,and differentiator *** silicon drift detector signals acquired from the analog-to-digital converter were *** experimental results indicated that the shaped pulses obtained using the proposed model had no undershoot,and the average peak base width of the output shaped pulses was reduced by 36%compared with that for a simple model proposed in a previous work[1].Offline processing results indicated that compared with the traditional IRS algorithm,the average peak base width of the output shaped pulses obtained using the proposed algorithm was reduced by 11%,and the total elapsed time required for pulse shaping was reduced by 26%.The proposed algorithm avoids recursive *** the sampling frequency of the digital system reaches 100 MHz,the proposed algorithm can be simplified to integer *** proposed IRS algorithm can be applied to high-resolution energy spectrum analysis,highcounting rate energy spectrum correction,and coincidence and anti-coincidence measurements.

关键词： Output-signal model Impulse response shaping C-R inverse system R-C inverse system Integer arithmetic

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New Progress and Challenges in Cloud–Aerosol–Radiation–Precipitation Interactions:Preface for a Special Issue※

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Advances in Atmospheric Sciences 2022年第12期39卷 1983-1985页

作者： Chuanfeng ZHAO yuan wang Husi LETU Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Department of Earth Atmosphericand Planetary SciencesPurdue UniversityWest LafayetteIN 47907USA State Key Laboratory of Remote Sensing Science The Aerospace Information Research InstituteChinese Academy of Sciences(CAS)Beijing 100101China

Clouds play essential roles in the Earth’s radiative energy balance and global hydrological ***,the particles suspended in the air,can change cloud properties by interacting with radiation or serving as cloud condensation ***,the variations in cloud properties subjected to aerosol context,and their impacts on radiation and precipitation,are related to many complicating factors such as land types,meteorological conditions,cloud types,aerosol properties,and their co-varied *** of cloud-aerosol-radiation-precipitation interactions makes representation of clouds one of the largest uncertainties in climate models for future climate *** has also become a prevailing topic in atmospheric sciences over the past several decades.

关键词： Cloud aerosol prevailing

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Incomplete radiofrequency ablation promotes the development of CD133+cancer stem cells in hepatocellular carcinoma cell line HepG2 via inducing SOX9 expression

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 416-422页

作者： Chun-wang yuan Zhen-Chang wang Kai Liu Dong-Jie Liu Department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Center of Interventional Oncology and Liver Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing 100069China Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer Beijing 100069China Department of Biochemistry and Molecular Biology Baotou Medical CollegeBaotou 014040China

Background: Cancer stem cells(CSCs) accelerate the growth of hepatocellular carcinoma(HCC) residual after incomplete radiofrequency ablation(In-RFA). The present study aimed to detect the effects of In-RFA on stemness transcription factors(STFs) expression which are important for the production and function of CSCs, and to find which STFs promote HCC stemness after In-RFA. Methods: HepG2 cells were used for in vitro and in vivo studies. Flow cytometry and sphere-formation assays were used to detect the level and function of CD133~+ CSCs in the models. PCR array and ELISA were applied to analyze the altered expression of 84 STFs in CD133~+ CSCs in two models. Specific lentiviral shRNA was used to knockdown STFs expression, followed by detecting In-RFA’s effects on the levels and function of CD133~+ CSCs. Results: In-RFA was identified to induce CD133~+ CSCs and increase their tumorigenesis ability in vitro and in vivo. The mRNA levels of 84 STFs in CD133~+ CSCs were detected by PCR array, showing that 15 and 22 STFs were up-regulated in two models, respectively. Meanwhile, the mRNA levels of seven common STFs were up-regulated in both models. ELISA assay demonstrated that only the protein of sex determining region Y-box 9(SOX9) was up-regulated in both models, the protein levels of the other 6 common STFs did not increase in both models. Finally, SOX9 was identified to play an important role in inducing, maintaining stemness and promoting tumorigenesis ability of CD133~+ CSCs in both models. Conclusion: In-RFA-induced SOX9 stimulates CD133~+ CSCs proliferation and increases their tumorigenesis ability, suggesting that SOX9 may be a good target for HCC treatment.

关键词： Hepatocellular carcinoma Radiofrequency ablation HepG2 Cancer stem cells

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Reconstructing Equation of State for Dark Energy in Double Complex Symmetric Gravitational Theory

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Communications in Theoretical Physics 2007年第6期47卷 1148-1152页

作者： SHAO Ying GUI yuan-Xing wang Wei Department of Physics Dalian University of Technology Dalian 116023 China

We propose to study the accelerating expansion of the universe in the double complex symmetric gravitational theory （DCSGT）. The universe we live in is taken as the real part of the whole spacetime MC^4（J）, which is double complex. By introducing the spatially flat FRW metric, not only the double Friedmann equations but also the two constraint conditions py = 0 and J^2 = 1 are obtained. Farthermore, using parametric DL（z） ansatz, we reconstruct the ω/（z） and V（Ф） for dark energy from real observational data. We find that in the two cases of J = i, pJ = 0, and J = ε, pJ≠0, the corresponding equations of state ω＇（z） remain close to -1 at present （z = 0） and change from below -1 to above -1. The results illustrate that the whole spacetime, i.e. the double complex spacetime MC^4（J）, may be either ordinary complex （J = i, pJ = 0） or hyperbolic complex （J = ε, pJ≠ 0）. And the fate of the universe would be Big Rip in the future.

关键词： double complex symmetric gravitational theory equation of state dark energy

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